Gene

KWMTBOMO13683

Pre Gene Modal

BGIBMGA011084

Annotation

PREDICTED:_protein_toll_[Bombyx_mori]

Location

Bomo_Chr23(+):6555406-6559107      View in EpiBrowser

Full name

Toll-like receptor 6      

Location in the cell

Nuclear   Reliability : 1.891

CDS

ATGATGTATAAAAGTTCATTAGACGATCGAAGTTTTGCACATTTAGTAAAACTGCGTGAACTTGTTTTAGATAACTGTAAAATTGGAAGATGGCCGCCTGGCGTACTTTCCGGCTTGAGAGACCTCCGTAATTTAACGATCCGAACGAAAAACACGGAGTGGGCCGCTATGAGTTTAGAGATAGCATCAGAAAGCTTTACCGCCGTTCGGCAGTTGGAAAAGTTGGATCTCAGCTTTAACAACATTTGGTCGTTTCCCGAGAACTTGTTTTGTCCGTTAACGAACTTGGTCTATTTGAATGTCTCTTCGAATCGTCTTCAAGATGTAAGCGATTTAGGATTCAGAGAACGCGCAGTTCATCAAGCGTTGATAAGTGAACAAGATGGACCGATACCTTCCACAGCATCGGCACACTCGACGTGTTCGCTAGACATCGAAGTCTTGGACGCCTCCAGCAATCATTTTGTGCTGATGCCAGAAAATGGATTTATGTCGCTACGTAGACTAAAGGAACTCCATATCCACGATAACGAAATTTCTATGGTAGCCGACAAATCACTATCCGGACTGAAACAATTGCAGATAATAGATCTCTCGAACAATAAGATCGTTGCTCTTCCCCAAGATCTATTTAAAGATTGCCGACCAGTGATAAAAGAAATATACTTACAAAATAACTCTATCAGTGTGCTTTCACCGAGTCTTTTCGCTAATTTGGAACAGCTGTTAGCACTGGACTTATCTAATAACCATCTAACAAGCACTTGGATAAATGAAAATACTTTCACTGGTCTCATAAGAATGGTATTGTTAAATTTGTCGAATAATAGACTAACTAAATTGGAACCGAAAATTTTCAAAGACCTGTACACTTTACAGATATTAAATGTTCAGCACAATATGCTTGAAAATATTGCTGCTGATACTTTTTCACCAATGAACAATTTACATACCTTGATTTTGTCCTACAACAAAATTACTCACATTGACGCTTATGCACTGAATGGTCTTTATGTTTTATCTTTATTATCGATTGATAACAATCGTCTCGAAGAACTTCACCCGAAAGCATTTCGTAATACATCTTCGTTGCAAGACTTGAATTTAAACGGGAATCGCTTAAAGAAAGTACCCATAGCACTAAGAAATATGCGATTGTTGAGAACTCTTGATCTTGGAGAAAATCAGATAACATCACTTGAAGAACCCGGCTTTGTCGGTTTGCATAATGTTTATGGGTTACGACTCATTGGAAATAAAATAGAAAATATAAGCAAAGATGTATTTTCAGATTTGCCTACGTTACAAATCTTGAATTTAGCACGAAACAAGCTGAAACATGTCGACGTTAATGCATTCGATACACTAACCAACCTCCAAGCAATTAGATTAGATGCAAACCGCCTCACTGATATACAGGGCCTATTTGTAAACATACCCTCTTTGTTGTGGCTAAACGTATCAGATAACCAAATAGAATGGTTTGATTATACTGTTATACCATCAGGACTTCAATGGTTGGATCTTCACAGCAACAACATCAAAGAATTAGGAAATAACTACCGCATGGACAAAGAGTTAAGGTTACAAACATTAGACGCGAGTTTCAATAAAATGACGAAAATATCAACTTATTCTATTCCCAGCAGCGTGGAGCTACTTTTCTTGAATGATAATCAAATTATACAAGTTGAGGCTCAAACTTTTGTTGGAAAAACCAATTTAACGAGAGTCGATTTGTATGCAAATCAGATAACTAGTATGGATCTCAATGCGCTTCGTCTAACTCCAGTCGATCCCGGCCGGCCGTTGCCCGAATTTTATATCGGTGGAAACCCATTTCAGTGTGATTGTACTATGGAATGGTTACAACGAATAAACAAACTCGATCATCTTAGACAACACCCGAGAGTGATGGACTTGGAAAGTATTTACTGCAAGTTGTTGTACAATCGTGAACGAACTTACATTCCGCTGATCGAAGCAGAATCATCGCAGTTTTTGTGTACATACAAAACTCACTGTTTTACGTTGTGTCAATGTTGTGATTTTGATGCCTGTGATTGTGAAATGACGTGCCCATCGAACTGTACGTGTTATCACGACCAGCCGTGGTCAGCGAATATTGTGGATTGTTCTGCGGCAGGGTATTCCGAAATACCCAATAGTATACCTATGGACGCTACTGAACTATATTTAGATGGTAATAATTTTGGTGGTTTAACAAGTCACGCTTTTATTGGACGTAAAAATTTAAAAATATTGTATGCAAATAATTCTAATATCGACGCTCTCTATAATAATACTTTTAGTGGACTAAAACGCTTAACAATTTTGCATTTAGAAAAGAACAATATAAAAGAGTTACTCGGTTTCGAACTATCGCCCTTAGAAAATTTACGAGAACTTCATCTTCAAGACAATAAAATACATTATATCGATAATAGGACTTTCATGGAGTTGAGGCATTTGGAAGTATTGCGATTGGAAGGCAACAATATTTATGGCTTTGCAGTATGGCAATTTACGATGAATCCGTATTTGGTGGAAATAAGTCTCTCTCGAAATCCTTGGTCATGTGACTGCCAATACATGCATAAATTTCGAAATTGGTTTAAGAACAACCTAGGTAAGGTTGAAGATGCAAATAAAATTACATGCGTATTCGACAATGTAACGAACGCCGTGGGCCCTCTTATGGCCGATTTCAATTCAACAATTTGCACGAGTCACGTTGGAGGGAGCTCATCTATAATCGAAAACCAAGTAATAAATGATTATCTTCCGTTACTGTTGATAGCCCTGTGTGTGTTCGTCGTGAGCTCGGCCTTAATATGCGGCGTGTTTTATTGGCGTCGTGAGCTAAGAGTATGGGTTTATTACCATTGTGGATTCCGAATGTGTTACAAAAGTACAACTTTCGACGAAGAAGCCGACAAAGATCGCCTTTTCGACGCTTACATAAGTTATAGCGTCAAAGATGAGGCTTTCGTCGCTCAAATGCTAGCGCCTGGCCTAGAATCCACCGATCCCAGTTTCCGTTTATGTCTACATTACCGCGATTTTAACGCTTCGGCGTACGTTGCGGATACGATAATAGAGGCCGTCGAGTCGTCAAAGAGGACGATCATTGTCCTATCTAAAAACTTTATCAACAATGAATGGTGTCGTTTCGAATTTAAGACGGCACTACACGAAGTACTGAAAGAGAGACGAAGAAGACTGATAATAATATTGCTAGGCGATATACCGAATAGGGACATCGATCCGGAGTTGCGTTTATGTTTGAAGGCGAATACGTGCATCGAATGGGGTGATAGACAGTTTTGGCAAAAGTTGAGGTTCGCGATGCCGGACTTGCGGAAGTGTCAGTATCACCGTTCCACAGTGAATATTTACGCTTCGGTGTCACCAGTGGGGGCAGGACGGGCGGCGGCGCCGCCCCCACCACCACCGCCGGGCAAGCTCCCCCCTCTGTTGGGCGACGGCCTGGCCATACCAGCCGGGGTCCACACGCGCGACCATCACACCCACCGCATGCCACCTCAAGCGCAGCTCTGGGCGTAG

Protein

MMYKSSLDDRSFAHLVKLRELVLDNCKIGRWPPGVLSGLRDLRNLTIRTKNTEWAAMSLEIASESFTAVRQLEKLDLSFNNIWSFPENLFCPLTNLVYLNVSSNRLQDVSDLGFRERAVHQALISEQDGPIPSTASAHSTCSLDIEVLDASSNHFVLMPENGFMSLRRLKELHIHDNEISMVADKSLSGLKQLQIIDLSNNKIVALPQDLFKDCRPVIKEIYLQNNSISVLSPSLFANLEQLLALDLSNNHLTSTWINENTFTGLIRMVLLNLSNNRLTKLEPKIFKDLYTLQILNVQHNMLENIAADTFSPMNNLHTLILSYNKITHIDAYALNGLYVLSLLSIDNNRLEELHPKAFRNTSSLQDLNLNGNRLKKVPIALRNMRLLRTLDLGENQITSLEEPGFVGLHNVYGLRLIGNKIENISKDVFSDLPTLQILNLARNKLKHVDVNAFDTLTNLQAIRLDANRLTDIQGLFVNIPSLLWLNVSDNQIEWFDYTVIPSGLQWLDLHSNNIKELGNNYRMDKELRLQTLDASFNKMTKISTYSIPSSVELLFLNDNQIIQVEAQTFVGKTNLTRVDLYANQITSMDLNALRLTPVDPGRPLPEFYIGGNPFQCDCTMEWLQRINKLDHLRQHPRVMDLESIYCKLLYNRERTYIPLIEAESSQFLCTYKTHCFTLCQCCDFDACDCEMTCPSNCTCYHDQPWSANIVDCSAAGYSEIPNSIPMDATELYLDGNNFGGLTSHAFIGRKNLKILYANNSNIDALYNNTFSGLKRLTILHLEKNNIKELLGFELSPLENLRELHLQDNKIHYIDNRTFMELRHLEVLRLEGNNIYGFAVWQFTMNPYLVEISLSRNPWSCDCQYMHKFRNWFKNNLGKVEDANKITCVFDNVTNAVGPLMADFNSTICTSHVGGSSSIIENQVINDYLPLLLIALCVFVVSSALICGVFYWRRELRVWVYYHCGFRMCYKSTTFDEEADKDRLFDAYISYSVKDEAFVAQMLAPGLESTDPSFRLCLHYRDFNASAYVADTIIEAVESSKRTIIVLSKNFINNEWCRFEFKTALHEVLKERRRRLIIILLGDIPNRDIDPELRLCLKANTCIEWGDRQFWQKLRFAMPDLRKCQYHRSTVNIYASVSPVGAGRAAAPPPPPPPGKLPPLLGDGLAIPAGVHTRDHHTHRMPPQAQLWA

Description

Toll-related receptor which binds to the neurotrophin spz5 (PubMed:10973475, PubMed:23892553). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1) (PubMed:25741726). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).

Similarity

Belongs to the Toll-like receptor family.

Keywords

Cell membrane   Complete proteome   Developmental protein   Disulfide bond   Glycoprotein   Leucine-rich repeat   Membrane   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Toll-like receptor 6

Uniprot

H9JNI1   A0A2H1V3C2   A0A2A4JZJ9   A0A0L7KXJ7   A0A194RAV9   A0A346RAF9   + More
A0A194PSM0   D6WCH0   A0A1Y1LF69   N6T878   A0A2P8Y3Q2   A0A212EM77   A0A067RKA9   M9ZVB4   E0VDA7   A0A173ADU1   A0A023F670   A0A173ADT8   A0A182Y1I7   A0A182GNI4   A0A182RFG9   A0A182PKB1   A0A182WEZ0   A0A182UU93   Q17NJ6   Q7Q0C5   A0A182WZS3   A0A182KSC6   A0A182U2Q8   A0A182HQB8   A0A1S4EWI6   A0A182MEI6   Q8WRE4   A0A182QAI7   A0A182MYV8   B0XGL6   A0A182JH61   A0A1B0DPS3   A0A1S4KD99   A0A182JPT0   A0A084WIV1   A0A1A9WFF1   A0A0L0CCR4   A0A1I8PD85   A0A1I8MM94   A0A1A9Y9P4   A0A1B0AXS9   A0A1B0F9C3   A0A0K8U8V2   A0A1A9Z367   W8B7B1   A0A1A9VMK3   A0A182FB35   A0A0M5JBM0   B4LGV7   B4L143   A0A1W4VP79   A0A0M4EIR3   B3M720   A0A0J9RVJ6   B4HI72   B4PCF0   B4QL09   Q9VUN0   B3NI13   A0A3B0JTH2   Q2M1B4   B4GUC8   A0A336KW30   B4N510   A0A2A3EJM3   B4IZ19   A0A088AAH3   A0A2A3EHP7   A0A0J7KGP6   A0A154PE74   A0A1J1HJK6   A0A026W5E1   A0A0C9RRL0   F4WCQ4   A0A195ESX3   A0A195BXP9   A0A158NHL8   A0A195DF69   A0A151WXH0   A0A2H8TNF7   J9JYA4   E2AHE5   E2B2I6   A0A2P8YSW8   A0A0P6IMT3   A0A067RGD1   A0A0A9WWW5   E0VDA3   A0A2J7QTA0   A0A226DZ29   A0A0C9QL90   A0A1Y1KGT6   E2B2J2   D6WCH6  

Pubmed

19121390    26227816    26354079    29910977    18362917    19820115    + More
28004739    23537049    29403074    22118469    24845553    23497397    20566863    25474469    25244985    26483478    17510324    12364791    14747013    17210077    20966253    12213252    24438588    26108605    25315136    24495485    17994087    22936249    17550304    10973475    10731132    12537572    12617819    21158756    23892553    25363762    25741726    15632085    24508170    30249741    21719571    21347285    20798317    25401762   

EMBL

BABH01019549    BABH01019550    ODYU01000326    SOQ34872.1    NWSH01000378    PCG76840.1    + More
JTDY01004789    KOB67759.1    KQ460473    KPJ14420.1    MH243025    AXS59159.1    KQ459600    KPI94120.1    KQ971311    EEZ99352.2    GEZM01061234    JAV70615.1    APGK01047889    KB741092    KB632050    ENN73923.1    ERL88314.1    PYGN01000961    PSN38886.1    AGBW02013909    OWR42576.1    KK852574    KDR21043.1    KC355235    AGK40935.1    DS235072    EEB11363.1    KX086266    ANG08889.1    GBBI01002003    JAC16709.1    KX086262    KK854170    ANG08885.1    PTY12514.1    JXUM01014709    KQ560411    KXJ82551.1    CH477198    EAT48319.1    AAAB01008986    EAA00379.2    APCN01003306    AXCM01003946    AF444781    AAL37902.1    AXCN02001022    DS233040    EDS27680.1    AJVK01001717    ATLV01023946    KE525347    KFB50145.1    JRES01000558    KNC30228.1    JXJN01005393    CCAG010016968    GDHF01029225    JAI23089.1    GAMC01009480    JAB97075.1    CP012525    ALC44681.1    CH940647    EDW70572.1    CH933809    EDW18200.1    ALC44677.1    CH902618    EDV40885.1    CM002912    KMY99728.1    CH480815    EDW41568.1    CM000159    EDW94860.1    CM000363    EDX10534.1    AF247766    AE014296    BT011445    BT057976    AAF86226.1    AAR99103.1    ACM16686.1    CH954178    EDV52099.1    OUUW01000002    SPP75991.1    CH379069    EAL30661.2    CH479191    EDW26211.1    UFQS01001004    UFQT01001004    SSX08491.1    SSX28407.1    CH964101    EDW79449.1    KZ288243    PBC31231.1    CH916366    EDV97727.1    PBC31228.1    LBMM01007785    KMQ89424.1    KQ434870    KZC09578.1    CVRI01000002    CRK86654.1    KK107403    QOIP01000011    EZA51292.1    RLU16709.1    GBYB01009991    JAG79758.1    GL888070    EGI68234.1    KQ981979    KYN31333.1    KQ976398    KYM92721.1    ADTU01001707    ADTU01001708    ADTU01001709    ADTU01001710    ADTU01001711    ADTU01001712    KQ980905    KYN11543.1    KQ982662    KYQ52629.1    GFXV01003899    MBW15704.1    ABLF02038379    GL439518    EFN67137.1    GL445145    EFN90101.1    PYGN01000379    PSN47339.1    GDIQ01002072    JAN92665.1    KK852482    KDR22931.1    GBHO01031375    JAG12229.1    EEB11359.1    NEVH01011197    PNF31819.1    LNIX01000009    OXA49951.1    GBYB01001357    JAG71124.1    GEZM01084756    JAV60699.1    EFN90107.1    EEZ99353.2   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000007266    + More
UP000019118    UP000030742    UP000245037    UP000007151    UP000027135    UP000009046    UP000076408    UP000069940    UP000249989    UP000075900    UP000075885    UP000075920    UP000075903    UP000008820    UP000007062    UP000076407    UP000075882    UP000075902    UP000075840    UP000075883    UP000075886    UP000075884    UP000002320    UP000075880    UP000092462    UP000075881    UP000030765    UP000091820    UP000037069    UP000095300    UP000095301    UP000092443    UP000092460    UP000092444    UP000092445    UP000078200    UP000069272    UP000092553    UP000008792    UP000009192    UP000192221    UP000007801    UP000001292    UP000002282    UP000000304    UP000000803    UP000008711    UP000268350    UP000001819    UP000008744    UP000007798    UP000242457    UP000001070    UP000005203    UP000036403    UP000076502    UP000183832    UP000053097    UP000279307    UP000007755    UP000078541    UP000078540    UP000005205    UP000078492    UP000075809    UP000007819    UP000000311    UP000008237    UP000235965    UP000198287   

PRIDE

H9JNI1    Q9VUN0   

Pfam

PF12799   LRR_4        + More
PF13855   LRR_8
PF01582   TIR
PF00400   WD40
PF00560   LRR_1
PF13306   LRR_5
PF13516   LRR_6
PF13676   TIR_2

Interpro

IPR003591   Leu-rich_rpt_typical-subtyp        + More
IPR000157   TIR_dom       
IPR001611   Leu-rich_rpt       
IPR032675   LRR_dom_sf       
IPR025875   Leu-rich_rpt_4       
IPR035897   Toll_tir_struct_dom_sf       
IPR000372   LRRNT       
IPR000483   Cys-rich_flank_reg_C       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR036322   WD40_repeat_dom_sf       
IPR026906   LRR_5       

SUPFAM

SSF52200   SSF52200        + More
SSF50978   SSF50978       

Gene 3D

3.40.50.10140     3.80.10.10     2.130.10.10    

ProteinModelPortal

H9JNI1   A0A2H1V3C2   A0A2A4JZJ9   A0A0L7KXJ7   A0A194RAV9   A0A346RAF9   + More
A0A194PSM0   D6WCH0   A0A1Y1LF69   N6T878   A0A2P8Y3Q2   A0A212EM77   A0A067RKA9   M9ZVB4   E0VDA7   A0A173ADU1   A0A023F670   A0A173ADT8   A0A182Y1I7   A0A182GNI4   A0A182RFG9   A0A182PKB1   A0A182WEZ0   A0A182UU93   Q17NJ6   Q7Q0C5   A0A182WZS3   A0A182KSC6   A0A182U2Q8   A0A182HQB8   A0A1S4EWI6   A0A182MEI6   Q8WRE4   A0A182QAI7   A0A182MYV8   B0XGL6   A0A182JH61   A0A1B0DPS3   A0A1S4KD99   A0A182JPT0   A0A084WIV1   A0A1A9WFF1   A0A0L0CCR4   A0A1I8PD85   A0A1I8MM94   A0A1A9Y9P4   A0A1B0AXS9   A0A1B0F9C3   A0A0K8U8V2   A0A1A9Z367   W8B7B1   A0A1A9VMK3   A0A182FB35   A0A0M5JBM0   B4LGV7   B4L143   A0A1W4VP79   A0A0M4EIR3   B3M720   A0A0J9RVJ6   B4HI72   B4PCF0   B4QL09   Q9VUN0   B3NI13   A0A3B0JTH2   Q2M1B4   B4GUC8   A0A336KW30   B4N510   A0A2A3EJM3   B4IZ19   A0A088AAH3   A0A2A3EHP7   A0A0J7KGP6   A0A154PE74   A0A1J1HJK6   A0A026W5E1   A0A0C9RRL0   F4WCQ4   A0A195ESX3   A0A195BXP9   A0A158NHL8   A0A195DF69   A0A151WXH0   A0A2H8TNF7   J9JYA4   E2AHE5   E2B2I6   A0A2P8YSW8   A0A0P6IMT3   A0A067RGD1   A0A0A9WWW5   E0VDA3   A0A2J7QTA0   A0A226DZ29   A0A0C9QL90   A0A1Y1KGT6   E2B2J2   D6WCH6  

PDB

4LI2     E-value=6.25254e-31,     Score=339

KEGG

101744630    no KO assigned | (RefSeq) protein toll

GO

GO:0016021   GO:0007165   GO:0045087   GO:0004721   GO:0060026   GO:0005030   GO:0070983   GO:0003401   GO:0005886   GO:0005515   GO:0043531   GO:0051276   GO:0016491   GO:0016620   GO:0016787   GO:0003676   GO:0015930  

Subcellular location

Cell membrane  

Length:

1188

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.9719399999999

Exp number, first 60 AAs:

0.00034

Total prob of N-in:

0.00090

outside

1  -  928

TMhelix

929  -  951

inside

952  -  1188

 

 

Pi

149.497979

Theta

162.14979

Tajima's D

-0.415863

CLR

14.092561

CSRT

0.254937253137343

Interpretation

Uncertain