Gene

KWMTBOMO13561  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010993

Annotation

PREDICTED:_tubulin-folding_cofactor_B_[Amyelois_transitella]

Location

Bomo_Chr23(+):1591886-1596363      View in EpiBrowser

Full name

Tubulin-folding cofactor B      

Alternative Name

Cytoskeleton-associated protein 1
Cytoskeleton-associated protein CKAPI
Tubulin-specific chaperone B

Location in the cell

Cytoplasmic   Reliability : 2.339

CDS

ATGGCTGACGTACTAGTTATAACTCAAGACTATGTTAATGTACACATTACAAAATCGGACAACGAAGATGCGGCGCCGATCGAACGTAGATTTAAAAAGGGAATCAATATTCTTGAATTTAAGACAAAATTAGAGCTACTCACCGGCGGGTCCCCAACCACAATGAAATTAAAATTATATGACAAGAAAAACAACTTTGTATGTGATATAGAAGATGATGAAAAACTTCTTGGCTCATACCCGATAGATGATGGAATGAGGATACATGTCATTGATAAGTTTTCTCTTGTCAATGATTTTGCTACTTCTGACAGCGCTGAGAGATTCCGGTTATCAGAAGAGGACTATGAGAAAAAGGGTGATACTCTCAGATCTTTCCTACAACGCAACAGGCTTGGTAAATATAATGAGGAAGAGATGAAGAAAATGAAGGAACAACAGGAAAAAGAGTTGGAGGAAGAGGCAAAGTTAGCGGAAGCTGTGTTGGTGGGGGCCCGCTGCGAGGTCCGCGTGCCGCAGCAGGGGGCGCGGCGAGGTGTGGTCCGGTACAACGGCACGCTCGCCGGCGCCAAGGGACTCTGGATCGGGGTGCAGTACGACGAGCCGCTCGGCAAGAACGATGGATCAGTGAATGGCAAGCGTTACTTCACATGCCCTCCTAAATATGGAGGATTTGTTCGTCCAGCTCATGTCATCGTCGGCGACTTCCCCAAAGAAAGCTTGGATCTCGACGACGAGATATGA

Protein

MADVLVITQDYVNVHITKSDNEDAAPIERRFKKGINILEFKTKLELLTGGSPTTMKLKLYDKKNNFVCDIEDDEKLLGSYPIDDGMRIHVIDKFSLVNDFATSDSAERFRLSEEDYEKKGDTLRSFLQRNRLGKYNEEEMKKMKEQQEKELEEEAKLAEAVLVGARCEVRVPQQGARRGVVRYNGTLAGAKGLWIGVQYDEPLGKNDGSVNGKRYFTCPPKYGGFVRPAHVIVGDFPKESLDLDDEI

Description

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.

Subunit

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Interacts with GAN. Interacts with DCTN1.

Similarity

Belongs to the TBCB family.

Keywords

Acetylation   Chaperone   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Differentiation   Microtubule   Neurogenesis   Phosphoprotein   Reference proteome   Ubl conjugation  

Feature

chain  Tubulin-folding cofactor B

Uniprot

A0A2A4JRF6   A0A2W1BSY8   A0A3S2LJ76   A0A194PXM3   S4PC11   A0A212EXN0   + More
A0A194RJH0   A0A2H1X0B9   A0A158P277   A0A195FI25   A0A195AVD3   E9IV17   A0A195E428   F4W6G6   A0A2R7WD05   A0A151X261   E2AJX1   A0A0N0U5B1   E2B379   A0A026X0I9   A0A195D2Y8   A0A088A001   A0A2A3E4L1   A0A0V0G7T1   T1HSK9   A0A2C9JQ22   A0A2J7RIX0   A0A1W4X704   A0A0T6AZV4   A0A154PIG3   A0A0B7AQI6   E9HZB4   T1IPT7   A0A0P5CX02   A0A1L8E5J9   A0A146LSI2   A0A1B6DM77   J3JYW7   A0A1Y1KBK1   H3AYZ5   A0A0J7KUI4   B4LNV9   D6WA48   A0A1S3K4I3   N6TZP5   T1E3Q6   Q3KPK1   A0A210QAF2   J3S5D7   F7BMV7   A0A1Q3FXS8   A0A1L8F877   A0A034WS45   Q6NU87   A0A0K8TUJ9   A0A0A1WQ56   A0A0K8VQP2   K7IN65   A0A232F6B8   A0A182SJD5   A0A1B6LRF3   E0VWL2   W5NCB8   Q17J51   B4KMF4   A0A023EN52   A0A1B6GVC1   A0A182HBT3   A0A1B6FPA8   G3P5E2   A0A182G519   W8BY41   A0A2G9RZT1   A0A182Y7U3   B4J617   A0A250YDA5   B4MRR4   A0A182W423   A0A151MLE3   A0A182NSK2   H0X4Y6   A0A023EKS5   Q5E951   G1TAM3   A0A182M1C2   A0A1I8Q3U5   K9IHW0   H0VKN9   A0A2K6F5Y8   A0A1B6HQ17   L8HTP9   I3MDH7   A0A1W7R9B3   A0A182QTR5   T1GT24   Q1RP74   A0A2H6NGD8   T1PJ46   M3X835  

Pubmed

28756777    26354079    23622113    22118469    21347285    21282665    + More
21719571    20798317    24508170    15562597    21292972    26823975    22516182    23537049    28004739    9215903    17994087    18362917    19820115    23758969    27762356    28812685    23025625    20431018    25348373    26369729    25830018    20075255    28648823    20566863    17510324    24945155    26483478    24495485    25244985    28087693    22293439    16305752    21993624    22751099    15489334    15057822    15632090    22673903    25315136    17975172   

EMBL

NWSH01000820    PCG74043.1    KZ149909    PZC78169.1    RSAL01000002    RVE55030.1    + More
RVE55083.1    KQ459595    KPI95900.1    GAIX01005702    JAA86858.1    AGBW02011749    OWR46194.1    KQ460313    KPJ16086.1    ODYU01012448    SOQ58753.1    ADTU01007008    KQ981523    KYN40345.1    KQ976731    KYM76193.1    GL766116    EFZ15554.1    KQ979657    KYN19908.1    GL887707    EGI70301.1    KK854477    PTY16185.1    KQ982580    KYQ54468.1    GL440100    EFN66287.1    KQ435784    KOX74594.1    GL445305    EFN89861.1    KK107054    EZA61588.1    KQ976885    KYN07268.1    KZ288379    PBC26628.1    GECL01002006    JAP04118.1    ACPB03006764    NEVH01003023    PNF40773.1    LJIG01022458    KRT80484.1    KQ434924    KZC11597.1    HACG01035391    CEK82256.1    GL733302    EFX62918.1    JH431265    GDIP01169802    LRGB01000243    JAJ53600.1    KZS20211.1    GFDF01000054    JAV14030.1    GDHC01007866    JAQ10763.1    GEDC01010517    GEDC01002545    JAS26781.1    JAS34753.1    BT128448    KB631924    AEE63405.1    ERL87188.1    GEZM01088993    GEZM01088992    GEZM01088991    GEZM01088990    GEZM01088989    GEZM01088988    GEZM01088985    GEZM01088984    GEZM01088983    GEZM01088979    GEZM01088978    GEZM01088977    GEZM01088976    GEZM01088975    GEZM01088973    GEZM01088971    JAV57791.1    AFYH01132883    AFYH01132884    AFYH01132885    LBMM01003135    KMQ93919.1    CH940648    EDW61128.1    KQ971312    EEZ98061.1    APGK01055130    KB741259    ENN71732.1    GAAZ01002740    JAA95203.1    BC106702    CM004481    AAI06703.1    OCT66131.1    NEDP02004417    OWF45699.1    JU176334    GBEX01003736    AFJ51857.1    JAI10824.1    AAMC01014591    AAMC01014592    GFDL01002742    JAV32303.1    CM004480    OCT67789.1    GAKP01001942    JAC57010.1    BC068710    AAH68710.1    GDAI01000013    JAI17590.1    GBXI01013108    JAD01184.1    GDHF01011115    JAI41199.1    NNAY01000810    OXU26381.1    GEBQ01013689    JAT26288.1    DS235822    EEB17768.1    AHAT01023888    AHAT01023889    CH477235    EAT46658.1    CH933808    EDW09842.1    GAPW01003804    JAC09794.1    GECZ01003377    JAS66392.1    JXUM01125673    KQ566972    KXJ69692.1    GECZ01017788    GECZ01015144    JAS51981.1    JAS54625.1    JXUM01042847    KQ561341    KXJ78908.1    GAMC01005052    JAC01504.1    KV929872    PIO32711.1    CH916367    EDW01875.1    GFFW01003180    JAV41608.1    CH963850    EDW74803.1    AKHW03005839    KYO25345.1    AAQR03125275    AAQR03125276    GAPW01003805    JAC09793.1    BT021069    BC102571    AXCM01021915    GABZ01007592    JAA45933.1    AAKN02042174    GECU01030928    JAS76778.1    JH883137    ELR47258.1    AGTP01117499    GFAH01000650    JAV47739.1    AXCN02001377    CAQQ02030742    AABR07002905    AABR07002975    BC126061    AB256046    AM258961    CH473979    AAI26062.1    BAE94256.1    CAJ88857.1    EDM07781.1    IACI01093598    LAA31958.1    KA648140    AFP62769.1    AANG04004572   

Proteomes

UP000218220    UP000283053    UP000053268    UP000007151    UP000053240    UP000005205    + More
UP000078541    UP000078540    UP000078492    UP000007755    UP000075809    UP000000311    UP000053105    UP000008237    UP000053097    UP000078542    UP000005203    UP000242457    UP000015103    UP000076420    UP000235965    UP000192223    UP000076502    UP000000305    UP000076858    UP000030742    UP000008672    UP000036403    UP000008792    UP000007266    UP000085678    UP000019118    UP000186698    UP000242188    UP000008143    UP000002358    UP000215335    UP000075901    UP000009046    UP000018468    UP000008820    UP000009192    UP000069940    UP000249989    UP000007635    UP000076408    UP000001070    UP000007798    UP000075920    UP000050525    UP000075884    UP000005225    UP000009136    UP000001811    UP000075883    UP000095300    UP000005447    UP000233160    UP000005215    UP000075886    UP000015102    UP000002494    UP000095301    UP000011712   

PRIDE

Q5E951   

Pfam

PF01302   CAP_GLY        + More
PF14560   Ubiquitin_2

Interpro

IPR000938   CAP-Gly_domain        + More
IPR029071   Ubiquitin-like_domsf       
IPR036859   CAP-Gly_dom_sf       
IPR000626   Ubiquitin_dom       

SUPFAM

SSF74924   SSF74924        + More
SSF54236   SSF54236       

Gene 3D

2.30.30.190    

ProteinModelPortal

A0A2A4JRF6   A0A2W1BSY8   A0A3S2LJ76   A0A194PXM3   S4PC11   A0A212EXN0   + More
A0A194RJH0   A0A2H1X0B9   A0A158P277   A0A195FI25   A0A195AVD3   E9IV17   A0A195E428   F4W6G6   A0A2R7WD05   A0A151X261   E2AJX1   A0A0N0U5B1   E2B379   A0A026X0I9   A0A195D2Y8   A0A088A001   A0A2A3E4L1   A0A0V0G7T1   T1HSK9   A0A2C9JQ22   A0A2J7RIX0   A0A1W4X704   A0A0T6AZV4   A0A154PIG3   A0A0B7AQI6   E9HZB4   T1IPT7   A0A0P5CX02   A0A1L8E5J9   A0A146LSI2   A0A1B6DM77   J3JYW7   A0A1Y1KBK1   H3AYZ5   A0A0J7KUI4   B4LNV9   D6WA48   A0A1S3K4I3   N6TZP5   T1E3Q6   Q3KPK1   A0A210QAF2   J3S5D7   F7BMV7   A0A1Q3FXS8   A0A1L8F877   A0A034WS45   Q6NU87   A0A0K8TUJ9   A0A0A1WQ56   A0A0K8VQP2   K7IN65   A0A232F6B8   A0A182SJD5   A0A1B6LRF3   E0VWL2   W5NCB8   Q17J51   B4KMF4   A0A023EN52   A0A1B6GVC1   A0A182HBT3   A0A1B6FPA8   G3P5E2   A0A182G519   W8BY41   A0A2G9RZT1   A0A182Y7U3   B4J617   A0A250YDA5   B4MRR4   A0A182W423   A0A151MLE3   A0A182NSK2   H0X4Y6   A0A023EKS5   Q5E951   G1TAM3   A0A182M1C2   A0A1I8Q3U5   K9IHW0   H0VKN9   A0A2K6F5Y8   A0A1B6HQ17   L8HTP9   I3MDH7   A0A1W7R9B3   A0A182QTR5   T1GT24   Q1RP74   A0A2H6NGD8   T1PJ46   M3X835  

PDB

1LPL     E-value=4.14397e-24,     Score=273

KEGG

101740451    K17262 tubulin-specific chaperone B | (RefSeq) tubulin-folding cofactor B

GO

GO:0031122   GO:0035089   GO:0072686   GO:0007309   GO:0005634   GO:0005938   GO:0005813   GO:0005829   GO:0005737   GO:0005874   GO:0007399   GO:0030154   GO:0005515   GO:0003676   GO:0043565   GO:0008235   GO:0019538   GO:0030145   GO:0016491   GO:0015930  

Subcellular location

Cytoplasm   Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.   With evidence from 1 publications.
Cytoskeleton   Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.   With evidence from 1 publications.

Length:

247

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0369200000000001

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.05110

outside

1  -  247

 

 

Pi

329.1697

Theta

208.079293

Tajima's D

1.639533

CLR

0.328214

CSRT

0.814409279536023

Interpretation

Uncertain