Gene

KWMTBOMO13411  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010852

Annotation

PREDICTED:_protein_transport_protein_Sec24A_[Bombyx_mori]

Location

Bomo_Chr22(+):16376663-16408137      View in EpiBrowser

Full name

Protein transport protein Sec24A      

Alternative Name

SEC24-related protein A

Location in the cell

Nuclear   Reliability : 3.722

CDS

ATGTCTAATTTGCCACCTAATCCGTTTGTAAGCCAGCCTGGAGCGAATGCAAACCCTGTGCAAGCCTTTAACCATAATCAATACGCTCAAGTACCATTGGGTCAGCTGCCCCCAGGATATGGAGGACTGAAGGACAACAATTCAAATAGTCCTCTTCATGGAACAATATCACCTCAAAATAATGCTATACAAAACATAAACAACTTCAATCAAAGTGCCAGTAGCTCACCAGCTTTCAATCAGCCTGGATTGGTGCAAGGTGGAATGCAAGGTTCGCCAATGAGACCTTTTCCACAAAGCTCTAAACCTCTAAATCAGATATCATCGCCTAGTCCTGTTTTTGTTTCCAATCCAAACCCTTATACCCCTAACTATCAACCTCAGAAACAAATCAACGATAATGTACCACCACTAGTACCCCCTAGTCAACATAATCAACCCCTTGTGAATGGGCCTCCTTTGGCTGCATCCATGCCAAACCCAACATCTAGTAGCTACAGTCCTGTGCCTCCACTAAATAGGCCTCCAGTGGGAGGATATGGCCCCAGTTCAATCAATCAATATGGTCCAGCTCCAAATACAAAGCCTTCAGGACCACAGTCACTGCCCATACAACATAGTACTCAGTTTCCAGGCCCACCTCTGGCTGGTCCAACAAATATAGGTACCTCAGTGCCTCCTGTCAGTAGAAATGTTGGGCCTTCAGTTCCTGGGCCTCTGAATCCACCTTATGCAAGTCCTATATCGGGTCCTGTCACTAACCCTCCAATAAGTGGCCCTCATATGGGTTTCTCAGTAAATGGACCACGCTCAAATGCCTTACCGCCAAATTCAGCAGTAGAAGCAAGGCCAGTGGGCCTAAATGGTCCTTTACCACCAGTCTCTGGACCTCCCAAGCAGTTCAGTTCTGCAAATCCTCTACCAATGATGCCATCTGTAAGCTCTCCACCTGGTCAACCTTATTTAAATCAACCTGTAAGTCAGCCAGGACTTAACTCCAATATTGGTTCAAATGTACCCACAGCACTAATACCGCCTATGAATCAAAATATACCAGTAAATCAACAAGCGGGGCCTCCAAGTGGACCAACTGGTGGGCCATTGAAAAGTAATATGCAGAGCAGATATCCTCAGATGCCACAGGCCAGTTACAATCAACAGTCTGCTCCGCAACAATCTACGAAATATCCACAGCAGTACAATGCTCAAGGTTTGACACAGCAAATGGGACAGTTGAGTGTAACCAAGCAAGGTTTTGATCAACTTTGGGGTCATCACATGATTGACTTGCTGCAAACTAGACATATATTGCCTGAATACCCTGAGGATCCTCCGGAAATTAAGCTCGGACACCAGTTTGCTGATTCGCCCAATTGTAGTCCTGAAATATTCAGATGCACGCTGAATAAGATACCAGAAACGAACAGCCTACTCCAGAAGTCAAGACTACCGTTGGGCATACTCATACATCCATTCAAGGATCTCAATCATCTACCAGTGATCCAGTGCGCTACGATAGTCCGCTGTCGGGCTTGTCGGACGTACATCAATCCGTTTGTCTACTTCGTCGATGCGAAGCGATGGAAATGCAATCTGTGTTATAGGGTCAATGACTTGCCAGAAGAGTTTCAATACGACCCGGTGAGCAAGTCGTACGGCGACCCGTCGCGGAGGCCGGAGATCAAGTCGGCGACCATAGAGTTCATCGCGCCCGGCGAGTACATGCTGCGACCCCCGCAGCCCGCGGTCTACCTGTTCTTGTTCGACGTGTCGCAGATAGCCAGAGACTCCGGCTACCTTCAGGTTGTCTGCGACGTGCTGATGAGCAACCTGGACCAGCTGCCGGGCGACGCGCGGACGCAGATCGGCTTCATCTGCTACGACACCCACGTGCACTACTACTCCATGGGCGAGGGGCTCGCCAGGCCCAAGGAGATGACCGTCCTGGACATCGACGATATATTCCTGCCGTCCCCGGAGTCGCTGCTGGTGAACCTGGGCGAGCGGCGCGAGGCGGTGTGCGCGCTGCTGGGCGCCCTCCCCGCGCGCGCCGCCCCCGCGCCCCGCGGCCCCGCGCCCCCCGCCTCCGCGCTGGGCGCCGCGCTGCAGGCCGCCTACAGGCTCATGGCGCCGACGGGCGGGCGCATCACGGTGTTCCAGACGTGCCTGCCCACCGCGGGCCCCGGCGCGCTGCACTCCAGAGAGGATCCCAACGCGAGATCTTCGAAAGATGTGAACCACTTGAACCCGGCGACCGACTTCTACAAACGTCTGGCTCTGGACTGCAGCGGCGCGCAGCTGTCCATCGACTTGTTCCTGTTGAACTCGCAGTACTCTGACCTTGCGACGTTAAGCGGCATGAGCAAGTTCAGCGGCGGGTCGGTGTACCACGTGCCGCTGTACTCGAGCGCGCGGCCGCAGCACGTGCGCACGCTGCAGCGCATGCTCACGCGCTACCTCACCAGGAAGATCGGCTTCGAGGCCGTCATGAGGGTCCGCTGCACCAGAGGAATCTCCATACACACGTTCCACGGCAACTTTTTCGTGCGGTCCACGGACCTGTTGTCGCTGCCCAACGTGTCCCCGGACGTGGGATTTGGCATGCAGCTCACCATCGAGGAGTCGCTGTCCGACCTGCAGCAGGTCTGCTTCCAGGCCGCGCTGCTCTACACCAGCAGCAAGGGCGAGAGGCGGATACGGGTGCACACGCTGGCGCTGCCGCTGGCCAGCACGCTGCCCGAGGTGCTGCACGCCGCCGACCAGCACTGCATCATAGGACTGGTCAGCAAAATGGCGGTGGACCGGTGCGTGTCGGCGTCGCTGGCGGAGGCGCGCGAGGCGCTGACCAACGTGGCGGCGGACGCGCTGAGCGCGCACCGCCTCGCGCAGAACGCGCCCGCCGCCGCGCCCGGCCTGCCCGCGCCCGCCGCGCTGCGCCTGCTGCCGCTCTACCTGCTCGCGCTGCTCAAGCGGAAAGCGTTCAGGACGGGCACGTCGACGCGGCTGGACGACCGCGTGGCCGACATGTGCTCGCTGAAGTGCCTGCCGCTGGAGCAGCTGCTGCGGCTCGTGTACCCCGCGCTGTACCCGCTGCACGCGCTCGCCCCCCCGGCCCCCCCGCACGACGCGCCCTGCCCCCCGCGCCTGCACCTGTCCGCCGAGAGGATCAACAGCAACGGCGCGTACCTGCTGGACGACGGCGAGTGCATGATCATCTACGTGTGCCACGGCGTCGCGCCCGCCTTCCTGGCCGACGCGTTCGGAGTCTCCGCGCATGCGCAGCTCGGCGACGAGGGCCGCGCCCTGCCGCGCCTCGACACCGAGCCCAGCGCGCTGCTGCACGCCTTCATAGACAAACTCAACGACGACAGACCTTACGCCTCCGAAATTTTGATATTGAAAGACAATTCCCCGTCGAGACACCTGTTCTTGGAGAGGCTGGTGGACGACCGAGTCGAGTCGGCATTCTCCTACTACGAGTTTCTGCAGCACATCAAGAGCTTAGTGAAATGA

Protein

MSNLPPNPFVSQPGANANPVQAFNHNQYAQVPLGQLPPGYGGLKDNNSNSPLHGTISPQNNAIQNINNFNQSASSSPAFNQPGLVQGGMQGSPMRPFPQSSKPLNQISSPSPVFVSNPNPYTPNYQPQKQINDNVPPLVPPSQHNQPLVNGPPLAASMPNPTSSSYSPVPPLNRPPVGGYGPSSINQYGPAPNTKPSGPQSLPIQHSTQFPGPPLAGPTNIGTSVPPVSRNVGPSVPGPLNPPYASPISGPVTNPPISGPHMGFSVNGPRSNALPPNSAVEARPVGLNGPLPPVSGPPKQFSSANPLPMMPSVSSPPGQPYLNQPVSQPGLNSNIGSNVPTALIPPMNQNIPVNQQAGPPSGPTGGPLKSNMQSRYPQMPQASYNQQSAPQQSTKYPQQYNAQGLTQQMGQLSVTKQGFDQLWGHHMIDLLQTRHILPEYPEDPPEIKLGHQFADSPNCSPEIFRCTLNKIPETNSLLQKSRLPLGILIHPFKDLNHLPVIQCATIVRCRACRTYINPFVYFVDAKRWKCNLCYRVNDLPEEFQYDPVSKSYGDPSRRPEIKSATIEFIAPGEYMLRPPQPAVYLFLFDVSQIARDSGYLQVVCDVLMSNLDQLPGDARTQIGFICYDTHVHYYSMGEGLARPKEMTVLDIDDIFLPSPESLLVNLGERREAVCALLGALPARAAPAPRGPAPPASALGAALQAAYRLMAPTGGRITVFQTCLPTAGPGALHSREDPNARSSKDVNHLNPATDFYKRLALDCSGAQLSIDLFLLNSQYSDLATLSGMSKFSGGSVYHVPLYSSARPQHVRTLQRMLTRYLTRKIGFEAVMRVRCTRGISIHTFHGNFFVRSTDLLSLPNVSPDVGFGMQLTIEESLSDLQQVCFQAALLYTSSKGERRIRVHTLALPLASTLPEVLHAADQHCIIGLVSKMAVDRCVSASLAEAREALTNVAADALSAHRLAQNAPAAAPGLPAPAALRLLPLYLLALLKRKAFRTGTSTRLDDRVADMCSLKCLPLEQLLRLVYPALYPLHALAPPAPPHDAPCPPRLHLSAERINSNGAYLLDDGECMIIYVCHGVAPAFLADAFGVSAHAQLGDEGRALPRLDTEPSALLHAFIDKLNDDRPYASEILILKDNSPSRHLFLERLVDDRVESAFSYYEFLQHIKSLVK

Description

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes.

Subunit

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with TMED2. Interacts (as part of the Sec23/24 complex) with SEC22B; recruits SEC22B into COPII-coated vesicles for its transport from the endoplasmic reticulum to the Golgi.

Similarity

Belongs to the SEC23/SEC24 family. SEC24 subfamily.

Keywords

Complete proteome   Cytoplasm   Cytoplasmic vesicle   Endoplasmic reticulum   ER-Golgi transport   Membrane   Metal-binding   Protein transport   Reference proteome   Transport   Zinc  

Feature

chain  Protein transport protein Sec24A

Uniprot

A0A194PYC5   A0A2H1VF17   A0A1W4WSS3   A0A0L7REF2   K7IVD2   A0A232FF65   + More
D1ZZP2   A0A067QNT2   A0A2J7Q7J0   N6TPB0   U4UTC1   A0A1W4V0T2   N6UPD7   B3N6U3   A0A0P6BZE5   B4HM94   A0A3Q2HJH6   H9G5K6   F6SQ27   F6S123   A0A3Q2HM39   A0A3Q2H496   A0A3Q2I2U7   L8IWB2   A6QNT8   A0A2I2UJD2   W5PXH3   U6CTI1   M3WJU9   A0A1U8DQ65   A0A2K6RWZ6   A0A2K6RX03   A0A2Y9INQ5   A0A2Y9IK30   A0A131Z1H0   A0A3Q0G0B1   A0A2Y9ILA0   A0A131Z398   H2PGK6   H9F532   F7C397   G7P8A9   G7MUC9   A0A2K5HR59  

Pubmed

26354079    20075255    28648823    18362917    19820115    24845553    + More
23537049    17994087    18057021    19892987    21881562    22751099    17975172    20809919    25362486    26830274    25319552    17431167    22002653   

EMBL

KQ459586    KPI98028.1    ODYU01002219    SOQ39419.1    KQ414612    KOC69209.1    + More
AAZX01005358    NNAY01000354    OXU28957.1    KQ971338    EFA01820.1    KK853114    KDR11196.1    NEVH01017442    PNF24547.1    APGK01057293    APGK01057294    KB741279    ENN71055.1    KB632354    ERL93365.1    APGK01011388    KB738455    ENN82596.1    CH954177    EDV58192.1    KQS70325.1    GDIP01007077    JAM96638.1    CH480816    EDW47171.1    AAWZ02020381    JH880615    ELR60253.1    BC148994    AANG04002524    AMGL01092887    AMGL01092888    AMGL01092889    AMGL01092890    HAAF01001970    CCP73796.1    GEDV01003957    JAP84600.1    GEDV01003956    JAP84601.1    ABGA01187099    ABGA01187100    ABGA01187101    ABGA01187102    ABGA01187103    ABGA01187104    ABGA01187105    ABGA01187106    ABGA01187107    ABGA01187108    NDHI03003414    PNJ59692.1    JU325985    AFE69741.1    JSUE03036962    JSUE03036963    JSUE03036964    JSUE03036965    JSUE03036966    AQIA01060553    AQIA01060554    AQIA01060555    CM001281    EHH54530.1    JU474074    CM001258    AFH30878.1    EHH26796.1   

Proteomes

UP000053268    UP000192223    UP000053825    UP000002358    UP000215335    UP000007266    + More
UP000027135    UP000235965    UP000019118    UP000030742    UP000192221    UP000008711    UP000001292    UP000002281    UP000001646    UP000009136    UP000011712    UP000002356    UP000189705    UP000233200    UP000248482    UP000001595    UP000006718    UP000009130    UP000233100    UP000233080   

PRIDE

F6S123    A6QNT8   

Pfam

PF04810   zf-Sec23_Sec24        + More
PF04815   Sec23_helical
PF08033   Sec23_BS
PF00626   Gelsolin
PF04811   Sec23_trunk

Interpro

IPR006896   Sec23/24_trunk_dom        + More
IPR041742   Sec24-like_trunk_dom       
IPR006900   Sec23/24_helical_dom       
IPR012990   Sec23_24_beta_S       
IPR036180   Gelsolin-like_dom_sf       
IPR007123   Gelsolin-like_dom       
IPR036174   Znf_Sec23_Sec24_sf       
IPR029006   ADF-H/Gelsolin-like_dom_sf       
IPR006895   Znf_Sec23_Sec24       
IPR036465   vWFA_dom_sf       
IPR036175   Sec23/24_helical_dom_sf       

SUPFAM

SSF82919   SSF82919        + More
SSF81811   SSF81811       
SSF82754   SSF82754       
SSF53300   SSF53300       

Gene 3D

3.40.20.10     3.40.50.410    

CDD

cd01479  Sec24-like

ProteinModelPortal

A0A194PYC5   A0A2H1VF17   A0A1W4WSS3   A0A0L7REF2   K7IVD2   A0A232FF65   + More
D1ZZP2   A0A067QNT2   A0A2J7Q7J0   N6TPB0   U4UTC1   A0A1W4V0T2   N6UPD7   B3N6U3   A0A0P6BZE5   B4HM94   A0A3Q2HJH6   H9G5K6   F6SQ27   F6S123   A0A3Q2HM39   A0A3Q2H496   A0A3Q2I2U7   L8IWB2   A6QNT8   A0A2I2UJD2   W5PXH3   U6CTI1   M3WJU9   A0A1U8DQ65   A0A2K6RWZ6   A0A2K6RX03   A0A2Y9INQ5   A0A2Y9IK30   A0A131Z1H0   A0A3Q0G0B1   A0A2Y9ILA0   A0A131Z398   H2PGK6   H9F532   F7C397   G7P8A9   G7MUC9   A0A2K5HR59  

PDB

3EH1     E-value=0,     Score=1868

KEGG

101736562    K14007 protein transport protein SEC24 | (RefSeq) protein transport protein Sec24A

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0006886   GO:0006888   GO:0008270   GO:0030127   GO:0015031   GO:0042632   GO:0090110   GO:0000139   GO:0050714   GO:0045714   GO:0005829   GO:0005789   GO:0005525   GO:0031386   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Cytoplasmic vesicle  
COPII-coated vesicle membrane  
Endoplasmic reticulum membrane  
Cytoplasm  
Cytosol  

Length:

1170

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.45648

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00000

outside

1  -  1170

 

 

Pi

5.984214

Theta

2.090011

Tajima's D

-1.120469

CLR

11.884742

CSRT

0.106694665266737

Interpretation

Uncertain