Gene

KWMTBOMO13566  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014563

Annotation

PREDICTED:_bifunctional_lysine-specific_demethylase_and_histidyl-hydroxylase_NO66_[Amyelois_transitella]

Location

Bomo_Chr23(+):1676596-1678569      View in EpiBrowser

Full name

Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66       + More
Ribosomal oxygenase 1      

Alternative Name

Histone lysine demethylase NO66
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66

Location in the cell

Nuclear   Reliability : 3.185

CDS

ATGAATTCACCAGTATCTGCATTCGCTGTGTATAGATCAAACAAGCAATCTAATTATGAGAAAAAGAAAAATAAATCTAAAAGAATAACGAACTCCTCAAAAGCACTTCCGATCTCCCCAAAAGCACTTTCGAAATCCCCAAAAGTTCATTCGAAACCGAAACCTATATCAGAAGAGGTGATGAAGAACGCCGCACAAAAACTGAAAAAAAATAAAAAAAAGAACGAATCTAAGAACATAATTAAAAAGAAGACTCACAAGAAGAAAAAATCGAAGAATACTAAAGCTACTAAAGGCGATGACGAGCAGCCGGTTATGAAAAGGAAAATTAAAAGAAACCGAGATGATAAACATGACAGTGATGATATTCCCTCATTAATACCTATATCTTTCACTAACTTCCACGAATCAAATTTGGATAGTGTTGATTCATGTTCAAGCAATGGCAGTATTGATTTTGAGCCTGTACAAACTGATAGTGTGGAGGAAGGTCTGAAAGTGTTTAAATGGATGATTGCTCCTTACAACCCAGAAGAATTCCTGAACAGAGTCTGGGAGAAGAAACCTCTCCATATAGCACGAAACAAGCCTGATTATTATAAAGAAATTATATCTACACCTATCATTGATGATATGCTAAGAAATGAAAGTATACAGTTCACTAAAAATATAGATATCACTTCTTATGTTGATAATAAAAGAGAAACACATAATCCTGAAGGTAGAGCTCTGCCACATATTGTATGGGATTTCTATTTAAATGGCTGCAGTATTAGGCTATTGAATCCACAAACCTACATACCAAAATTACACTTAGTCAATGCTACTATGCAAGAATTCTTTAATTCCTTTGTTGGAGCTAATGCTTACCTAACACCACCAGATAGTCAAGGTTTTGCTCCCCACTATGATGACATTGAAGCATTTATTCTGCAAACTGAAGGTAAAAAACATTGGCGTATCTATAAGCCCTTGAATGAAAATGAAATTTTACCTAGAGTTTCATCTAAAAATTTTAGTCAGGAAGATATTGGAGATCCTATAATGGAAGTCACTTTAGAAGCGGGAGACATGTTGTATTTTCCACGAGGTTACATCCACCAAGGAGTAACCATTGATGGAGAGCACTCCTTACATGTTACAATTAGTATGTACCAGAAACACTCATGGGCTGACCTTTTTGAGAAAATGATTCCTGCTGCATTACAAATGGCTATAAATGAAAATGTAGAATTAAGACAAGGTCTCCCTTTTGATATTTATGATAACTTTGGTATAGTCAATTCAGACTTGACTACTCCACGTCGAAAAGAACTAGAACTTATAATACACAATCTGTTTGAGAAAATCAAACAACACCTGCCGTTAGATGATGCAGTTGATCAAATGCACAAAAATTTCCAACAAGACGCTCTTCCTCCTGTTCTGAATGATATGGAAAAATCAGTAACTGTATTTGGTGATACAGATGTCATGATAGAAAATGGTAAAGTTATAAACAGAGTTGAAATAAGTTTGGATACAAGAATAAGACTATTACGGAAAAACATACTAAGAATGGTCTCGGAAGACAAAATCAAGCTTTATTATTACATAGAAAACTCCTTAGAATATCACGGGAATGAAATGCCTTATTTAGAAGTTGATGAAGGTTTAGCACCAGCCATTGAAACACTAATAACATCATATCCCAATTATATAGCAGTGGAAAATCTTGAAATACCAAATGATTCAGATAAACTTCAATTGGCTGATGCCCTGTGGTCTAGAGGAATAATAATGACTGAATTCCCATTACAGAATATAGATGATGATTAA

Protein

MNSPVSAFAVYRSNKQSNYEKKKNKSKRITNSSKALPISPKALSKSPKVHSKPKPISEEVMKNAAQKLKKNKKKNESKNIIKKKTHKKKKSKNTKATKGDDEQPVMKRKIKRNRDDKHDSDDIPSLIPISFTNFHESNLDSVDSCSSNGSIDFEPVQTDSVEEGLKVFKWMIAPYNPEEFLNRVWEKKPLHIARNKPDYYKEIISTPIIDDMLRNESIQFTKNIDITSYVDNKRETHNPEGRALPHIVWDFYLNGCSIRLLNPQTYIPKLHLVNATMQEFFNSFVGANAYLTPPDSQGFAPHYDDIEAFILQTEGKKHWRIYKPLNENEILPRVSSKNFSQEDIGDPIMEVTLEAGDMLYFPRGYIHQGVTIDGEHSLHVTISMYQKHSWADLFEKMIPAALQMAINENVELRQGLPFDIYDNFGIVNSDLTTPRRKELELIIHNLFEKIKQHLPLDDAVDQMHKNFQQDALPPVLNDMEKSVTVFGDTDVMIENGKVINRVEISLDTRIRLLRKNILRMVSEDKIKLYYYIENSLEYHGNEMPYLEVDEGLAPAIETLITSYPNYIAVENLEIPNDSDKLQLADALWSRGIIMTEFPLQNIDDD

Description

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region (By similarity).

Catalytic Activity

2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate
2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate

Cofactor

Fe(2+)

Similarity

Belongs to the ROX family. NO66 subfamily.

Keywords

Chromatin regulator   Complete proteome   Dioxygenase   Iron   Metal-binding   Nucleus   Oxidoreductase   Reference proteome   Repressor   Transcription   Transcription regulation   Phosphoprotein  

Feature

chain  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66

Uniprot

A0A2A4JIV8   A0A0L7KXI5   A0A2W1BX21   A0A194RET9   A0A2H1VJE0   S4PBP8   + More
A0A2J7PKY7   A0A067RL93   A0A2J7PKZ5   A0A088A9Z5   A0A2A3ET43   A0A1J1IQY0   A0A0N7ZCR3   A0A154PJT4   E2AWK0   U5ETG2   A0A026W2C5   A0A336L1S4   A0A2D4GEB0   A0A2D4J357   A0A1I8MGH8   B0WMG3   E9IQW4   V8P177   A0A1I8Q8M4   Q16W06   A0A2K7P6C1   M7CFB5   A0A1Q3EYJ7   A0A1B0CIU9   K1PS42   A0A1B6J5X3   A0A0C9RAF1   A0A034V3K1   A0A1V4KEW3   A0A3Q0HKR2   A0A0A1WL93   A0A1L8G801   A0A0K8U7R9   A0A3M0JHW3   A0A1B6GDQ5   W5NFB5   W5NFB4   E2BDN8   A0A1A9ZVD4   H2M7R3   A0A210Q472   T1J5W2   H3BDR0   U3KIE9   A0A3P9L5N7   A0A1A9UPJ3   A0A1B0FGL3   A0A1B0ATA7   A0A1L8DHH0   A0A1A9XAJ5   A0A1B6LY87   W8AWA9   F1NJ46   A0A3B3CUC7   A0A3Q3L9I0   A0A1B6DAA9   Q5ZMM1   A0A3P9NUY6   A0A2P4TH79   A0A182H1Z3   M4ARI1   A0A1Z5L6B4   V3ZTI6   F6Y3P3   A0A1A9X4M9   A0A3B5KX45   A0A0Q3MHS1   A0A1S3H2A1   A0A3Q1J5N4   A0A3Q3F7V3   A0A3Q3X5F1   A0A182IW50   A0A2R5L4F9   A0A182VR16   A0A3B1IY12   A0A0F8CS36   A0A2M3ZBJ4   A0A2M3ZGG2   A0A293MUS7   B4NP88   A0A315VW41   A0A131YUT1   A0A3Q3BA12   Q4S728   A0A3B4DT88   A0A2U9CUH5   A0A084VS35   A0A2M4CRH4  

Pubmed

26227816    28756777    26354079    23622113    24845553    20798317    + More
24508170    25315136    21282665    24297900    17510324    23624526    22992520    25348373    25830018    27762356    17554307    28812685    9215903    24495485    15592404    29451363    15642098    26483478    23542700    28528879    23254933    20431018    25329095    25835551    17994087    29703783    26830274    15496914    24438588   

EMBL

NWSH01001228    PCG72035.1    JTDY01004596    KOB67967.1    KZ149909    PZC78174.1    + More
KQ460313    KPJ16092.1    ODYU01002881    SOQ40916.1    GAIX01004511    JAA88049.1    NEVH01024529    PNF17004.1    KK852559    KDR21380.1    PNF17005.1    KZ288186    PBC34850.1    CVRI01000057    CRL01956.1    GDRN01061767    JAI65168.1    KQ434924    KZC11548.1    GL443346    EFN62164.1    GANO01001932    JAB57939.1    KK107475    EZA50148.1    UFQS01000833    UFQT01000833    SSX07140.1    SSX27483.1    IACJ01128801    LAA58111.1    IACK01141842    LAA90906.1    DS231997    GL764978    EFZ17039.1    AZIM01001247    ETE67582.1    CH477578    KB516251    EMP39572.1    GFDL01014685    JAV20360.1    AJWK01013788    JH817298    EKC24473.1    GECU01021508    GECU01013136    JAS86198.1    JAS94570.1    GBYB01003766    JAG73533.1    GAKP01021848    JAC37104.1    LSYS01003385    OPJ83009.1    GBXI01014846    JAC99445.1    CM004474    OCT79861.1    GDHF01029610    JAI22704.1    QRBI01000144    RMC00503.1    GECZ01009195    JAS60574.1    AHAT01008246    AHAT01008247    AHAT01008248    AHAT01008249    AHAT01008250    GL447678    EFN86200.1    NEDP02005067    OWF43534.1    JH431868    AFYH01020998    AFYH01020999    AFYH01021000    AFYH01021001    AFYH01021002    AFYH01021003    AFYH01021004    AGTO01000952    CCAG010010420    JXJN01003231    GFDF01008188    JAV05896.1    GEBQ01011407    GEBQ01005472    JAT28570.1    JAT34505.1    GAMC01013320    JAB93235.1    AADN05000303    GEDC01021703    GEDC01014773    GEDC01012247    JAS15595.1    JAS22525.1    JAS25051.1    AJ719363    PPHD01000270    POI35699.1    JXUM01104415    JXUM01104416    KQ564884    KXJ71619.1    GFJQ02004376    JAW02594.1    KB202849    ESO87692.1    AAMC01027526    AAMC01027527    LMAW01002136    KQK81864.1    GGLE01000204    MBY04330.1    KQ041516    KKF25973.1    GGFM01005110    MBW25861.1    GGFM01006858    MBW27609.1    GFWV01019141    MAA43869.1    CH964291    NHOQ01001000    PWA27555.1    GEDV01005820    JAP82737.1    CAAE01014723    CAG03554.1    CP026262    AWP20277.1    ATLV01015797    KE525036    KFB40779.1    GGFL01003701    MBW67879.1   

Proteomes

UP000218220    UP000037510    UP000053240    UP000235965    UP000027135    UP000005203    + More
UP000242457    UP000183832    UP000076502    UP000000311    UP000053097    UP000095301    UP000002320    UP000095300    UP000008820    UP000031443    UP000092461    UP000005408    UP000190648    UP000189705    UP000186698    UP000269221    UP000018468    UP000008237    UP000092445    UP000001038    UP000242188    UP000008672    UP000016665    UP000265180    UP000078200    UP000092444    UP000092460    UP000092443    UP000000539    UP000261560    UP000261640    UP000242638    UP000069940    UP000249989    UP000002852    UP000030746    UP000008143    UP000091820    UP000261380    UP000051836    UP000085678    UP000265040    UP000261660    UP000261620    UP000075880    UP000075920    UP000018467    UP000007798    UP000264800    UP000261440    UP000246464    UP000030765   

PRIDE

B0WMG3    Q16W06    Q5ZMM1   

Pfam

PF08007   Cupin_4

Interpro

IPR003347   JmjC_dom        + More
IPR039994   JmjC_protein       

ProteinModelPortal

A0A2A4JIV8   A0A0L7KXI5   A0A2W1BX21   A0A194RET9   A0A2H1VJE0   S4PBP8   + More
A0A2J7PKY7   A0A067RL93   A0A2J7PKZ5   A0A088A9Z5   A0A2A3ET43   A0A1J1IQY0   A0A0N7ZCR3   A0A154PJT4   E2AWK0   U5ETG2   A0A026W2C5   A0A336L1S4   A0A2D4GEB0   A0A2D4J357   A0A1I8MGH8   B0WMG3   E9IQW4   V8P177   A0A1I8Q8M4   Q16W06   A0A2K7P6C1   M7CFB5   A0A1Q3EYJ7   A0A1B0CIU9   K1PS42   A0A1B6J5X3   A0A0C9RAF1   A0A034V3K1   A0A1V4KEW3   A0A3Q0HKR2   A0A0A1WL93   A0A1L8G801   A0A0K8U7R9   A0A3M0JHW3   A0A1B6GDQ5   W5NFB5   W5NFB4   E2BDN8   A0A1A9ZVD4   H2M7R3   A0A210Q472   T1J5W2   H3BDR0   U3KIE9   A0A3P9L5N7   A0A1A9UPJ3   A0A1B0FGL3   A0A1B0ATA7   A0A1L8DHH0   A0A1A9XAJ5   A0A1B6LY87   W8AWA9   F1NJ46   A0A3B3CUC7   A0A3Q3L9I0   A0A1B6DAA9   Q5ZMM1   A0A3P9NUY6   A0A2P4TH79   A0A182H1Z3   M4ARI1   A0A1Z5L6B4   V3ZTI6   F6Y3P3   A0A1A9X4M9   A0A3B5KX45   A0A0Q3MHS1   A0A1S3H2A1   A0A3Q1J5N4   A0A3Q3F7V3   A0A3Q3X5F1   A0A182IW50   A0A2R5L4F9   A0A182VR16   A0A3B1IY12   A0A0F8CS36   A0A2M3ZBJ4   A0A2M3ZGG2   A0A293MUS7   B4NP88   A0A315VW41   A0A131YUT1   A0A3Q3BA12   Q4S728   A0A3B4DT88   A0A2U9CUH5   A0A084VS35   A0A2M4CRH4  

PDB

4E4H     E-value=2.10324e-111,     Score=1031

KEGG

101739566    K16914 bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [EC:1.14.11.- 1.14.11.

GO

GO:0008168   GO:0016706   GO:0070544   GO:0005506   GO:0045892   GO:0051864   GO:0005634   GO:0034720   GO:0032453   GO:0045668   GO:0005730   GO:0005654  

PANTHER

PTHR13096  

Subcellular location

Nucleus  
Nucleolus  
Nucleoplasm  

Length:

605

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00039

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00025

outside

1  -  605

 

 

Pi

134.054703

Theta

179.408591

Tajima's D

-0.790264

CLR

1064.724283

CSRT

0.177991100444978

Interpretation

Uncertain