Gene

KWMTBOMO13605

Pre Gene Modal

BGIBMGA010956

Annotation

PREDICTED:_serine/threonine-protein_kinase_PAK_3_[Papilio_polytes]

Location

Bomo_Chr23(-):2583333-2588103      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase      

Location in the cell

Cytoplasmic   Reliability : 3.574

CDS

ATGAGTGGGCGATCGGGTCGTGGTGTGTTCGGGAAGCTTTTCTCTAAGAAGCAACACAAGGAACGAGATGAGAGAGCTACGGAGATCGGGATGCCTACAAACGTGAAACAACATCTACACGTTAGTAAAAATTCCGAGACTGGTATGTTAGAAGGTCTGCCAACGGCATGGCTGCGACTCATAAATACACAAATTACGGCGGCCGAACAAAGCGAAAACCCTGATGCTGCCATCCAGGCCGTGAAATTCCACATGTACACGATAAAAAAGGAAAAAGCGCAAGATGAACCATTCAAACCTTTTGTTACGCAAGAAGTCATTACTGAAGAGGATATAGAGATTGAGAAGCTTTTGGATCACAAGAAAGCACATCAAAGCCAGGATTCGGACCTGTCTATTGGCCAGAGCAGTGAGGAGGAAACTACACACTACAATGCACCTTCAGAAAGACAGACAATGCCCATATCTCCGTCCAAACACAGCCTTAAAAAGAAAGATGCACTAATGGACATGGCGGCTGTAGTCCAAGATTTGACACTCATTGGTGATGACAATGACGAAAGCCCAATGCTTCGGAAGAAGGAGCTGAGTTATTCTAAACTCTCCGATGAAGAAATATATGAAGAGTTGAAGAGAATCTGCAATAAGGATGATCCCTATGTTAGATTTGAAAAAATCAAACAACTTGGTGCTGGTGCTTCTGGTGTCGTGTTCATTGCCATAGACAGCAAAGACAATTCAAGAGTCGCCATAAAGGACATTGACCTAACAAAACAGTCCAAGAAGGAATTAATACTCAATGAAATCAACGTACTCAAGGGGTTCCACCATAAGAACCTTGTGAATTTCCTTGACGCATTCCTAAGCTATGATCATTTGTGGGTTGCCATGGAACTTCTCGATGGAGGTTCTCTCACGGACGTCGTAACTGAAGTGGTCATGAAAGAAGGACAGATAGCTGCTGTGTGCCGGGAAACCCTGCAGGCCGTCGCTTTCCTCCACTCTAAAGGTACAATCCATAGGGACATTAAATCCGATAATGTCCTACTCGGAATGGATGGGACCGTCAAAGTAACTGATTTCGGTTTCTGTGCGAACATCGTTGGTGATGAGAAACGACAGACCATGGTCGGCACGCCGTATTGGATGGCGCCCGAAGTGGTTACCAGGAAGCAGTACGGGAAGAAGGTGGACGTTTGGTCCCTTGGTATAATGGCGATCGAAATGATCGAAGGCGAACCGCCATACATGAAAGAGACGCCTTTAAGGGCGCTGTACCTGATCGCGGCTGTCGGGCGCCCGAAAATACCACGTTGGGGAGAGCTGTCCCCGAAATTCCAGGACTTCTTGGATAAATGCCTCCAAGTTGACGTGGACATGAGAGCATCCGCCGAAGAATTACTAGAACATCCCTTCCTGGAGTGCGCAATGGAACTGAGGACTCTTACGCCCCTCATCAAAGCCGCCCAGAAAATATTGCACAAGTGCTACGATTAA

Protein

MSGRSGRGVFGKLFSKKQHKERDERATEIGMPTNVKQHLHVSKNSETGMLEGLPTAWLRLINTQITAAEQSENPDAAIQAVKFHMYTIKKEKAQDEPFKPFVTQEVITEEDIEIEKLLDHKKAHQSQDSDLSIGQSSEEETTHYNAPSERQTMPISPSKHSLKKKDALMDMAAVVQDLTLIGDDNDESPMLRKKELSYSKLSDEEIYEELKRICNKDDPYVRFEKIKQLGAGASGVVFIAIDSKDNSRVAIKDIDLTKQSKKELILNEINVLKGFHHKNLVNFLDAFLSYDHLWVAMELLDGGSLTDVVTEVVMKEGQIAAVCRETLQAVAFLHSKGTIHRDIKSDNVLLGMDGTVKVTDFGFCANIVGDEKRQTMVGTPYWMAPEVVTRKQYGKKVDVWSLGIMAIEMIEGEPPYMKETPLRALYLIAAVGRPKIPRWGELSPKFQDFLDKCLQVDVDMRASAEELLEHPFLECAMELRTLTPLIKAAQKILHKCYD

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.

Uniprot

A0A0N0PB56   A0A194PSB5   A0A2A4JCM8   A0A2H1WZB5   A0A2W1BX50   A0A0L7KQT3   + More
A0A212EJI5   E2A8V1   A0A2J7QMF3   A0A232EUM7   A0A088API4   A0A2A3EM97   A0A0J7NH18   A0A026WLK1   A0A3L8E4M0   A0A154PR06   A0A151IJ90   A0A151JTA7   F4WLN5   A0A151WY39   A0A151K1F8   A0A1W4WJW8   A0A158NWF6   A0A195EC88   A0A2P8ZH85   E2BI30   A0A1Q3FYW6   A0A182GWN6   A0A1Y1N6H9   A0A0L7R685   A0A084VWM1   Q17P09   A0A182J975   A0A0C9Q6I7   A0A182RUM2   A0A182XV76   A0A0T6AUS6   A0A182TW38   A0A182X2S7   Q7PY81   A0A182HGU5   A0A182KB96   A0A182UWN0   A0A182MGF1   A0A182QQP4   E0VQ90   A0A1B0CJ03   A0A1L8DKI0   A0A182T1Y6   N6U9I5   D7EIT3   A0A0N8AZG9   A0A0P5JKG8   A0A336LPE7   A0A0P5BP82   A0A1D2NFS8   B0WFH2   A0A0P6HYT2   A0A0P6I0R5   A0A0P5Z4T6   A0A0P5BQE6   A0A2P2I238   A0A226D8Y6   A0A2M4BJQ9   A0A293N3T9   A0A131YU74   A0A224Z0T1  

EC Number

2.7.11.1

Pubmed

26354079    28756777    26227816    22118469    20798317    28648823    + More
24508170    30249741    21719571    21347285    29403074    26483478    28004739    24438588    17510324    25244985    12364791    14747013    17210077    20566863    23537049    18362917    19820115    27289101    26830274    28797301   

EMBL

KQ461153    KPJ08648.1    KQ459595    KPI95858.1    NWSH01002102    PCG69182.1    + More
ODYU01012190    SOQ58368.1    KZ149909    PZC78204.1    JTDY01007236    KOB65354.1    AGBW02014457    OWR41644.1    GL437663    EFN70180.1    NEVH01013208    PNF29774.1    NNAY01002109    OXU22055.1    KZ288219    PBC32326.1    LBMM01005092    KMQ91820.1    KK107154    EZA56828.1    QOIP01000001    RLU27413.1    KQ435066    KZC14346.1    KQ977362    KYN03302.1    KQ981972    KYN31660.1    GL888212    EGI64863.1    KQ982651    KYQ52820.1    LKEW01001106    KYN45473.1    ADTU01002970    KQ979074    KYN22840.1    PYGN01000058    PSN55862.1    GL448433    EFN84656.1    GFDL01002317    JAV32728.1    JXUM01093784    KQ564079    KXJ72819.1    GEZM01012225    JAV93078.1    KQ414648    KOC66348.1    ATLV01017659    KE525181    KFB42365.1    CH477194    EAT48491.1    GBYB01009718    JAG79485.1    LJIG01022766    KRT78826.1    AAAB01008987    EAA01184.5    APCN01005946    AXCM01000915    AXCN02000034    AAZO01004362    DS235405    EEB15546.1    AJWK01013937    AJWK01013938    GFDF01007116    JAV06968.1    APGK01043768    KB741017    KB631644    ENN75262.1    ERL84946.1    DS497688    EFA12369.1    GDIQ01227707    JAK24018.1    GDIQ01203709    GDIP01136487    JAK48016.1    JAL67227.1    UFQS01000038    UFQT01000038    SSW98053.1    SSX18439.1    GDIP01182228    JAJ41174.1    LJIJ01000054    ODN04138.1    DS231918    EDS26240.1    GDIP01145741    GDIP01136436    GDIQ01036939    LRGB01000626    JAJ77661.1    JAN57798.1    KZS17452.1    GDIQ01019039    JAN75698.1    GDIP01049249    JAM54466.1    GDIP01182229    JAJ41173.1    IACF01002428    LAB68082.1    LNIX01000032    OXA40716.1    GGFJ01004050    MBW53191.1    GFWV01022719    MAA47446.1    GEDV01005778    JAP82779.1    GFPF01010403    MAA21549.1   

Proteomes

UP000053240    UP000053268    UP000218220    UP000037510    UP000007151    UP000000311    + More
UP000235965    UP000215335    UP000005203    UP000242457    UP000036403    UP000053097    UP000279307    UP000076502    UP000078542    UP000078541    UP000007755    UP000075809    UP000078540    UP000192223    UP000005205    UP000078492    UP000245037    UP000008237    UP000069940    UP000249989    UP000053825    UP000030765    UP000008820    UP000075880    UP000075900    UP000076408    UP000075902    UP000076407    UP000007062    UP000075840    UP000075881    UP000075903    UP000075883    UP000075886    UP000009046    UP000092461    UP000075901    UP000019118    UP000030742    UP000007266    UP000094527    UP000002320    UP000076858    UP000198287   

Pfam

PF00786   PBD        + More
PF00069   Pkinase

Interpro

IPR000095   CRIB_dom        + More
IPR000719   Prot_kinase_dom       
IPR036936   CRIB_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR033923   PAK_BD       
IPR008271   Ser/Thr_kinase_AS       

SUPFAM

SSF56112   SSF56112       

Gene 3D

3.90.810.10    

CDD

cd01093  CRIB_PAK_like

ProteinModelPortal

A0A0N0PB56   A0A194PSB5   A0A2A4JCM8   A0A2H1WZB5   A0A2W1BX50   A0A0L7KQT3   + More
A0A212EJI5   E2A8V1   A0A2J7QMF3   A0A232EUM7   A0A088API4   A0A2A3EM97   A0A0J7NH18   A0A026WLK1   A0A3L8E4M0   A0A154PR06   A0A151IJ90   A0A151JTA7   F4WLN5   A0A151WY39   A0A151K1F8   A0A1W4WJW8   A0A158NWF6   A0A195EC88   A0A2P8ZH85   E2BI30   A0A1Q3FYW6   A0A182GWN6   A0A1Y1N6H9   A0A0L7R685   A0A084VWM1   Q17P09   A0A182J975   A0A0C9Q6I7   A0A182RUM2   A0A182XV76   A0A0T6AUS6   A0A182TW38   A0A182X2S7   Q7PY81   A0A182HGU5   A0A182KB96   A0A182UWN0   A0A182MGF1   A0A182QQP4   E0VQ90   A0A1B0CJ03   A0A1L8DKI0   A0A182T1Y6   N6U9I5   D7EIT3   A0A0N8AZG9   A0A0P5JKG8   A0A336LPE7   A0A0P5BP82   A0A1D2NFS8   B0WFH2   A0A0P6HYT2   A0A0P6I0R5   A0A0P5Z4T6   A0A0P5BQE6   A0A2P2I238   A0A226D8Y6   A0A2M4BJQ9   A0A293N3T9   A0A131YU74   A0A224Z0T1  

PDB

6FD3     E-value=1.53534e-100,     Score=936

KEGG

101743592    K04409 p21-activated kinase 1 [EC:2.7.11.1] | (RefSeq) serine/threonine-protein kinase PAK 3

PATHWAY

04392    Hippo signaling pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0004672   GO:0004674   GO:0050770   GO:0048365   GO:0005737   GO:0016477   GO:0023014   GO:0043408   GO:0032147   GO:0031098   GO:0006468   GO:0006508   GO:0008237   GO:0008152   GO:0016787   GO:0003676   GO:0016491   GO:0015930  

Length:

498

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00182

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00147

outside

1  -  498

 

 

Pi

249.308933

Theta

186.786911

Tajima's D

0.41719

CLR

0.692976

CSRT

0.491775411229439

Interpretation

Uncertain