Gene

KWMTBOMO13334  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010951

Annotation

PREDICTED:_exocyst_complex_component_4_[Bombyx_mori]

Location

Bomo_Chr22(-):13929303-13943551      View in EpiBrowser

Full name

Exocyst complex component 4      

Alternative Name

Exocyst complex component Sec8

Location in the cell

Mitochondrial   Reliability : 1.872

CDS

ATGTCCTCTCCTCCACCAACGAAACCACCCCGTGGGGTTAAGCAAGGAAAAGAAACGAGTGGCCTGCTAATGTCGGTGATCAGAACACTGTCAGCGAGTGAGACCAATGAACAACGTGAAAAGGAACGCGCTAAACTTGAGAAAGAGTACAAGAAGAGCGATGCAAGGCTGGATGAGCTAGTTGCTGTTCATGCACAGGAGATTACGGATGTTATGCAAAAATTCACAGCTGTGGGTACAGCCTTATCAGTATGGGGACAGCATTGTGAGGCAGCAGTGGCTCGTCTGGGCGCATGCCGAGGTTTGTTACGATTAAGACGTGATGACCTAAGAAGATTGTGGGCGGATGCAAGAACCCATCACTATGCACTACAGATGTTAACTGATATAGAACGTGTAGTAGTTTCGGAACGTGAAACTCGCGAATCGTTATCAGCTGGTCGTGTACTAGCTGCAGCTTATACATTGAAAGCTGCCCTAGATACAGCAGACACTACACTGTCCCATGTTGATGCATTAAACACCACAAGGCAGCATTTGCAGGCAAAAAAACGTGAACTGGTAGATGTCATTGTTCGTCGAGTGAATGATGCTGTCTATCGTGGCGAAACAGCACCAATGACGAGAAGACTATCTGCTAGAAGGCGTACAGCAATCCTGTTGGCCGAACTGACAAAGAATGAAGAAGTGACTGATGCTTATCTACAAGATATCACCCCTGAGTACGAAGCGTCACTTTCTGAAGATGACAAAACATTCGAGAGTACTGTTATGATATCACTAGAAGCCTTAGGAGTATTGGAACAACTGAAGGAAGCTACTGAGAAATTCAAGGTGCAAATTCAAAATGAATTATTAGAGGTCATCGATTCGGTCTCTCGCCGAATCATCGATGAAGGCGATGTAGAAATTGACCAGGAGTGTGACGAGGATGGCGAGACACAAGAAGCCGAGGGAGTGACAGAGGCCGGGAGACCACTCGCCAGACTGGTCGCTAGTCTGGGAGAAGAGCTTAGGGCGTGCGCTGCAAGAAATAAGAGGCTTTTGCAGTTATGGCGAGGTGCCTTACAGAAACATCGACTGTCTGATGCAACTCTGCACACAGAACAACACTACTGGAGTGCCGTACAACAAGTTCTTCAACTTCTGCTGACTGAATACTTGGAGATAGAGAGCGTGAACTTAGCAGCTCAGCGCTCTGGCACTACCACAGTAGAAGCGGCCGGTTCCCAACTACGTCTGACCGACTACTTCTCCAAGAAACGACCTCAGAGGCAACACACCAAACTCTTCAGATTTACAGGCCCTACCGCAGTGACGCCCAGTCTGCAGGCTCGCCGGCACGGGTACCCGCTGGTGTGCCGCGCCGACCCGGCTCATCTGCACGCGGTGTTGCCAGCTCTGCACGCCTTGTGTGCCGACATCGAACCTCTTACAGGTGGCGGCGAATGTTCGTTACGTGCGTTTATAACGGACTACGTGCGCACAGGCGAAAGCGAGAGACTGGCTAGTATCGCGCGCGCCGCTATTGACGAGGCCATGAGATCTCCGTCCGCTTGGAGAGAAAGAGTTCCACCACCCGCTACCAACGCTAAATCTGGGGAGCGTCACCGCGTCGTGTTCGCGTGCTGCGCGTACAGCTGGCAGGCGGTGCACGGCGCGATGCGGCACGCGCGTCGCTGCGGCGCGAGCGGCGGCACGGAGGCGGCGCGCGCGGTGGCGGGTACATTGACCCCGCTGGCGACACAGTGCCGCGCGTGCCCGCACGCCGCGCCGCCCGCCGCCGCGCGCGCCGCCCGCTGGCTCGCCGACGACGACATCGTGCGGTTCCTGCAGTCGCTGCACAACTGGAAGGCGATGACCGGCGACGTGCCCGAAACCAAACAGAGCGCTCAGGAACTGAAACAGGCCTACGAACGGGAAGCCGAGATCTTGGGTTCGAGTTTGGGCGACGGCGCCGTTACACGCAAAGAAATCATATCGGACATGAATACGCTCGCCGACATAGCCGTCCTGTGCGAGACAATGGATTGGCTAAGTGCAAATATAAGAAGCATTCCCTCAATGTTATCCGGTGCAATAAAGCTCTCCGAGAAATTCCTGAACGACATATCTGCTGCAGCGTCTGTATTCGATGAGATAACACATAAATGCTTGCTTTTCTTGCATTTGGAGATGCGCATAGAGTGCTTTCATTATTTGGGTCAAGAGGATCGCGAAGGTGAAAACGGCTCCGAAGCGGACAGCCAACAGTCCGGAGGAGCAGCGCAGCTGGCCCACGCGCTGCTGGCCTTCCACGAACACGCGTCGGCTGTACTGGCGCCCTCTAGGCTCGCTTATATATTCAACGGTATAGGCGAGATGATGTCGGCCGCGGTAGTGTGGAGGTGGCAGGGGGAGCGCGGGGCGGAGGGCGGGGCGGCGGCTCGACTCGCGACACTGCGCCACTGTCTCGCTGCGCTACATCTACCTCACGATGGCTTACATAGAGCGCACGCGTACTTACATCTGTTAGCGTGTACTCCGCAGGAAATAATAACGTCAGTACGCGAAAAGGGTGCTCAATTCACGGAGTTGGAGTATTTGAACGCTTTCAAGGTTATCGGCGTTCGGCGTAACGTGTCCTCGGGCGACATGAAAATACATCTAAAACAACTATCGACCGCTCTGGGTCACGTCGGTGTTACCGTGTGA

Protein

MSSPPPTKPPRGVKQGKETSGLLMSVIRTLSASETNEQREKERAKLEKEYKKSDARLDELVAVHAQEITDVMQKFTAVGTALSVWGQHCEAAVARLGACRGLLRLRRDDLRRLWADARTHHYALQMLTDIERVVVSERETRESLSAGRVLAAAYTLKAALDTADTTLSHVDALNTTRQHLQAKKRELVDVIVRRVNDAVYRGETAPMTRRLSARRRTAILLAELTKNEEVTDAYLQDITPEYEASLSEDDKTFESTVMISLEALGVLEQLKEATEKFKVQIQNELLEVIDSVSRRIIDEGDVEIDQECDEDGETQEAEGVTEAGRPLARLVASLGEELRACAARNKRLLQLWRGALQKHRLSDATLHTEQHYWSAVQQVLQLLLTEYLEIESVNLAAQRSGTTTVEAAGSQLRLTDYFSKKRPQRQHTKLFRFTGPTAVTPSLQARRHGYPLVCRADPAHLHAVLPALHALCADIEPLTGGGECSLRAFITDYVRTGESERLASIARAAIDEAMRSPSAWRERVPPPATNAKSGERHRVVFACCAYSWQAVHGAMRHARRCGASGGTEAARAVAGTLTPLATQCRACPHAAPPAAARAARWLADDDIVRFLQSLHNWKAMTGDVPETKQSAQELKQAYEREAEILGSSLGDGAVTRKEIISDMNTLADIAVLCETMDWLSANIRSIPSMLSGAIKLSEKFLNDISAAASVFDEITHKCLLFLHLEMRIECFHYLGQEDREGENGSEADSQQSGGAAQLAHALLAFHEHASAVLAPSRLAYIFNGIGEMMSAAVVWRWQGERGAEGGAAARLATLRHCLAALHLPHDGLHRAHAYLHLLACTPQEIITSVREKGAQFTELEYLNAFKVIGVRRNVSSGDMKIHLKQLSTALGHVGVTV

Description

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Involved in regulation of synaptic microtubule formation, and also regulation of synaptic growth and glutamate receptor trafficking. Does not appear to be required for basal neurotransmission.

Subunit

The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, exo70/Exoc7 and Exo84/Exoc8.
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP. Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity).
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP. Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity).

Similarity

Belongs to the SEC8 family.

Keywords

Coiled coil   Complete proteome   Exocytosis   Phosphoprotein   Protein transport   Reference proteome   Transport   Acetylation   Cell projection  

Feature

chain  Exocyst complex component 4

Uniprot

A0A2A4JLQ5   A0A2H1VE64   A0A3S2LH57   A0A1Y1MN89   A0A2J7RD24   A0A2R7W5Z1   + More
E0VYL8   A0A1S4FCS9   A0A0A1WKB7   A0A034VXR8   N6UTL6   W8C7F2   A0A0A9WJT2   Q177C5   A0A0M5J293   N6UM97   A0A0P8XZU2   A0A0P8YNW5   A0A0P9CB80   A0A0P9ASV3   A0A0P8Y106   A0A0P9A174   U3PXA7   Q9VNH6   B4QXJ5   A0A0R1E4E3   A0A0R1E437   B4PUX9   A0A0R1E4M2   B0W348   B4I471   B4G494   B3P2J6   B4LYP8   A0A0Q9WPT0   A0A0Q9WEQ2   A0A0Q9WQM2   A0A0Q9WM61   B4JGG6   A0A0Q9WR03   A0A3B0KBU3   A0A182PSL1   A0A1Q3F4T8   A0A1Q3F4V2   A0A3B0JLP9   A0A0R3NHL8   A0A0R3NHU1   A0A0R3NHK5   A0A0R3NHP2   A0A0R3NHX4   A0A0R3NHJ2   A0A0R3NN99   Q297L0   A0A1W4UWY8   A0A1W4UWN3   A0A1W4UYC1   A0A1W4UJ65   A0A1W4UWY3   A0A182GVJ4   A0A1A9US47   A0A1B6JSP4   A0A1I8MP57   A0A1B0C0Z3   A0A0C9R726   A0A224XIS8   A0A1B6EHB1   B4NJI7   A0A1I8Q9N4   J9JN16   A0A1A9X8H5   A0A023F027   D6X531   A0A0T6BEF7   A0A1B6M4H7   A0A1L8GZQ8   Q52KN6   G1MEJ2   A0A2Y9T8J7   A0A341AT54   A0A383ZQ17   G3T7D1   M3X5B6   M0RBF8   A0A2K5EGU0   A0A2K6U1P2   Q62824   U3F757   Q69ZD1   O35382  

Pubmed

28004739    20566863    17510324    25830018    25348373    23537049    + More
24495485    25401762    26823975    17994087    18057021    16351720    10731132    12537572    12537569    18327897    17550304    15632085    23185243    26483478    25315136    25474469    18362917    19820115    27762356    20010809    17975172    15057822    22673903    7568183    17827149    21658605    25243066    15368895    9441674    15489334    21183079   

EMBL

NWSH01001154    PCG72340.1    ODYU01001879    SOQ38702.1    RSAL01000125    RVE46593.1    + More
GEZM01026226    JAV87132.1    NEVH01005303    PNF38735.1    KK854366    PTY15102.1    DS235845    EEB18474.1    GBXI01014788    JAC99503.1    GAKP01010841    JAC48111.1    APGK01016463    KB739858    ENN82092.1    GAMC01000587    JAC05969.1    GBHO01036831    GBHO01036828    GDHC01004978    JAG06773.1    JAG06776.1    JAQ13651.1    CH477378    EAT42267.1    CP012526    ALC46761.1    APGK01017822    KB740053    KB632360    ENN81811.1    ERL93516.1    CH902617    KPU80453.1    KPU80454.1    KPU80455.1    KPU80450.1    KPU80451.1    KPU80452.1    KPU80456.1    BT150369    AGW52179.1    AY905551    AE014297    AY119660    CM000364    EDX11781.1    CM000160    KRK03961.1    KRK03964.1    EDW97786.2    KRK03962.1    KRK03965.1    KRK03967.1    DS231830    EDS30756.1    CH480821    EDW55014.1    CH479179    EDW25132.1    CH954181    EDV47946.1    CH940650    EDW66975.2    KRF83039.1    KRF83032.1    KRF83038.1    KRF83031.1    KRF83033.1    KRF83034.1    CH916369    EDV93663.1    KRF83035.1    OUUW01000007    SPP83156.1    GFDL01012475    JAV22570.1    GFDL01012453    JAV22592.1    SPP83155.1    CM000070    KRT00545.1    KRT00548.1    KRT00553.1    KRT00551.1    KRT00555.1    KRT00546.1    KRT00544.1    KRT00547.1    EAL28195.2    JXUM01019055    JXUM01019056    KQ560531    KXJ81967.1    GECU01005497    JAT02210.1    JXJN01023829    GBYB01002566    JAG72333.1    GFTR01007934    JAW08492.1    GEDC01000034    JAS37264.1    CH964272    EDW83911.1    ABLF02040311    GBBI01004321    JAC14391.1    KQ971382    EEZ97195.1    LJIG01001216    KRT85724.1    GEBQ01009146    JAT30831.1    CM004470    OCT89261.1    BC094262    AAH94262.1    ACTA01107034    ACTA01115034    ACTA01123034    ACTA01131034    ACTA01139034    ACTA01147033    ACTA01155032    ACTA01163031    ACTA01171029    ACTA01179027    AANG04000096    AABR07060165    AABR07060166    AABR07060167    AABR07060168    AABR07060169    AABR07060170    AABR07060171    AABR07060172    AABR07060173    AABR07060174    U32498    GAMT01006800    GAMS01007446    GAMR01008084    GAMQ01007070    GAMP01000616    JAB05061.1    JAB15690.1    JAB25848.1    JAB34781.1    JAB52139.1    AK173235    BAD32513.1    AF022962    BC034644   

Proteomes

UP000218220    UP000283053    UP000235965    UP000009046    UP000019118    UP000008820    + More
UP000092553    UP000030742    UP000007801    UP000000803    UP000000304    UP000002282    UP000002320    UP000001292    UP000008744    UP000008711    UP000008792    UP000001070    UP000268350    UP000075885    UP000001819    UP000192221    UP000069940    UP000249989    UP000078200    UP000095301    UP000092460    UP000007798    UP000095300    UP000007819    UP000092443    UP000007266    UP000186698    UP000008912    UP000248484    UP000252040    UP000261681    UP000007646    UP000011712    UP000002494    UP000233020    UP000233220    UP000008225    UP000000589   

PRIDE

U3PXA7    Q9VNH6    M0RBF8    Q62824    Q69ZD1    O35382    + More

Pfam

PF04048   Sec8_exocyst        + More
PF03096   Ndr
PF02828   L27

Interpro

IPR039682   Sec8/EXOC4        + More
IPR007191   Sec8_exocyst       
IPR029058   AB_hydrolase       
IPR004142   NDRG       
IPR014775   L27_C       

SUPFAM

SSF53474   SSF53474       

Gene 3D

3.40.50.1820    

ProteinModelPortal

A0A2A4JLQ5   A0A2H1VE64   A0A3S2LH57   A0A1Y1MN89   A0A2J7RD24   A0A2R7W5Z1   + More
E0VYL8   A0A1S4FCS9   A0A0A1WKB7   A0A034VXR8   N6UTL6   W8C7F2   A0A0A9WJT2   Q177C5   A0A0M5J293   N6UM97   A0A0P8XZU2   A0A0P8YNW5   A0A0P9CB80   A0A0P9ASV3   A0A0P8Y106   A0A0P9A174   U3PXA7   Q9VNH6   B4QXJ5   A0A0R1E4E3   A0A0R1E437   B4PUX9   A0A0R1E4M2   B0W348   B4I471   B4G494   B3P2J6   B4LYP8   A0A0Q9WPT0   A0A0Q9WEQ2   A0A0Q9WQM2   A0A0Q9WM61   B4JGG6   A0A0Q9WR03   A0A3B0KBU3   A0A182PSL1   A0A1Q3F4T8   A0A1Q3F4V2   A0A3B0JLP9   A0A0R3NHL8   A0A0R3NHU1   A0A0R3NHK5   A0A0R3NHP2   A0A0R3NHX4   A0A0R3NHJ2   A0A0R3NN99   Q297L0   A0A1W4UWY8   A0A1W4UWN3   A0A1W4UYC1   A0A1W4UJ65   A0A1W4UWY3   A0A182GVJ4   A0A1A9US47   A0A1B6JSP4   A0A1I8MP57   A0A1B0C0Z3   A0A0C9R726   A0A224XIS8   A0A1B6EHB1   B4NJI7   A0A1I8Q9N4   J9JN16   A0A1A9X8H5   A0A023F027   D6X531   A0A0T6BEF7   A0A1B6M4H7   A0A1L8GZQ8   Q52KN6   G1MEJ2   A0A2Y9T8J7   A0A341AT54   A0A383ZQ17   G3T7D1   M3X5B6   M0RBF8   A0A2K5EGU0   A0A2K6U1P2   Q62824   U3F757   Q69ZD1   O35382  

KEGG

101739257    K06111 exocyst complex component 4 | (RefSeq) exocyst complex component 4

GO

GO:0000145   GO:0090522   GO:0006904   GO:0016028   GO:0000212   GO:0009925   GO:0007009   GO:0007298   GO:0016324   GO:0007286   GO:0007110   GO:0007111   GO:0045887   GO:0000916   GO:0007269   GO:0016080   GO:0050803   GO:0016192   GO:0005737   GO:0016081   GO:0098793   GO:0016020   GO:0015031   GO:0005886   GO:0016021   GO:0032584   GO:0006612   GO:0045202   GO:0007268   GO:0006887   GO:0006893   GO:0047485   GO:0017160   GO:0035748   GO:0048341   GO:0030165   GO:0005902   GO:0044091   GO:0050850   GO:0043025   GO:0032991   GO:0031252   GO:0043209   GO:0006903   GO:0090543   GO:0030426   GO:0048709   GO:0030010   GO:0043005   GO:0055108   GO:0043198   GO:0051223   GO:0014069   GO:0008021   GO:0044877  

PANTHER

PTHR14146  

Subcellular location

Midbody   Colocalizes with CNTRL/centriolin at the midbody ring (By similarity). Localizes at the leading edge of migrating cells (PubMed:21658605).   With evidence from 3 publications.
Midbody ring   Colocalizes with CNTRL/centriolin at the midbody ring (By similarity). Localizes at the leading edge of migrating cells (PubMed:21658605).   With evidence from 3 publications.
Cell projection   Colocalizes with CNTRL/centriolin at the midbody ring (By similarity). Localizes at the leading edge of migrating cells (PubMed:21658605).   With evidence from 3 publications.

Length:

897

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00005

outside

1  -  897

 

 

Pi

296.445444

Theta

172.42627

Tajima's D

2.163553

CLR

0.359698

CSRT

0.908204589770511

Interpretation

Uncertain