Gene

KWMTBOMO13402

Annotation

PREDICTED:_integrator_complex_subunit_5_[Bombyx_mori]

Location

Bomo_Chr22(-):16163126-16178062      View in EpiBrowser

Full name

Integrator complex subunit 5      

Alternative Name

Protein oocyte maintenance defects

Location in the cell

Cytoplasmic   Reliability : 0.962

CDS

ATGAACACCTCCAGCAAGTCCACTGCACTATCTGCAGATCTAAATAACTTTGTATACGGTGTTTCGAGACGAAACACTCAGAGTACCCCGGAGCTCACCAAAACTGGTATAAGTTTGTTAAAAACCTTTCCGGCGGCAAGAGACGCTGTGTTAGAGTTTTTCTCGATTGTGTTTCAAGAAGCCGTTAACGTTGCCATCAGTCAAACTGACTATGAAGCTGATCCAAATGCTAATAGTCTTTTGGAGAGTGTCAGTATGATTGGACCTGAGCTATGCAACCTGGGAGAGTCATGGGCACCCTTCATAGCTCCATGGTGTGTCAATTTGATAATTGACATTTCCACTAACAAGTCAAATGTGCCAAACTCCACCCTCCAGAGTGCTGAGCCTGTCAGGGTGCTGTTGGATATAACAACACAAAATTTAACTTTATTAGGTCCAGAGGAAAAAGCTACATGCATTGATATGATGCTTGAATCTCGCTGGTGCGGCTGGGCTGTGGGTCGCGTGGTGAGGGCGGAGGCCGGGCTGGTGGCTCTAGTGGCTCCGCGGGCGCTGGCTCTGGGCGCAGACGCGGCGCGTGCGTTGCTAGCCCAGCTGGCGCACCACGCACCCGCACTCGCGCACCTGAAACGAGCACTACAAACTTTGTTTCACGATGTGATAAGGGAGGACAGTATGCCGGAGAGTAAGCGTGACGTCATACCGTATCTACTGAATTTAGCTTCGAAGTCCGATGTAGTCCTGAAAGCCTTCACGCAAGATATAGAACAAACGCTGTCGGATGAGGTGGTGCGTCGTCTGGGCGCGGTGTGCGGGGGCGGGGCGCGGTGGGAGGGCGCGGCGCCGGCGTCGCTGGTGCAGCTGCTGATGCGGACGGACGCCAGGTGTTTGCTGCTGCTCCTCAGACACGCTCGGAACTACCAGTTCTGCAGGCAGTTGCTTGAGCACCTCCTACAGAAGCTAGAATACGAATGTCTCTTCCCGGACAAAACTATACCGCTGTTGACGAGCGCCGCTGAGGAGATACACATGATCCGGGAGAAGCTGCTGGACGGGAATCAGCTGGAGAAGTATTCACTCGCGCGACTGCTCATCCTGATTTGCTACAACCAGCCCTCGGAGTTCGTATCGACCATAAGCTACCTGCTGCAGTACAGCCGCGACGACGCGACCCTCGCGCTGCTGGTGCGCATCATGTCCGGCACCGCCTCCATGCACGTGCCCAACGACACCCCCGACATCAGCACCGACACCGAGCGGTACCAGGACTTCATCAGGACGGGCGTGGAGCACGCCCTCAGGGACGCCGCCATGTCCGACACACAGATAAAGAGGTGCTTCATCGAGGGAAACGTTCCTAAGGATCAAAAGACGTACATGCATTATTTTTGTCTGAACATCATTAAGCTGTTGAGATGGGAGAGCTCGAAGCGCGTGTCGCAGCTGCGCGGGCGGGCGGTGGGGCGCGCGGTGCAGGCCAGCCTGTACCGGCTGGGCGCGGCGCTGCAGCACTACGCGGCGCTGCTGCGCGACCCGCAGCTGCACCACTGCACCATGAGGTCGCTCAACGAGATGCCCACGTGCCACGCCCTCGCCGAGGTACTAGACAGAGTGGACATGTCCGGCACGAAGGGCCCGCTGCCGAGCGTGGAGAGCGTGCTCAAAGTCGTACAAGCGACCGTCAAATATTTCTTCAGGTGCATCCACGAGCCAGACGTAATGAACAAAGTCCGGGGCACACAGACCGCGTGCCGACTGCTCCGCAAGCTGTGCGGGCACAGCAAGCTGGCCCGCGCCGTCGGCCTGCGCGACCTGCTCGAGGCCGCCATGTTCCGCGAGGAGCGCGCCTTCGGGACCCGCGCCGAGCCCCGCGCACCCGACACCGACGACCTCCTCATACACTTGAACCAAAAACACGGCCCGATCACGCAGCTGACGCAGAGCCACACGTCAGTGTTCCACGCGGGCATCATCGGTAAAGGAGTTAGGAAGAAGAGCTCCCACGACGAGAACTCACTACCGCCGATCCTCACCACCAACAACGAGCTGCTGATGGGCGCGCTGATGGCTTGTATGGACGGGAACAGCGGTGTGGTGGAAGGCGCGACCTCCGTGGCGCTGTTGCTGGTGGAGCTGGTGTCTCCCGACGTCATGTACAACGGCCTGCCGTGGCCCGACGAGGACTTTACCAAGCAAGTGAGCATCGAGCGCGAGCTGTACATGCGCGCGGCGCTGGAGGCGAGCCCGGTGTGTCGCGCGGCACTGCGGCGCTGCGGCGGCGCCCGCCCCGCGCTGTGCCTCGCCTCCGCGCTGCTGCGCGCCGCCGCCGCCACGCTGCTGCACCGCCTGCGCGCCCTGCTAGGTACCGCCGCTGCGCCTTAA

Protein

MNTSSKSTALSADLNNFVYGVSRRNTQSTPELTKTGISLLKTFPAARDAVLEFFSIVFQEAVNVAISQTDYEADPNANSLLESVSMIGPELCNLGESWAPFIAPWCVNLIIDISTNKSNVPNSTLQSAEPVRVLLDITTQNLTLLGPEEKATCIDMMLESRWCGWAVGRVVRAEAGLVALVAPRALALGADAARALLAQLAHHAPALAHLKRALQTLFHDVIREDSMPESKRDVIPYLLNLASKSDVVLKAFTQDIEQTLSDEVVRRLGAVCGGGARWEGAAPASLVQLLMRTDARCLLLLLRHARNYQFCRQLLEHLLQKLEYECLFPDKTIPLLTSAAEEIHMIREKLLDGNQLEKYSLARLLILICYNQPSEFVSTISYLLQYSRDDATLALLVRIMSGTASMHVPNDTPDISTDTERYQDFIRTGVEHALRDAAMSDTQIKRCFIEGNVPKDQKTYMHYFCLNIIKLLRWESSKRVSQLRGRAVGRAVQASLYRLGAALQHYAALLRDPQLHHCTMRSLNEMPTCHALAEVLDRVDMSGTKGPLPSVESVLKVVQATVKYFFRCIHEPDVMNKVRGTQTACRLLRKLCGHSKLARAVGLRDLLEAAMFREERAFGTRAEPRAPDTDDLLIHLNQKHGPITQLTQSHTSVFHAGIIGKGVRKKSSHDENSLPPILTTNNELLMGALMACMDGNSGVVEGATSVALLLVELVSPDVMYNGLPWPDEDFTKQVSIERELYMRAALEASPVCRAALRRCGGARPALCLASALLRAAAATLLHRLRALLGTAAAP

Description

Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).

Subunit

Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.

Similarity

Belongs to the Integrator subunit 5 family.

Keywords

Complete proteome   Cytoplasm   Membrane   Nucleus   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Integrator complex subunit 5

Uniprot

A0A194PXL7   A0A212ES16   A0A067R9K9   A0A154PAL4   A0A0C9QQX7   A0A0M8ZQI6   + More
A0A310SDQ2   A0A195FAF5   A0A158NK46   F4W8D4   A0A2J7QVU0   A0A195BA51   A0A151X293   A0A0C9QYZ4   A0A2A3E3D8   A0A087ZSI9   A0A2P8Y6E3   A0A026WQ17   A0A195C2U6   A0A0J7L8E8   A0A151JME2   A0A0L7RA27   E2B700   A0A1Y1KVU4   U4UJ96   A0A182UMI5   Q7QBI6   A0A182XE75   A0A182VQ75   A0A182LC99   A0A182HJ48   A0A182TMB7   A0A1B0DPW1   A0A1W4X5W2   A0A1W4WWF7   A0A1W4X798   B4M0X2   A0A1Q3EZY9   B4JI97   A0A0M4ERW6   Q173A6   B4PQH5   B4HFP9   A0A1W4V669   Q9VFS6   Q297P5   B3P419   B4G2U2   B4NKN0   B3LXB0   A0A182Y7B5   A0A3B0K0J7  

Pubmed

26354079    22118469    24845553    21347285    21719571    29403074    + More
24508170    30249741    20798317    28004739    23537049    12364791    14747013    17210077    20966253    17994087    17510324    17550304    10731132    12537572    12537569    21078872    23097424    15632085    23185243    25244985   

EMBL

KQ459586    KPI98067.1    AGBW02012888    OWR44283.1    KK852801    KDR16305.1    + More
KQ434857    KZC08892.1    GBYB01006134    JAG75901.1    KQ435903    KOX69070.1    KQ760974    OAD58560.1    KQ981693    KYN37605.1    ADTU01018656    ADTU01018657    GL887908    EGI69425.1    NEVH01009770    PNF32705.1    KQ976537    KYM81411.1    KQ982579    KYQ54555.1    GBYB01005902    JAG75669.1    KZ288446    PBC25611.1    PYGN01000872    PSN39828.1    KK107133    QOIP01000011    EZA58122.1    RLU16460.1    KQ978344    KYM94915.1    LBMM01000281    KMR01804.1    KQ978928    KYN27489.1    KQ414619    KOC67713.1    GL446071    EFN88542.1    GEZM01072445    JAV65519.1    KB632381    ERL94154.1    AAAB01008879    EAA08442.5    APCN01002124    AJVK01018647    AJVK01018648    CH940650    EDW67383.1    GFDL01014178    JAV20867.1    CH916369    EDV92978.1    CP012526    ALC45267.1    CH477428    EAT41122.1    CM000160    EDW97271.1    CH480815    EDW42284.1    AE014297    BT011415    AY061608    AAL29156.1    AAR96207.1    CM000070    EAL28160.4    KRT00509.1    CH954181    EDV49193.1    CH479179    EDW24137.1    CH964272    EDW84091.1    CH902617    EDV41710.1    OUUW01000013    SPP87835.1   

Proteomes

UP000053268    UP000007151    UP000027135    UP000076502    UP000053105    UP000078541    + More
UP000005205    UP000007755    UP000235965    UP000078540    UP000075809    UP000242457    UP000005203    UP000245037    UP000053097    UP000279307    UP000078542    UP000036403    UP000078492    UP000053825    UP000008237    UP000030742    UP000075903    UP000007062    UP000076407    UP000075920    UP000075882    UP000075840    UP000075902    UP000092462    UP000192223    UP000008792    UP000001070    UP000092553    UP000008820    UP000002282    UP000001292    UP000192221    UP000000803    UP000001819    UP000008711    UP000008744    UP000007798    UP000007801    UP000076408    UP000268350   

PRIDE

Q9VFS6   

Pfam

PF14837   INTS5_N        + More
PF14838   INTS5_C

Interpro

IPR016024   ARM-type_fold        + More
IPR029445   INTS5_N       
IPR029444   INTS5_C       
IPR040316   INTS5       

SUPFAM

SSF48371   SSF48371       

ProteinModelPortal

A0A194PXL7   A0A212ES16   A0A067R9K9   A0A154PAL4   A0A0C9QQX7   A0A0M8ZQI6   + More
A0A310SDQ2   A0A195FAF5   A0A158NK46   F4W8D4   A0A2J7QVU0   A0A195BA51   A0A151X293   A0A0C9QYZ4   A0A2A3E3D8   A0A087ZSI9   A0A2P8Y6E3   A0A026WQ17   A0A195C2U6   A0A0J7L8E8   A0A151JME2   A0A0L7RA27   E2B700   A0A1Y1KVU4   U4UJ96   A0A182UMI5   Q7QBI6   A0A182XE75   A0A182VQ75   A0A182LC99   A0A182HJ48   A0A182TMB7   A0A1B0DPW1   A0A1W4X5W2   A0A1W4WWF7   A0A1W4X798   B4M0X2   A0A1Q3EZY9   B4JI97   A0A0M4ERW6   Q173A6   B4PQH5   B4HFP9   A0A1W4V669   Q9VFS6   Q297P5   B3P419   B4G2U2   B4NKN0   B3LXB0   A0A182Y7B5   A0A3B0K0J7  

KEGG

101744312    K13142 integrator complex subunit 5 | (RefSeq) integrator complex subunit 5

GO

GO:0032039   GO:0016021   GO:0034472   GO:0031965   GO:0005634   GO:0005737   GO:0016301  

PANTHER

PTHR31697  

Subcellular location

Nucleus membrane  
Nucleus  
Cytoplasm  

Length:

794

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10767

Exp number, first 60 AAs:

0.00249

Total prob of N-in:

0.00209

outside

1  -  794

 

 

Pi

12.943283

Theta

4.47335

Tajima's D

-1.759556

CLR

232.715855

CSRT

0.0272486375681216

Interpretation

Possibly Positive selection