Gene

KWMTBOMO13406  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010905

Annotation

PREDICTED:_NAD(P)H-hydrate_epimerase_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr22(-):16221220-16222532      View in EpiBrowser

Full name

NAD(P)H-hydrate epimerase      

Alternative Name

NAD(P)HX epimerase
Apolipoprotein A-I-binding protein

Location in the cell

Cytoplasmic   Reliability : 1.353

CDS

ATGTTATTGTACAGGTTGTTCGGGAGTGCTCTAATATTGCGTGTAGCAAAACTGTATAACATCGGAACTATGACGAGCAGTATGAATCAATGCAACACTGTGACGCGGTACCTCAATCAGTCAGAAGCGGCAGCACTGGACCAGGATCTTTTCACTGAATACAAGTTTAGTGTCGATCAACTTATGGAACTTGCTGGCCTGAGTGTTGCTAGTGCCATTGCCAAGGTCTTCCCACCCTCAACTCACTCATCAGCTCTTATAGTGTGCGGGCCAGGAAATAATGGAGGAGATGGTTTAGTAGCCGCAAGACATATGCAGTTGTTCGGATACAATGTATCGGTACATTATCCTAAACGCACACCCAAACCTTTGTATGAAAACCTTCTGGAACAATGCATAAGATTCAATGTTAATATAATTGATAAATTACCAGACACTAAAGATTTAAATAATGAATATAAGGTACTTGTTGATGCCTTATTTGGGTTTAGTTTTAAACCACCAGTACGGGAAGAATTGAAGCCAGCATTGGATGCGCTAATTGATTCTAATTTACCCGTATGCAGTGTCGATATACCTAGTGGCTGGGATGTCGAAAAAGGCCCAGGTGAAGGAAGAGCATTAAAACCTGCACTACTAATATCACTTTCTGCACCTAAGCTATGCGCCAAACCAGAGTTCTTAAGGAACACCAAACATTATTTGGGAGGAAGATTTCTGCCAACTGATATATTGAAGAAATATAATTTAGAAATTCCACAATATCCTGATCAGGAACAAATTGTAAAATTATCTTGTTAA

Protein

MLLYRLFGSALILRVAKLYNIGTMTSSMNQCNTVTRYLNQSEAAALDQDLFTEYKFSVDQLMELAGLSVASAIAKVFPPSTHSSALIVCGPGNNGGDGLVAARHMQLFGYNVSVHYPKRTPKPLYENLLEQCIRFNVNIIDKLPDTKDLNNEYKVLVDALFGFSFKPPVREELKPALDALIDSNLPVCSVDIPSGWDVEKGPGEGRALKPALLISLSAPKLCAKPEFLRNTKHYLGGRFLPTDILKKYNLEIPQYPDQEQIVKLSC

Description

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Catalytic Activity

(6R)-NADHX = (6S)-NADHX
(6R)-NADPHX = (6S)-NADPHX

Cofactor

K(+)

Subunit

Homodimer. Interacts with APOA1 and APOA2.

Similarity

Belongs to the NnrE/AIBP family.

Keywords

Complete proteome   Isomerase   Metal-binding   NAD   NADP   Nucleotide-binding   Potassium   Reference proteome  

Feature

chain  NAD(P)H-hydrate epimerase

Uniprot

H9JN02   I4DJD1   A0A194PZ98   A0A212ES08   A0A194REC1   A0A2H1VD52   + More
S4P9G2   A0A0L7LJE4   A0A1I8NXH4   A0A2J7PV51   A0A1I8MED9   A0A1I8MEE1   A0A1I8NXH1   A0A1A9XSK8   A0A2P2HYV2   A0A1B6IYC6   A0A1D1VUN2   A0A0L0BMM8   A0A1B0AQF8   A0A1B0FQ06   A0A0M4ELW0   A0A1B0ADN8   A0A1B6BW71   B4PXF5   B4IDM2   A0A1W4XFC5   A0A1A9UEH7   A0A1W4XG95   A0A2H8THR4   Q9W2Y3   A0A1W4VT60   B3NW64   U5ENH0   A0A232F3J8   A0A1B6FG01   A0A2S2R3C1   A0A2P8YTF1   B4M2R8   K7J0J5   A0A2L2YH12   A0A2L2YH78   A0A2S2NJE0   B4JJQ3   E0V9D8   A0A2M4CM60   A0A131YXU3   A0A0Q9XGV8   B4L8C7   A0A240SWD5   A0A131XAT8   A0A0K8TQJ0   A0A087TYU7   A0A1E1X9A9   C4WWT2   A0A224YTS0   L7M079   A0A182XXJ0   A0A0L7RGT2   A0A1P1D2U2   B4NEH6   B3N0Q8   A0A182NL96   A0A182VXQ3   A0A139WMH1   A0A336MYT6   A0A067RFB5   L7LT50   E3XA68   A0A1Y1MAN0   L7LTQ4   G3MST7   E9JD26   A0A182FAX6   A0A182V5V6   A0A267F0U6   A0A182GXY1   A0A034WUI3   A0A0A1WEZ1   A0A0J7KYL4   A0A267F1S2   A0A034WVP8   A0A1E1XSR1   A0A1B6MF98   A0A1U7SUL3   A0A3P9QK69   E9HCD7   Q7Q0G5   A0A182XKF6   F4WSY9   A0A1L8DZV7   A0A2R7WRK1   A0A182MNW3   Q17GW6   A0A195AYV2   A0A182RJ76   A0A182PBG4   A0A195F6C2   A0A158NYD4   A0A2M4AZC0   A0A0K8V209  

EC Number

5.1.99.6

Pubmed

19121390    22651552    26354079    22118469    23622113    26227816    + More
25315136    27649274    26108605    17994087    10731132    12537572    12537569    28648823    29403074    20075255    26561354    20566863    26830274    18057021    28049606    26369729    28503490    28797301    25576852    25244985    20920257    18362917    19820115    24845553    28004739    22216098    21282665    26483478    25348373    25830018    29209593    12364791    21292972    21719571    17510324    21347285   

EMBL

BABH01029173    AK401399    BAM18021.1    KQ459586    KPI98064.1    AGBW02012888    + More
OWR44280.1    KQ460323    KPJ15937.1    ODYU01001647    SOQ38164.1    GAIX01009075    JAA83485.1    JTDY01000878    KOB75577.1    NEVH01020984    PNF20216.1    IACF01001231    LAB66943.1    GECU01015794    JAS91912.1    BDGG01000008    GAV02684.1    JRES01001642    KNC21262.1    JXJN01001847    CCAG010020168    CP012528    ALC48558.1    GEDC01031751    JAS05547.1    CM000162    EDX02906.1    CH480830    EDW45680.1    GFXV01001841    MBW13646.1    AE014298    AY094914    BT050512    CH954180    EDV46197.1    GANO01000615    JAB59256.1    NNAY01001055    OXU25321.1    GECZ01020637    JAS49132.1    GGMS01015220    MBY84423.1    PYGN01000371    PSN47526.1    CH940651    EDW65972.1    IAAA01022721    LAA07399.1    IAAA01022720    LAA07397.1    GGMR01004682    MBY17301.1    CH916370    EDV99805.1    DS234992    GGFL01002238    MBW66416.1    GEDV01005195    JAP83362.1    CH933814    KRG07493.1    EDW05702.1    GEFH01004924    JAP63657.1    GDAI01000971    JAI16632.1    KK117371    KFM70286.1    GFAC01003351    JAT95837.1    ABLF02014751    AK342249    BAH72352.1    GFPF01006074    MAA17220.1    GACK01008496    JAA56538.1    KQ414596    KOC70039.1    CH964239    EDW82145.1    CH902644    EDV34787.1    KQ971315    KYB29015.1    UFQS01002464    UFQT01002464    SSX14101.1    SSX33517.1    KK852669    KDR18838.1    GACK01010039    JAA54995.1    ADMH02000300    ETN67052.1    GEZM01036219    JAV82892.1    GACK01010052    JAA54982.1    JO844938    AEO36555.1    GL771866    EFZ09283.1    NIVC01001485    PAA67400.1    JXUM01096457    KQ564265    KXJ72506.1    GAKP01001092    JAC57860.1    GBXI01017252    JAC97039.1    LBMM01001988    KMQ95441.1    NIVC01001519    PAA66962.1    GAKP01001094    JAC57858.1    GFAA01001079    JAU02356.1    GEBQ01005350    JAT34627.1    AAAB01008982    GL732619    GL888331    EGI62693.1    GFDF01002155    JAV11929.1    KK855361    PTY22189.1    AXCM01004705    CH477255    KQ976701    KYM77215.1    KQ981768    KYN36018.1    ADTU01003758    GGFK01012806    MBW46127.1    GDHF01030654    GDHF01019438    GDHF01015252    JAI21660.1    JAI32876.1    JAI37062.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000037510    UP000095300    + More
UP000235965    UP000095301    UP000092443    UP000186922    UP000037069    UP000092460    UP000092444    UP000092553    UP000092445    UP000002282    UP000001292    UP000192223    UP000078200    UP000000803    UP000192221    UP000008711    UP000215335    UP000245037    UP000008792    UP000002358    UP000001070    UP000009046    UP000009192    UP000091820    UP000054359    UP000007819    UP000076408    UP000053825    UP000007798    UP000007801    UP000075884    UP000075920    UP000007266    UP000027135    UP000000673    UP000069272    UP000075903    UP000215902    UP000069940    UP000249989    UP000036403    UP000189704    UP000000305    UP000007062    UP000076407    UP000007755    UP000075883    UP000008820    UP000078540    UP000075900    UP000075885    UP000078541    UP000005205   

PRIDE

H9JN02    Q9W2Y3   

Pfam

PF03853   YjeF_N

Interpro

IPR032976   YJEFN_prot_eukaryotes        + More
IPR004443   YjeF_N_dom       
IPR036652   YjeF_N_dom_sf       

SUPFAM

SSF64153   SSF64153       

Gene 3D

3.40.50.10260    

ProteinModelPortal

H9JN02   I4DJD1   A0A194PZ98   A0A212ES08   A0A194REC1   A0A2H1VD52   + More
S4P9G2   A0A0L7LJE4   A0A1I8NXH4   A0A2J7PV51   A0A1I8MED9   A0A1I8MEE1   A0A1I8NXH1   A0A1A9XSK8   A0A2P2HYV2   A0A1B6IYC6   A0A1D1VUN2   A0A0L0BMM8   A0A1B0AQF8   A0A1B0FQ06   A0A0M4ELW0   A0A1B0ADN8   A0A1B6BW71   B4PXF5   B4IDM2   A0A1W4XFC5   A0A1A9UEH7   A0A1W4XG95   A0A2H8THR4   Q9W2Y3   A0A1W4VT60   B3NW64   U5ENH0   A0A232F3J8   A0A1B6FG01   A0A2S2R3C1   A0A2P8YTF1   B4M2R8   K7J0J5   A0A2L2YH12   A0A2L2YH78   A0A2S2NJE0   B4JJQ3   E0V9D8   A0A2M4CM60   A0A131YXU3   A0A0Q9XGV8   B4L8C7   A0A240SWD5   A0A131XAT8   A0A0K8TQJ0   A0A087TYU7   A0A1E1X9A9   C4WWT2   A0A224YTS0   L7M079   A0A182XXJ0   A0A0L7RGT2   A0A1P1D2U2   B4NEH6   B3N0Q8   A0A182NL96   A0A182VXQ3   A0A139WMH1   A0A336MYT6   A0A067RFB5   L7LT50   E3XA68   A0A1Y1MAN0   L7LTQ4   G3MST7   E9JD26   A0A182FAX6   A0A182V5V6   A0A267F0U6   A0A182GXY1   A0A034WUI3   A0A0A1WEZ1   A0A0J7KYL4   A0A267F1S2   A0A034WVP8   A0A1E1XSR1   A0A1B6MF98   A0A1U7SUL3   A0A3P9QK69   E9HCD7   Q7Q0G5   A0A182XKF6   F4WSY9   A0A1L8DZV7   A0A2R7WRK1   A0A182MNW3   Q17GW6   A0A195AYV2   A0A182RJ76   A0A182PBG4   A0A195F6C2   A0A158NYD4   A0A2M4AZC0   A0A0K8V209  

PDB

3ROZ     E-value=7.23326e-64,     Score=617

KEGG

101743875    K17759 NAD(P)H-hydrate epimerase [EC:5.1.99.6] | (RefSeq) NAD(P)H-hydrate epimerase

GO

GO:0052856   GO:0046872   GO:0000166   GO:0005739   GO:0052857   GO:0005929   GO:0005829   GO:0005654   GO:0042803   GO:0044297   GO:0005615   GO:0051289   GO:0046496  

PANTHER

PTHR13232  

Subcellular location

Mitochondrion   In sperm, secretion gradually increases during capacitation.   With evidence from 1 publications.
Secreted   In sperm, secretion gradually increases during capacitation.   With evidence from 1 publications.

Length:

266

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05567

Exp number, first 60 AAs:

0.05362

Total prob of N-in:

0.00865

outside

1  -  266

 

 

Pi

18.718916

Theta

17.864766

Tajima's D

0.351234

CLR

0.696137

CSRT

0.47627618619069

Interpretation

Uncertain