Gene

KWMTBOMO13405  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010906

Annotation

PREDICTED:_proliferating_cell_nuclear_antigen_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr22(-):16216565-16220312      View in EpiBrowser

Full name

Proliferating cell nuclear antigen      

Alternative Name

Cyclin
Mutagen-sensitive 209 protein

Location in the cell

Nuclear   Reliability : 4.469

CDS

ATGTTTGAGGCACGTTTACTCCGAAGCTCTATCTTAAAGAAGGTCTTGGAGGCTATTAAAGATCTGCTGACACAGGCCACTTTCGATTGCGATGACAATGGAATTCAGTTACAGGCTATGGACAACTCTCATGTGTCTCTCGTGTCACTCACTCTCCGAGCTGATGGCTTTGACAAGTACCGCTGCGATAGGAACATCTCAATGGGCATGAATCTAGGCAGCATGTCAAAGATTCTCAAATGTGCTGGAGATAAGGATACAGTTACAATAAAAGCACAGGATAATGCTGACAATGTCACATTTGTTTTTGAGAGCCCAAATCAAGAGAAAGTCTCTGATTACGAGATGAAGCTTATGAATTTGGATCTTGAACATTTAGGTATTCCAGAGACTGAATACAGCTGCACTATTCGCATGCCAAGTTCTGAATTTGCTAGAATCTGCCGGGATCTCTCACAGTTTGGAGAATCAATGGTGATTTCATGCACAAAAGAAGGAGTAAAGTTCTCGGCAACAGGCGACATCGGCTCAGCGAACGTCAAGCTGGCCCAGACCGCTTCTATTGACAAAGAGGAAGAGGCAGTCGTCATTGAAATGGAAGAGCCCGTCACTCTGACGTTTGCCTGCCAGTACCTCAACTATTTCACTAAAGCTACTTCTCTCAGCCCTCAGGTGCAGCTGTCGATGTCAGCAGACGTTCCTTTGGTGGTGGAGTACCGCATCCCGGACATTGGCCACATCCGCTACTACCTGGCGCCTAAGATCGAGGAAGAAGACAGCTGA

Protein

MFEARLLRSSILKKVLEAIKDLLTQATFDCDDNGIQLQAMDNSHVSLVSLTLRADGFDKYRCDRNISMGMNLGSMSKILKCAGDKDTVTIKAQDNADNVTFVFESPNQEKVSDYEMKLMNLDLEHLGIPETEYSCTIRMPSSEFARICRDLSQFGESMVISCTKEGVKFSATGDIGSANVKLAQTASIDKEEEAVVIEMEEPVTLTFACQYLNYFTKATSLSPQVQLSMSADVPLVVEYRIPDIGHIRYYLAPKIEEEDS

Description

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

Subunit

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).
Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity). Interacts with E2f.

Similarity

Belongs to the PCNA family.

Keywords

Complete proteome   DNA replication   DNA-binding   Nucleus   Reference proteome   3D-structure   Direct protein sequencing  

Feature

chain  Proliferating cell nuclear antigen

Uniprot

H9JN03   Q8MYA5   Q8MYA4   O01377   S4PB42   A0A212ES54   + More
A0A2A4J0R7   A0A194RJ19   I4DQ38   A0A2J7Q7K9   A0A067QR99   A0A1L8ECY7   A0A1J1I1Z1   A0A336KDE0   A0A2P8Y1H5   A0A1I8PWB0   A0A224XM68   A0A0P4VTM6   A0A023F9X0   R4G4N7   E9HC90   U5EWY5   A0A164ZBV7   A0A2Z5TRD7   T1P852   A0A0L0CN76   Q4PKD7   A0A023EMS3   R4V0H7   A0A182JD53   A0A084WD25   A0A0P6D7Z5   Q4PKD8   A0A0P5UH05   A0A182YHC7   A0A182T2U7   A0A182R6W2   A0A0P6EFX2   A0A0P5WMK4   A0A0N8C701   A0A1Q3EVV1   A0A0P5TGP9   A0A1B6GBS0   A0A1B6IC67   A0A0P5HVH6   A0A0P5DE32   A0A0P5MR45   A0A0N8CWA4   A0A0P4YU64   A0A0P5XF32   A0A0P6A769   G1E6N7   A0A1D8DDR6   A0A0P6HFC2   A0A182PV54   A0A182N8Q9   A0A182VSY1   A0A182UNS0   A0A182JPH1   A0A182TUZ9   A0A182KJS9   A0A182XB68   Q7Q0Q0   A0A182I0R2   W5JM12   A0A182FMV3   A0A1A9Y549   A0A1B0BXV0   A0A0P6EHN8   B5SP70   A0A1B0CN07   B1A9K0   A0A0P6DIL4   A0A1B6KVA0   A0A1L8DX45   A0A0P6DME1   A0A0P5P6P2   B0WPF0   A0A182QF77   O16852   A0A0P5P1J3   A0A1A9ZP02   A0A0P5NQD1   D3TQX0   A0A2A4J1Z5   W8B157   A0A1A9WKC2   A0A1A9VQ32   B4MRX3   B4KS28   A0A0K8W5Y1   A0A034WQG3   A0A3B0JJA1   Q28ZI4   B4GHQ3   A0A1W4V4B4   B3MHM6   B3NK47   P17917   A0A2H4T2M1  

Pubmed

19121390    9498568    23622113    22118469    26354079    22651552    + More
24845553    29403074    27129103    25474469    21292972    26760975    25315136    26108605    16640730    17510324    24945155    26483478    24438588    25244985    24728082    20966253    12364791    14747013    17210077    20920257    23761445    18678269    20230291    9714841    20353571    24495485    17994087    25348373    15632085    1968224    10731132    12537572    12537569    1973166    7907981    9310333    19081076   

EMBL

BABH01029174    AB069854    AB174843    BAC02929.1    BAD13299.1    AB069855    + More
AB174894    BAC02930.1    BAD13316.1    AB002264    AB002265    GAIX01006122    JAA86438.1    AGBW02012888    OWR44281.1    NWSH01003854    PCG65757.1    KQ460323    KPJ15936.1    AK403915    BAM20028.1    NEVH01017442    PNF24568.1    KK853114    KDR11193.1    GFDG01002287    JAV16512.1    CVRI01000038    CRK94227.1    UFQS01000086    UFQT01000086    SSW99110.1    SSX19492.1    PYGN01001050    LT717627    PSN38108.1    SIW61619.1    GFTR01004242    JAW12184.1    GDKW01000724    JAI55871.1    GBBI01000517    JAC18195.1    ACPB03017886    GAHY01000616    JAA76894.1    GL732619    EFX70582.1    GANO01001211    JAB58660.1    LRGB01000745    KZS16181.1    FX985793    BBA93680.1    KA644757    AFP59386.1    JRES01000147    KNC33798.1    DQ075690    CH477894    AAY82461.1    EAT35273.1    JXUM01032592    GAPW01003453    KQ560961    JAC10145.1    KXJ80195.1    KC632288    AGM32102.1    ATLV01022923    KE525338    KFB48119.1    GDIQ01221864    GDIQ01095506    GDIQ01081966    GDIQ01073817    JAN12771.1    DQ075689    AAY82460.1    GDIP01113057    JAL90657.1    GDIQ01064324    GDIQ01064270    GDIQ01038938    JAN30467.1    GDIP01084101    JAM19614.1    GDIQ01108651    JAL43075.1    GFDL01015612    JAV19433.1    GDIP01132362    JAL71352.1    GECZ01010026    JAS59743.1    GECU01023180    JAS84526.1    GDIQ01224562    GDIQ01097258    GDIQ01095557    JAK27163.1    GDIP01158842    JAJ64560.1    GDIQ01153189    JAK98536.1    GDIP01092615    JAM11100.1    GDIP01223549    JAI99852.1    GDIP01073120    JAM30595.1    GDIP01034204    JAM69511.1    JN034913    JN034649    QCYY01002249    AEJ89927.1    AEJ89928.1    ROT71780.1    KU380336    AOS87743.1    GDIQ01020242    JAN74495.1    AAAB01008980    EAA13806.2    APCN01005234    ADMH02001180    ETN63819.1    JXJN01022373    GDIQ01076566    JAN18171.1    EF051247    ABM66815.1    AJWK01019585    EU431336    ACA09718.1    GDIQ01076568    JAN18169.1    GEBQ01024656    JAT15321.1    GFDF01003095    JAV10989.1    GDIQ01076567    JAN18170.1    GDIQ01139294    JAL12432.1    DS232023    EDS32329.1    AXCN02001859    AF020427    GDIQ01139296    JAL12430.1    GDIQ01139295    JAL12431.1    CCAG010006225    EZ423822    ADD20098.1    PCG65756.1    GAMC01014318    JAB92237.1    CH963850    EDW74862.1    CH933808    EDW10464.1    GDHF01005855    JAI46459.1    GAKP01002385    JAC56567.1    OUUW01000001    SPP73306.1    CM000071    EAL25629.1    CH479183    EDW36023.1    CH902619    EDV35862.1    CH954179    EDV55282.1    M33950    AE013599    AY122197    KY438972    ATY70175.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053240    UP000235965    UP000027135    + More
UP000183832    UP000245037    UP000095300    UP000015103    UP000000305    UP000076858    UP000095301    UP000037069    UP000008820    UP000069940    UP000249989    UP000075880    UP000030765    UP000076408    UP000075901    UP000075900    UP000283509    UP000075885    UP000075884    UP000075920    UP000075903    UP000075881    UP000075902    UP000075882    UP000076407    UP000007062    UP000075840    UP000000673    UP000069272    UP000092443    UP000092460    UP000092461    UP000002320    UP000075886    UP000092445    UP000092444    UP000091820    UP000078200    UP000007798    UP000009192    UP000268350    UP000001819    UP000008744    UP000192221    UP000007801    UP000008711    UP000000803   

PRIDE

H9JN03    O01377    P17917   

Pfam

PF02747   PCNA_C        + More
PF00705   PCNA_N

Interpro

IPR022648   Pr_cel_nuc_antig_N        + More
IPR022659   Pr_cel_nuc_antig_CS       
IPR000730   Pr_cel_nuc_antig       
IPR022649   Pr_cel_nuc_antig_C       
IPR010916   TonB_box_CS       

ProteinModelPortal

H9JN03   Q8MYA5   Q8MYA4   O01377   S4PB42   A0A212ES54   + More
A0A2A4J0R7   A0A194RJ19   I4DQ38   A0A2J7Q7K9   A0A067QR99   A0A1L8ECY7   A0A1J1I1Z1   A0A336KDE0   A0A2P8Y1H5   A0A1I8PWB0   A0A224XM68   A0A0P4VTM6   A0A023F9X0   R4G4N7   E9HC90   U5EWY5   A0A164ZBV7   A0A2Z5TRD7   T1P852   A0A0L0CN76   Q4PKD7   A0A023EMS3   R4V0H7   A0A182JD53   A0A084WD25   A0A0P6D7Z5   Q4PKD8   A0A0P5UH05   A0A182YHC7   A0A182T2U7   A0A182R6W2   A0A0P6EFX2   A0A0P5WMK4   A0A0N8C701   A0A1Q3EVV1   A0A0P5TGP9   A0A1B6GBS0   A0A1B6IC67   A0A0P5HVH6   A0A0P5DE32   A0A0P5MR45   A0A0N8CWA4   A0A0P4YU64   A0A0P5XF32   A0A0P6A769   G1E6N7   A0A1D8DDR6   A0A0P6HFC2   A0A182PV54   A0A182N8Q9   A0A182VSY1   A0A182UNS0   A0A182JPH1   A0A182TUZ9   A0A182KJS9   A0A182XB68   Q7Q0Q0   A0A182I0R2   W5JM12   A0A182FMV3   A0A1A9Y549   A0A1B0BXV0   A0A0P6EHN8   B5SP70   A0A1B0CN07   B1A9K0   A0A0P6DIL4   A0A1B6KVA0   A0A1L8DX45   A0A0P6DME1   A0A0P5P6P2   B0WPF0   A0A182QF77   O16852   A0A0P5P1J3   A0A1A9ZP02   A0A0P5NQD1   D3TQX0   A0A2A4J1Z5   W8B157   A0A1A9WKC2   A0A1A9VQ32   B4MRX3   B4KS28   A0A0K8W5Y1   A0A034WQG3   A0A3B0JJA1   Q28ZI4   B4GHQ3   A0A1W4V4B4   B3MHM6   B3NK47   P17917   A0A2H4T2M1  

PDB

4CS5     E-value=1.19049e-112,     Score=1037

KEGG

692356    K04802 proliferating cell nuclear antigen | (RefSeq) Pcna; proliferating cell nuclear antigen

PATHWAY

03030    DNA replication - Bombyx mori (domestic silkworm)
03410    Base excision repair - Bombyx mori (domestic silkworm)
03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)
03430    Mismatch repair - Bombyx mori (domestic silkworm)

GO

GO:0006260   GO:0003677   GO:0030337   GO:0005634   GO:0006275   GO:0006298   GO:0006272   GO:0043626   GO:0019985   GO:0016021   GO:0019730   GO:0007052   GO:0006289   GO:0007307   GO:0006261   GO:0008017   GO:0005525   GO:0031386   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Nucleus  

Length:

260

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00032

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01924

outside

1  -  260

 

 

Pi

19.370683

Theta

18.682668

Tajima's D

-0.256169

CLR

1.152863

CSRT

0.305184740762962

Interpretation

Uncertain