Gene

KWMTBOMO13632

Pre Gene Modal

BGIBMGA011067

Annotation

tyramine_receptor_[Bombyx_mori]

Location

Bomo_Chr23(+):3666910-3668722      View in EpiBrowser

Full name

Octopamine receptor       + More
Tyramine receptor 1      
Putative tyramine receptor 2      
Tyramine/octopamine receptor      

Alternative Name

Tyr-Loc1
Tyr-Loc2
Tyr/Oct-Dro

Location in the cell

PlasmaMembrane   Reliability : 4.853

CDS

ATGGGTCAAGCAGCTACTCACGATGCAAATAACTACACCTCCATTAATTACACGGAGATTTACGACGTGATTGAAGACGAAAAGGACGTATGCGCCGTCGCTGACGAACCTAAATATCCTAGTAGTTTTGGAATAAGTTTAGCTGTTCCAGAATGGGAAGCTATTTGTACAGCTATAATACTAACGATGATTATAATTTCAACGGTGGTCGGAAACATTCTTGTTATATTAAGTGTATTTACCTACAAACCCCTTAGAATTGTTCAGAACTTCTTCATTGTATCCTTAGCTGTGGCAGATTTAACCGTAGCCATATTAGTTCTGCCGTTGAACGTTGCATATTCTATCCTCGGACAATGGGTCTTTGGCATTTACGTCTGTAAAATGTGGCTCACTTGCGACATAATGTGTTGTACGTCGTCCATTCTAAACCTTTGCGCCATCGCCTTAGATAGATATTGGGCCATTACGGATCCCATAAATTACGCACAAAAAAGAACATTGGAACGAGTTCTCTTTATGATCGGAATCGTTTGGATACTGTCGCTTGTGATTAGTTCTCCACCTTTACTTGGATGGAACGATTGGCCTGAAGTGTTCGAACCTGATACACCATGTCGCTTAACTTCGCAACCAGGGTTTGTAATATTTTCATCATCTGGCTCCTTCTACATTCCGCTTGTCATAATGACTGTAGTTTATTTCGAAATCTATTTAGCGACCAAAAAGAGACTAAGGGACCGAGCTAAAGCAACCAAAATCAGTACGATTTCCAGCGGTCGGAATAAATATGAAACTAAAGAAAGTGATCCTAACGACCAGGATTCGGTCAGCTCGGATGCTAATCCCAACGAACATCAAGGGAGTACACGTCTTGTTGCGGAAAACGAGAAGAAACACAGGACAAGAAAATTGACCCCAAAAAAGAAACCGAAGCGCCGATACTGGAGCAAAGATGATAAATCACACAACAAACTGATAATCCCAATATTATCTAATGAAAACTCCGTTACAGATATCGGAGAAAATCTCGAAAATAGAAACACATCTTCCGAAAGTAATTCCAAGGAAACTCACGAGGATAATATGATAGAAATAACTGAGGCGGCGCCCGTGAAAATACAAAAACGTCCTAAACAAAATCAAACTAACGCAGTTTATCAGTTTATTGAAGAGAAACAAAGAATATCGCTTACGAGAGAACGAAGAGCTGCAAGGACCCTAGGTATCATAATGGGCGTTTTCGTGGTATGCTGGCTTCCTTTCTTTGTCATCTACCTCGTTATACCATTCTGTGTTAGCTGTTGCCTCTCAAATAAGTTTATAAACTTCATAACTTGGCTGGGCTACGTTAATTCAGCTTTAAATCCTTTGATTTACACCATCTTTAACATGGACTTCAGGCGAGCGTTCAAGAAACTTTTATTCATTAAATGCTAA

Protein

MGQAATHDANNYTSINYTEIYDVIEDEKDVCAVADEPKYPSSFGISLAVPEWEAICTAIILTMIIISTVVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIYVCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPINYAQKRTLERVLFMIGIVWILSLVISSPPLLGWNDWPEVFEPDTPCRLTSQPGFVIFSSSGSFYIPLVIMTVVYFEIYLATKKRLRDRAKATKISTISSGRNKYETKESDPNDQDSVSSDANPNEHQGSTRLVAENEKKHRTRKLTPKKKPKRRYWSKDDKSHNKLIIPILSNENSVTDIGENLENRNTSSESNSKETHEDNMIEITEAAPVKIQKRPKQNQTNAVYQFIEEKQRISLTRERRAARTLGIIMGVFVVCWLPFFVIYLVIPFCVSCCLSNKFINFITWLGYVNSALNPLIYTIFNMDFRRAFKKLLFIKC

Description

Receptor for octopamine. Octopamine (OA) is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine.
Receptor for both octopamine and tyramine, invertebrate neurotransmitters, and neuromodulators. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The rank order of potency for agonists is tyramine > octopamine > dopamine > epinephrine > norepinephrine > serotonin > histamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > cyproheptadine > dihydroergotamine > clonidine > synephrine. Tyramine has a functional role in the olfactory system as a neurotransmitter or a neuromodulator.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   Complete proteome   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix   Disulfide bond   Signal  

Feature

chain  Octopamine receptor

Uniprot

Q75Q62   Q17232   A0A2W1BLA9   A0A2A4JX52   Q25188   C0KUC4   + More
Q9BMA9   K7X591   B6VCU4   H9TVJ1   A0A0L7L1P8   Q5TLF2   H6V946   A0A194R9Q7   A0A194PXG8   H6V941   A0A0L7KX43   H6V955   A0A067RA39   A0A182GM86   A0A2J7PXP3   A0A1S4FER2   Q174N1   A0A0S1VX60   A0A2P8ZMW5   A0A1B6KR70   A0A1A9YS13   A0A1A9WE30   A0A1B0B8P5   A0A1B0FFH5   A0A1A9UJK3   A0A239QQ38   A0A1B0AE24   A0A084VAR5   A0A1I8N989   A0A1B6HUG0   W8BRJ9   A0A182P966   N6T3X1   A0A1W4XD11   B4L014   A0A182SS06   A0A291L8I9   N6U8N0   A0A034VDT7   A0A1I8PZN3   D6WB14   U4UPW3   H7C947   Q25321   A0A3B0J3V2   Q25322   X2KVP8   A0A2R7WKB4   A0A0T6BFE4   A0A0A1WN68   A0A1B0DBN2   B4H8P5   Q29DM9   A0A0M5JAY1   D9U2B9   T1HXE2   B4J0Q1   A0A1S3D2H7   B3NJ22   B3MAJ7   A0A067RCP4   A0A3R7QA23   B4QKQ5   A0A0J9RZQ0   B4IAY2   B4ITB5   E1JI27   P22270   A0A336K1A1   A0A0L0BXB5   A0A1B3P974   A0A084WLP0   A0A195C6Z9   A0A195ES94   A0A195D7X6   F4W7W3   A0A158NDV6   A0A151X4P8   E9IGQ7   Q9NG02   A0A026WCQ7   A0A2A3EQ07   S4VN83   A0A0L7RBY0   E2C5H6   B2G4W4   A0A310S7D4   A0A3R7MAV2   A0A2J7PXP4   A0A2H1WAD4   E0VJ37   A0A0L7L8Z9  

Pubmed

12752654    15373809    19121390    9014328    28756777    23129510    + More
26227816    15544938    22504014    26354079    24845553    26483478    17510324    29403074    24438588    25315136    24495485    23537049    17994087    29018364    25348373    18054377    18025266    18362917    18316733    20068045    19820115    21843505    23604020    21603928    7760020    24646461    25830018    15632085    20558147    22936249    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    2156539    2170118    10713442    26108605    21719571    21347285    21282665    10693920    24508170    30249741    20798317    20566863   

EMBL

BABH01019289    AB162828    BAD11157.1    X95607    KZ149986    PZC75678.1    + More
NWSH01000445    PCG76356.1    X95606    FJ640850    ACN12797.1    AF343878    AAK14402.1    JX649102    AFX62896.1    FJ374691    ACJ06651.1    JQ416145    AFG26689.1    JTDY01003643    KOB69231.1    AB182633    BAD72869.1    JN815181    AFA55168.1    KQ460473    KPJ14377.1    KQ459595    KPI95840.1    JN815176    AFA55167.1    JTDY01004721    KOB67833.1    JN815190    AFA55169.1    KK852786    KDR16545.1    JXUM01073908    KQ562800    KXJ75097.1    NEVH01020853    PNF21105.1    CH477408    EAT41524.2    KR998320    ALM55746.1    PYGN01000014    PSN57836.1    GEBQ01026050    JAT13927.1    JXJN01010026    CCAG010005169    LT900530    SNT95699.1    ATLV01004137    KE524190    KFB35059.1    GECU01029390    JAS78316.1    GAMC01004788    JAC01768.1    APGK01053236    KB741223    KB632273    ENN72328.1    ERL91072.1    CH933809    EDW19049.2    MF377527    ATI14907.1    APGK01044538    APGK01044539    KB741026    ENN74962.1    GAKP01017466    JAC41486.1    BK005861    KQ971311    DAA64498.1    EEZ99333.1    KB632309    ERL92065.1    AB621975    BAL72847.1    X69520    OUUW01000002    SPP76394.1    X69521    KJ152562    AHN85845.1    KK854880    PTY19440.1    LJIG01000889    KRT86051.1    GBXI01014161    JAD00131.1    AJVK01013732    CH479224    EDW35088.1    CH379070    EAL30385.2    CP012525    ALC43118.1    EU233816    ABY71758.1    ACPB03005322    CH916366    EDV97906.1    CH954178    EDV52739.1    CH902618    EDV41284.1    KDR16544.1    QCYY01002139    ROT72525.1    CM000363    EDX11470.1    CM002912    KMZ01142.1    CH480826    EDW44445.1    CH891687    EDW99628.1    AE014296    ACZ94765.1    M60789    X54794    AB073914    BT025156    UFQS01000022    UFQT01000022    SSW97582.1    SSX17968.1    JRES01001184    KNC24708.1    KU710373    AOG14369.1    ATLV01024268    KE525351    KFB51134.1    KQ978251    KYM95951.1    KQ981993    KYN30772.1    KQ981153    KYN08957.1    GL887888    EGI69633.1    ADTU01013033    KQ982548    KYQ55264.1    GL763054    EFZ20203.1    DQ863217    DQ863218    AJ245824    ABI94393.1    CAB76374.1    KK107274    QOIP01000008    EZA53718.1    RLU19586.1    KZ288203    PBC33352.1    KC814694    AGO81728.1    KQ414617    KOC68266.1    GL452770    EFN76789.1    AM990461    CAQ48240.1    KQ773785    OAD52348.1    QCYY01001606    ROT76826.1    PNF21102.1    ODYU01007351    SOQ50041.1    DS235219    EEB13393.1    JTDY01002289    KOB71731.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000027135    + More
UP000069940    UP000249989    UP000235965    UP000008820    UP000245037    UP000092443    UP000091820    UP000092460    UP000092444    UP000078200    UP000092445    UP000030765    UP000095301    UP000075885    UP000019118    UP000030742    UP000192223    UP000009192    UP000075901    UP000095300    UP000007266    UP000268350    UP000092462    UP000008744    UP000001819    UP000092553    UP000015103    UP000001070    UP000079169    UP000008711    UP000007801    UP000283509    UP000000304    UP000001292    UP000002282    UP000000803    UP000037069    UP000078542    UP000078541    UP000078492    UP000007755    UP000005205    UP000075809    UP000005203    UP000053097    UP000279307    UP000242457    UP000053825    UP000008237    UP000009046   

PRIDE

Q75Q62    Q17232    Q25188    E1JI27    P22270   

Pfam

PF00001   7tm_1

Interpro

IPR017452   GPCR_Rhodpsn_7TM        + More
IPR000276   GPCR_Rhodpsn       
IPR002002   Octopmn_rcpt       

CDD

cd15060  7tmA_tyramine_octopamine_R-lik

ProteinModelPortal

Q75Q62   Q17232   A0A2W1BLA9   A0A2A4JX52   Q25188   C0KUC4   + More
Q9BMA9   K7X591   B6VCU4   H9TVJ1   A0A0L7L1P8   Q5TLF2   H6V946   A0A194R9Q7   A0A194PXG8   H6V941   A0A0L7KX43   H6V955   A0A067RA39   A0A182GM86   A0A2J7PXP3   A0A1S4FER2   Q174N1   A0A0S1VX60   A0A2P8ZMW5   A0A1B6KR70   A0A1A9YS13   A0A1A9WE30   A0A1B0B8P5   A0A1B0FFH5   A0A1A9UJK3   A0A239QQ38   A0A1B0AE24   A0A084VAR5   A0A1I8N989   A0A1B6HUG0   W8BRJ9   A0A182P966   N6T3X1   A0A1W4XD11   B4L014   A0A182SS06   A0A291L8I9   N6U8N0   A0A034VDT7   A0A1I8PZN3   D6WB14   U4UPW3   H7C947   Q25321   A0A3B0J3V2   Q25322   X2KVP8   A0A2R7WKB4   A0A0T6BFE4   A0A0A1WN68   A0A1B0DBN2   B4H8P5   Q29DM9   A0A0M5JAY1   D9U2B9   T1HXE2   B4J0Q1   A0A1S3D2H7   B3NJ22   B3MAJ7   A0A067RCP4   A0A3R7QA23   B4QKQ5   A0A0J9RZQ0   B4IAY2   B4ITB5   E1JI27   P22270   A0A336K1A1   A0A0L0BXB5   A0A1B3P974   A0A084WLP0   A0A195C6Z9   A0A195ES94   A0A195D7X6   F4W7W3   A0A158NDV6   A0A151X4P8   E9IGQ7   Q9NG02   A0A026WCQ7   A0A2A3EQ07   S4VN83   A0A0L7RBY0   E2C5H6   B2G4W4   A0A310S7D4   A0A3R7MAV2   A0A2J7PXP4   A0A2H1WAD4   E0VJ37   A0A0L7L8Z9  

PDB

5V54     E-value=1.60493e-32,     Score=349

KEGG

693055    K22815 octopamine/tyramine receptor | (RefSeq) octopamine receptor

GO

GO:0004989   GO:0016021   GO:0005886   GO:0010578   GO:0007211   GO:0007608   GO:0005887   GO:1900738   GO:0007188   GO:0004935   GO:0071880   GO:0004930   GO:0008227   GO:0004715   GO:0007186   GO:0016491   GO:0016620   GO:0016787   GO:0003676   GO:0015930  

Subcellular location

Cell membrane  

Length:

479

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

156.73842

Exp number, first 60 AAs:

3.63831

Total prob of N-in:

0.05554

outside

1  -  56

TMhelix

57  -  79

inside

80  -  90

TMhelix

91  -  113

outside

114  -  127

TMhelix

128  -  150

inside

151  -  170

TMhelix

171  -  193

outside

194  -  212

TMhelix

213  -  235

inside

236  -  408

TMhelix

409  -  431

outside

432  -  440

TMhelix

441  -  463

inside

464  -  479

 

 

Pi

324.464404

Theta

227.683094

Tajima's D

1.40764

CLR

0

CSRT

0.766961651917404

Interpretation

Uncertain