Gene

KWMTBOMO13417

Pre Gene Modal

BGIBMGA010900

Annotation

PREDICTED:_antichymotrypsin-2-like_[Bombyx_mori]

Location

Bomo_Chr22(-):16649087-16652042      View in EpiBrowser

Full name

Serpin B11       + More
Neuroserpin      

Alternative Name

Peptidase inhibitor 12
Serine protease inhibitor 17
Serpin I1

Location in the cell

Mitochondrial   Reliability : 1.483

CDS

ATGCAAAGTGAAATCGATTTAAAAACTTTGTATACCAAGATAGGAGTAACTTCGATTTTCGACAGTGAAAATTCAGGTCTAACAAAAATAGCTAAAGGTGAAAATTTAATTGTCAGTAAAGCAATACAAAAGGCCGTCATTGACCTAAACGAGATGGGAACGGAGGCTAGTGCAGCTTCAGCACTGGTAATAACAAAGCTGTCGCTCGTAGAACGATTACACGTGGAAGTGAACTGCCCGTTTTTGTTCCTTGTTAAAGTTAATAAGAATGCACTTTTTGCTGGCGTTTTAAATGACCCCGAACAATAA

Protein

MQSEIDLKTLYTKIGVTSIFDSENSGLTKIAKGENLIVSKAIQKAVIDLNEMGTEASAASALVITKLSLVERLHVEVNCPFLFLVKVNKNALFAGVLNDPEQ

Description

Inhibitor of serine proteases. Has moderate inhibitory activity for trypsin-like peptidases, but also some activity with cysteine peptidases, cathepsin L, K, and V, and the serine peptidase, tryptase gamma.
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9364046, PubMed:11557034). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).

Similarity

Belongs to the serpin family.
Belongs to the serpin family. Ov-serpin subfamily.

Keywords

Complete proteome   Cytoplasm   Protease inhibitor   Reference proteome   Serine protease inhibitor   3D-structure   Cytoplasmic vesicle   Glycoprotein   Secreted   Signal  

Feature

chain  Serpin B11

Uniprot

H9JMZ7   A0A0N1INT1   A0A194PXF9   A0A2W1BH42   G9F9F1   G9F9J6   + More
U3IXC3   R0L2Z6   A0A091EHN6   A0A2D4JHH5   S9X2R7   A0A212EZX5   A0A3P9LWX2   A0A2A4J192   H3A971   B7NZ94   G1U7R0   A0A139WD36   A0A1W6F7J9   A0A1S3N8R9   G3X2D8   G3X2D7   A0A2K6Q0P4   J7HI16   A0A2K6KP97   I3M9Q9   A0A060Y4L9   V9KR25   A0A3N5HY71   K4FRK3   G1TFV7   A0A3B3S197   I3WWD7   A0A3S2MIL1   A0A093PGJ8   A0A2P4TDN0   A0A3Q0RPD7   G1KWY8   G1TDU9   A0A0E9Y1M5   F7CJ66   A0A0E9Y335   A0A061RXC6   A0A3P9H4A5   A0A0A0AH46   A0A226NJY0   A0A3P8XZA0   A0A0E9WN39   A0A3P8SE55   A0A3B5AAT0   A0A288CG58   S9XBH6   A0A3P8SDK2   A0A093IR83   U3IY44   A0A091T9B9   K7FUR6   A0A096NYG6   A0A0F6VZ15   A0A2K5MZB5   A0A0D9R5V5   G7PK70   G7N922   I0FSM3   A0A2K5VHT2   F7HSW0   A0A2K6AUR9   A0A2K5YHM4   A0A2K6AUR7   A0A2K5MZ64   A0A2K5YHL9   A0A3Q2CUL1   K7F6G6   A0A2K6G928   A0A2I3LSA4   R0JS12   B7Q2U8   V8N7G3   A0A2Y9RE07   A0A093PP27   A0A3B3RZZ9   Q9CQV3   A0A091S7M7   A0A2D0RBM0   A0A2I6BQM3   A0A0A7RLT8   A0A1S3SEA9   A0A091JCG9   Q08FY2   G3HQ98   O35684   A0A091HKS0   G1PYR4   B7QL36   A0A091KM96   B3S0N6   A0A093GVB9   A0A1U7T7X9   S7NS03  

Pubmed

19121390    26354079    28756777    23749191    23149746    22118469    + More
17554307    9215903    21993624    18362917    19820115    21709235    25362486    24755649    24402279    30086797    23056606    29240929    23702291    18464734    25069045    25613341    17381049    22002653    25319552    17431167    24297900    15203215    16141072    15489334    17562709    25499033    15613325    21804562    9364046    9729122    17040209    11557034    18719581   

EMBL

BABH01029132    BABH01029133    KQ460874    KPJ11667.1    KQ459586    KPI98031.1    + More
KZ150134    PZC73004.1    JN033696    AEW46849.1    JN033741    AEW46894.1    ADON01084978    KB743257    EOA99913.1    KK718430    KFO56122.1    IACK01192924    LAA95939.1    KB016902    EPY82738.1    AGBW02011206    OWR47055.1    NWSH01004342    PCG65210.1    AFYH01208278    AFYH01208279    AFYH01208280    DP001025    ACJ72835.1    AAGW02050668    AAGW02050669    AAGW02050670    KQ971361    KYB25824.1    KY471047    ARK36664.1    AEFK01055100    JN400442    AFQ01141.1    AGTP01028249    FR906406    CDQ84324.1    JW868285    AFP00803.1    RPRA01000344    RPH80944.1    JX052305    AFK10533.1    JQ801453    AFL47815.1    CM012454    RVE60220.1    KL669381    KFW76008.1    PPHD01001761    POI34460.1    AAGW02014508    AAGW02014509    AAGW02014510    GAYW01000155    JAI08823.1    GAYW01000144    JAI08834.1    GBEZ01019928    GBEZ01010483    JAC66692.1    JAC75196.1    KL871763    KGL93456.1    MCFN01000025    OXB68013.1    GBXM01016815    JAH91762.1    AEMK02000101    KE537708    EPY72526.1    KK565735    KFW04168.1    ADON01084982    KK441673    KFQ70387.1    AGCU01156237    AHZZ02004600    CP011125    AKF03077.1    AQIB01003059    AQIB01003060    AQIB01003061    AQIB01003062    AQIB01003063    AQIB01003064    AQIA01016051    CM001287    EHH55211.1    JU322670    CM001264    AFE66426.1    EHH21722.1    JV047378    AFI37449.1    JSUE03009718    AGCU01117346    AGCU01117347    AGCU01117348    AGCU01117349    AGCU01117350    AGCU01117351    AGCU01117352    AGCU01117353    AGCU01117354    AGCU01117355    EOA99916.1    ABJB010096961    DS846142    EEC13170.1    AZIM01007341    ETE58035.1    KFW76005.1    AY367772    AK009003    AK009855    BC010313    KK812362    KFQ36460.1    MF966153    AUI80580.1    KM675701    AJA36136.1    KK501734    KFP17425.1    AY689436    ABI99175.1    JH000603    EGV96960.1    AJ001700    AK032152    AK051756    BC006776    KL217494    KFO95712.1    AAPE02018185    ABJB010065261    ABJB010111356    ABJB010321224    ABJB010418850    ABJB011011198    ABJB011037238    ABJB011135496    DS963588    EEC19558.1    KK750622    KFP41679.1    DS985246    EDV23672.1    KL217157    KFV74243.1    KE164845    EPQ20489.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000016666    UP000052976    UP000007151    + More
UP000265180    UP000218220    UP000008672    UP000001811    UP000007266    UP000087266    UP000007648    UP000233200    UP000233180    UP000005215    UP000193380    UP000261540    UP000053258    UP000261340    UP000001646    UP000002279    UP000265200    UP000053858    UP000198323    UP000265140    UP000265080    UP000261400    UP000008227    UP000007267    UP000028761    UP000034883    UP000233060    UP000029965    UP000009130    UP000233100    UP000006718    UP000233120    UP000233140    UP000265020    UP000233160    UP000001555    UP000248480    UP000000589    UP000221080    UP000053119    UP000000866    UP000001075    UP000054308    UP000001074    UP000009022    UP000053875    UP000189704   

PRIDE

H9JMZ7    Q9CQV3    G3HQ98    O35684   

Pfam

PF00079   Serpin        + More
PF00096   zf-C2H2
PF00531   Death
PF00791   ZU5
PF17217   UPA
PF00090   TSP_1
PF07679   I-set

Interpro

IPR036186   Serpin_sf        + More
IPR000215   Serpin_fam       
IPR042178   Serpin_sf_1       
IPR042185   Serpin_sf_2       
IPR023796   Serpin_dom       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR023795   Serpin_CS       
IPR033772   UPA       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR000488   Death_domain       
IPR013783   Ig-like_fold       
IPR000906   ZU5_dom       
IPR011029   DEATH-like_dom_sf       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR037936   UNC5       
IPR000884   TSP1_rpt       
IPR036383   TSP1_rpt_sf       
IPR013098   Ig_I-set       
IPR000240   Serpin_B9/Maspin       
IPR015557   Serpin_B1       

SUPFAM

SSF56574   SSF56574        + More
SSF57667   SSF57667       
SSF48726   SSF48726       
SSF82895   SSF82895       
SSF47986   SSF47986       

Gene 3D

2.30.39.10     3.30.497.10     2.20.100.10     2.60.40.10    

ProteinModelPortal

H9JMZ7   A0A0N1INT1   A0A194PXF9   A0A2W1BH42   G9F9F1   G9F9J6   + More
U3IXC3   R0L2Z6   A0A091EHN6   A0A2D4JHH5   S9X2R7   A0A212EZX5   A0A3P9LWX2   A0A2A4J192   H3A971   B7NZ94   G1U7R0   A0A139WD36   A0A1W6F7J9   A0A1S3N8R9   G3X2D8   G3X2D7   A0A2K6Q0P4   J7HI16   A0A2K6KP97   I3M9Q9   A0A060Y4L9   V9KR25   A0A3N5HY71   K4FRK3   G1TFV7   A0A3B3S197   I3WWD7   A0A3S2MIL1   A0A093PGJ8   A0A2P4TDN0   A0A3Q0RPD7   G1KWY8   G1TDU9   A0A0E9Y1M5   F7CJ66   A0A0E9Y335   A0A061RXC6   A0A3P9H4A5   A0A0A0AH46   A0A226NJY0   A0A3P8XZA0   A0A0E9WN39   A0A3P8SE55   A0A3B5AAT0   A0A288CG58   S9XBH6   A0A3P8SDK2   A0A093IR83   U3IY44   A0A091T9B9   K7FUR6   A0A096NYG6   A0A0F6VZ15   A0A2K5MZB5   A0A0D9R5V5   G7PK70   G7N922   I0FSM3   A0A2K5VHT2   F7HSW0   A0A2K6AUR9   A0A2K5YHM4   A0A2K6AUR7   A0A2K5MZ64   A0A2K5YHL9   A0A3Q2CUL1   K7F6G6   A0A2K6G928   A0A2I3LSA4   R0JS12   B7Q2U8   V8N7G3   A0A2Y9RE07   A0A093PP27   A0A3B3RZZ9   Q9CQV3   A0A091S7M7   A0A2D0RBM0   A0A2I6BQM3   A0A0A7RLT8   A0A1S3SEA9   A0A091JCG9   Q08FY2   G3HQ98   O35684   A0A091HKS0   G1PYR4   B7QL36   A0A091KM96   B3S0N6   A0A093GVB9   A0A1U7T7X9   S7NS03  

PDB

4KDS     E-value=1.79612e-12,     Score=168

KEGG

105841351    no KO assigned | (RefSeq) antichymotrypsin-2-like

GO

GO:0005615   GO:0003676   GO:0016021   GO:0005042   GO:0008233   GO:0004867   GO:0010757   GO:0002244   GO:0010951   GO:0034774   GO:0043025   GO:0050974   GO:0033363   GO:0030308   GO:0031594   GO:0008285   GO:0062023   GO:0031232   GO:0048505   GO:0090331   GO:0005102   GO:0021683   GO:0042628   GO:0010766   GO:0048711   GO:0042177   GO:0014067   GO:0008201   GO:0045879   GO:0007596   GO:0060291   GO:0031091   GO:0051966   GO:0061108   GO:0032940   GO:0005829   GO:0060384   GO:0016740   GO:0005737   GO:0060205   GO:0043204   GO:0010976   GO:0030155  

PANTHER

PTHR11461   PTHR12582   PTHR11461:SF180  

Subcellular location

Cytoplasm  
Secreted  
Cytoplasmic vesicle  
Secretory vesicle lumen  
Perikaryon  

Length:

102

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01352

Exp number, first 60 AAs:

0.00118

Total prob of N-in:

0.18827

outside

1  -  102

 

 

Pi

23.966408

Theta

29.536149

Tajima's D

-0.535867

CLR

2.546642

CSRT

0.23738813059347

Interpretation

Uncertain