Gene

KWMTBOMO13649

Pre Gene Modal

BGIBMGA011037

Annotation

18_wheeler_[Operophtera_brumata]

Location

Bomo_Chr23(-):4913750-4918081      View in EpiBrowser

Full name

Toll-like receptor 7      

Location in the cell

Extracellular   Reliability : 1.309 Nuclear   Reliability : 1.15 PlasmaMembrane   Reliability : 1.674

CDS

ATGTACGCCATTGCAGCTGTGTTTTGTGCGCTGCTTCACTTCGGCTGGACTCTGATGCCGAACAACGCGGACAAATGCGCCCGTGTAACCGACAGAGGATTTGAATCGGCTGTCTGCAAGATCCGAACCCTTGAGAGCGAGGGAACTGCTATAGCTTCAGTATCCTCTGATACTAGCCGACTCTCTATAGAATGTAATCACCTGCTCTTCTTTGAAAGCTCTCTAAAGGCTCACTACTTTAAGCCCGTTCCAGGTCTTGTTGATTTGTCAATAAGCAACTGTAAGCTTCTAAGCGTACCAGACAACACATTCCATGGCCTAAGGAAACTTAAAAAGTTGCAACTAAGATCGAAAAACTTCGAGTGGAGCCCTACTAAGAATTTGGAGTTGTCTTTGAACGCGTTCAATGGATTATCGGAACTGCAGTCGTTGGATCTCGCTCAAAATAACATCAAATTCATTCCTTCCGGTGTGTTCTGCGTTTTGGAGAATTTAAACACACTCAACTTAACTTACAATCGAATCAAAACCGTTGGACAGATCGGCTTTGGACAAGGATGCGGATCTAGTTTACAAAGTCTGGATCTAAGTCATAATATGATTAAAACTATATCGGATGGTTCTGAATTGCTGAAATTAAGAAGTTTGCAACATTTATATCTACAGCATAATAATATCACCGACATATCAAATGAAGCATTTGACGGGCTTATATCTATGAGAGTTTTAAACATATCCCACAACCGCTTGCACACATTGCCCGAAGGACTGTTTGTGAATGCCAGAGAATTAAGAGAAATATACTTAAACGATAACAGCATTTATGAGTTGGCTCGAGGTATATTTCATCGTCTAGAACAGTTGATTGTTTTAGATATTTCGAGTAATCAACTTACGAGCAATCACATTGATGACGGCACTTTCTTGGGCTTAATCCGGTTGATCGTTCTGAATTTATCTAACAACGCACTAACAAGAGTGGACGGGAAAACGTTTAAAGACTTGTTCGTTTTACAAATACTTAATTTGAAAAACAACTCGATTGGATACATCGAAGATAACGCTTTTTTGCCACTCTACAACCTGCACACGCTCAATTTAGCCGAAAACCGTCTTCACACAATAGACGAGAATTTGTTCAACGGCTTATTTGTTCTCAGCAAATTGACCCTCAACAACAATTTACTCGTCAACATCGACCGTAAAGCATTTAAAAATTGCTCGGACTTAAAAGAATTGGACCTCAGCTCTAATCAGCTACTGGAAGTACCCGAAGCTTTGTGGGAGCTTCCGTTTCTGAAAACGCTCGATTTAGGAGAAAATCAGTTATCTAACTTCAGAAATGGCTCTTTCAAGAACTTGAACCAATTAACCGGCCTGAGGTTGATTGACAATCAAATAGGAAACTTGAGCGTCGGAATGTTTTGGGATTTGCCGAGTTTACAAGTTTTGAATATCGCAAAGAACAAAATTCTGTCAATTGAAAGAGAAACGTTTATTCGCAACACACAACTAGAAGCAATACGTCTGGACGGCAATTTTCTGTCGGACATCAACGGTGTTTTCTCAACGCTCGCGAGTCTTTTGTGGTTGAACTTATCGGAAAATCATCTTGTGTGGTTTGATTATGCGTTTGTGCCTAGTAATCTAAAGTGGTTAGACATTCATGGAAATTTCATTGAACATTTAGGCAACTATTACAAGTTGCAAGAAGAAATTCGTATAAAGACCTTAGATGTTAGTCATAATCGTATTTCGGAAATATCGCCAATGGCAATACCTAATAGTGTTGAATTACTGTTCATAAACAATAACTTTTTGAATGCAATTCATGTGAATACGTTTTTCGATAAAAAGAATTTGACGCGAGTGGATATGTATGCAAATGAAATCAATCATTTAGAATTGAATAGCTTACGTTTGTCGACAGTGCCGGGAAACAAAACACTACCGGAATTTTATATTGGCGGTAATCCTTTTCAGTGTGACTGTACTATGGAGTGGCTCCCAATTATAAATAATATGACCGCTATGAGACAATATCCGCGAGTGATGGACTTAGAAAATGTTTTGTGTAAGATGACAAATACACGTAGTGGAACGCATGTGCCCTTAACTAACCTTAAGACGACAGACTTTCTTTGTAAGTATGAGACTCATTGTTTTGCTATCTGTCACTGCTGCGACTATGATGCGTGTGACTGTGAAATGACCTGCCCTCACAATTGCACCTGCTACCACGATCCATTGTGGAACACAAATGTTGTCGATTGTTCGGGGCAATCTTCAATGGAAATACCACAGAAAATACCCATGGATGCAACAGAAGTGTTTTTAGATGGCAATAATATTCGGGAATTGCAGAATCACGTGTTTATCGGAAGACAGAAGATGAGAACACTGTATGTTAATAATAGTAACGTAGATAGCATTCAAAACAGAACTTTCTCTGGTTTGAACTCGTTACAAATACTGCACTTGGGTAACAATAAACTCAAAGAATTAAAAGGATACGAATTCCAACAGTTGAATAACCTAAAAGAACTATTCTTACAAAACAATCTAATCAGTCATATCGCAAACATATCATTTTTATCTCTTAAGTCCCTAGAGTTGTTACGCCTTGACGGCAATAGACTCGTAGACTTCGGAGTATGGAGCTTTAGTAACAATCTAAACTTGAAGGCATTATCATTAGGAAATAATTTGTGGTCCTGCAAATGTCGCTACCTGCAAGAGCTAACTGCGTTTTTGGCGGAGAATGCGCAAAAAATTATTGACATTACGGACGTGTGGTGTTGGAATGGCGACGCGAAACCGCCGCAGAAAAAAGAACTCAACTTAAATGGCACTGCCTGCAGCGATTATTACGCCGATAATTCAGTCATTGGAAACATGTTGGTCTCAAACTATGTTCCCATGATGGTTTCAACTCTAACCGGGTTCATGTTAATTTTACTGGCTCTGGTCCTGCTGTTTCTTTTTAGAGATTCACTGAGAGTGTGGCTGTATACAAATTGCGGCATTAGAGTGTTTTCGTTACCCGGAACTTTTGAGGAGAATCAAAAATTATACGACGCCTACGTTTGCTATAGCCCAAAAGACGAAGAGTCTGTCGTGCAGTCGTTAGTGAATGAGCTAGAAAACGGGAATCCATCGTACCATCTTTGCCTTCATTACCGTGACATTCCACATCACGGCGCTCAGTACATGCAATGCGCGCCGCCAGACGTCGAGACCGCGGAAGCATCCAAACGAATAATTATCGTCCTAACGAGAAATTTCATGCAAACCGAGTGGTCCCGATACGAATTCCGACAAGGTCTGCACGAAGCATTAAAAGGGTGTATTTATAAACTCGTTCTAATAGAAGAGTGTTCTGTGGTGGCGGACGCAATGTGCGACCCCGATTTACGACCCTACCTCAAGACGGGATCGCGGCTGAGGTGGGGACAGAAAGGGTTCTGGGAGCGTCTCAGGTATATAATGCCCGATTCGACGCATTCAAGCCATAAATCGCGATCTCATAGTTATAGAAGAAGTATTAACACGTATACATTAGATTCGTCTGTGCCTAACGGAGGGAATCGCACGATGGCTTTTCCTGATAAGTCGCCTGTGTTGGGAGTTGCGAATCAGGGGGCTAGTGCGCCACCGGAATACGTCACAGAGGTCCGACAGTCACCTTCTGTTGTTAGACAAACCCAGGGCGTCGCTTACGGGCCGGACGGCAGGCCGATCTCAGATCACATATATTCCTCGATAGATTCTGACTATTCATCCTTGGAACATGGTATGGCCCCGGGCAGGCGGCGAGACATCCGCCAGTGGCCCCCGCCCCCGCCTCTCGTCGACACGGGCAACGCCGTGCAAGCCTACCTAGTCTAA

Protein

MYAIAAVFCALLHFGWTLMPNNADKCARVTDRGFESAVCKIRTLESEGTAIASVSSDTSRLSIECNHLLFFESSLKAHYFKPVPGLVDLSISNCKLLSVPDNTFHGLRKLKKLQLRSKNFEWSPTKNLELSLNAFNGLSELQSLDLAQNNIKFIPSGVFCVLENLNTLNLTYNRIKTVGQIGFGQGCGSSLQSLDLSHNMIKTISDGSELLKLRSLQHLYLQHNNITDISNEAFDGLISMRVLNISHNRLHTLPEGLFVNARELREIYLNDNSIYELARGIFHRLEQLIVLDISSNQLTSNHIDDGTFLGLIRLIVLNLSNNALTRVDGKTFKDLFVLQILNLKNNSIGYIEDNAFLPLYNLHTLNLAENRLHTIDENLFNGLFVLSKLTLNNNLLVNIDRKAFKNCSDLKELDLSSNQLLEVPEALWELPFLKTLDLGENQLSNFRNGSFKNLNQLTGLRLIDNQIGNLSVGMFWDLPSLQVLNIAKNKILSIERETFIRNTQLEAIRLDGNFLSDINGVFSTLASLLWLNLSENHLVWFDYAFVPSNLKWLDIHGNFIEHLGNYYKLQEEIRIKTLDVSHNRISEISPMAIPNSVELLFINNNFLNAIHVNTFFDKKNLTRVDMYANEINHLELNSLRLSTVPGNKTLPEFYIGGNPFQCDCTMEWLPIINNMTAMRQYPRVMDLENVLCKMTNTRSGTHVPLTNLKTTDFLCKYETHCFAICHCCDYDACDCEMTCPHNCTCYHDPLWNTNVVDCSGQSSMEIPQKIPMDATEVFLDGNNIRELQNHVFIGRQKMRTLYVNNSNVDSIQNRTFSGLNSLQILHLGNNKLKELKGYEFQQLNNLKELFLQNNLISHIANISFLSLKSLELLRLDGNRLVDFGVWSFSNNLNLKALSLGNNLWSCKCRYLQELTAFLAENAQKIIDITDVWCWNGDAKPPQKKELNLNGTACSDYYADNSVIGNMLVSNYVPMMVSTLTGFMLILLALVLLFLFRDSLRVWLYTNCGIRVFSLPGTFEENQKLYDAYVCYSPKDEESVVQSLVNELENGNPSYHLCLHYRDIPHHGAQYMQCAPPDVETAEASKRIIIVLTRNFMQTEWSRYEFRQGLHEALKGCIYKLVLIEECSVVADAMCDPDLRPYLKTGSRLRWGQKGFWERLRYIMPDSTHSSHKSRSHSYRRSINTYTLDSSVPNGGNRTMAFPDKSPVLGVANQGASAPPEYVTEVRQSPSVVRQTQGVAYGPDGRPISDHIYSSIDSDYSSLEHGMAPGRRRDIRQWPPPPPLVDTGNAVQAYLV

Description

Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).

Similarity

Belongs to the Toll-like receptor family.

Keywords

Cell membrane   Complete proteome   Developmental protein   Disulfide bond   Immunity   Innate immunity   Leucine-rich repeat   Membrane   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Toll-like receptor 7

Uniprot

Q8T0X1   A0A2H1VXV0   A0A2A4JD34   A0A0L7L3D8   A0A194RAT4   A0A346RAG0   + More
A0A212F1C8   A0A2W1BKS6   A0A2H1WH37   H9JND5   A0A0L7LBL5   A0A194RA63   A0A194PQU4   A0A1Y1NCG7   D6WCJ1   T1IG77   A0A146M9V9   A0A1B6E502   A0A2P8XAF7   M9ZTX3   A0A173ADU3   A0A2J7QT93   A0A1W4WLF1   N6UJG9   E0VWG3   U4U379   A0A067RBC6   A0A173ADY6   A0A0C9RIS5   A0A2S2NF12   J9K725   A0A2H8TJ66   A0A2A4JYD0   Q28YE4   A0A0L7KRA1   A0A3B0J6P4   B4GD91   A0A2H1X3K5   A0A084WHM2   Q7KIN0   B4HPS5   B4QEI1   A0A1W4V4Y2   B4PAQ8   A0A3Q0ISR8   Q2XXU6   Q2XXU3   Q2XXU7   A0A0Q5VXA9   B3NJH1   Q2XXU5   A0A0A1XH20   A0A0K8U6D8   A0A346RAG1   Q2XXU4   W8B2C2   E7ELW1   A0A0M3QVP6   B4LPR4   A0A1A9XFX2   B0XB33   A0A1B0G962   A0A1B0AU10   B3MH72   B4JWD8   A0A1A9VLS3   A0A1A9ZAN6   A0A194PP46   A0A1S4K8X0   A0A182IQI1   B4KRL5   A0A182W929   A0A1A9X128   B4MRV0   A0A194REP8   A0A0L0BQY6   A0A182P6H8   A0A182KDD0   A0A182Y1P8   A0A182MF65   A0A1I8NHY3   A0A182R5A9   A0A182U8S0   A0A182MYM9   A0A151WZV2   A0A182WZL3   A0A1S4H8Z7   A0A195F2L8   A0A182HQ59   A0A182VKY1   A0A182FVB0   Q7Q090   A0A195BLE7   A0A1I8PIB1   A0A158P0I1   A0A1B0DF24   E2ADM1   E2B6V0   A0A182GI66   A0A182QS18  

Pubmed

19121390    26227816    26354079    29910977    22118469    28756777    + More
28004739    18362917    19820115    26823975    29403074    23497397    23537049    20566863    24845553    15632085    17994087    24438588    10973475    10731132    12537572    16120803    12617819    21158756    22464169    23892553    25741726    22936249    17550304    25830018    24495485    26108605    25244985    25315136    12364791    21347285    20798317    26483478   

EMBL

BABH01019412    AB070579    BAB85498.1    ODYU01005119    SOQ45671.1    NWSH01001862    + More
PCG69881.1    JTDY01003195    KOB69977.1    KQ460473    KPJ14395.1    MH243026    AXS59160.1    AGBW02010899    OWR47539.1    KZ149988    PZC75639.1    ODYU01008633    SOQ52385.1    BABH01019375    JTDY01001788    KOB72878.1    KPJ14394.1    KQ459595    KPI95821.1    GEZM01011983    JAV93317.1    KQ971311    EEZ99327.1    ACPB03002369    GDHC01002096    JAQ16533.1    GEDC01004297    JAS33001.1    PYGN01018333    PSN28975.1    KC355236    AGK40936.1    KX086263    KK854062    ANG08886.1    PTY10520.1    NEVH01011197    PNF31811.1    APGK01021779    APGK01021780    KB740363    ENN80811.1    DS235819    EEB17714.1    KB631964    ERL87512.1    KK852574    KDR21050.1    KX086267    ANG08890.1    GBYB01008155    JAG77922.1    GGMR01003079    MBY15698.1    ABLF02028882    GFXV01002236    MBW14041.1    NWSH01000423    PCG76493.1    CM000071    EAL26021.2    JTDY01006633    KOB65817.1    OUUW01000001    SPP75502.1    CH479181    EDW32586.1    ODYU01013217    SOQ59911.1    ATLV01023858    KE525347    KFB49716.1    AF247765    DQ138914    AE013599    BT125656    AAF86225.1    ABA86520.1    ADN32842.1    CH480816    EDW48643.1    CM000362    CM002911    EDX07855.1    KMY95189.1    CM000158    EDW91449.1    DQ138916    ABA86522.1    DQ138919    ABA86525.1    DQ138915    ABA86521.1    CH954179    KQS62206.1    EDV55258.1    DQ138917    ABA86523.1    GBXI01004062    JAD10230.1    GDHF01031799    GDHF01030188    JAI20515.1    JAI22126.1    MH243027    AXS59161.1    DQ138918    ABA86524.1    GAMC01019149    JAB87406.1    HQ852232    ADV41489.1    CP012524    ALC42769.1    CH940648    EDW60302.1    DS232609    EDS44003.1    CCAG010007790    JXJN01003494    CH902619    EDV36849.1    CH916375    EDV98276.1    KQ459597    KPI94753.1    CH933808    EDW10441.1    CH963850    EDW74839.1    KPJ14406.1    JRES01001589    KNC21654.1    AXCM01003257    KQ982629    KYQ53430.1    AAAB01008986    KQ981856    KYN34631.1    APCN01003296    EAA00348.4    KQ976440    KYM86510.1    ADTU01005045    AJVK01058481    GL438820    EFN68383.1    GL446009    EFN88591.1    JXUM01065388    KQ562345    KXJ76106.1    AXCN02001040   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000007151    UP000053268    + More
UP000007266    UP000015103    UP000245037    UP000235965    UP000192223    UP000019118    UP000009046    UP000030742    UP000027135    UP000007819    UP000001819    UP000268350    UP000008744    UP000030765    UP000000803    UP000001292    UP000000304    UP000192221    UP000002282    UP000079169    UP000008711    UP000092553    UP000008792    UP000092443    UP000002320    UP000092444    UP000092460    UP000007801    UP000001070    UP000078200    UP000092445    UP000075880    UP000009192    UP000075920    UP000091820    UP000007798    UP000037069    UP000075885    UP000075881    UP000076408    UP000075883    UP000095301    UP000075900    UP000075902    UP000075884    UP000075809    UP000076407    UP000078541    UP000075840    UP000075903    UP000069272    UP000007062    UP000078540    UP000095300    UP000005205    UP000092462    UP000000311    UP000008237    UP000069940    UP000249989    UP000075886   

PRIDE

Q8T0X1    H9JND5    Q7KIN0   

Pfam

PF13855   LRR_8        + More
PF01582   TIR
PF13306   LRR_5
PF00560   LRR_1
PF13516   LRR_6
PF13676   TIR_2

Interpro

IPR032675   LRR_dom_sf        + More
IPR035897   Toll_tir_struct_dom_sf       
IPR000157   TIR_dom       
IPR001611   Leu-rich_rpt       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR000372   LRRNT       
IPR026906   LRR_5       
IPR000483   Cys-rich_flank_reg_C       

SUPFAM

SSF52200   SSF52200       

Gene 3D

3.40.50.10140     3.80.10.10    

ProteinModelPortal

Q8T0X1   A0A2H1VXV0   A0A2A4JD34   A0A0L7L3D8   A0A194RAT4   A0A346RAG0   + More
A0A212F1C8   A0A2W1BKS6   A0A2H1WH37   H9JND5   A0A0L7LBL5   A0A194RA63   A0A194PQU4   A0A1Y1NCG7   D6WCJ1   T1IG77   A0A146M9V9   A0A1B6E502   A0A2P8XAF7   M9ZTX3   A0A173ADU3   A0A2J7QT93   A0A1W4WLF1   N6UJG9   E0VWG3   U4U379   A0A067RBC6   A0A173ADY6   A0A0C9RIS5   A0A2S2NF12   J9K725   A0A2H8TJ66   A0A2A4JYD0   Q28YE4   A0A0L7KRA1   A0A3B0J6P4   B4GD91   A0A2H1X3K5   A0A084WHM2   Q7KIN0   B4HPS5   B4QEI1   A0A1W4V4Y2   B4PAQ8   A0A3Q0ISR8   Q2XXU6   Q2XXU3   Q2XXU7   A0A0Q5VXA9   B3NJH1   Q2XXU5   A0A0A1XH20   A0A0K8U6D8   A0A346RAG1   Q2XXU4   W8B2C2   E7ELW1   A0A0M3QVP6   B4LPR4   A0A1A9XFX2   B0XB33   A0A1B0G962   A0A1B0AU10   B3MH72   B4JWD8   A0A1A9VLS3   A0A1A9ZAN6   A0A194PP46   A0A1S4K8X0   A0A182IQI1   B4KRL5   A0A182W929   A0A1A9X128   B4MRV0   A0A194REP8   A0A0L0BQY6   A0A182P6H8   A0A182KDD0   A0A182Y1P8   A0A182MF65   A0A1I8NHY3   A0A182R5A9   A0A182U8S0   A0A182MYM9   A0A151WZV2   A0A182WZL3   A0A1S4H8Z7   A0A195F2L8   A0A182HQ59   A0A182VKY1   A0A182FVB0   Q7Q090   A0A195BLE7   A0A1I8PIB1   A0A158P0I1   A0A1B0DF24   E2ADM1   E2B6V0   A0A182GI66   A0A182QS18  

KEGG

100144599    no KO assigned | (RefSeq) 18w, Bm18w, BmToll7-2; 18 wheeler

GO

GO:0007165   GO:0016021   GO:0045087   GO:0004721   GO:0007411   GO:0005030   GO:0051607   GO:0010508   GO:0009897   GO:0050688   GO:0046790   GO:0008329   GO:0002752   GO:0005515   GO:0005694   GO:0051276   GO:0016491   GO:0016620   GO:0016787   GO:0003676   GO:0015930  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 23,         Likelihood:  0.900784

 

 

Length:

1295

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

25.19204

Exp number, first 60 AAs:

2.12128

Total prob of N-in:

0.11592

outside

1  -  972

TMhelix

973  -  995

inside

996  -  1295

 

 

Pi

244.233917

Theta

211.983452

Tajima's D

0.637163

CLR

0.117354

CSRT

0.555772211389431

Interpretation

Uncertain