Gene

KWMTBOMO13453  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010866

Annotation

PREDICTED:_uncharacterized_protein_HI_1014-like_[Amyelois_transitella]

Location

Bomo_Chr22(+):17422821-17424022      View in EpiBrowser

Full name

D-erythronate dehydrogenase      

Location in the cell

PlasmaMembrane   Reliability : 1.278

CDS

ATGAAAGTGGTCATAACAGGAGCTGCTGGCTTTTTGGGTTCGCGTTTAGCTGATGCTTTGCTAAAACCAAATTCCGAACTGTGTGTGACTGAATTGGTGTTAGTGGATACGATCTTACCACCCTCCCGAAAAGATCCACGAGTAATAACACTCGCCCTCGATATCACAACACCCGAGGCTGCGCGTAAACTCGTTGATACTGATACCGATGTACTGTTTCATTTGGCTGCAGTCGTAAGTGGACATGCTGAAGAAGACTTCGATCTTGGAATGAAAGTGAATTTCAACGCAACGAGATCATTGCTGGAGGCAGCGAGACATCGAGCTACGAAGCTTCGTTTTGTTTTTACCAGTACTGTTGGGGTGTTCGGAGGTGACCTGCCCCCTATTATAACTGATCAAACTGCCGCAACACCTCAGAACTCTTACGGCATTGCTAAGGCTATGAGCGAGCTTCTTATCAATGATTACTCTAGACGAGGTTTCGTTGATGGGAGAGTTGTTCGTCTTCCAACAGTTAGTATTCGCGCCGGAACTGCCAACAGAGCCGTGACATCTTTTGCAAGCGGAATTATCAGGGAGCCATTGAATGGTGAAGTAGCTATCTGCCCCGTTCCACCTGATCAAGAGTTATGGCTTTCAAGTCCTGGATCTGTTGTGTATAATTTAATACACGCTGCTACTTTACTTAGCTCCGAATTAGAGAAATGGAGAGTGATAAATCTACCTGGAATCAGTGTCACAGTTCGTAAAATGATTTCCTCGTTGTGTGAAGTTTCTGGAAGCAAGGTTGCTAAGCTGGTACGCTATGAACACGATGAGACCATAAGTGCAATGGTCGGCAGTTTCCCAAGCAGGTTCGACAACTCACGAGCATTGAGGCTTGGATTTCGAGTGGATTCTAATTTTACGGATGTGATACGGTCCTATATATTGGAAGATCTAAAACAGGTTAGCTTCGGTTTTTGA

Protein

MKVVITGAAGFLGSRLADALLKPNSELCVTELVLVDTILPPSRKDPRVITLALDITTPEAARKLVDTDTDVLFHLAAVVSGHAEEDFDLGMKVNFNATRSLLEAARHRATKLRFVFTSTVGVFGGDLPPIITDQTAATPQNSYGIAKAMSELLINDYSRRGFVDGRVVRLPTVSIRAGTANRAVTSFASGIIREPLNGEVAICPVPPDQELWLSSPGSVVYNLIHAATLLSSELEKWRVINLPGISVTVRKMISSLCEVSGSKVAKLVRYEHDETISAMVGSFPSRFDNSRALRLGFRVDSNFTDVIRSYILEDLKQVSFGF

Description

Catalyzes oxidation of D-erythronate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).

Catalytic Activity

D-erythronate + NAD(+) = 2-dehydro-D-erythronate + H(+) + NADH

Biophysicochemical Properties

0.23 mM for NAD(+)
0.61 mM for NADP(+)

Similarity

Belongs to the NAD(P)-dependent epimerase/dehydratase family.

Keywords

Carbohydrate metabolism   Complete proteome   NAD   NADP   Oxidoreductase   Reference proteome  

Feature

chain  D-erythronate dehydrogenase

Uniprot

H9JMW3   A0A2A4K0H4   H9JL84   A0A2H1WVB3   A0A194REB2   A0A194PYH2   + More
A0A212F134   A0A0L7L4Y4   C7BIG8   A0A2X5ELF4   D4DXV8   A0A0F7HA47   A0A3S5F1B9   A0A2V4FZ93   A0A2R3GWM3   A0A3F3KTC8   A0A329X2G6   A0A1C0U4Z5   A0A3S5DF99   A0A0U6JXX8   A0A126VBV8   L0MC25   D1P6T1   A0A329WP49   A0A329WIY6   A0A329WL77   A0A1G5RLF7   A0A379G080   A0A3G2FNV5   K8VZG1   A0A329XCE1   A0A1C0NQJ7   W3YBA5   A0A168I068   U2MBC8   A0A3R2DK46   Q7N442   A0A2S8QS65   A0A329VHS3   A0A1J0E352   K8VXV8   B6XDF6   A0A1C7WBC2   A0A291E7M3   X6QE30   A0A1S8CHY3   A0A081S1B7   A0A1Q4P2P9   A0A1B7JRJ0   T0P4M0   A0A292A9P0   A0A022PMD3   A0A1S1HR13   A0A370S2E9   A0A140NJZ1   A0A379HFI3   B2PVQ6   A0A335E9J2   A0A379GWD1   A0A1Q5VIB9   U7R030   D4BZD2   A0A3N1ZEI9   A0A1B8SX17   A0A254MIU1   A0A379FLP5   A0A3R8XBY2   A0A345LXR4   A0A2S8QSR2   A0A356D437   A0A0U4IAJ3   W1IV05   A0A2S8Q7N3   A0A068QYJ7   A0A2D0LCE0   A0A1B8YJN0   A0A2V1HC65   A0A2S8QGB1   A0A1I5CQ49   A0A0A0CVG1   A0A2G0Q4H6   A0A1Q5TVI1   W3V3V3   A0A1V3JTD1   B0UWX0   Q0I1A7   A0A1Y0IZ38   A0A1V4B0X9   A0A2X4XS93   A0A0Y0BN71   A0A0E1SQ33   A0A1V3KLI0   A0A2X4I057   A0A2S9RQZ9   A0A2S9RL90   P44094   A0A380TPX1   A4N1V8   A0A1J4QC82   A0A3E1QXW8  

EC Number

1.1.1.410

Pubmed

19121390    26354079    22118469    26227816    19583835    29877789    + More
23516234    23145767    24233592    14528314    27547538    24029767    22740665    30148503    28993611    17172329    17550610    7542800    27402745   

EMBL

BABH01029054    NWSH01000283    PCG77775.1    BABH01011773    ODYU01011283    SOQ56922.1    + More
KQ460323    KPJ15927.1    KQ459586    KPI98073.1    AGBW02010988    OWR47421.1    JTDY01002925    KOB70475.1    FM162591    CAQ84106.1    LS483492    SQJ30205.1    ADBY01000017    EFE97450.1    CP011254    AKG69622.1    LR134492    VEI63131.1    QJPU01000002    PYA07746.1    CP023268    AVJ16073.1    NSCN01000005    RAX11134.1    LOMY01000069    OCQ52997.1    LR134155    VEA71535.1    FCGE01000077    QJPV01000002    QMDQ01000001    CVA98068.1    PYA41669.1    RAU89417.1    CP003942    AGB80847.1    ABXV02000046    EFB70778.1    NSCL01000001    RAX06309.1    NSCJ01000001    RAX04691.1    NSCK01000001    RAX04360.1    FMWJ01000050    SCZ74221.1    UGUA01000002    SUC34419.1    CP033055    AYM93289.1    AKKL01000055    EKT52931.1    NSCM01000001    RAX14509.1    LJDX02000239    OCO18733.1    AZYZ01000045    ETS98960.1    FKZE01000007    SAQ07981.1    ASZB01000005    ERK14048.1    RCUM01001136    RCUN01000468    MNG78800.1    MNH81218.1    BX571867    CAE14886.1    PUWX01000015    PQQ38146.1    NSCI01000015    RAW90597.1    CP027418    AVL73910.1    AKKN01000014    EKT53073.1    ABXW01000019    EEB46654.1    LXKR01000022    OCJ38748.1    CP023536    ATG15145.1    JACS01000029    ETT06604.1    MOXD01000008    OMQ21308.1    JGVH01000004    KER04720.1    MJAO01000006    OKB67394.1    LXEW01000037    OAT50516.1    AUXQ01000051    EQB99291.1    CP023956    ATM75617.1    JFGV01000014    EYU16133.1    LVIE01000163    OHT24272.1    QRAU01000031    RDL13920.1    CP003488    AFH93425.1    UGUC01000003    SUC77871.1    ABJD02000048    EDU61443.1    UFMN01000011    SST04674.1    UGUB01000002    SUC45221.1    MQRH01000003    OKP30420.1    AXDT01000145    ERT12156.1    ACCI02000050    EFE53506.1    RJVN01000019    ROR48497.1    LYBX01000002    NOWC01000008    NXKD01000030    QUAF01000008    UAUG01000013    OBY37303.1    OZS74922.1    PCQ36096.1    RFT08249.1    SPZ21381.1    MYFJ01000048    OWO80501.1    UGTZ01000001    SUC29724.1    RHRR01000009    RRW33366.1    CP031123    AXH62904.1    PUWW01000144    PQQ38239.1    DOEH01000012    HBO22375.1    CP013913    ALX93215.1    CBXF010000057    CDL81673.1    PUWT01000007    PQQ28851.1    FO704550    CDG18900.1    NJCX01000012    PHM73358.1    LOIC01000042    OCA55298.1    PYUJ01000048    PVZ82863.1    PUWU01000009    PQQ34307.1    FOVO01000029    SFN89135.1    JQOC01000001    KGM29618.1    NJAI01000005    PHM54120.1    MKGR01000022    OKP04237.1    AYSJ01000013    ETS30596.1    MLHQ01000006    OOF59978.1    CP000947    ACA31698.1    CP000436    ABI24297.1    CP018803    ARU65821.1    UGHF01000001    STO59451.1    LS483480    SQI78949.1    FCYU01000003    CVP60354.1    AAZI01000001    EDK12402.1    MLAE01000023    OOF78521.1    LS483411    SQG88488.1    NEBY01000142    LS483392    LR134490    PRJ63462.1    SQG36978.1    VEI56924.1    NEBH01000014    PRJ32470.1    L42023    UFRQ01000003    SUT88921.1    AAZE01000001    EDJ91816.1    MDKE01000055    OIN05547.1    QVIZ01000004    RFN95431.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000002747    UP000249094    UP000005723    UP000034699    UP000270487    UP000248086    UP000238421    UP000251048    UP000093476    UP000271603    UP000054899    UP000247670    UP000251655    UP000011001    UP000005512    UP000251134    UP000251359    UP000251400    UP000183223    UP000255129    UP000281837    UP000009336    UP000250919    UP000050507    UP000019057    UP000078180    UP000016623    UP000002514    UP000250870    UP000239526    UP000010290    UP000003729    UP000093001    UP000217606    UP000022577    UP000216021    UP000028002    UP000185770    UP000078224    UP000015813    UP000221800    UP000023464    UP000179588    UP000255042    UP000005012    UP000254690    UP000004506    UP000262355    UP000254419    UP000186436    UP000017133    UP000003321    UP000273646    UP000216001    UP000218329    UP000250984    UP000260960    UP000197563    UP000254208    UP000275009    UP000256296    UP000239084    UP000263856    UP000061771    UP000019202    UP000239550    UP000032721    UP000221101    UP000092665    UP000244888    UP000239784    UP000199011    UP000029997    UP000225433    UP000186277    UP000018957    UP000188602    UP000008543    UP000001970    UP000195281    UP000254329    UP000248560    UP000248527    UP000005706    UP000189114    UP000249265    UP000238532    UP000249751    UP000278034    UP000237959    UP000000579    UP000254649    UP000003798    UP000243073    UP000261070   

PRIDE

H9JMW3    H9JL84   

Pfam

PF01370   Epimerase

Interpro

IPR001509   Epimerase_deHydtase        + More
IPR036291   NAD(P)-bd_dom_sf       
IPR020904   Sc_DH/Rdtase_CS       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

H9JMW3   A0A2A4K0H4   H9JL84   A0A2H1WVB3   A0A194REB2   A0A194PYH2   + More
A0A212F134   A0A0L7L4Y4   C7BIG8   A0A2X5ELF4   D4DXV8   A0A0F7HA47   A0A3S5F1B9   A0A2V4FZ93   A0A2R3GWM3   A0A3F3KTC8   A0A329X2G6   A0A1C0U4Z5   A0A3S5DF99   A0A0U6JXX8   A0A126VBV8   L0MC25   D1P6T1   A0A329WP49   A0A329WIY6   A0A329WL77   A0A1G5RLF7   A0A379G080   A0A3G2FNV5   K8VZG1   A0A329XCE1   A0A1C0NQJ7   W3YBA5   A0A168I068   U2MBC8   A0A3R2DK46   Q7N442   A0A2S8QS65   A0A329VHS3   A0A1J0E352   K8VXV8   B6XDF6   A0A1C7WBC2   A0A291E7M3   X6QE30   A0A1S8CHY3   A0A081S1B7   A0A1Q4P2P9   A0A1B7JRJ0   T0P4M0   A0A292A9P0   A0A022PMD3   A0A1S1HR13   A0A370S2E9   A0A140NJZ1   A0A379HFI3   B2PVQ6   A0A335E9J2   A0A379GWD1   A0A1Q5VIB9   U7R030   D4BZD2   A0A3N1ZEI9   A0A1B8SX17   A0A254MIU1   A0A379FLP5   A0A3R8XBY2   A0A345LXR4   A0A2S8QSR2   A0A356D437   A0A0U4IAJ3   W1IV05   A0A2S8Q7N3   A0A068QYJ7   A0A2D0LCE0   A0A1B8YJN0   A0A2V1HC65   A0A2S8QGB1   A0A1I5CQ49   A0A0A0CVG1   A0A2G0Q4H6   A0A1Q5TVI1   W3V3V3   A0A1V3JTD1   B0UWX0   Q0I1A7   A0A1Y0IZ38   A0A1V4B0X9   A0A2X4XS93   A0A0Y0BN71   A0A0E1SQ33   A0A1V3KLI0   A0A2X4I057   A0A2S9RQZ9   A0A2S9RL90   P44094   A0A380TPX1   A4N1V8   A0A1J4QC82   A0A3E1QXW8  

PDB

2HRZ     E-value=1.72637e-61,     Score=597

KEGG

101740633    no KO assigned | (RefSeq) UDP-glucuronic acid decarboxylase 6-like

GO

GO:0003824   GO:0050662   GO:0016491   GO:0003978   GO:0005975   GO:0005978   GO:0005737   GO:0048869   GO:0003676   GO:0015930  

Length:

322

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.12484

Exp number, first 60 AAs:

0.00227

Total prob of N-in:

0.02720

outside

1  -  322

 

 

Pi

18.2039

Theta

18.915094

Tajima's D

-0.240706

CLR

2.111558

CSRT

0.312884355782211

Interpretation

Uncertain