Gene

KWMTBOMO13627  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011064

Annotation

PREDICTED:_delta-1-pyrroline-5-carboxylate_synthase_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr23(+):3382082-3410056      View in EpiBrowser

Full name

Delta-1-pyrroline-5-carboxylate synthase      

Location in the cell

Mitochondrial   Reliability : 1.924 Nuclear   Reliability : 1.556

CDS

ATGTGTTACAAATTCATGTTTTATTTGAGAGCCGGTGTCCGTTGTAATAATTTATTGAATTCGTTCGTTTCTCAAAAGAGAAGTTTCTCAGTTCACGGGATATCTTTGAATGGCTTGAGCGTAGACAAGAGAGCATTGGCTAGCGCTGAAAGGAAGCAGAGAACCTTCACTGACAGATCGCAGCTAAAGTACGCCAGAAGATTGGTTGTGAAGTTAGGTAGTGCTGTGATTACGAGAGAAGATGGAAACGGACTAGCTCTCGGTCGACTCGCTTCTATTATAGAACAGGTCGCCGAATGTCATCACGAAGGACGCGAATGCATAATGGTGACGAGCGGCGCCGTAGCGTTCGGGCGGCAGAAACTGACGCAGGAGCTGCTCATGTCTTTATCCATGCGGGAGACTTTGTCACCAAGCGATCACACTAGAGAGGACGCAGGCAGCATTTTGGATCCGAGGGCCGCTGCGGCGGTCGGTCAGTCGGAGCTCATGTCGATGTATGATGCCATGTTCTCTCAGTACAATGTCAAAATTGCACAGGTATTAGTGACGAAACCAGACTTCTACAATGAGGAGACTAGGAAAAATCTCTTCTGCACGCTATCGGAGCTGATCTCTCTTAACATTGTACCGATCGTGAATACCAATGATGCCGTCAGCCCTCCTATGTACATTCACGACGACACCGTTGTACCTGGGACTGGAAAAAAGGTATGTCTAGAATGA

Protein

MCYKFMFYLRAGVRCNNLLNSFVSQKRSFSVHGISLNGLSVDKRALASAERKQRTFTDRSQLKYARRLVVKLGSAVITREDGNGLALGRLASIIEQVAECHHEGRECIMVTSGAVAFGRQKLTQELLMSLSMRETLSPSDHTREDAGSILDPRAAAAVGQSELMSMYDAMFSQYNVKIAQVLVTKPDFYNEETRKNLFCTLSELISLNIVPIVNTNDAVSPPMYIHDDTVVPGTGKKVCLE

Catalytic Activity

ATP + L-glutamate = ADP + L-glutamyl 5-phosphate
L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH

Similarity

In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
In the N-terminal section; belongs to the glutamate 5-kinase family.

Uniprot

A0A2A4JN75   I4DQ43   H9JNG1   A0A2A4JNZ9   A0A2W1BSE8   A0A0N0PB61   + More
A0A194PRA6   A0A3S2NZJ0   A0A212EQ50   A0A1A9WE28   A0A1B6F4B1   A0A0K8VFY9   A0A1B6HS61   A0A1B6LSZ5   A0A1I8Q8P0   A0A0K8WK30   A0A1B0FY33   T1DQS7   A0A0T6B002   A0A0K8UYL4   T1PC19   A0A182YRH0   A0A182SXN5   U5ERF6   A0A0L0CA23   D6WB12   A0A182MCJ1   A0A182IPP9   A0A1L8EDS1   A0A1L8E2V4   E2AXK1   A0A182RGV7   A0A0K8VLQ1   A0A0A9YV85   A0A182NRQ5   A0A182QGH8   A0A0A9YWU5   A0A084VAR3   A0A182VWS8   W8BEN1   A0A2M4BER9   A0A2M4BET7   A0A2M4BER7   A0A2R7W1S4   A0A2M4BEU6   A0A2M4A2W4   A0A2M3YY87   A0A2M3YY67   D3TQ43   A0A0R3P6N1   A0A1I8NYW2   A0A1S6KZB3   Q7QC97   A0A182FRI6   A0A182V8L0   A0A034WHU4   A0A0A1X3I7   A0A182TJE6   A0A2M4BDG8   A0A171AHN0   A0A182HSU2   A0A182XHW0   A0A0J7L3R9   A0A2M4CFX4   A0A2M4CFZ6   A0A182P967   A0A1B6CSU1   W5J3P0   A0A182JZU9   A0A158NE63   A0A154PN15   B4QKQ1   B4N4G2   A0A026WDH3   A0A195BPM8   B4J0Q4   N6TSS3   B4L010   B4H8Q1   A0A195C506   Q174N2   A0A2J7PXP9   B3MAJ3   A0A2S2P4C9   A0A2H8TF50   B4IAX9   Q9VNW6   T1I111   B4LHT5   A0A232EWC8   Q29DN1   J9JKH0   K7INN6   A0A1W4VBE6   B4IUN5   B4PI54   A0A336LQW4   A0A0J9S007   A0A224X845   B3NJ19  

Pubmed

22651552    19121390    28756777    26354079    22118469    25315136    + More
25244985    26108605    18362917    19820115    20798317    25401762    24438588    24495485    20353571    15632085    17994087    24330026    12364791    14747013    17210077    25348373    25830018    20920257    23761445    21347285    24508170    30249741    23537049    17510324    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28648823    20075255    17550304    22936249   

EMBL

NWSH01000935    PCG73487.1    AK403922    BAM20033.1    BABH01019270    BABH01019271    + More
BABH01019272    PCG73486.1    KZ149986    PZC75680.1    KQ461153    KPJ08668.1    KQ459595    KPI95842.1    RSAL01000015    RVE53123.1    AGBW02013317    OWR43609.1    GECZ01025066    JAS44703.1    GDHF01014547    JAI37767.1    GECU01030225    JAS77481.1    GEBQ01013175    JAT26802.1    GDHF01000905    JAI51409.1    AJVK01014138    AJVK01014139    AJVK01014140    AJVK01014141    GAMD01000990    JAB00601.1    LJIG01016401    KRT80713.1    GDHF01020608    JAI31706.1    KA646316    AFP60945.1    GANO01002826    JAB57045.1    JRES01000704    KNC29065.1    KQ971311    EEZ98981.2    AXCM01001347    GFDG01001995    JAV16804.1    GFDF01001182    JAV12902.1    GL443590    EFN61839.1    GDHF01012515    JAI39799.1    GBHO01007522    GBHO01007520    GBHO01007519    GBRD01004385    JAG36082.1    JAG36084.1    JAG36085.1    JAG61436.1    AXCN02000008    GBHO01007521    GBHO01007518    GBHO01007516    JAG36083.1    JAG36086.1    JAG36088.1    ATLV01004137    KE524190    KFB35057.1    GAMC01014894    JAB91661.1    GGFJ01002408    MBW51549.1    GGFJ01002424    MBW51565.1    GGFJ01002409    MBW51550.1    KK854147    PTY12145.1    GGFJ01002423    MBW51564.1    GGFK01001806    MBW35127.1    GGFM01000466    MBW21217.1    GGFM01000471    MBW21222.1    EZ423545    ADD19821.1    CH379070    KRT08887.1    KC223160    AQT27063.1    AAAB01008859    EAA07467.4    GAKP01005035    JAC53917.1    GBXI01008408    JAD05884.1    GGFJ01001958    MBW51099.1    GEMB01001057    JAS02090.1    APCN01000361    LBMM01000770    KMQ97532.1    GGFL01000064    MBW64242.1    GGFL01000065    MBW64243.1    GEDC01026095    GEDC01020712    GEDC01009703    GEDC01003316    JAS11203.1    JAS16586.1    JAS27595.1    JAS33982.1    ADMH02002105    ETN58982.1    ADTU01013028    ADTU01013029    ADTU01013030    KQ434977    KZC12854.1    CM000363    EDX11466.1    CH964095    EDW79036.2    KK107274    QOIP01000008    EZA53716.1    RLU19584.1    KQ976424    KYM88465.1    CH916366    EDV97909.1    APGK01053233    KB741223    KB632273    ENN72325.1    ERL91075.1    CH933809    EDW19045.1    CH479224    EDW35094.1    KQ978251    KYM95952.1    CH477408    EAT41523.1    NEVH01020853    PNF21094.1    CH902618    EDV41280.1    GGMR01011615    MBY24234.1    GFXV01000932    MBW12737.1    CH480826    EDW44442.1    AE014296    AY069110    AAF51799.1    AAL39255.1    ACPB03013319    ACPB03013320    ACPB03013321    ACPB03013322    CH940647    EDW70660.1    NNAY01001889    OXU22631.1    EAL30383.2    ABLF02026058    ABLF02026061    CH891973    EDX00099.2    CM000159    EDW95502.1    UFQT01000054    SSX19073.1    CM002912    KMZ01138.1    GFTR01007911    JAW08515.1    CH954178    EDV52736.1   

Proteomes

UP000218220    UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    + More
UP000091820    UP000095300    UP000092462    UP000095301    UP000076408    UP000075901    UP000037069    UP000007266    UP000075883    UP000075880    UP000000311    UP000075900    UP000075884    UP000075886    UP000030765    UP000075920    UP000001819    UP000007062    UP000069272    UP000075903    UP000075902    UP000075840    UP000076407    UP000036403    UP000075885    UP000000673    UP000075881    UP000005205    UP000076502    UP000000304    UP000007798    UP000053097    UP000279307    UP000078540    UP000001070    UP000019118    UP000030742    UP000009192    UP000008744    UP000078542    UP000008820    UP000235965    UP000007801    UP000001292    UP000000803    UP000015103    UP000008792    UP000215335    UP000007819    UP000002358    UP000192221    UP000002282    UP000008711   

PRIDE

H9JNG1    Q9VNW6   

Pfam

PF00696   AA_kinase        + More
PF00171   Aldedh

Interpro

IPR005715   Glu_5kinase/COase_Synthase        + More
IPR016161   Ald_DH/histidinol_DH       
IPR020593   G-glutamylP_reductase_CS       
IPR036393   AceGlu_kinase-like_sf       
IPR001048   Asp/Glu/Uridylate_kinase       
IPR005766   P5_carboxy_syn       
IPR041744   G5K_ProBA       
IPR001057   Glu/AcGlu_kinase       
IPR019797   Glutamate_5-kinase_CS       
IPR016163   Ald_DH_C       
IPR016162   Ald_DH_N       
IPR000965   GPR_dom       
IPR015590   Aldehyde_DH_dom       
IPR011529   Glu_5kinase       

SUPFAM

SSF53633   SSF53633        + More
SSF53720   SSF53720       

Gene 3D

3.40.1160.10     3.40.309.10     3.40.605.10    

CDD

cd04256  AAK_P5CS_ProBA
cd07079  ALDH_F18-19_ProA-GPR

ProteinModelPortal

A0A2A4JN75   I4DQ43   H9JNG1   A0A2A4JNZ9   A0A2W1BSE8   A0A0N0PB61   + More
A0A194PRA6   A0A3S2NZJ0   A0A212EQ50   A0A1A9WE28   A0A1B6F4B1   A0A0K8VFY9   A0A1B6HS61   A0A1B6LSZ5   A0A1I8Q8P0   A0A0K8WK30   A0A1B0FY33   T1DQS7   A0A0T6B002   A0A0K8UYL4   T1PC19   A0A182YRH0   A0A182SXN5   U5ERF6   A0A0L0CA23   D6WB12   A0A182MCJ1   A0A182IPP9   A0A1L8EDS1   A0A1L8E2V4   E2AXK1   A0A182RGV7   A0A0K8VLQ1   A0A0A9YV85   A0A182NRQ5   A0A182QGH8   A0A0A9YWU5   A0A084VAR3   A0A182VWS8   W8BEN1   A0A2M4BER9   A0A2M4BET7   A0A2M4BER7   A0A2R7W1S4   A0A2M4BEU6   A0A2M4A2W4   A0A2M3YY87   A0A2M3YY67   D3TQ43   A0A0R3P6N1   A0A1I8NYW2   A0A1S6KZB3   Q7QC97   A0A182FRI6   A0A182V8L0   A0A034WHU4   A0A0A1X3I7   A0A182TJE6   A0A2M4BDG8   A0A171AHN0   A0A182HSU2   A0A182XHW0   A0A0J7L3R9   A0A2M4CFX4   A0A2M4CFZ6   A0A182P967   A0A1B6CSU1   W5J3P0   A0A182JZU9   A0A158NE63   A0A154PN15   B4QKQ1   B4N4G2   A0A026WDH3   A0A195BPM8   B4J0Q4   N6TSS3   B4L010   B4H8Q1   A0A195C506   Q174N2   A0A2J7PXP9   B3MAJ3   A0A2S2P4C9   A0A2H8TF50   B4IAX9   Q9VNW6   T1I111   B4LHT5   A0A232EWC8   Q29DN1   J9JKH0   K7INN6   A0A1W4VBE6   B4IUN5   B4PI54   A0A336LQW4   A0A0J9S007   A0A224X845   B3NJ19  

PDB

4Q1T     E-value=4.20452e-17,     Score=213

KEGG

101746787    K12657 delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41] | (RefSeq) delta-1-pyrrolin

GO

GO:0004350   GO:0005737   GO:0004349   GO:0006561   GO:0016301   GO:0055129   GO:0005524   GO:0005739   GO:0016491   GO:0016021   GO:0016620   GO:0005743   GO:0017084   GO:0019509   GO:0046872   GO:0006508   GO:0008237   GO:0008152   GO:0016787   GO:0003676   GO:0015930  

Length:

241

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03539

Exp number, first 60 AAs:

0.000970000000000001

Total prob of N-in:

0.05978

outside

1  -  241

 

 

Pi

166.618327

Theta

153.123167

Tajima's D

0

CLR

0.708815

CSRT

0.362081895905205

Interpretation

Uncertain