Silkworm Genome Informatics Database

Gene

KWMTBOMO13661

Pre Gene Modal

BGIBMGA011034

Annotation

toll_receptor_18_wheeler_[Spodoptera_frugiperda]

Location

Bomo_Chr23(-):5291573-5295480 View in EpiBrowser

Full name

Toll-like receptor 7

Location in the cell

Nuclear Reliability : 2.18 PlasmaMembrane Reliability : 1.535

CDS

ATGGACACAGTTGTTATTAAAATGATAATAAACACAATATTCTTTTGTTTTGTGATGGGCGCGGCGCTTACGGAAGCACCGGACGATGCAGATGCGTGTTTTCGTGTGGCAAGTGTGGACGGTATGGTGGAGTGCAATGTACGGACGTTGTCGTCGGACAGAGATGTCGTCGGTTCGATGCACTCGGATGGCACGGAGCGGCTCACAATCCGCTGTAGCCAGCTCCTGATCGAGAGCACCCTCAGGGATCATCATTTTGGAAAGATGCAAGGTCTAGCGGAGATATCGATTCACAATTGCAAGATATTGCGACTTCCGGGCAACGTCTTCGAGGGCTTGCGAGGTCTGAAGTCGTTGAAGATACGTTCGATGAACAACGAATGGGGCATAAATAAAGAGCTGGACTTTACGTTGGGCGCTTTCAACGGGTTGCGAGAGCTCCACACTTTGGACCTCGCTTATAATAACATCAGAAAAATACCATCTGATCTCTTCTGTGCTTTGGAAAATATAATATCTCTTAATTTAACTCACAACAAAATTAAATTTGTGGACGAACTGGGTTTCGGGCACAAATGTGGCTCTACGCTACAAAGGATAGATTTGAGTTTCAACGACATTATGTCCTTGCCGGCTGACTCCGAAATTTTACATTTAAGGAGGCTGACGCAGCTGTTTTTACAGAACAATAAAATAAGCGAGTTGCCGACTGAAGTTTTTAGTGATCTACTCTCGCTGAAAGTGGTGAACATTTCCGATAACGCTATTAACTATTTACCCGAAGGATTGTTTCATAATACAAGAGAGATTCGAGAAATTTACATGCAAAATAATGAGCTGGAAATTCTGCCGAAGAGAATATTTAATCGGTTGGAACAATTGCTCGTTTTAGATCTTTCGGCGAATAAATTGAAGAGCGACCACATAGAAGATGAAACGTTTAGCGGTCTAATAAGATTAATCGTGCTCGACCTATCGCATAACGTACTCACGCGGATTACTCGCAACATATTTAAGGACCTCTTTTGTTTACAAATACTCAGTTTAAATAATAATTCCATTGGATATGTTGAAGATAACGCCTTTTCGCCGCTTTATAACTTGCATACACTAAATTTGGGCCAGAATATGTTACACGCTGTAGAGGACCACATGTTTAATGGTTTATTTATTTTGAATAAACTAAACGTAAACAATAACTTACTGTCTTTTGTAAGTGTAAATGCATTTAAGAATTGTTCGGATTTGAAAGAATTAGACCTCAGTTCGAATAAGTTAACAAAAATACCGGAAGCAATATTGCAGTTACCTTTCTTGAAATCGTTGGACCTCGGAGAAAATTTATTAACGGAAATAACCAATAATTCATTTCAAAATCTATCGCAGTTGACCGGGTTACGTTTAATCGACAATCAAATTGGAAACCTTACCGCGGGCATGTTCTGGGCCTTGCCTGGCTTGCAAGTGCTTAATTTGGCGAAAAATAAAATTCAATCTATCGAAACTGAAACCTTTCAAAAGAACACACAATTGGAAGCCGTTCGTCTGGATGGTAACTTCGTTTCTGATATTAATGGTGTGTTCGTGGCTTTGACCAAATTGTTATGGTTGAATTTATCGGAGAATCATTTGGTTTGGTTCGATTACGCTTTTATACCAGGTAACTTGAAATGGTTGGATATTCATGCAAATTTCATTGAAATTCTCGGCAATTATTATAAAATTCAAAAAGAGTTACACATTAAAACTTTAGATGTTAGTCACAATCGTTTAGCAACTATATCGCCAATGTCAATACCAAATAGTGTTGAACTTTTATTTATAAACAACAATTTAATATCGAGCGTAGAGACGGACACCTTTCTAGAGAAGAGAAACTTGACTCGCGTCGATATGTATGCCAATGAGATTGAAAGTTTGGATATAAATAGTTTACGCATTTCGAGAGTGTCCGAAGATCGAACATTACCCGAGTTTTATATCAGCGGGAATCCATTTCGTTGCGATTGCAACATGAAATGGCTTTTGCTCATTAACTCCATCACATCGAGGCAATACCCGAGAGTGATGGATTTAGAAAATGTTATTTGTAAAGAGTCTTATGTACGCGGTGTTAAATATCTCTCAGTAACTTCGTTGCATCTTAAAGACTTCTTGTGTAAGTACGAAACCTATTGTCCGGATAATTGTGAATGCTGCGATTTAAATGACTGCGACTGTAAAACTTACTGTCCTACAAACTGTTCATGTTATCACGATTCTAGTAAAAGCACGAGCGTTGTTGATTGTTCTGTGCAACAATTAAAAGTAGTGCCTACAGCCTTTCCCATCGACGCGACACACATTTATTTAGACGGAAATGTTTACAGTGAACTCGGCGAAACCTTTTTCGATTCAATGCGCAACGCTTACGTCATTTATCTTAACGCTAGTAACATTATTATAATCAGGAATAATACGTTTAGTCAACTCCGAGACCTGAGGATATTACATTTAGACAACAATAAACTTAAACAATTACGGGGCCTCGAATTCTCAAAGTTAAGCAGCTTGAAAGAACTCTACCTCCAAAGTAATTTAATTGAGTATATTTCGAACGAAACTTTTTCTCAGTTGGGAGCGCTAGAAGTTTTGCGTTTGGACGGGAACCGGCTCGTGAATTACGGACTGTGGCATTTGGACAATAACAAAAAGTTACAAACATTGTTTATTGGAAACAACAATTGGTCATGCGATTGTAAATATTTACAAGGGTTCTTGACGTATGTGTCTCAGAATATTGAAAAAGTACTCGATATTCATAGTTTGTGGTGTGTGAATGAAAAACTAAAACCAGTTAAGAAGCCTTTGAATTTAAATATTACAGTTTGTAGTGAAATAAGTGAAAACTCAATGATGAGCGCCTTCTTTGTTTCCCACAACCTTCCGTTATTGGCGTCTGCCATCACCGGCTTCATGCTCATTTTATTAATATTGGCTTTGATATTCACATTTAGATATGCTTGTAGAATGTGGCTGTATTCGAACTGTGGAATTAAATTGTCCCCTTTGGCCTTTAAGGATACCGATAAACTTTACGACGCGTACGTCTGCTATAGCCCTAAAGACGAGGAGTTTGTAATAGAAACGTTGGCCCGAGAATTAGAAAACGGGTATCCGTCGTATCATCTCTGCCTTCATTACAGAGATGTACCACATTTTGAGGCGACATACGCACAGTTTCCAGACTTGGTAGTCGAAGCTACGGAAGCTTCAAGGCGTATCATAGTGGTGTTAACAAATAATTTCATTACAACGGAGTGGTCTCAGATAGAATTCCGACAAGCCCTGCAGAAAGCACTCCGAAAGAATCCAAACAAATTAATAATCGTCGCCGTAGGGCCCGTCCCACGAGATCCGGAGTTGAAGTCATATTTCAAAACGGGTTTGGAGATAACATGGAAGGAGAAACGGTTTTGGGAAAGGTTACGTTATGCGATGCCGTCTTCAAAGCGGCACGGGCATAAGTTAAAAATACTTAATTACGGAAGAAATTCTAATACGTACACAATGGACGCGTCGGTGTTAAACAGTACGTGCCAGACGCTCTGCGGAAAGTCTGCAAATTCTGCAGAGCGTTCGCCCTGTGATCGCCCCCTATCCGAACACATATATTCTACAATAGATTCGGATTACTCGTCAACAGATTTCCAAGGCCGACACAATCAGCCGCAGTCTGTGGTTTTCCAACATACTGTTCAAACGTACCTGGTATAA

Protein

MDTVVIKMIINTIFFCFVMGAALTEAPDDADACFRVASVDGMVECNVRTLSSDRDVVGSMHSDGTERLTIRCSQLLIESTLRDHHFGKMQGLAEISIHNCKILRLPGNVFEGLRGLKSLKIRSMNNEWGINKELDFTLGAFNGLRELHTLDLAYNNIRKIPSDLFCALENIISLNLTHNKIKFVDELGFGHKCGSTLQRIDLSFNDIMSLPADSEILHLRRLTQLFLQNNKISELPTEVFSDLLSLKVVNISDNAINYLPEGLFHNTREIREIYMQNNELEILPKRIFNRLEQLLVLDLSANKLKSDHIEDETFSGLIRLIVLDLSHNVLTRITRNIFKDLFCLQILSLNNNSIGYVEDNAFSPLYNLHTLNLGQNMLHAVEDHMFNGLFILNKLNVNNNLLSFVSVNAFKNCSDLKELDLSSNKLTKIPEAILQLPFLKSLDLGENLLTEITNNSFQNLSQLTGLRLIDNQIGNLTAGMFWALPGLQVLNLAKNKIQSIETETFQKNTQLEAVRLDGNFVSDINGVFVALTKLLWLNLSENHLVWFDYAFIPGNLKWLDIHANFIEILGNYYKIQKELHIKTLDVSHNRLATISPMSIPNSVELLFINNNLISSVETDTFLEKRNLTRVDMYANEIESLDINSLRISRVSEDRTLPEFYISGNPFRCDCNMKWLLLINSITSRQYPRVMDLENVICKESYVRGVKYLSVTSLHLKDFLCKYETYCPDNCECCDLNDCDCKTYCPTNCSCYHDSSKSTSVVDCSVQQLKVVPTAFPIDATHIYLDGNVYSELGETFFDSMRNAYVIYLNASNIIIIRNNTFSQLRDLRILHLDNNKLKQLRGLEFSKLSSLKELYLQSNLIEYISNETFSQLGALEVLRLDGNRLVNYGLWHLDNNKKLQTLFIGNNNWSCDCKYLQGFLTYVSQNIEKVLDIHSLWCVNEKLKPVKKPLNLNITVCSEISENSMMSAFFVSHNLPLLASAITGFMLILLILALIFTFRYACRMWLYSNCGIKLSPLAFKDTDKLYDAYVCYSPKDEEFVIETLARELENGYPSYHLCLHYRDVPHFEATYAQFPDLVVEATEASRRIIVVLTNNFITTEWSQIEFRQALQKALRKNPNKLIIVAVGPVPRDPELKSYFKTGLEITWKEKRFWERLRYAMPSSKRHGHKLKILNYGRNSNTYTMDASVLNSTCQTLCGKSANSAERSPCDRPLSEHIYSTIDSDYSSTDFQGRHNQPQSVVFQHTVQTYLV

Description

Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).

Similarity

Belongs to the Toll-like receptor family.

Keywords

Cell membrane Complete proteome Developmental protein Disulfide bond Immunity Innate immunity Leucine-rich repeat Membrane Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix

Feature

chain Toll-like receptor 7

Uniprot

A0A2A4JYD0 E7ELW1 A0A2H1X3K5 A0A0L7KRA1 A0A346RAG1 A0A194REP8 + More
A0A194PP46 Q8T0X1 A0A2W1BKS6 A0A0L7L3D8 A0A2H1WH37 A0A194RAT4 A0A2H1VXV0 A0A346RAG0 A0A2A4JD34 A0A194RA63 H9JND5 A0A194PQU4 A0A0L7LBL5 A0A212F1C8 A0A146M9V9 T1IG77 M9ZTX3 A0A1Y1NCG7 A0A1B6E502 D6WCJ1 A0A2P8XAF7 A0A2J7QT93 E0VWG3 A0A1W4WLF1 A0A173ADU3 A0A067RBC6 N6UJG9 U4U379 A0A0C9RIS5 A0A310SL87 A0A154P956 A0A0L7R9C9 A0A195F2L8 E2B6V0 A0A151WZV2 A0A026WNV7 E2ADM1 A0A3Q0ISR8 A0A195BLE7 A0A0J7KY78 A0A158P0I1 Q58NA4 E9IT41 A0A195CNS2 J9K725 A0A0K8U6D8 W8B2C2 A0A2S2NF12 A0A0A1XH20 A0A2H8TJ66 A0A084WHM2 A0A0L0BQY6 A0A182FVB0 A0A0L0BNV8 Q28YE4 B4GD91 A0A1I8PIB1 A0A0M3QVP6 A0A182IQI1 A0A1I8NHY3 A0A3B0J6P4 B0XB33 A0A1I8PJR2 A0A1S4K8X0 B4HPS5 Q2XXU6 A0A1A9X128 B4QEI1 Q7KIN0 Q2XXU7 A0A1I8NI86 Q17HM5 A0A182GI66 A0A1A9UI85 Q2XXU5 A0A1A9ZAJ4 A0A1B0FMZ9 A0A1A9YCW7 A0A1B0AU49 Q2XXU3 Q2XXU4 A0A0Q5VXA9 B3NJH1 B4PAQ8 A0A1A9WM65 A0A182P6H8 A0A182W929 A0A182MYM9 B4MRV0 B4KRL5 A0A182R5A9 A0A182Y1P8 B4LPR4 A0A182MF65

Pubmed

26227816 29910977 26354079 19121390 28756777 22118469 + More
26823975 23497397 28004739 18362917 19820115 29403074 20566863 24845553 23537049 20798317 24508170 30249741 21347285 21282665 24495485 25830018 24438588 26108605 15632085 17994087 25315136 16120803 22936249 10973475 10731132 12537572 12617819 21158756 22464169 23892553 25741726 17510324 26483478 17550304 25244985

EMBL

NWSH01000423 PCG76493.1 HQ852232 ADV41489.1 ODYU01013217 SOQ59911.1 + More
JTDY01006633 KOB65817.1 MH243027 AXS59161.1 KQ460473 KPJ14406.1 KQ459597 KPI94753.1 BABH01019412 AB070579 BAB85498.1 KZ149988 PZC75639.1 JTDY01003195 KOB69977.1 ODYU01008633 SOQ52385.1 KPJ14395.1 ODYU01005119 SOQ45671.1 MH243026 AXS59160.1 NWSH01001862 PCG69881.1 KPJ14394.1 BABH01019375 KQ459595 KPI95821.1 JTDY01001788 KOB72878.1 AGBW02010899 OWR47539.1 GDHC01002096 JAQ16533.1 ACPB03002369 KC355236 AGK40936.1 GEZM01011983 JAV93317.1 GEDC01004297 JAS33001.1 KQ971311 EEZ99327.1 PYGN01018333 PSN28975.1 NEVH01011197 PNF31811.1 DS235819 EEB17714.1 KX086263 KK854062 ANG08886.1 PTY10520.1 KK852574 KDR21050.1 APGK01021779 APGK01021780 KB740363 ENN80811.1 KB631964 ERL87512.1 GBYB01008155 JAG77922.1 KQ764513 OAD54497.1 KQ434835 KZC07924.1 KQ414628 KOC67361.1 KQ981856 KYN34631.1 GL446009 EFN88591.1 KQ982629 KYQ53430.1 KK107139 QOIP01000003 EZA57742.1 RLU24395.1 GL438820 EFN68383.1 KQ976440 KYM86510.1 LBMM01002090 KMQ95281.1 ADTU01005045 AY937243 AAX33677.1 GL765434 EFZ16266.1 KQ977580 KYN01749.1 ABLF02028882 GDHF01031799 GDHF01030188 JAI20515.1 JAI22126.1 GAMC01019149 JAB87406.1 GGMR01003079 MBY15698.1 GBXI01004062 JAD10230.1 GFXV01002236 MBW14041.1 ATLV01023858 KE525347 KFB49716.1 JRES01001589 KNC21654.1 KNC21696.1 CM000071 EAL26021.2 CH479181 EDW32586.1 CP012524 ALC42769.1 OUUW01000001 SPP75502.1 DS232609 EDS44003.1 CH480816 EDW48643.1 DQ138916 ABA86522.1 CM000362 CM002911 EDX07855.1 KMY95189.1 AF247765 DQ138914 AE013599 BT125656 AAF86225.1 ABA86520.1 ADN32842.1 DQ138915 ABA86521.1 CH477246 EAT46215.1 JXUM01065388 KQ562345 KXJ76106.1 DQ138917 ABA86523.1 CCAG010000917 JXJN01003516 DQ138919 ABA86525.1 DQ138918 ABA86524.1 CH954179 KQS62206.1 EDV55258.1 CM000158 EDW91449.1 CH963850 EDW74839.1 CH933808 EDW10441.1 CH940648 EDW60302.1 AXCM01003257

Proteomes

UP000218220 UP000037510 UP000053240 UP000053268 UP000005204 UP000007151 + More
UP000015103 UP000007266 UP000245037 UP000235965 UP000009046 UP000192223 UP000027135 UP000019118 UP000030742 UP000076502 UP000053825 UP000078541 UP000008237 UP000075809 UP000053097 UP000279307 UP000000311 UP000079169 UP000078540 UP000036403 UP000005205 UP000005203 UP000078542 UP000007819 UP000030765 UP000037069 UP000069272 UP000001819 UP000008744 UP000095300 UP000092553 UP000075880 UP000095301 UP000268350 UP000002320 UP000001292 UP000091820 UP000000304 UP000000803 UP000008820 UP000069940 UP000249989 UP000078200 UP000092445 UP000092444 UP000092443 UP000092460 UP000008711 UP000002282 UP000075885 UP000075920 UP000075884 UP000007798 UP000009192 UP000075900 UP000076408 UP000008792 UP000075883

PRIDE

Q8T0X1 H9JND5 Q7KIN0

Pfam

PF13855   LRR_8        + More
PF13306   LRR_5
PF01582   TIR
PF00560   LRR_1
PF13516   LRR_6
PF01462   LRRNT
PF13676   TIR_2

Interpro

IPR035897   Toll_tir_struct_dom_sf        + More
IPR032675   LRR_dom_sf
IPR000157   TIR_dom
IPR001611   Leu-rich_rpt
IPR003591   Leu-rich_rpt_typical-subtyp
IPR000372   LRRNT
IPR026906   LRR_5
IPR000483   Cys-rich_flank_reg_C

SUPFAM

SSF52200 SSF52200

Gene 3D

3.40.50.10140 3.80.10.10

ProteinModelPortal

A0A2A4JYD0 E7ELW1 A0A2H1X3K5 A0A0L7KRA1 A0A346RAG1 A0A194REP8 + More
A0A194PP46 Q8T0X1 A0A2W1BKS6 A0A0L7L3D8 A0A2H1WH37 A0A194RAT4 A0A2H1VXV0 A0A346RAG0 A0A2A4JD34 A0A194RA63 H9JND5 A0A194PQU4 A0A0L7LBL5 A0A212F1C8 A0A146M9V9 T1IG77 M9ZTX3 A0A1Y1NCG7 A0A1B6E502 D6WCJ1 A0A2P8XAF7 A0A2J7QT93 E0VWG3 A0A1W4WLF1 A0A173ADU3 A0A067RBC6 N6UJG9 U4U379 A0A0C9RIS5 A0A310SL87 A0A154P956 A0A0L7R9C9 A0A195F2L8 E2B6V0 A0A151WZV2 A0A026WNV7 E2ADM1 A0A3Q0ISR8 A0A195BLE7 A0A0J7KY78 A0A158P0I1 Q58NA4 E9IT41 A0A195CNS2 J9K725 A0A0K8U6D8 W8B2C2 A0A2S2NF12 A0A0A1XH20 A0A2H8TJ66 A0A084WHM2 A0A0L0BQY6 A0A182FVB0 A0A0L0BNV8 Q28YE4 B4GD91 A0A1I8PIB1 A0A0M3QVP6 A0A182IQI1 A0A1I8NHY3 A0A3B0J6P4 B0XB33 A0A1I8PJR2 A0A1S4K8X0 B4HPS5 Q2XXU6 A0A1A9X128 B4QEI1 Q7KIN0 Q2XXU7 A0A1I8NI86 Q17HM5 A0A182GI66 A0A1A9UI85 Q2XXU5 A0A1A9ZAJ4 A0A1B0FMZ9 A0A1A9YCW7 A0A1B0AU49 Q2XXU3 Q2XXU4 A0A0Q5VXA9 B3NJH1 B4PAQ8 A0A1A9WM65 A0A182P6H8 A0A182W929 A0A182MYM9 B4MRV0 B4KRL5 A0A182R5A9 A0A182Y1P8 B4LPR4 A0A182MF65

PDB

4KT1 E-value=3.18231e-25, Score=290

KEGG

101737382 no KO assigned | (RefSeq) slit homolog 3 protein-like

GO

GO:0016021 GO:0007165 GO:0045087 GO:0004721 GO:0007411 GO:0005030 GO:0051607 GO:0010508 GO:0009897 GO:0050688 GO:0046790 GO:0008329 GO:0002752 GO:0005515 GO:0015074 GO:0051276 GO:0016491 GO:0016620 GO:0016787 GO:0003676 GO:0015930

Subcellular location

Cell membrane

SignalP

Position: 1 - 24, Likelihood: 0.856658

Length:

1251

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

31.3027399999999

Exp number, first 60 AAs:

8.18221

Total prob of N-in:

0.40517

outside

1 - 974

TMhelix

975 - 997

inside

998 - 1251

Pi

305.708881

Theta

219.119112

Tajima's D

1.259663

CLR

0

CSRT

0.731513424328784

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics

Multiple alignment of Orthologues

Gene Tree