Gene

KWMTBOMO13459

Pre Gene Modal

BGIBMGA010868

Annotation

silk_gland_factor_3_[Bombyx_mori]

Location

Bomo_Chr22(+):17578401-17579775      View in EpiBrowser

Full name

POU domain protein       + More
Silk gland factor 3      
POU domain protein CF1A      

Alternative Name

POU domain protein M1
Chorion factor 1A
Protein drifter
Ventral veins lacking protein

Transcription factor

Pou

Location in the cell

Nuclear   Reliability : 4.182

CDS

ATGGCGGCGACCACGTACATGCCCGCCGAGATGGAGCTCGGCAACATCGGCGGGTACCACGCGGCGTCGCCGCGTAGTGCTGAGCCTGCCGACATGAAGTACCAGCATCCGTTGCACTCGGGCGGGTCGCCGTCCCCGGGGGCGCCCGTGATAGGGAACCCTTGGACGTCACTGCCACCCGCCGACCCCTGGGCGATGCACCAGCATCACGCACACGCACATCAACCAGACGTGAAGCCTCCCCCGGCTCCTCACGACCACCGCCACTTGCAGCATGCGGCCCACGGCTGGCACGCGCCCGTCGTCAGCCCGCATTACGGTGCGGGCTCGCCCGTCACACTGCATGGAGGATACCCAATGCCCGTGCACCAACACCATATGCTCAGAGACATCCAGCCCTCGCCGCATCCGCTGCATCATCACGCCATGGAGCGGGATCAGCCCGAGGAGGACACCCCCACGAGCGACGACCTCGAAGCATTCGCCAAACAGTTCAAGCAGCGCCGCATCAAGCTCGGTTTCACGCAGGCGGACGTCGGGCTCGCGCTCGGCACGCTCTACGGGAATGTGTTTTCACAGACGACTATCTGTCGTTTCGAAGCGTTACAGCTCAGTTTTAAAAATATGTGTAAATTAAAGCCGCTGCTGCAGAAGTGGCTCGAGGAGGCGGACTCGACGACGGGCAGCCCGACCAGCATCGACAAAATAGCGGCGCAGGGTCGGAAGAGGAAGAAGCGCACCTCTATAGAGGTTTCGGTGAAAGGTGCGCTAGAGCAACACTTCCACAAGCAGCCGAAACCGTCCGCTCAAGAAATCACGTCGTTAGCGGACAGCCTGCAGCTGGAGAAAGAGGTGGTGCGCGTGTGGTTCTGCAACAGGAGACAGAAAGAGAAGAGGATGACGCCACCGAACACGCTCGGCGGCGAGATGATGGAGGGCATGGGGCACGCACACTACGGACACGGAGACGTGCACGGGTCCCCGCTGCAGCACTCCCCGCCGGGCCTGTCCCCGCAGCACGGGCTGCCGCAGGGCGCCCACACACTGGCAGCGCACTAA

Protein

MAATTYMPAEMELGNIGGYHAASPRSAEPADMKYQHPLHSGGSPSPGAPVIGNPWTSLPPADPWAMHQHHAHAHQPDVKPPPAPHDHRHLQHAAHGWHAPVVSPHYGAGSPVTLHGGYPMPVHQHHMLRDIQPSPHPLHHHAMERDQPEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEADSTTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHKQPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLGGEMMEGMGHAHYGHGDVHGSPLQHSPPGLSPQHGLPQGAHTLAAH

Description

Binds to a DNA sequence element required for the expression of the dopa decarboxylase gene (Ddc) in specific dopaminergic neurons. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.

Similarity

Belongs to the POU transcription factor family.
Belongs to the POU transcription factor family. Class-3 subfamily.

Keywords

Activator   Complete proteome   Developmental protein   Differentiation   DNA-binding   Homeobox   Neurogenesis   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Silk gland factor 3

Uniprot

Q7YXU2   H9JMW5   A0A2H1WB21   A0A2W1BRD0   A0A2A4IWG0   Q6R516   + More
Q17237   A0A3S2NSD0   A0A194PZB2   A0A0L7KVG2   Q17F60   A0A182GR34   T1PHK4   A0A1W4XE40   T1DCX3   T1D2C6   A0A1U9WT19   A0A1J1I7R7   D6WLH0   U4UAX2   A0A336K378   A0A1Y1MSE7   A0A1B6EDS5   A0A1I8NA50   B0XIM7   B0W5A2   W8BSC8   A0A1B0DF49   A0A1I8Q0W2   A0A2R7WHJ3   A0A0A9Y3X6   C0KZ11   A0A0A1WH02   A0A0L0BWL7   A0A067RJQ9   A0A2Z6BDV3   A0A023F541   A0A1S4E8K4   A0A0P4VUY4   T1IDT4   A0A0K8V8N9   A0A026WKZ9   A0A151I195   A0A158NG23   A0A195E819   F4WTK7   A0A195F253   A0A151XB75   E9J5X9   A0A0C9PLS1   E2A9J6   A0A195CHW9   A0A146LMW3   E2BMZ1   A0A0J7KXK6   A0A0L7RIF4   A0A088AHI2   A0A154PTP7   A0A1A9WCV2   A0A1B6EVQ3   A0A1A9Y9X6   A0A1B0BJW3   A0A1A9VMT4   A0A1B0G5J4   A0A2J7QVR4   A8E6G8   P16241   A0A2P8XWY5   A0A1B6IIN9   A0A1A9Z8U6   B4J3G5   T1IUA9   C5ILC6   A0A0J9RRN7   E1JI48   A0A0S0WNN1   O17487   A0A0M9A8P9   E0W3K3   B4HUY1   A0A0S0WGV5   A0A0M5J0I3   B4QJT7   A0A1W4V996   A0A0P4WSY5   A0A0P8XWA9   A0A1B0CWG3  

Pubmed

14766018    19121390    28756777    19320969    7690034    26354079    + More
26227816    17510324    26483478    24330624    18362917    19820115    23537049    28004739    25315136    24495485    25401762    26823975    25830018    26108605    24845553    25474469    27129103    24508170    30249741    21347285    21719571    21282665    20798317    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    1673230    1680380    1967821    8986770    29403074    17994087    21911072    22936249    10495289    20566863   

EMBL

AY334012    AAP93140.1    BABH01029049    ODYU01007158    SOQ49694.1    KZ149966    + More
PZC76175.1    NWSH01006175    PCG63613.1    PCG63614.1    AY513764    AAR97922.1    M64781    RSAL01000106    RVE47313.1    KQ459586    KPI98079.1    JTDY01005243    KOB67208.1    CH477275    EAT45151.1    JXUM01081731    KQ563265    KXJ74175.1    KA648159    AFP62788.1    GALA01001662    JAA93190.1    GALA01001663    JAA93189.1    KX364398    AQY56479.1    CVRI01000043    CRK96333.1    KQ971343    EFA04675.1    KB632224    ERL90207.1    UFQS01000063    UFQT01000063    SSW98871.1    SSX19257.1    GEZM01023028    JAV88613.1    GEDC01010984    GEDC01001225    JAS26314.1    JAS36073.1    DS233335    EDS29475.1    DS231842    EDS35222.1    GAMC01014441    JAB92114.1    AJVK01058528    KK854814    PTY18979.1    GBHO01016726    GBHO01016725    GBRD01013883    GBRD01013882    GDHC01009475    JAG26878.1    JAG26879.1    JAG51943.1    JAQ09154.1    FJ647801    ACN43331.1    GBXI01016130    JAC98161.1    JRES01001238    KNC24417.1    KK852588    KDR20766.1    LC373551    BBD17794.1    GBBI01002543    JAC16169.1    GDKW01000049    JAI56546.1    ACPB03015558    GDHF01017015    JAI35299.1    KK107185    QOIP01000012    EZA55784.1    RLU16005.1    KQ976580    KYM79921.1    ADTU01014932    KQ979568    KYN20972.1    GL888341    EGI62428.1    KQ981864    KYN34174.1    KQ982335    KYQ57625.1    GL768221    EFZ11704.1    GBYB01002038    JAG71805.1    GL437917    EFN69886.1    KQ977721    KYN00335.1    GDHC01010487    JAQ08142.1    GL449382    EFN82895.1    LBMM01002108    KMQ95262.1    KQ414583    KOC70747.1    KQ435119    KZC14728.1    GECZ01027818    JAS41951.1    JXJN01015647    CCAG010022773    NEVH01009772    PNF32673.1    BT030760    AE014296    ABV82142.1    AHN57982.1    X58435    M81959    BT003517    X52252    PYGN01001222    PSN36525.1    GECU01020920    JAS86786.1    CH916366    EDV96167.1    JH431526    FJ952936    ACR47965.1    CM002912    KMY97964.1    ACZ94626.2    ALI30462.1    Y15070    CAA75353.1    KQ435726    KOX78159.1    DS235882    EEB20209.1    CH480817    EDW50752.1    ALI30463.1    CP012525    ALC43748.1    CM000363    EDX09478.1    GDRN01026523    JAI67681.1    CH902618    KPU78977.1    AJWK01032379   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000037510    UP000008820    + More
UP000069940    UP000249989    UP000192223    UP000183832    UP000007266    UP000030742    UP000095301    UP000002320    UP000092462    UP000095300    UP000037069    UP000027135    UP000079169    UP000015103    UP000053097    UP000279307    UP000078540    UP000005205    UP000078492    UP000007755    UP000078541    UP000075809    UP000000311    UP000078542    UP000008237    UP000036403    UP000053825    UP000005203    UP000076502    UP000091820    UP000092443    UP000092460    UP000078200    UP000092444    UP000235965    UP000000803    UP000245037    UP000092445    UP000001070    UP000053105    UP000009046    UP000001292    UP000092553    UP000000304    UP000192221    UP000007801    UP000092461   

PRIDE

Q7YXU2    H9JMW5    Q17237    P16241   

Pfam

PF00157   Pou        + More
PF00046   Homeodomain
PF00096   zf-C2H2

Interpro

IPR016362   TF_POU_3        + More
IPR009057   Homeobox-like_sf       
IPR000327   POU_dom       
IPR013847   POU       
IPR001356   Homeobox_dom       
IPR010982   Lambda_DNA-bd_dom_sf       
IPR017970   Homeobox_CS       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF47413   SSF47413        + More
SSF46689   SSF46689       
SSF57667   SSF57667       

CDD

cd00086  homeodomain

ProteinModelPortal

Q7YXU2   H9JMW5   A0A2H1WB21   A0A2W1BRD0   A0A2A4IWG0   Q6R516   + More
Q17237   A0A3S2NSD0   A0A194PZB2   A0A0L7KVG2   Q17F60   A0A182GR34   T1PHK4   A0A1W4XE40   T1DCX3   T1D2C6   A0A1U9WT19   A0A1J1I7R7   D6WLH0   U4UAX2   A0A336K378   A0A1Y1MSE7   A0A1B6EDS5   A0A1I8NA50   B0XIM7   B0W5A2   W8BSC8   A0A1B0DF49   A0A1I8Q0W2   A0A2R7WHJ3   A0A0A9Y3X6   C0KZ11   A0A0A1WH02   A0A0L0BWL7   A0A067RJQ9   A0A2Z6BDV3   A0A023F541   A0A1S4E8K4   A0A0P4VUY4   T1IDT4   A0A0K8V8N9   A0A026WKZ9   A0A151I195   A0A158NG23   A0A195E819   F4WTK7   A0A195F253   A0A151XB75   E9J5X9   A0A0C9PLS1   E2A9J6   A0A195CHW9   A0A146LMW3   E2BMZ1   A0A0J7KXK6   A0A0L7RIF4   A0A088AHI2   A0A154PTP7   A0A1A9WCV2   A0A1B6EVQ3   A0A1A9Y9X6   A0A1B0BJW3   A0A1A9VMT4   A0A1B0G5J4   A0A2J7QVR4   A8E6G8   P16241   A0A2P8XWY5   A0A1B6IIN9   A0A1A9Z8U6   B4J3G5   T1IUA9   C5ILC6   A0A0J9RRN7   E1JI48   A0A0S0WNN1   O17487   A0A0M9A8P9   E0W3K3   B4HUY1   A0A0S0WGV5   A0A0M5J0I3   B4QJT7   A0A1W4V996   A0A0P4WSY5   A0A0P8XWA9   A0A1B0CWG3  

PDB

2XSD     E-value=1.69597e-76,     Score=727

KEGG

693025    K09365 POU domain transcription factor, class 3 | (RefSeq) SGF3, Pou-m1, Pou-m2; POU domain protein

GO

GO:0006357   GO:0005634   GO:0003700   GO:0043565   GO:0007420   GO:0030154   GO:0003677   GO:0000980   GO:0001228   GO:0008045   GO:0048813   GO:0007422   GO:0002807   GO:0035284   GO:0045944   GO:0000977   GO:0048814   GO:0016021   GO:0006355   GO:0006412   GO:0005737   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Nucleus  

Length:

352

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.47355

Exp number, first 60 AAs:

0.00035

Total prob of N-in:

0.03642

outside

1  -  352

 

 

Pi

6.180932

Theta

8.21769

Tajima's D

-0.719188

CLR

0.46817

CSRT

0.193490325483726

Interpretation

Uncertain