Gene

KWMTBOMO13686

Pre Gene Modal

BGIBMGA011023

Annotation

PREDICTED:_lysine-specific_histone_demethylase_1A_[Bombyx_mori]

Location

Bomo_Chr23(-):6780050-6791259      View in EpiBrowser

Full name

Probable lysine-specific histone demethylase 1       + More
Lysine-specific histone demethylase      

Location in the cell

PlasmaMembrane   Reliability : 1.591

CDS

ATGTCGTTAAAGTGTGATGATAACGCTAAAGAGTACAAAATAACGTACTTTCGTAACGGGTATTCCTGCGTGCCCGTCGCTCTGTCAGAAGACTTGGACATCAGGCTCGGGACCTCGGTAACTGATATCAACTACGAAGGCCCAGGAGTAACAGTTAAAGCTAATAGTTCTCGCAATCCGAACCAGCCACAGGTCTTTAAAGGAGATGTAGTCTTATGTACATTGCCTTTGGGAGTGTTAAAGGTTGCAGTGGCAAGCAATGGACAGAATCAACAGAACTTCACCACTTTTAATCCCCCCCTGCCCGAGTGGAAGGTGGCAGCTATCAAGCGTCTCGGTTATGGAAATTTGAACAAAGTGGTTTTGTGCTTCGAACGAACCTTCTGGGACCCGAGTGCCAATCTATTTGGGCACGTTGGTACGACCACCGCAAGCAGAGGAGAACTTTTCCTTTTCTGGAACCTCTATAGTGCGCCGGTACTCCTAGCTTTGGTAGCAGGAGAGGCAGCGGCTGTAATGGAAAACGTCACCGATGACGTCATCGTCGGTAGATGTATCGCCGTACTGAAGAGCATATTTGGTCACGCGGCCGTGCCGCAACCCAAAGAATGCATAGTAACTAGATGGCGTGCCGATCCATTCGCTCGCGGCTCGTACAGTTTTGTAGCGGTAGGGTCGTCTGGTACTGACTACGATCTCCTGGCCGCCCCTATACCTGGAACTGATGGAGAGAATAGACTTTTCTTTGCCGGTGAGCACACGATGCGGAACTATCCAGCAACGGTGCACGGAGCATTCTTATCGGGTTTAAGGGAAGCTGGGAGATTGGCCGACATGTTGCTTCCTCTGCCACCAATCACTAGCTCGAGTGTCGCTGCCGTGACGGCAAACAATTCCGCATGA

Protein

MSLKCDDNAKEYKITYFRNGYSCVPVALSEDLDIRLGTSVTDINYEGPGVTVKANSSRNPNQPQVFKGDVVLCTLPLGVLKVAVASNGQNQQNFTTFNPPLPEWKVAAIKRLGYGNLNKVVLCFERTFWDPSANLFGHVGTTTASRGELFLFWNLYSAPVLLALVAGEAAAVMENVTDDVIVGRCIAVLKSIFGHAAVPQPKECIVTRWRADPFARGSYSFVAVGSSGTDYDLLAAPIPGTDGENRLFFAGEHTMRNYPATVHGAFLSGLREAGRLADMLLPLPPITSSSVAAVTANNSA

Description

Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me.

Cofactor

FAD

Similarity

Belongs to the flavin monoamine oxidase family.

Feature

chain  Lysine-specific histone demethylase

Uniprot

A0A194PL11   A0A2A4K937   A0A212ES90   A0A194RER2   A0A2H1V084   A0A1B6CNV3   + More
A0A1B6F811   A0A1B6LH74   E0VDA5   A0A2P8XW97   A0A139WNH8   A0A067RCK0   A0A0T6B3R9   A0A1W4WU62   A0A2T7PGM5   A0A2J7QZ86   T1HJ69   A0A0S7LFX9   A0A1Y1LPN4   A0A2I4C8Q9   A0A146PHN5   A0A1A8HYI7   A0A0P4WIF3   A0A2D4FJW5   C3RZ91   G3P5A9   K1PSW2   K9KDA9   A0A1A8CDQ2   A0A091PYN2   A0A026W5K8   V3ZE46   A0A2D4FJX6   A0A3L8D8C0   A0A087VAN2   A0A2H8TSG7   A0A2I0TTJ3   A0A1A8FXG4   A0A210QFJ1   K7JWZ3   K9IT43   A0A0A9XBP8   J9LER4   A0A2K6G369   A0A2I3GMX2   G2HF04   A0A069DWN6   A0A3L7I8K4   A0A147A4N6   A0A087UR95   A0A0P5C548   A0A0P5YFY9   A0A3P8PZC4   A0A3P9B3Z1   A0A1E1XDE1   A0A0L8IEY1   A0A0P5C2W2   A0A0P5XQ71   A0A023F516   A0A2L2Y9V1   A0A3P8TNG1   A0A3Q1BH70   A0A3B4GQ09   A0A0P5UZB8   M4A829   A0A3P9NB14   A0A3B3XUA6   A0A0P5YP84   A0A0P4W046   V9KEM0   A0A3B3SYF8   A0A3P9LB88   G3P5B5   A0A146WGX6   A0A3Q0SCS9   A0A3B4YR59   A0A1A6GE51   A0A3Q2FX39   A0A3Q2XZ25   S9Y4V3   A0A2R5L6N5   A0A293N5M7   A0A3Q2QKI9   A0A131YYD9   A0A091G9L6   H2MB66   I3JBC0   A0A0L7R4F2   A0A093PTF6   A0A3P9LBI8   A0A3Q3LKE1   A0A091JUT6   A0A093QUK5   A0A3B3UW04   A0A3Q2E7G6   A0A146WJI3   A0A091LCQ0   A0A3Q2V816   A0A3P9NAZ4  

EC Number

1.-.-.-

Pubmed

26354079    22118469    20566863    29403074    18362917    19820115    + More
24845553    28004739    22992520    24508170    23254933    30249741    28812685    20075255    25401762    21484476    26334808    29704459    25186727    28503490    25474469    26561354    23542700    27129103    24402279    29240929    17554307    23149746    26830274   

EMBL

KQ459600    KPI94121.1    NWSH01000020    PCG80717.1    AGBW02012844    OWR44347.1    + More
KQ460473    KPJ14421.1    ODYU01000058    SOQ34186.1    GEDC01022148    JAS15150.1    GECZ01023736    JAS46033.1    GEBQ01016932    JAT23045.1    DS235072    EEB11361.1    PYGN01001252    PSN36278.1    KQ971311    KYB29464.1    KK852727    KDR17628.1    LJIG01016034    KRT81813.1    PZQS01000004    PVD32566.1    NEVH01009072    PNF33900.1    ACPB03003082    GBYX01171309    GBYX01171306    GBYX01171303    JAO88370.1    GEZM01050266    GEZM01050265    JAV75644.1    GCES01142891    JAQ43431.1    HAED01003630    SBQ89618.1    GDRN01087837    JAI60978.1    IACJ01076167    LAA47763.1    EU661933    ACH71255.1    JH818227    EKC24738.1    JL623189    AEP99694.1    HADZ01013858    SBP77799.1    KK680533    KFQ12431.1    KK107403    EZA51288.1    KB202619    ESO89368.1    IACJ01076170    LAA47773.1    QOIP01000011    RLU16747.1    KL486279    KFO09674.1    GFXV01004343    MBW16148.1    KZ507299    PKU37124.1    HAEB01016939    SBQ63466.1    NEDP02003873    OWF47510.1    AAZX01007402    AAZX01008991    AAZX01010111    AAZX01020796    GABZ01001325    JAA52200.1    GBHO01027367    GBHO01027366    GBRD01005696    GBRD01005695    JAG16237.1    JAG16238.1    JAG60125.1    ABLF02038378    ADFV01066899    ADFV01066900    AK305318    BAK62312.1    GBGD01000772    JAC88117.1    RAZU01000087    RLQ74525.1    GCES01013171    JAR73152.1    KK121162    KFM79884.1    GDIP01180078    JAJ43324.1    GDIP01058244    JAM45471.1    GFAC01001923    JAT97265.1    KQ415861    KOG00015.1    GDIP01191877    JAJ31525.1    GDIP01081243    JAM22472.1    GBBI01002569    JAC16143.1    IAAA01016543    LAA04952.1    GDIP01106692    JAL97022.1    GDIP01056385    JAM47330.1    GDKW01001469    JAI55126.1    JW863742    AFO96259.1    GCES01057083    JAR29240.1    LZPO01099511    OBS63602.1    KB016923    EPY82441.1    GGLE01000994    MBY05120.1    GFWV01022972    MAA47699.1    GEDV01005037    JAP83520.1    KL447872    KFO78046.1    AERX01059979    KQ414657    KOC65704.1    KL669044    KFW75387.1    KK529928    KFP27703.1    KL224637    KFW62424.1    GCES01057081    JAR29242.1    KL310194    KFP52940.1   

Proteomes

UP000053268    UP000218220    UP000007151    UP000053240    UP000009046    UP000245037    + More
UP000007266    UP000027135    UP000192223    UP000245119    UP000235965    UP000015103    UP000192220    UP000007635    UP000005408    UP000053097    UP000030746    UP000279307    UP000242188    UP000002358    UP000007819    UP000233160    UP000001073    UP000273346    UP000054359    UP000265100    UP000265160    UP000053454    UP000265080    UP000257160    UP000261460    UP000002852    UP000242638    UP000261480    UP000261540    UP000265180    UP000261340    UP000261360    UP000092124    UP000265020    UP000264820    UP000265000    UP000053760    UP000001038    UP000005207    UP000053825    UP000053258    UP000261640    UP000054081    UP000261500    UP000264840   

Pfam

PF01593   Amino_oxidase        + More
PF04433   SWIRM

Interpro

IPR002937   Amino_oxidase        + More
IPR036188   FAD/NAD-bd_sf       
IPR007526   SWIRM       
IPR017366   Hist_Lys-spec_deMease       
IPR036388   WH-like_DNA-bd_sf       
IPR009057   Homeobox-like_sf       

SUPFAM

SSF51905   SSF51905        + More
SSF46689   SSF46689       

Gene 3D

3.50.50.60     1.10.10.10    

ProteinModelPortal

A0A194PL11   A0A2A4K937   A0A212ES90   A0A194RER2   A0A2H1V084   A0A1B6CNV3   + More
A0A1B6F811   A0A1B6LH74   E0VDA5   A0A2P8XW97   A0A139WNH8   A0A067RCK0   A0A0T6B3R9   A0A1W4WU62   A0A2T7PGM5   A0A2J7QZ86   T1HJ69   A0A0S7LFX9   A0A1Y1LPN4   A0A2I4C8Q9   A0A146PHN5   A0A1A8HYI7   A0A0P4WIF3   A0A2D4FJW5   C3RZ91   G3P5A9   K1PSW2   K9KDA9   A0A1A8CDQ2   A0A091PYN2   A0A026W5K8   V3ZE46   A0A2D4FJX6   A0A3L8D8C0   A0A087VAN2   A0A2H8TSG7   A0A2I0TTJ3   A0A1A8FXG4   A0A210QFJ1   K7JWZ3   K9IT43   A0A0A9XBP8   J9LER4   A0A2K6G369   A0A2I3GMX2   G2HF04   A0A069DWN6   A0A3L7I8K4   A0A147A4N6   A0A087UR95   A0A0P5C548   A0A0P5YFY9   A0A3P8PZC4   A0A3P9B3Z1   A0A1E1XDE1   A0A0L8IEY1   A0A0P5C2W2   A0A0P5XQ71   A0A023F516   A0A2L2Y9V1   A0A3P8TNG1   A0A3Q1BH70   A0A3B4GQ09   A0A0P5UZB8   M4A829   A0A3P9NB14   A0A3B3XUA6   A0A0P5YP84   A0A0P4W046   V9KEM0   A0A3B3SYF8   A0A3P9LB88   G3P5B5   A0A146WGX6   A0A3Q0SCS9   A0A3B4YR59   A0A1A6GE51   A0A3Q2FX39   A0A3Q2XZ25   S9Y4V3   A0A2R5L6N5   A0A293N5M7   A0A3Q2QKI9   A0A131YYD9   A0A091G9L6   H2MB66   I3JBC0   A0A0L7R4F2   A0A093PTF6   A0A3P9LBI8   A0A3Q3LKE1   A0A091JUT6   A0A093QUK5   A0A3B3UW04   A0A3Q2E7G6   A0A146WJI3   A0A091LCQ0   A0A3Q2V816   A0A3P9NAZ4  

PDB

2HKO     E-value=5.82638e-96,     Score=894

KEGG

101739058    K11450 lysine-specific histone demethylase 1A [EC:1.-.-.-] | (RefSeq) lysine-specific histone demeth

GO

GO:0016491   GO:0003677   GO:0034720   GO:0006355   GO:0005634   GO:0050660   GO:0008168   GO:0008134   GO:0000122   GO:0003682   GO:0045944   GO:0034648   GO:0000790   GO:1900052   GO:0007399   GO:1903706   GO:0007165   GO:0043531   GO:0051276   GO:0016620   GO:0016787   GO:0003676   GO:0015930   GO:0055114  

Subcellular location

Nucleus  

Length:

300

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

10.53759

Exp number, first 60 AAs:

0.00115

Total prob of N-in:

0.44953

outside

1  -  300

 

 

Pi

226.507006

Theta

167.552819

Tajima's D

1.402522

CLR

0.069962

CSRT

0.76341182940853

Interpretation

Uncertain