Gene

KWMTBOMO13530  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001307

Annotation

superoxide_dismutase_[Cu-Zn]_[Bombyx_mori]

Location

Bomo_Chr23(-):784310-788037      View in EpiBrowser

Full name

Superoxide dismutase [Cu-Zn]      

Alternative Name

Superoxide dismutase 1

Location in the cell

Cytoplasmic   Reliability : 3.742

CDS

ATGCCCGCCAAAGCAGTTTGCGTACTTCGTGGTGATGTTAGCGGAACTGTTTTCTTCGATCAGCAGGATGAAAAGTCACCTGTTGTTGTTTCTGGAGAGGTCCAGGGCTTGACTAAGGGTAAACACGGTTTCCATGTGCACGAATTTGGTGACAACACAAACGGTTGCACATCAGCTGGAGCTCATTTCAACCCTGAAAAACAAGATCATGGTGGTCCCAGTTCTGCTGTACGCCATGTCGGCGACCTCGGTAACATTGAGGCAATTGAAGACTCTGGAGTCACTAAAGTATCAATCCAAGATTCCCAGATCTCTCTTCATGGACCTAACAGCATCATTGGTCGCACTTTAGTTGTCCATGCTGACCCTGATGACTTGGGACTCGGTGGCCATGAGCTAAGTAAGACCACTGGTAATGCCGGTGGCCGTATTGCTTGTGGAGTCATTGGCTTGGCCAAGATTTAA

Protein

MPAKAVCVLRGDVSGTVFFDQQDEKSPVVVSGEVQGLTKGKHGFHVHEFGDNTNGCTSAGAHFNPEKQDHGGPSSAVRHVGDLGNIEAIEDSGVTKVSIQDSQISLHGPNSIIGRTLVVHADPDDLGLGGHELSKTTGNAGGRIACGVIGLAKI

Description

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic Activity

2 H(+) + 2 superoxide = H2O2 + O2

Cofactor

Cu cation
Zn(2+)

Subunit

Homodimer.

Similarity

Belongs to the Cu-Zn superoxide dismutase family.

Keywords

3D-structure   Antioxidant   Complete proteome   Copper   Cytoplasm   Direct protein sequencing   Disulfide bond   Metal-binding   Oxidoreductase   Reference proteome   Zinc  

Feature

chain  Superoxide dismutase [Cu-Zn]

Uniprot

Q5TLU4   A0JKF3   P82205   A7BI63   A0A170QHN4   A0A1B1RSA9   + More
A0A212FDT2   S4PG22   A0A2Z4N444   A0A194PR57   I4DJ15   A0A3S5HJH2   G4XH81   A0A2A4JHM4   A0A194RFH4   A0A2S0RQR7   C3RSN1   A0A2H1V9V5   H9BEW2   A0A0L7LLQ0   A0A2W1BUB5   Q60FS5   A0A1I8N7L1   Q6SCL6   A0A0U2SX80   A0A0S2A460   A0A1L8E4S1   A0A1B0CUF9   A0A1L8EFB3   A0A0S2A496   A0A1I8Q6I1   A0A1A9XY61   A0A1B0BND7   E0W322   A0A1W4W7H5   A0A1A9UFW7   A0A076G467   A0A023EH27   U5EW44   A0A109WQA1   A0A1A9ZKK9   A0A2R4LGJ8   D2A2T2   Q1HRN3   A0A385HVY4   A0A1Y1MBB2   R4V538   D3TRM9   A0A0C9RW85   M1JNK3   F4MI33   A0A0L0BQ22   A0A0N7EJN0   A0A0K8TQF3   A0A3G9D4Q3   W8BWU5   P28755   A0A2J7PGY8   A0A1A9W501   A0A1Q3FJF2   A0A2P1H680   Q6W5R8   A0A0A1WUB5   A0A067R0S2   A0A154P938   E2A8Y6   A6YPT7   R4WNL0   A0A023FAY3   A0A2Z4G643   A0A0V0G2Z1   Q7YXM6   A0A088A933   A0A1B6KJY5   V9IJ95   H6UWL0   A0A0P4VTN9   T1HRT6   A0A195AZY4   A0A158NMI6   A0A026WG66   B0X9L3   A0A1B6CIU5   P41973   B4IY00   Q103C4   Q07182   A0A1S3D1W5   A0A0M5J141   A0A069DPF3   A0A226DYR0   E3VSS4   C5NS97   D2Y3W7   B8YNX4   A0A0L7R2N7   G9C5D1   G9D320   A0A182GVF6   A0A2C9GUA8  

EC Number

1.15.1.1

Pubmed

15784978    11280994    22118469    23622113    26354079    22651552    + More
26227816    28756777    25315136    20566863    25042129    24945155    26483478    18362917    19820115    17204158    17510324    28004739    20353571    25348373    21569254    26108605    26369729    26760975    24495485    1342926    29527172    14993600    25830018    24845553    20798317    18207082    23691247    25474469    29889877    11932240    16139867    27129103    21347285    24508170    30249741    7926818    17994087    16730205    1343773    26334808    21835214    21937434   

EMBL

AB179561    LC377907    BAD69805.2    BBD52302.1    EF077625    AM410997    + More
ABK60176.1    CAL69462.1    AY461705    AAR97568.1    AB290453    BAF73670.1    KT984953    AMY63172.1    KU549181    ANU04687.1    AGBW02008999    OWR51892.1    GAIX01003807    JAA88753.1    MG431817    AWX63640.1    KQ459595    KPI95936.1    AK401283    BAM17905.1    MH374163    AZK16057.1    JF811436    AEP43785.1    NWSH01001445    PCG71218.1    KQ460313    KPJ16050.1    MF797881    RSAL01000069    AWA45435.1    RVE49227.1    EU263634    ABX11259.1    ODYU01001173    SOQ37014.1    JQ009331    AFC98366.1    JTDY01000644    KOB76355.1    KZ149964    PZC76236.1    AB189024    BAD52256.1    AY460107    KA644700    AAR23787.1    AFP59329.1    KT270580    ALR99794.1    KT002138    KT002143    ALN12440.1    ALN12445.1    GFDF01000552    JAV13532.1    AJWK01029153    GFDG01001520    JAV17279.1    KT002146    ALN12448.1    JXJN01017347    DS235881    EEB20028.1    KF527568    AII26027.1    JXUM01073365    GAPW01005443    GAPW01005442    GAPW01005441    GAPW01005440    KQ562770    JAC08156.1    KXJ75156.1    GANO01001597    JAB58274.1    KP642166    ALM23457.1    MH006694    AVW80115.1    KP342269    KQ971339    AKH80544.1    EFA02790.1    DQ440061    CH477769    CH477190    ABF18094.1    EAT36424.1    EAT48702.1    MG601765    AXY54993.1    GEZM01037908    JAV81850.1    KC741174    AGM32998.1    CCAG010001380    EZ424081    ADD20357.1    GBYB01012041    JAG81808.1    JX263431    GAKP01008857    AGE89777.1    JAC50095.1    EZ617714    ADH94607.1    JRES01001549    KNC22106.1    KR072549    ALF39391.1    GDAI01001488    JAI16115.1    FX985484    BAX90092.1    GAMC01002843    JAC03713.1    M76975    NEVH01025158    PNF15606.1    GFDL01007346    JAV27699.1    MF776705    AVN67038.1    AY309973    AAQ81639.1    GBXI01012274    JAD02018.1    KK853022    KDR12362.1    KQ434829    KZC07670.1    GL437703    EFN70085.1    EF639098    GEMB01003510    ABR27983.1    JAR99707.1    AK417231    BAN20446.1    GBBI01000075    JAC18637.1    MG983778    AWV96613.1    GECL01003765    JAP02359.1    AY329355    AAP93581.1    GEBQ01028209    JAT11768.1    JR050197    KM244765    AEY61198.1    AIU41504.1    JN700517    KZ288318    AEZ57109.1    PBC28279.1    GDKW01000598    JAI55997.1    ACPB03006759    KQ976697    KYM77514.1    ADTU01020601    KK107238    QOIP01000007    EZA54646.1    RLU20399.1    DS232541    EDS43182.1    GEDC01023958    JAS13340.1    L13281    CH964101    CH916366    EDV97543.1    DQ096569    AAZ79896.1    X61687    CP012525    ALC44136.1    GBGD01003323    JAC85566.1    LNIX01000009    OXA49934.1    HQ230310    ADO20320.1    AB475105    BAH83704.1    GU300109    ADB54843.2    FJ554532    HQ326578    HQ326579    HQ326580    HQ326581    HQ326582    HQ326583    ACL80663.2    ADO79626.1    ADO79627.1    ADO79628.1    ADO79629.1    ADO79630.1    ADO79631.1    KQ414666    KOC65098.1    HQ851372    AEV89750.1    JF770428    JF770430    AET83766.1    AET83768.1    JXUM01090826    JXUM01090827    JXUM01090828    KQ563868    KXJ73139.1    AXCM01002647   

Proteomes

UP000005204    UP000007151    UP000053268    UP000218220    UP000053240    UP000283053    + More
UP000037510    UP000095301    UP000092461    UP000095300    UP000092443    UP000092460    UP000009046    UP000192223    UP000078200    UP000069940    UP000249989    UP000092445    UP000007266    UP000008820    UP000092444    UP000037069    UP000235965    UP000091820    UP000027135    UP000076502    UP000000311    UP000005203    UP000242457    UP000015103    UP000078540    UP000005205    UP000053097    UP000279307    UP000002320    UP000007798    UP000001070    UP000079169    UP000092553    UP000198287    UP000053825    UP000075883   

PRIDE

P82205    A7BI63    Q07182   

Pfam

PF00080   Sod_Cu

Interpro

IPR024134   SOD_Cu/Zn_/chaperone        + More
IPR018152   SOD_Cu/Zn_BS       
IPR036423   SOD-like_Cu/Zn_dom_sf       
IPR001424   SOD_Cu_Zn_dom       

SUPFAM

SSF49329   SSF49329       

Gene 3D

2.60.40.200    

CDD

cd00305  Cu-Zn_Superoxide_Dismutase

ProteinModelPortal

Q5TLU4   A0JKF3   P82205   A7BI63   A0A170QHN4   A0A1B1RSA9   + More
A0A212FDT2   S4PG22   A0A2Z4N444   A0A194PR57   I4DJ15   A0A3S5HJH2   G4XH81   A0A2A4JHM4   A0A194RFH4   A0A2S0RQR7   C3RSN1   A0A2H1V9V5   H9BEW2   A0A0L7LLQ0   A0A2W1BUB5   Q60FS5   A0A1I8N7L1   Q6SCL6   A0A0U2SX80   A0A0S2A460   A0A1L8E4S1   A0A1B0CUF9   A0A1L8EFB3   A0A0S2A496   A0A1I8Q6I1   A0A1A9XY61   A0A1B0BND7   E0W322   A0A1W4W7H5   A0A1A9UFW7   A0A076G467   A0A023EH27   U5EW44   A0A109WQA1   A0A1A9ZKK9   A0A2R4LGJ8   D2A2T2   Q1HRN3   A0A385HVY4   A0A1Y1MBB2   R4V538   D3TRM9   A0A0C9RW85   M1JNK3   F4MI33   A0A0L0BQ22   A0A0N7EJN0   A0A0K8TQF3   A0A3G9D4Q3   W8BWU5   P28755   A0A2J7PGY8   A0A1A9W501   A0A1Q3FJF2   A0A2P1H680   Q6W5R8   A0A0A1WUB5   A0A067R0S2   A0A154P938   E2A8Y6   A6YPT7   R4WNL0   A0A023FAY3   A0A2Z4G643   A0A0V0G2Z1   Q7YXM6   A0A088A933   A0A1B6KJY5   V9IJ95   H6UWL0   A0A0P4VTN9   T1HRT6   A0A195AZY4   A0A158NMI6   A0A026WG66   B0X9L3   A0A1B6CIU5   P41973   B4IY00   Q103C4   Q07182   A0A1S3D1W5   A0A0M5J141   A0A069DPF3   A0A226DYR0   E3VSS4   C5NS97   D2Y3W7   B8YNX4   A0A0L7R2N7   G9C5D1   G9D320   A0A182GVF6   A0A2C9GUA8  

PDB

3L9E     E-value=2.94523e-74,     Score=702

KEGG

692639    K04565 superoxide dismutase, Cu-Zn family [EC:1.15.1.1] | (RefSeq) SOD, inx2; Cu/Zn superoxide dismu

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0004784   GO:0005737   GO:0005507   GO:0019430   GO:0005634   GO:0005829   GO:0004601   GO:0006801   GO:0008235   GO:0019538   GO:0030145   GO:0003676   GO:0016491   GO:0015930   GO:0055114  

PANTHER

PTHR10003  

Subcellular location

Cytoplasm  

Length:

154

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00053

Exp number, first 60 AAs:

0

Total prob of N-in:

0.18437

outside

1  -  154

 

 

Pi

203.293713

Theta

167.220048

Tajima's D

0.712496

CLR

0.020045

CSRT

0.576171191440428

Interpretation

Uncertain