Gene

KWMTBOMO13357

Annotation

PREDICTED:_elongation_of_very_long_chain_fatty_acids_protein_4-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr22(-):14807631-14811344      View in EpiBrowser

Full name

Elongation of very long chain fatty acids protein       + More
Elongation of very long chain fatty acids protein 4      

Alternative Name

Very-long-chain 3-oxoacyl-CoA synthase
3-keto acyl-CoA synthase ELOVL4
ELOVL fatty acid elongase 4
Very long chain 3-ketoacyl-CoA synthase 4
Very long chain 3-oxoacyl-CoA synthase 4

Location in the cell

PlasmaMembrane   Reliability : 3.475

CDS

ATGAAGCAACGCGAACCTTACAAACTGAAGAGCTTGCTTTTGTTTTACAACTGTTTTCAAGTCGCTTTCTCTGCTTATTTGGTTTTTATTTATTCCAGGTATATTCTAAGTTACGGTGTGATCACAAAAAGATGTCCCAAAGGTGAAGATTTACAAGCGGTTATCAAAGAAATCTATCCATATTTCATAGCAAAGCACCTTGATCTACTAGATACAGTGTTCTTCGTTCTGAGAAAGAAAGACAACCAAGTGACTTTCCTTCATCTTTACCACCACAACACCATGGTGACTTGGACCTGGCTCCATTTAATGTACCATCCCGCAGATCACTTTGTGGTGGTTGGCATGTTGAATAGCTTCGTTCATGTGCTGATGTATGCTTATTATGGGATATCGTCTCTGGGCCCGAAGTATGCTAAGTTTGTTTGGTGGAAGAAACATTTGACTAAGGTGCAACTGGTGCAGTTCGTCTTAGTTACTTCCCACCTGCACTACCAGCAGAAGTTGACGCCTTGTCCTCTACCAACGTTTTTCCATTACTTCTGCGTGTCACTTATTTGCTCCTTTTTCTTATTGTTCATGAAATTCTACGTTCAGAGCTACAGAGTTAGAAAGGAGAGGAAAGCGAACGATTTAAATGTGGGAAATAAGTTAGGCGGGGAGCGATTGTTAAAGGGACTTTGA

Protein

MKQREPYKLKSLLLFYNCFQVAFSAYLVFIYSRYILSYGVITKRCPKGEDLQAVIKEIYPYFIAKHLDLLDTVFFVLRKKDNQVTFLHLYHHNTMVTWTWLHLMYHPADHFVVVGMLNSFVHVLMYAYYGISSLGPKYAKFVWWKKHLTKVQLVQFVLVTSHLHYQQKLTPCPLPTFFHYFCVSLICSFFLLFMKFYVQSYRVRKERKANDLNVGNKLGGERLLKGL

Description

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.

Catalytic Activity

a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA

Subunit

Oligomer.

Similarity

Belongs to the ELO family.
Belongs to the ELO family. ELOVL4 subfamily.

Uniprot

A0A2H1VZH1   A0A2A4JNZ7   A0A2A4IT40   A0A212EWG2   A0A194Q3Y4   A0A194RIW9   + More
A0A194RE66   A0A194PZF1   A0A212EWL1   A0A194PXS2   A0A2H1X1Z6   A0A194REJ3   T1PEI5   A0A1E1WEQ6   B4JF47   A0A1I8NVN9   A0A1W4X4I5   B3P8N4   A0A1E1WBM7   A0A1W4WV07   B4R0M2   B4HEP6   A0A2A4IYB4   A0A194PYL9   B4K959   B4PMB5   Q9VCY7   B3M000   C6SV14   A0A336MEX6   A0A0A1XAS6   A0A0M4F374   A0A2H1WW52   B4M164   A0A1A9V750   A0A1A9Z486   W8AWR6   A0A1A9XJ22   A0A1B0BXZ2   A0A1Y1LS48   A0A2A4IXM4   K1R6N6   B4NJS5   A0A336M748   Q29BK4   A0A1W4VR29   B4GP37   A0A1A9W5Z6   A0A3B0JF55   A0A194RDG5   A0A336KLJ3   A0A3B0JEF4   A0A2H1VQJ9   A0A2A4J2V1   A0A1W4WV09   E0VAZ6   F1RQL1   A0A069DYC2   T1HHY5   A0A336L063   A0A084VMT0   A0A034WG82   A0A287A8V2   A0A034WKC9   A0A182Q5E2   A0A075QRX8   A0A0K8VXE8   A0A0L0CGV6   I3LVJ0   A0A336K2J4   A0A1B0FQK1   A0A023F182   A0A182F0V8   A0A2H1X1Z5   A0A194PYM4   H9JN16   A0A158NN74   H3A2B9   E0VQR5   A0A154PBW3   A0A1I8NHJ7   H9JN18   W5J2I2   A0A1W2W9A1   H9JN19   A0A151I3K9   H0X3V6   A0A1B0D768   A0A2H1WH44   A0A2R7WMF5   A0A182IU15   G3WRL1   A0A336M016   A0A1S3MP43   A0A2A4IWR2   S4PNY7   A0A060WDY9   H9JN15   A0A158NS34   A0A091MTW9  

EC Number

2.3.1.199

Pubmed

22118469    26354079    25315136    17994087    18057021    17550304    + More
10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25830018    24495485    28004739    22992520    15632085    23185243    20566863    26334808    24438588    25348373    24970595    26108605    25474469    19121390    21347285    9215903    20920257    23761445    21709235    23622113    24755649   

EMBL

ODYU01005098    SOQ45634.1    NWSH01000869    PCG73785.1    NWSH01008171    PCG62666.1    + More
AGBW02011990    OWR45832.1    KQ459586    KPI98120.1    KQ460323    KPJ15886.1    KPJ15887.1    KPI98119.1    OWR45834.1    KPI98122.1    ODYU01012860    SOQ59370.1    KPJ15884.1    KA647151    AFP61780.1    GDQN01005618    JAT85436.1    CH916369    EDV93328.1    CH954182    EDV54129.1    GDQN01006662    JAT84392.1    CM000364    EDX13945.1    CH480815    EDW43207.1    NWSH01005494    PCG64160.1    KPI98123.1    CH933806    EDW14472.1    KRG01026.1    CM000160    EDW98020.1    AE014297    AY061182    AAF56018.1    AAL28730.1    CH902617    EDV44190.1    KPU80676.1    BT089006    ACT88147.1    UFQT01000742    SSX26877.1    GBXI01008419    GBXI01006261    JAD05873.1    JAD08031.1    CP012526    ALC45632.1    ODYU01011454    SOQ57196.1    CH940650    EDW67475.1    KRF83305.1    GAMC01021294    GAMC01021292    JAB85261.1    JXJN01022417    GEZM01052596    JAV74396.1    NWSH01004932    PCG64575.1    JH818916    EKC39214.1    CH964272    EDW85037.1    UFQT01000651    SSX26132.1    CM000070    EAL26992.1    CH479186    EDW38920.1    OUUW01000005    SPP80765.1    KPJ15883.1    UFQS01000651    SSX05774.1    SSX26133.1    SPP80764.1    ODYU01003837    SOQ43090.1    NWSH01003488    PCG66199.1    DS235019    EEB10552.1    AEMK02000001    GBGD01002495    JAC86394.1    ACPB03001018    UFQS01000742    SSX06530.1    SSX26879.1    ATLV01014624    KE524975    KFB39274.1    GAKP01004356    JAC54596.1    GAKP01004357    JAC54595.1    AXCN02000640    KF964010    AIG21331.1    GDHF01008780    JAI43534.1    JRES01000413    KNC31471.1    UFQS01000065    UFQT01000065    SSW98909.1    SSX19295.1    CCAG010007298    CCAG010007299    GBBI01003435    JAC15277.1    ODYU01012850    SOQ59355.1    KPI98128.1    BABH01030565    BABH01030566    ADTU01021114    ADTU01021115    AFYH01242903    AFYH01242904    AFYH01242905    AFYH01242906    AFYH01242907    AFYH01242908    AFYH01242909    AFYH01242910    AFYH01242911    DS235435    EEB15720.1    KQ434856    KZC08758.1    BABH01030564    ADMH02002132    ETN58472.1    BABH01030562    KQ976475    KYM83922.1    AAQR03130013    AAQR03130014    AJVK01012348    AJVK01012349    ODYU01008314    SOQ51794.1    KK854897    PTY19585.1    AEFK01168560    AEFK01168561    AEFK01168562    SSX19298.1    PCG64161.1    GAIX01000552    JAA92008.1    FR904503    CDQ65367.1    BABH01030569    ADTU01024445    ADTU01024446    ADTU01024447    ADTU01024448    ADTU01024449    ADTU01024450    ADTU01024451    ADTU01024452    KK516525    KFP64935.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000095301    UP000001070    + More
UP000095300    UP000192223    UP000008711    UP000000304    UP000001292    UP000009192    UP000002282    UP000000803    UP000007801    UP000092553    UP000008792    UP000078200    UP000092445    UP000092443    UP000092460    UP000005408    UP000007798    UP000001819    UP000192221    UP000008744    UP000091820    UP000268350    UP000009046    UP000008227    UP000015103    UP000030765    UP000075886    UP000037069    UP000092444    UP000069272    UP000005204    UP000005205    UP000008672    UP000076502    UP000000673    UP000078540    UP000005225    UP000092462    UP000075880    UP000007648    UP000087266    UP000193380   

PRIDE

Q9VCY7    C6SV14    F1RQL1    I3LVJ0    H9JN16    H9JN18    + More
H9JN19    H9JN15   

Pfam

PF01151   ELO

Interpro

IPR002076   ELO_fam        + More
IPR030457   ELO_CS       
IPR033678   ELOVL4       

ProteinModelPortal

A0A2H1VZH1   A0A2A4JNZ7   A0A2A4IT40   A0A212EWG2   A0A194Q3Y4   A0A194RIW9   + More
A0A194RE66   A0A194PZF1   A0A212EWL1   A0A194PXS2   A0A2H1X1Z6   A0A194REJ3   T1PEI5   A0A1E1WEQ6   B4JF47   A0A1I8NVN9   A0A1W4X4I5   B3P8N4   A0A1E1WBM7   A0A1W4WV07   B4R0M2   B4HEP6   A0A2A4IYB4   A0A194PYL9   B4K959   B4PMB5   Q9VCY7   B3M000   C6SV14   A0A336MEX6   A0A0A1XAS6   A0A0M4F374   A0A2H1WW52   B4M164   A0A1A9V750   A0A1A9Z486   W8AWR6   A0A1A9XJ22   A0A1B0BXZ2   A0A1Y1LS48   A0A2A4IXM4   K1R6N6   B4NJS5   A0A336M748   Q29BK4   A0A1W4VR29   B4GP37   A0A1A9W5Z6   A0A3B0JF55   A0A194RDG5   A0A336KLJ3   A0A3B0JEF4   A0A2H1VQJ9   A0A2A4J2V1   A0A1W4WV09   E0VAZ6   F1RQL1   A0A069DYC2   T1HHY5   A0A336L063   A0A084VMT0   A0A034WG82   A0A287A8V2   A0A034WKC9   A0A182Q5E2   A0A075QRX8   A0A0K8VXE8   A0A0L0CGV6   I3LVJ0   A0A336K2J4   A0A1B0FQK1   A0A023F182   A0A182F0V8   A0A2H1X1Z5   A0A194PYM4   H9JN16   A0A158NN74   H3A2B9   E0VQR5   A0A154PBW3   A0A1I8NHJ7   H9JN18   W5J2I2   A0A1W2W9A1   H9JN19   A0A151I3K9   H0X3V6   A0A1B0D768   A0A2H1WH44   A0A2R7WMF5   A0A182IU15   G3WRL1   A0A336M016   A0A1S3MP43   A0A2A4IWR2   S4PNY7   A0A060WDY9   H9JN15   A0A158NS34   A0A091MTW9  

KEGG

101743614    K10249 elongation of very long chain fatty acids protein 4 [EC:2.3.1.199] | (RefSeq) elongation of v

PATHWAY

00062    Fatty acid elongation - Bombyx mori (domestic silkworm)
01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0102338   GO:0016021   GO:0102756   GO:0102337   GO:0006633   GO:0102336   GO:0007110   GO:0007112   GO:0042761   GO:0051225   GO:0009922   GO:0000212   GO:0030497   GO:0042811   GO:0000915   GO:0007111   GO:0034626   GO:0030148   GO:0019367   GO:0030176   GO:0034625   GO:0006636   GO:0035338   GO:0006508   GO:0007017   GO:0005200   GO:0005525   GO:0031386   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

PANTHER

PTHR11157  

Subcellular location

Endoplasmic reticulum membrane  

Length:

227

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

82.76128

Exp number, first 60 AAs:

22.40638

Total prob of N-in:

0.83110

POSSIBLE N-term signal

sequence

inside

1  -  12

TMhelix

13  -  35

outside

36  -  83

TMhelix

84  -  103

inside

104  -  109

TMhelix

110  -  132

outside

133  -  175

TMhelix

176  -  198

inside

199  -  227

 

 

Pi

182.676473

Theta

172.920545

Tajima's D

-0.545287

CLR

129.557249

CSRT

0.235438228088596

Interpretation

Uncertain