Gene

KWMTBOMO13628  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011064

Annotation

PREDICTED:_delta-1-pyrroline-5-carboxylate_synthase_isoform_X1_[Papilio_polytes]

Location

Bomo_Chr23(+):3411392-3418559      View in EpiBrowser

Full name

Delta-1-pyrroline-5-carboxylate synthase      

Location in the cell

Cytoplasmic   Reliability : 1.617 Mitochondrial   Reliability : 2.148

CDS

ATGATGTCGGATGTCGATGGTATTTACAACAAACCGCCCTGGGAAGACGGCGCGCGGATGATGCACACATTCACTTCCAACGAGATGGACCAGGTTCAGTTTGGGAAGAAATCTAAGGTGGGAACAGGTGGTATGGATTCCAAAGTCAATGCCGCCACTTGGGCCATGGCGCGTGGAGTCAGTGTGGTCATCTGTAACGGTATGCAAGAGAAGGCGATAAAAACCATTATTAGCGGTAGAAAAGTGGGAACATTTTTTACGGACTATGTTACTAGCTCCACCACTTCTGTCGATGAATTGGCTGAGAATGCTCGTACTGGTGGTCGAGCTCTTCAGCAACTGACTCCTCTAGACAGAGCGTCTGCTATTCACTCGTTAGCAGATTTACTATTGAGCAGACAAGATCAGATATTAGAAGCAAACAACAAAGATTTGGAGGAAGCTACCAAAAATGGTGTAGCGAAACCATTGCTAAACAGGCTGTCGCTCAGCCAAAGTAAATTAAAAACTTTATCGGTAGGATTGAAACAAATAGCTGATTCAAGTTACGAAAACGTCGGCAGGGTGCTTAGGAAGACCAAATTGGCTGAAAATCTCATTCTAAGACAAGTTACTGTACCTATAGGTGTATTGCTAGTTATATTTGAATCTAGGCCTGATTCGCTACCACAAGTCGCGGCCTTAGCTATGGCATCAGCTAACGGTCTTTTACTCAAAGGCGGAAAGGAAGCAGCGTACTCGAATAAAGCATTAATGGGGCTAGTTAAGGAATCTCTTAAAACGGTCGGAGCCGAAGATGCTATTTCTTTGATTTCGACACGGGAAGAAATAAGTGATTTGTTAGCTATGGACAAACACATTGATTTGATAATACCGAGAGGATCGTCGGAACTTGTTCAAAGTATACAGAAACAGTCGCAGCACATTCCCGTATTGGGACACGCTGAAGGAATATGTCATGTGTATTTAGATAAAGACGCCGACACAACTAAAGCTTTGAAGATAGTACGCGATGCGAAATGCGATTATCCGGCCGCTTGTAATGCTATGGAAACCTTACTTGTGCACGAGGACCACATCTCAGGATCATTGTTCACTGACGTTTGTAATATGTTGAAGAACGAAGGTGTGATAATCCACGCCGGTCCAAAACTAGCGAGACAGTTAACCTTCGGTCCTGCGCCGGCGAGGACCATGCGTCATGAGTACGGAGCCTTGGAGTGTTGTATTGAAGTCGTCAAGGATCTGGATGAAGCTGTTGATCATGTCCACAAATTCGGCAGCTCGCACACTGACGTTATTGTCACGGAAAACGAAAACGCAGCAAAACGGTTCTTGACGGCAGTGGATAGCGCCTGTGTTTTCCACAACGTGTCGTCTAGATTCGCTGATGGCTTCAGATTTGGTTTAGGGGCGGAAGTCGGAATATCGACTGCAAGGATACACGCAAGAGGTCCAGTCGGTGTAGAAGGTCTGTTAACAACGAAATGGATATTGGAGGGAACTGATCACACTGCAGCCGAGTTCAATGAGGGCAAACGAAACTGGATACACGAGAAAATGCCAGTCGCATGA

Protein

MMSDVDGIYNKPPWEDGARMMHTFTSNEMDQVQFGKKSKVGTGGMDSKVNAATWAMARGVSVVICNGMQEKAIKTIISGRKVGTFFTDYVTSSTTSVDELAENARTGGRALQQLTPLDRASAIHSLADLLLSRQDQILEANNKDLEEATKNGVAKPLLNRLSLSQSKLKTLSVGLKQIADSSYENVGRVLRKTKLAENLILRQVTVPIGVLLVIFESRPDSLPQVAALAMASANGLLLKGGKEAAYSNKALMGLVKESLKTVGAEDAISLISTREEISDLLAMDKHIDLIIPRGSSELVQSIQKQSQHIPVLGHAEGICHVYLDKDADTTKALKIVRDAKCDYPAACNAMETLLVHEDHISGSLFTDVCNMLKNEGVIIHAGPKLARQLTFGPAPARTMRHEYGALECCIEVVKDLDEAVDHVHKFGSSHTDVIVTENENAAKRFLTAVDSACVFHNVSSRFADGFRFGLGAEVGISTARIHARGPVGVEGLLTTKWILEGTDHTAAEFNEGKRNWIHEKMPVA

Catalytic Activity

ATP + L-glutamate = ADP + L-glutamyl 5-phosphate
L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH

Similarity

In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
In the N-terminal section; belongs to the glutamate 5-kinase family.

Uniprot

H9JNG1   A0A3S2NZJ0   A0A0N0PB61   A0A194PRA6   A0A212EQ50   A0A2H1VTG9   + More
A0A0L0CA23   A0A1I8NYW2   W8BEN1   T1PC19   Q29DN1   D3TQ43   B4PI54   A0A0J9S007   A0A1B0FQZ3   B4IAX9   A0A1L8EDS1   Q9VNW6   A0A1W4VBE6   A0A0P9AMM0   B3MAJ3   B3NJ19   A0A1Q3FKP5   A0A1Q3FKM4   A0A1Q3FKQ6   A0A0A1X3I7   B4L010   B4N4G2   A0A0K8VLQ1   A0A034WHU4   B0X119   Q174N2   D6WB12   A0A3B0J4E6   A0A182GWK4   A0A3B0JZ58   A0A2A4JN75   B4LHT5   A0A2A4JNZ9   A0A0M4EL01   U5ERF6   A0A0M4EJR2   B4J0Q4   A0A2M4BDG8   A0A2W1BSE8   A0A2M4BEU6   A0A2M4BER7   A0A2M4BER9   A0A0T6B002   A0A2M4A2W4   A0A2M4BET7   A0A182FRI6   A0A182TJE6   A0A2M4CFX4   A0A182P967   A0A182RGV7   A0A182V8L0   A0A182VWS8   A0A182SXN5   Q7QC97   A0A1J1HN75   W5J3P0   A0A182XHW0   A0A182IPP9   A0A2M4CFZ6   A0A182LEX3   A0A2M3YY67   A0A182HSU2   A0A182NRQ5   A0A182YRH0   A0A2M3YY87   A0A084VAR3   A0A182QGH8   A0A182JZU9   A0A0C5LC29   A0A1W4WY76   A0A1B0CT44   A0A336LQW4   A0A1L8E2V4   A0A232EWC8   K7INN6   A0A2A3EQN3   V9IDN8   V9ICB8   A0A1S6KZB3   A0A1B6CSU1   A0A0L7RBT4   A0A088A822   A0A023F5I9   A0A0C9QX27   A0A154PN15   J9JKH0   A0A2S2P4C9   A0A2H8TF50   N6TSS3   E0VJ34   A0A026WDH3   A0A224X845   A0A310SDF6   A0A1Y1LVX2  

Pubmed

19121390    26354079    22118469    26108605    24495485    25315136    + More
15632085    17994087    20353571    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25830018    25348373    17510324    18362917    19820115    26483478    28756777    12364791    14747013    17210077    20920257    23761445    20966253    25244985    24438588    25450565    28648823    20075255    24330026    25474469    23537049    20566863    24508170    30249741    28004739   

EMBL

BABH01019270    BABH01019271    BABH01019272    RSAL01000015    RVE53123.1    KQ461153    + More
KPJ08668.1    KQ459595    KPI95842.1    AGBW02013317    OWR43609.1    ODYU01004343    SOQ44117.1    JRES01000704    KNC29065.1    GAMC01014894    JAB91661.1    KA646316    AFP60945.1    CH379070    EAL30383.2    EZ423545    ADD19821.1    CM000159    EDW95502.1    CM002912    KMZ01138.1    CCAG010001599    CH480826    EDW44442.1    GFDG01001995    JAV16804.1    AE014296    AY069110    AAF51799.1    AAL39255.1    CH902618    KPU79024.1    EDV41280.1    CH954178    EDV52736.1    GFDL01006971    JAV28074.1    GFDL01006991    JAV28054.1    GFDL01006961    JAV28084.1    GBXI01008408    JAD05884.1    CH933809    EDW19045.1    CH964095    EDW79036.2    GDHF01012515    JAI39799.1    GAKP01005035    JAC53917.1    DS232250    EDS38411.1    CH477408    EAT41523.1    KQ971311    EEZ98981.2    OUUW01000002    SPP76397.1    JXUM01019982    KQ560560    KXJ81895.1    SPP76398.1    NWSH01000935    PCG73487.1    CH940647    EDW70660.1    PCG73486.1    CP012525    ALC44951.1    GANO01002826    JAB57045.1    ALC45240.1    CH916366    EDV97909.1    GGFJ01001958    MBW51099.1    KZ149986    PZC75680.1    GGFJ01002423    MBW51564.1    GGFJ01002409    MBW51550.1    GGFJ01002408    MBW51549.1    LJIG01016401    KRT80713.1    GGFK01001806    MBW35127.1    GGFJ01002424    MBW51565.1    GGFL01000064    MBW64242.1    AAAB01008859    EAA07467.4    CVRI01000004    CRK87689.1    ADMH02002105    ETN58982.1    GGFL01000065    MBW64243.1    GGFM01000471    MBW21222.1    APCN01000361    GGFM01000466    MBW21217.1    ATLV01004137    KE524190    KFB35057.1    AXCN02000008    KJ802127    AJP75147.1    AJWK01027055    AJWK01027056    UFQT01000054    SSX19073.1    GFDF01001182    JAV12902.1    NNAY01001889    OXU22631.1    KZ288203    PBC33351.1    JR039595    AEY58772.1    JR039596    AEY58773.1    KC223160    AQT27063.1    GEDC01026095    GEDC01020712    GEDC01009703    GEDC01003316    JAS11203.1    JAS16586.1    JAS27595.1    JAS33982.1    KQ414617    KOC68265.1    GBBI01002284    JAC16428.1    GBYB01005227    JAG74994.1    KQ434977    KZC12854.1    ABLF02026058    ABLF02026061    GGMR01011615    MBY24234.1    GFXV01000932    MBW12737.1    APGK01053233    KB741223    KB632273    ENN72325.1    ERL91075.1    AAZO01002758    DS235219    EEB13390.1    KK107274    QOIP01000008    EZA53716.1    RLU19584.1    GFTR01007911    JAW08515.1    KQ773785    OAD52349.1    GEZM01049917    JAV75756.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000037069    + More
UP000095300    UP000095301    UP000001819    UP000002282    UP000092444    UP000001292    UP000000803    UP000192221    UP000007801    UP000008711    UP000009192    UP000007798    UP000002320    UP000008820    UP000007266    UP000268350    UP000069940    UP000249989    UP000218220    UP000008792    UP000092553    UP000001070    UP000069272    UP000075902    UP000075885    UP000075900    UP000075903    UP000075920    UP000075901    UP000007062    UP000183832    UP000000673    UP000076407    UP000075880    UP000075882    UP000075840    UP000075884    UP000076408    UP000030765    UP000075886    UP000075881    UP000192223    UP000092461    UP000215335    UP000002358    UP000242457    UP000053825    UP000005203    UP000076502    UP000007819    UP000019118    UP000030742    UP000009046    UP000053097    UP000279307   

PRIDE

H9JNG1    Q9VNW6    A0A088A822   

Pfam

PF00696   AA_kinase        + More
PF00171   Aldedh

Interpro

IPR000965   GPR_dom        + More
IPR016162   Ald_DH_N       
IPR015590   Aldehyde_DH_dom       
IPR016161   Ald_DH/histidinol_DH       
IPR005715   Glu_5kinase/COase_Synthase       
IPR001048   Asp/Glu/Uridylate_kinase       
IPR005766   P5_carboxy_syn       
IPR036393   AceGlu_kinase-like_sf       
IPR041744   G5K_ProBA       
IPR016163   Ald_DH_C       
IPR001057   Glu/AcGlu_kinase       
IPR019797   Glutamate_5-kinase_CS       
IPR020593   G-glutamylP_reductase_CS       

SUPFAM

SSF53720   SSF53720        + More
SSF53633   SSF53633       

Gene 3D

3.40.1160.10     3.40.309.10     3.40.605.10    

CDD

cd04256  AAK_P5CS_ProBA
cd07079  ALDH_F18-19_ProA-GPR

ProteinModelPortal

H9JNG1   A0A3S2NZJ0   A0A0N0PB61   A0A194PRA6   A0A212EQ50   A0A2H1VTG9   + More
A0A0L0CA23   A0A1I8NYW2   W8BEN1   T1PC19   Q29DN1   D3TQ43   B4PI54   A0A0J9S007   A0A1B0FQZ3   B4IAX9   A0A1L8EDS1   Q9VNW6   A0A1W4VBE6   A0A0P9AMM0   B3MAJ3   B3NJ19   A0A1Q3FKP5   A0A1Q3FKM4   A0A1Q3FKQ6   A0A0A1X3I7   B4L010   B4N4G2   A0A0K8VLQ1   A0A034WHU4   B0X119   Q174N2   D6WB12   A0A3B0J4E6   A0A182GWK4   A0A3B0JZ58   A0A2A4JN75   B4LHT5   A0A2A4JNZ9   A0A0M4EL01   U5ERF6   A0A0M4EJR2   B4J0Q4   A0A2M4BDG8   A0A2W1BSE8   A0A2M4BEU6   A0A2M4BER7   A0A2M4BER9   A0A0T6B002   A0A2M4A2W4   A0A2M4BET7   A0A182FRI6   A0A182TJE6   A0A2M4CFX4   A0A182P967   A0A182RGV7   A0A182V8L0   A0A182VWS8   A0A182SXN5   Q7QC97   A0A1J1HN75   W5J3P0   A0A182XHW0   A0A182IPP9   A0A2M4CFZ6   A0A182LEX3   A0A2M3YY67   A0A182HSU2   A0A182NRQ5   A0A182YRH0   A0A2M3YY87   A0A084VAR3   A0A182QGH8   A0A182JZU9   A0A0C5LC29   A0A1W4WY76   A0A1B0CT44   A0A336LQW4   A0A1L8E2V4   A0A232EWC8   K7INN6   A0A2A3EQN3   V9IDN8   V9ICB8   A0A1S6KZB3   A0A1B6CSU1   A0A0L7RBT4   A0A088A822   A0A023F5I9   A0A0C9QX27   A0A154PN15   J9JKH0   A0A2S2P4C9   A0A2H8TF50   N6TSS3   E0VJ34   A0A026WDH3   A0A224X845   A0A310SDF6   A0A1Y1LVX2  

PDB

2H5G     E-value=1.23617e-147,     Score=1342

KEGG

101746787    K12657 delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41] | (RefSeq) delta-1-pyrrolin

PATHWAY

00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0055129   GO:0004350   GO:0005524   GO:0004349   GO:0005739   GO:0006561   GO:0005743   GO:0017084   GO:0005737   GO:0008152   GO:0016491   GO:0016620   GO:0016787   GO:0003676   GO:0015930   GO:0055114  

Length:

524

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.19709

Exp number, first 60 AAs:

0.00542

Total prob of N-in:

0.01148

outside

1  -  524

 

 

Pi

28.909404

Theta

19.184357

Tajima's D

0.305249

CLR

1.900067

CSRT

0.469226538673066

Interpretation

Uncertain