Gene

KWMTBOMO13666

Pre Gene Modal

BGIBMGA011030

Annotation

PREDICTED:_exportin-4-like_[Bombyx_mori]

Location

Bomo_Chr23(-):5349566-5354950      View in EpiBrowser

Full name

Exportin-4      

Location in the cell

PlasmaMembrane   Reliability : 1.888

CDS

ATGCCGCAATCCGTTTTCTACAATGAGATGTCTCCGATATTGGAATCAGCGTTTGGACGTGGCTCCCGTGGATCATCCTGGGTGGTGTCCCGGCTGGCGGCCCGAGCTGGTACCTGCCTCAGGTACCTGTCCGCTCAGCCGACGGCCGCCTTCCACGCACTCAAACTGCTGACGACATTGGCCCACGCGCACCATAAACAGAATCCTTCGGAGAGCTGCGAGGAGTTCTTGGCGCTGATCGCCTGGGAGGCGGCCGGAAGCAACTTGCCCGGTGAACTGAGGAAAGAATTGCACCGAGCATTCGCAATCGCCGCCACTTACGCTCAGGGAAATGTGAGGACCCGCCTGCTGGACAGCACTGAGGCGCTCCAGAAGAAGTTAATCAACATACTGAACATGGAATCCGACACGGAACCCGTGCGGAGCATGCTCGCCGATACCCTGGACTGCTTCATCGGGGTCACCGAAGGTGTTCTCGAGGTCGGAGCGATGGACGAACAGTTTGTGATGTTAATCGGCGCCTTAGACAAAGTACCGGGTATCTTGTACAGATATCACAACTACCCCGGCGTTGTGTTGCCAGCACTGAATTTGTTATCGAAAAGCGCCAAGAGAATGCTGCACTCGGTTCAACCTCAAAACGTTGATAAGTTCTTAGAAGTATGCAATACTACATTTGAAGTTTATAAACAATGGAATTCTGGAAAGATCTCGAGTATACCACAAGACGCTGAGGATGAAGTGTATGAGGATATATGCGCAATAATGGAACTGATCTGTAGTATAGCGCGGTCAGGAGCCCACACTAACGTTAATGAGACCTGCGCCCGGGGACTGCGACTGTTGCTGCCCTTGATCACTCCTCCGCTGTTGGCACTGCCGTCACTGGCCCAGCACGCATATCGAATGATTAGGGATTTGGATAATTGTGATCAGCTCACAAATCTACCGATAGAGGACTTCAACATGGTGATATCGGCGTTACGCGTCGGGCTGACGGCGGTCTCGTGCGACGTCTCGACGCTGTGCTGCGATACCATCGTGGGCCTGGCGAACAGAGCGCGGACGCTGGGCGACAACAATCCTTACGCCATGTCCTTACTGACGCTGGCCGAACTCTTACTAATGTTGATAATTAAAATGGAAATACCCCCGGACTCGATACCGGCTGCCGGCTCGGCGATATACGCCTTGACGTGCGTGAAGCCGGCTCTCTTAGAGGGCTTAGCCAGACAGCTGATCGAAGCGTACGCGGTCAACGACCCCGCGAACGTGCCCAGATTAGAGGAGGCCTTCAGTCTCCTAACCAACGGTGTACTGTTCGACGGCCTGAGACCTCACAAGATACGCTTCCAAGATAACTTCGATAAGTTCCTAGCCAGCGTTCACGGATTTCTGATTGTCAAATAA

Protein

MPQSVFYNEMSPILESAFGRGSRGSSWVVSRLAARAGTCLRYLSAQPTAAFHALKLLTTLAHAHHKQNPSESCEEFLALIAWEAAGSNLPGELRKELHRAFAIAATYAQGNVRTRLLDSTEALQKKLINILNMESDTEPVRSMLADTLDCFIGVTEGVLEVGAMDEQFVMLIGALDKVPGILYRYHNYPGVVLPALNLLSKSAKRMLHSVQPQNVDKFLEVCNTTFEVYKQWNSGKISSIPQDAEDEVYEDICAIMELICSIARSGAHTNVNETCARGLRLLLPLITPPLLALPSLAQHAYRMIRDLDNCDQLTNLPIEDFNMVISALRVGLTAVSCDVSTLCCDTIVGLANRARTLGDNNPYAMSLLTLAELLLMLIIKMEIPPDSIPAAGSAIYALTCVKPALLEGLARQLIEAYAVNDPANVPRLEEAFSLLTNGVLFDGLRPHKIRFQDNFDKFLASVHGFLIVK

Description

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Subunit

Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner (By similarity).

Similarity

Belongs to the exportin family.

Keywords

3D-structure   Complete proteome   Cytoplasm   Nucleus   Phosphoprotein   Protein transport   Reference proteome   Transport  

Feature

chain  Exportin-4

Uniprot

A0A2A4JXK4   A0A194PN01   A0A2H8TXU3   A0A1B6L6R1   A0A1B6GDH0   U4TTX0   + More
A0A139W8Z2   A0A2J7PKI5   A0A2S2NWP7   J9JVS3   A0A067QJT8   A0A1B6DTD9   A0A1B6DRC6   A0A2J7PKJ3   A0A1W4XDI0   A0A1Y1LL39   E1ZX91   A0A1Y1LTQ0   A0A1Y1LR33   A0A0V0G7Q3   A0A023EZX8   A0A3L8E119   A0A026WPC1   A0A232EWA4   A0A0P5HI45   K7J792   A0A0P5YUR6   A0A0P5XG18   A0A0P6GGT4   A0A0P5M0Z2   A0A0P5X0Z8   A0A0P6CGU8   E9GHT5   A0A0P5P761   A0A164KE70   A0A0P5EH49   A0A0P6I566   V3ZDV8   A0A0A9W5H9   T1IB11   A0A3P8ZL51   A0A2R5LMJ3   W5UAJ4   A0A2D0R8X3   W5KDP9   A0A146LH98   A0A3B4C0H8   A0A060W0L8   A0A0P5MHY3   E0W318   A0A0R4J254   G3H8I5   Q9ESJ0   A0A1S3NYA4   A0A1S3NYA9   A0A2K6GH78   A0A1A8EQ88   A0A2U9CCM8   H3AB58   A0A061IM28   A0A1A8HGJ4   F6Z8P9   A0A0R4IGB7   A0A1A8K4X0   A0A1A7X4Y7   B0S8I3   A0A1A8AKM7   A0A1A8NK60   A0A1A8LMQ3   A0A1A8R8A1   A0A1A8CQN6   A0A1A8URI1   A0A1A7XZ44   A0A1A8MX12   A0A1A8D7X6   A0A3B3R8S2   A0A1A8PCV0   A0A1A8SDP8   F1RVA6   A0A287AJ95   A0A3B3RA17   A0A0P6DYZ6   A0A3Q0CYP5   A0A2Y9RTG0   A0A1A8JB32   A0A1L8HAY2   Q4R6Q6   G3VUX8   A0A2Y9S296   W5MYC2   A0A1S3NXZ9   W5MYC9  

Pubmed

26354079    23537049    18362917    19820115    24845553    28004739    + More
20798317    25474469    30249741    24508170    28648823    20075255    21292972    23254933    25401762    25069045    23127152    25329095    26823975    24755649    20566863    19468303    21183079    21804562    10944119    14621295    9215903    23929341    17495919    23594743    29240929    26319212    28071753    27762356    15944441    21709235   

EMBL

NWSH01000423    PCG76496.1    KQ459600    KPI94109.1    GFXV01007320    MBW19125.1    + More
GEBQ01020627    JAT19350.1    GECZ01009271    JAS60498.1    KB630032    KB631870    ERL83353.1    ERL86848.1    KQ972864    KXZ75751.1    NEVH01024539    PNF16846.1    GGMR01009042    MBY21661.1    ABLF02035477    ABLF02035479    ABLF02035487    KK853274    KDR09117.1    GEDC01008367    JAS28931.1    GEDC01009089    JAS28209.1    PNF16845.1    GEZM01052643    GEZM01052642    JAV74369.1    GL435030    EFN74181.1    GEZM01052644    JAV74367.1    GEZM01052645    JAV74365.1    GECL01001969    JAP04155.1    GBBI01003900    JAC14812.1    QOIP01000001    RLU26404.1    KK107154    EZA56944.1    NNAY01001887    OXU22639.1    GDIQ01229280    JAK22445.1    GDIP01066432    JAM37283.1    GDIP01073643    JAM30072.1    GDIQ01043843    JAN50894.1    GDIQ01173192    JAK78533.1    GDIP01078928    JAM24787.1    GDIP01008821    JAM94894.1    GL732545    EFX80996.1    GDIQ01137010    JAL14716.1    LRGB01003325    KZS03187.1    GDIQ01269764    JAJ81960.1    GDIQ01009415    JAN85322.1    KB202619    ESO89303.1    GBHO01040953    JAG02651.1    ACPB03005775    ACPB03005776    GGLE01006630    MBY10756.1    JT410421    AHH39051.1    GDHC01012769    JAQ05860.1    FR904354    CDQ60596.1    GDIQ01167149    JAK84576.1    DS235881    EEB20024.1    AC154504    AC154675    JH000211    EGV92223.1    AF145021    AK129430    HAEB01002114    SBQ48641.1    CP026256    AWP13536.1    AFYH01134860    AFYH01134861    AFYH01134862    AFYH01134863    AFYH01134864    AFYH01134865    AFYH01134866    AFYH01134867    AFYH01134868    AFYH01134869    KE666079    ERE88314.1    HAEC01015114    SBQ83335.1    CR392366    CU151884    HAEE01006679    SBR26699.1    HADW01011575    SBP12975.1    BX936339    HADY01017104    SBP55589.1    HAEH01002612    SBR69274.1    HAEF01007685    SBR45174.1    HAEH01015252    SBS02261.1    HADZ01018133    SBP82074.1    HAEJ01009764    SBS50221.1    HADX01001114    SBP23346.1    HAEF01020234    SBR61393.1    HAEA01001742    SBQ30222.1    HAEG01007355    SBR79053.1    HAEI01013893    SBS16362.1    AEMK02000075    GDIQ01070583    JAN24154.1    HAED01020424    SBR06980.1    CM004469    OCT93171.1    AB169124    BAE01218.1    AEFK01117146    AEFK01117147    AEFK01117148    AEFK01117149    AHAT01003647    AHAT01003648    AHAT01003649    AHAT01003650    AHAT01003651    AHAT01003652    AHAT01003653   

Proteomes

UP000218220    UP000053268    UP000030742    UP000007266    UP000235965    UP000007819    + More
UP000027135    UP000192223    UP000000311    UP000279307    UP000053097    UP000215335    UP000002358    UP000000305    UP000076858    UP000030746    UP000015103    UP000265140    UP000221080    UP000018467    UP000261440    UP000193380    UP000009046    UP000000589    UP000001075    UP000087266    UP000233160    UP000246464    UP000008672    UP000030759    UP000002280    UP000000437    UP000261540    UP000008227    UP000189706    UP000248480    UP000186698    UP000007648    UP000018468   

PRIDE

A0A0R4J254    G3H8I5    Q9ESJ0    F1RVA6   

Pfam

PF08767   CRM1_C        + More
PF15022   DUF4522

Interpro

IPR016024   ARM-type_fold        + More
IPR001494   Importin-beta_N       
IPR011989   ARM-like       
IPR014877   XPO1_C_dom       
IPR027825   DUF4522       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

ProteinModelPortal

A0A2A4JXK4   A0A194PN01   A0A2H8TXU3   A0A1B6L6R1   A0A1B6GDH0   U4TTX0   + More
A0A139W8Z2   A0A2J7PKI5   A0A2S2NWP7   J9JVS3   A0A067QJT8   A0A1B6DTD9   A0A1B6DRC6   A0A2J7PKJ3   A0A1W4XDI0   A0A1Y1LL39   E1ZX91   A0A1Y1LTQ0   A0A1Y1LR33   A0A0V0G7Q3   A0A023EZX8   A0A3L8E119   A0A026WPC1   A0A232EWA4   A0A0P5HI45   K7J792   A0A0P5YUR6   A0A0P5XG18   A0A0P6GGT4   A0A0P5M0Z2   A0A0P5X0Z8   A0A0P6CGU8   E9GHT5   A0A0P5P761   A0A164KE70   A0A0P5EH49   A0A0P6I566   V3ZDV8   A0A0A9W5H9   T1IB11   A0A3P8ZL51   A0A2R5LMJ3   W5UAJ4   A0A2D0R8X3   W5KDP9   A0A146LH98   A0A3B4C0H8   A0A060W0L8   A0A0P5MHY3   E0W318   A0A0R4J254   G3H8I5   Q9ESJ0   A0A1S3NYA4   A0A1S3NYA9   A0A2K6GH78   A0A1A8EQ88   A0A2U9CCM8   H3AB58   A0A061IM28   A0A1A8HGJ4   F6Z8P9   A0A0R4IGB7   A0A1A8K4X0   A0A1A7X4Y7   B0S8I3   A0A1A8AKM7   A0A1A8NK60   A0A1A8LMQ3   A0A1A8R8A1   A0A1A8CQN6   A0A1A8URI1   A0A1A7XZ44   A0A1A8MX12   A0A1A8D7X6   A0A3B3R8S2   A0A1A8PCV0   A0A1A8SDP8   F1RVA6   A0A287AJ95   A0A3B3RA17   A0A0P6DYZ6   A0A3Q0CYP5   A0A2Y9RTG0   A0A1A8JB32   A0A1L8HAY2   Q4R6Q6   G3VUX8   A0A2Y9S296   W5MYC2   A0A1S3NXZ9   W5MYC9  

PDB

5DLQ     E-value=6.16063e-17,     Score=215

KEGG

101737801    no KO assigned | (RefSeq) exportin-4-like

GO

GO:0006886   GO:0005623   GO:0008536   GO:0005737   GO:0006611   GO:0005049   GO:0005643   GO:0005654   GO:0005829   GO:0046827   GO:0016021  

Subcellular location

Cytoplasm   Shuttles between the nucleus and the cytoplasm.   With evidence from 3 publications.
Nucleus   Shuttles between the nucleus and the cytoplasm.   With evidence from 3 publications.

Length:

469

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.351820000000001

Exp number, first 60 AAs:

0.00417

Total prob of N-in:

0.00680

outside

1  -  469

 

 

Pi

310.81928

Theta

197.589434

Tajima's D

2.429942

CLR

0.113494

CSRT

0.935003249837508

Interpretation

Uncertain