Gene

KWMTBOMO13664

Pre Gene Modal

BGIBMGA011032

Annotation

PREDICTED:_protein_inturned_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr23(-):5323064-5335390      View in EpiBrowser

Full name

Protein inturned      

Alternative Name

Inturned planar cell polarity effector homolog
PDZ domain-containing protein 6

Location in the cell

Nuclear   Reliability : 3.661

CDS

ATGAGTAACTTTAAGGGTGTGAACTACGACAGCCCTTGTGATACTGATGACGATTGGACAGATTCATCTGACGATTCGAAATATTCTGATTCCGCAAGTTCTGTACCAGAATGGGACTCTGATGTTGAAGAGAATGGTGAACTGGTATTTATAAGAATTAAAAGAAGAAAAGAAAAATGTAATGAAAATAAAGCACCATTGTTAGAGAACTGTGAAACTTTTAAACTGAGAAATAATTTTAAAAGAACCTCAACTAGGCGATCGACGAAAGGTAAAATCTTTAAAGTATTAAAGGGACAAAGCTCAAAAAATAAAGCACAAAGCAAGAAGAAAGATTTAGAAAATATTAGAGCCACAAGTACTGCTACTTTAAACACAAATGAACTGACAGAAAATCCTAAAGAATCTGTAATAATTCAGGTAAGCAGGAATATGATTTTCAGCAGTGAAAAGAATTGCCAAATAGAAAAGTTGTTTGGTATTAGTTTGGAAACCCATTCTGATGGAAAATCTTTGATTGTTGCTGATTTTTTAACAGAAGCAATGCCTATTTATGGATCTAAAGTGAAAAAAGGTTACTACCTTACAAAAGTCAATGGCATTGAAGTAAATTCTTATAATATAAATAACATCCTCCAAAGAGTTTATGAGGAACCCAATAATCCAAAACTACAGTTTCAAATGCCTGAGGAGAGCTCTTTAATATCATTAGAACGACTTTTGAAATCAAAGAATTTACTAGAAAATAAGTCAACACAATTACTAAAAGATTTCTCATGTTCTGTATTATACATTTCCTGCAATGATATAGAAAACACTAGAAATGATGATAAAGGAGTAATATACTGTTATCCAAGGCCTTTCAGTCAAAATTTTTTGTACAACACAAGAGGTGCTTACCTAACATTAAACCATTTAGCACCAAAGTCATTGGGAACTAGTGAGCCAACATGTTCAACAGTTCTTCACAATGACAACTTAATTCATGTGAATTACACATCCCACTGTAACGATTTGCTACTAATAACATTTCCAAATAAATACATAGATGCATTTTCATCCAAAAAAGTAAATGCAGACATAGTGAAACTATTGGAATTTTTGTATGGATCATTGAAAACTTGCTTCACAAAACCTAACAATGTTGACAGACTGGATAGTTTATTCTGTAGAATTTTTGTTACTTTGCTATTCAATAATGAGCAAGCAAGTGCTTCTGATGTTCACTTTGAAGATATCTTAGCTGCATATTCTGTAACCTTGCCATTAGAAGTAAGAGTGCAAGTTGATGACGCCATTACAGAATTGGAAGCTGCTGATTATAGAGAATGGACAGATGATTTTGAAAACTTTCAACGTCTCTACACAGTAATAGGGTCATGTCTGTATTACTCTGGTCATTTGTTAAGTTCTCATTTACAAGATGAAGACTTGAAAGAAATAAATGCTTTTTTAAAACTTAACGGAGTATTGGCATTAAGTACTGATAATGAACTGGAAAAACTTGTTATGTGGAAAGAAGTTTTTATTCACGAACATAGAAAGCAAAGCAAAAATGATGGGCAGGACTACAGGATACCCGATGGGCGTTGGTTCTTACTCGTAGTTGGCAAGGGGCATTTCATTTTAGCTACATTAATGGAAGCCGGTGGATGTACCGAAGACGCTGTTGGTGTTACACCCCCTTCGCCGTTTTACGTAGAAGAATGCGAGAGCTGCCTCGAACTTTTCTATGAAGTAAGTCTGGATAAATATCTCGCTTCATGGCTGTCATCAAATACACACCCGCAGATCGAAACAACTCCAGAACGTCTCACTAAATATGGGAAGAAAATGAAGGAAATGAACTCCTTTAGAGCAGACACGCTAAGACCAACACTGAGAACATCAAAATCATCAGCAGATCTAAAGAAACGCCACAGTTCCTCTGAACAAATATACATGGGGTCCAGTTTGAGTGATAATTCTAATTACGGAAGCCATCACAACCTTTACAGTCAATGGTATCATGGCACGCAGAAGTACAGACACTCTAGTTTAGATGTCAGCCATTCAGAGGACTCGAACAGCCTCAAGAGTAACAGTGAAATCAGCGACGATAGAGTCCAAGGTAGAAGAGCAGATAGAGAACAAAGAAACCGTAGAGATTCTTCGGGATCCGATTCCGATTGGGACAGACAGGATGGTAGCAGAGCCAGCGGCAGCATCGACATGACCGACATCAGAAAGTCTTTACTGAACGAAATTAATCGGGTAACTGTTCACCGTATCACAACGGGCGAAGAAAACGTTTTGTTTCACTTCATACAACTCGAAGCAGAGAAAGGAATGTTCATAGCTCCCGTGCGGAACATCGAGGAGCAGGCCAATAACGTTTTGTATTCGTTTATCATACGAACATTTCGGAGCGCGTGTAAAAAAATACACGAATTACTTCAGCAAAGTATTAGGTTCAAAAGGAATCACGCTCCAGTGAATCCATTAAACAAAATTCTGGTTGCAGTTAAAGAATATGGAATGCTATTTCAAGTTCCACAGGATGTATTGAATCAATGCACTTCCAGCAGGAAAACCAATGAAATATTTAAATTTTGGGTTGTGGGACGTATCTTCAGTGAACCTGAACCGAGAGAGTTGTATATCTGCTACCACGAATCAATACCACAAGACCTGACTGAAGTTGGATATATGCTATCTTATTTGGAATGA

Protein

MSNFKGVNYDSPCDTDDDWTDSSDDSKYSDSASSVPEWDSDVEENGELVFIRIKRRKEKCNENKAPLLENCETFKLRNNFKRTSTRRSTKGKIFKVLKGQSSKNKAQSKKKDLENIRATSTATLNTNELTENPKESVIIQVSRNMIFSSEKNCQIEKLFGISLETHSDGKSLIVADFLTEAMPIYGSKVKKGYYLTKVNGIEVNSYNINNILQRVYEEPNNPKLQFQMPEESSLISLERLLKSKNLLENKSTQLLKDFSCSVLYISCNDIENTRNDDKGVIYCYPRPFSQNFLYNTRGAYLTLNHLAPKSLGTSEPTCSTVLHNDNLIHVNYTSHCNDLLLITFPNKYIDAFSSKKVNADIVKLLEFLYGSLKTCFTKPNNVDRLDSLFCRIFVTLLFNNEQASASDVHFEDILAAYSVTLPLEVRVQVDDAITELEAADYREWTDDFENFQRLYTVIGSCLYYSGHLLSSHLQDEDLKEINAFLKLNGVLALSTDNELEKLVMWKEVFIHEHRKQSKNDGQDYRIPDGRWFLLVVGKGHFILATLMEAGGCTEDAVGVTPPSPFYVEECESCLELFYEVSLDKYLASWLSSNTHPQIETTPERLTKYGKKMKEMNSFRADTLRPTLRTSKSSADLKKRHSSSEQIYMGSSLSDNSNYGSHHNLYSQWYHGTQKYRHSSLDVSHSEDSNSLKSNSEISDDRVQGRRADREQRNRRDSSGSDSDWDRQDGSRASGSIDMTDIRKSLLNEINRVTVHRITTGEENVLFHFIQLEAEKGMFIAPVRNIEEQANNVLYSFIIRTFRSACKKIHELLQQSIRFKRNHAPVNPLNKILVAVKEYGMLFQVPQDVLNQCTSSRKTNEIFKFWVVGRIFSEPEPRELYICYHESIPQDLTEVGYMLSYLE

Description

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (PubMed:20067783, PubMed:21761479). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Subunit

Interacts with CPLANE1. Interacts with FUZ and WDPCP; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex.

Similarity

Belongs to the inturned family.

Keywords

Alternative splicing   Cell projection   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Phosphoprotein   Reference proteome  

Feature

chain  Protein inturned
splice variant  In isoform 2.

Uniprot

H9JNC9   A0A2A4JWW1   A0A2H1V0W4   A0A194R991   A0A1E1WHI3   A0A212ETC1   + More
A0A0L7L8E9   A0A1W4XFE3   A0A2J7Q0J0   A0A1Y1LB14   F4X4V5   A0A151X4Y2   A0A0J7KR91   A0A151IC77   A0A151HYF8   A0A0C9R4Y2   A0A1B6LS24   A0A0L7RB70   A0A088A7Y1   A0A2A3EQC4   A0A1Y1LIJ3   A0A154PGN3   K7IS93   N6UPW1   U4UFL2   A0A232FBI9   F1RRA5   H0WSR5   D6WAP3   A0A287BJX7   A0A3Q2I9D3   A0A3Q2IB45   A0A2J8XPJ7   L8I0N1   Q059U7   K6ZXW4   A0A3L8S558   A0A2K5DUS1   F7H686   H2PEA3   F1MDL2   H0YV07   A0A3Q7V188   D2HIW7   U3IN26   G1L742   A0A2Y9LSG8   A0A341BEZ1   A0A2Y9M038   A0A2Y9LTG0   A0A2Y9M5K0   A0A2U3V4M8   A0A2Y9F1Y7   A0A2Y9F1Q0   A0A2Y9F3M8   A0A384BK17   U3K0D8   A0A383ZB40   L5K7F1   A0A091H150   A0A2J8XPJ5   G1MZG2   A0A1S3GPY4   A0A1B0CUG2  

Pubmed

19121390    26354079    22118469    26227816    28004739    21719571    + More
20075255    23537049    28648823    18362917    19820115    19892987    22751099    16141072    19468303    15489334    12693553    21183079    20067783    21761479    27158779    30282656    19393038    20360741    20010809    23749191    23258410    20838655   

EMBL

BABH01019453    NWSH01000423    PCG76495.1    ODYU01000159    SOQ34459.1    KQ460473    + More
KPJ14408.1    GDQN01004687    JAT86367.1    AGBW02012603    OWR44730.1    JTDY01002347    KOB71620.1    NEVH01019967    PNF22079.1    GEZM01060857    JAV70849.1    GL888679    EGI58528.1    KQ982522    KYQ55457.1    LBMM01004153    KMQ92754.1    KQ978069    KYM97363.1    KQ976730    KYM76422.1    GBYB01011364    JAG81131.1    GEBQ01013532    JAT26445.1    KQ414617    KOC68088.1    KZ288203    PBC33426.1    GEZM01060859    GEZM01060858    JAV70847.1    KQ434899    KZC11003.1    APGK01021787    KB740364    ENN80777.1    KB632275    ERL91148.1    NNAY01000462    OXU28206.1    AEMK02000067    AAQR03120824    AAQR03120825    AAQR03120826    AAQR03120827    AAQR03120828    AAQR03120829    AAQR03120830    AAQR03120831    AAQR03120832    KQ971312    EEZ98662.1    NDHI03003363    PNJ83951.1    JH882370    ELR49728.1    AK040233    AK035092    AC146980    AC163023    CH466530    BC125523    BC132387    AK122485    GABC01001267    GABF01007874    GABD01001472    NBAG03000277    JAA10071.1    JAA14271.1    JAA31628.1    PNI51887.1    QUSF01000060    RLV97358.1    ABGA01280517    ABGA01280518    ABGA01280519    ABGA01280520    ABGA01280521    ABGA01280522    ABGA01280523    DAAA02044649    ABQF01042439    GL192894    EFB27959.1    ADON01045679    ADON01045680    ACTA01073838    ACTA01081838    ACTA01089838    ACTA01097838    AGTO01001194    KB030951    ELK07644.1    KL448083    KFO80072.1    PNJ83954.1    AJWK01029153   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000037510    UP000192223    + More
UP000235965    UP000007755    UP000075809    UP000036403    UP000078542    UP000078540    UP000053825    UP000005203    UP000242457    UP000076502    UP000002358    UP000019118    UP000030742    UP000215335    UP000008227    UP000005225    UP000007266    UP000002281    UP000000589    UP000276834    UP000233020    UP000008225    UP000001595    UP000009136    UP000007754    UP000286642    UP000016666    UP000008912    UP000248483    UP000252040    UP000245320    UP000248484    UP000261680    UP000016665    UP000261681    UP000010552    UP000053760    UP000001645    UP000081671    UP000092461   

PRIDE

H9JNC9    F1RRA5    Q059U7    F1MDL2   

Interpro

IPR039151   INTU        + More
IPR036034   PDZ_sf       
IPR001478   PDZ       

SUPFAM

SSF50156   SSF50156       

ProteinModelPortal

H9JNC9   A0A2A4JWW1   A0A2H1V0W4   A0A194R991   A0A1E1WHI3   A0A212ETC1   + More
A0A0L7L8E9   A0A1W4XFE3   A0A2J7Q0J0   A0A1Y1LB14   F4X4V5   A0A151X4Y2   A0A0J7KR91   A0A151IC77   A0A151HYF8   A0A0C9R4Y2   A0A1B6LS24   A0A0L7RB70   A0A088A7Y1   A0A2A3EQC4   A0A1Y1LIJ3   A0A154PGN3   K7IS93   N6UPW1   U4UFL2   A0A232FBI9   F1RRA5   H0WSR5   D6WAP3   A0A287BJX7   A0A3Q2I9D3   A0A3Q2IB45   A0A2J8XPJ7   L8I0N1   Q059U7   K6ZXW4   A0A3L8S558   A0A2K5DUS1   F7H686   H2PEA3   F1MDL2   H0YV07   A0A3Q7V188   D2HIW7   U3IN26   G1L742   A0A2Y9LSG8   A0A341BEZ1   A0A2Y9M038   A0A2Y9LTG0   A0A2Y9M5K0   A0A2U3V4M8   A0A2Y9F1Y7   A0A2Y9F1Q0   A0A2Y9F3M8   A0A384BK17   U3K0D8   A0A383ZB40   L5K7F1   A0A091H150   A0A2J8XPJ5   G1MZG2   A0A1S3GPY4   A0A1B0CUG2  

KEGG

101743909    K22862 protein inturned | (RefSeq) protein inturned

GO

GO:0001736   GO:0060271   GO:0051782   GO:0030216   GO:0044458   GO:0021513   GO:1905515   GO:0031514   GO:0042733   GO:0021915   GO:0036064   GO:0010839   GO:0045880   GO:0030278   GO:0005737   GO:0031069   GO:0007399   GO:0060173   GO:0008589   GO:0009986  

PANTHER

PTHR21082  

Subcellular location

Cytoplasm  
Cell surface  
Cytoskeleton  
Cilium basal body  

Length:

902

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00134

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00007

outside

1  -  902

 

 

Pi

315.955584

Theta

208.27559

Tajima's D

1.850035

CLR

0.402729

CSRT

0.855857207139643

Interpretation

Uncertain