Gene

KWMTBOMO13329  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004681

Annotation

alpha-tubulin_[Bombyx_mori]

Location

Bomo_Chr22(+):13854912-13862386      View in EpiBrowser

Full name

Tubulin alpha chain      

Alternative Name

Alpha-tubulin
Alpha T6

Location in the cell

Cytoplasmic   Reliability : 2.496

CDS

ATGAGGGAGTGCATATCCGTACACGTGGGCCAAGCCGGGGTCCAGATGGGCGTCGCGTGCTGGCAGCTATACTGCTTGGAGCACGGGATCCGACCTGACGGAACCCTGCCCGCTTGTGAAACTGATCCTAATACAGCGGATTCCTGCTTCAATACGTTTTTTTCTGAGGCTGATCGAGGGAAGATGGTGCCGAGGGTCGTGATGGTTGATTTAGAGGCTACTGTTATAGACGAAGTTCGTTCCGGTGAATACCGCCAACTGTATCACCCTGAACAGTTGATAACTGGTAAAGAAGACGCGGCGAATAACTACGCGAGAGGGCACTATTCGACCGGACGCGAGGTTCTCAGTCCGGTTATGGAGCGAATTAGGAAACTTGCCGATCAATGTACCGGACTACAGGGTTTCTTCGTGTTTCATTCGTTTGGAGGTGGCACAGGATCTGGATTCACATCGCTACTGATGGAGAAGCTATCTGACGAGTTTGGAAAGAAGAGTAAACTGGAATTTGCCATATATCCTGCGCCACAAGTGTCAACTGCGGTAGTGGAGCCATACAACGCGGTGCTAACTACGCACGCGACCATCAGTCATTCGGATTGCGCCTTCATGGTGGACAATGAAGCTATCTACGACATTTGCAGGCGAAGGCTGTCTATAGAGAGACCTTCTTATGCAAATTTGAATAGGCTTATCTCACAAGTAGTTTCGTCTATAACGGCTTCACTACGATTCGATGGCGCCCTAAATGTGGATTTGACGGAATTCCAAACGAATCTCGTTCCCTACCCAAGGATACATTTTCCACTAGCCGCGTACGCACCCGTTGTTTCTGCTGATAAGGCGTACCACGAAGGTATGTCTGTGTCGGAGATCACTGCGGAACTGTTCGAGCCCCAGAACCAGATGGTGAAGTGCGATCCTCGAGACGGAAAGTACATGGCGTGCTGCCTGCTGTACAGGGGAGACGTGGTCCCGAAGGACGTGAACGCGGCTATAGCGGCCATGAAGGGCAGGGCCGGAATACGGTTTGTGGATTGGTGTCCTACCGGTTTTAAAGTTGGTATAAACTATCAGCCGCCGTCTGTGGTGACGGGCGGGGATCTGGCCCAAGTGAAGCGGGCCGCCTCTATGCTCAGTAACACCACCGCTATAGCGGAGGCCTGGGGCAAGCTTGACCACAAGTTCGACCTCATGTATTCCAAGCGAGCTTTTGTGCATTGGTATGTAGGCGAAGGGATGGAGGAAGGCGAATTCTCTGAAGCGAGAGAAGATTTGGCAGCTCTGGAACGAGATTACGATGAAGTGGCTATTGAGACGTCAGACATGCAGCCCGGCGCCGATGATGAGTTATGA

Protein

MRECISVHVGQAGVQMGVACWQLYCLEHGIRPDGTLPACETDPNTADSCFNTFFSEADRGKMVPRVVMVDLEATVIDEVRSGEYRQLYHPEQLITGKEDAANNYARGHYSTGREVLSPVMERIRKLADQCTGLQGFFVFHSFGGGTGSGFTSLLMEKLSDEFGKKSKLEFAIYPAPQVSTAVVEPYNAVLTTHATISHSDCAFMVDNEAIYDICRRRLSIERPSYANLNRLISQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLAAYAPVVSADKAYHEGMSVSEITAELFEPQNQMVKCDPRDGKYMACCLLYRGDVVPKDVNAAIAAMKGRAGIRFVDWCPTGFKVGINYQPPSVVTGGDLAQVKRAASMLSNTTAIAEAWGKLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYDEVAIETSDMQPGADDEL

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Similarity

Belongs to the tubulin family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Cytoskeleton   GTP-binding   Isopeptide bond   Microtubule   Nucleotide-binding   Reference proteome   Allergen  

Feature

chain  Tubulin alpha chain

Uniprot

Q8T8B4   A0A2A4JX96   A0A2H1WZY3   A0A3S2NFZ3   H9J591   A0A212EQV5   + More
A0A194REY2   A0A088AEZ4   A0A2A3ECG0   A0A026X3W6   A0A0L7QL05   A0A3L8DJ67   A0A151I9S0   A0A154PGT8   E2BYM3   A0A0J7KVC1   A0A1Y1MUS0   A0A0M8ZUN7   A0A195FGK2   A0A2P8YMG0   E2A2Y4   W6UDI6   A0A195E3R3   A0A1Y1N000   S7Q4Z3   B7ZTG2   Q28IX8   Q9YHW2   A0A2I4D018   A0A3Q3L447   A0A3P8QCW6   V4A2S7   A0A0K8RDS4   V4CNQ5   R7T6Z8   B7QP06   Q8WQ47   A0A3Q3E9D2   A0A3B3ICA2   A0A3P9IA60   A0A3P8QDU8   Q6DD58   W4ZJ54   A0A3B3YZV5   A0A2I4D484   A0A096M087   A0A3Q3F4W5   A0A3B3VZH0   A0A2R5LLI8   A0A1A9YUF9   A0A1A9XMZ8   A0A1B0C2X1   A0A1Z5KXS7   A0A1B0A8T1   A0A069DZ13   A0A1A9W6N7   A0A0R3WDD2   A0A3Q1JWL4   A0A3P8QDI8   H3AGU2   A0A1Y3BTA3   A0A131XVH2   A0A068J741   A0A3S4R6E6   A0A0R3TZZ1   W5MXH5   A0A3B1JFU0   A0A3P9H4L4   H3AGU3   Q52PV9   A0A226EVU5   V4CGI5   A0A131ZV00   A0A1L8HHQ5   G3PCL3   A0A3N0Z1J9   F6U388   A0A068XPQ2   A0A1I8PKP1   A0A0L0CGN0   P36220   A0A1L8H9K3   A0A3Q2PC85   A0A3B3TDV4   G3PCE1   A0A3B3DK83   A0A3B4TNK3   A0A0B8RPP3   A0A3P9DDJ3   J3SDL3   A0A2U9C1Z1   Q8AWD6   H2MPB8   A0A250YI73   L5LYK7   A0A3Q7SMU8   A0A224XCE3   A0A0P4VZJ1   A0A1A9UJX4   R4G8S7  

Pubmed

12459208    19121390    22118469    26354079    24508170    30249741    + More
20798317    28004739    29403074    24013640    9852102    23254933    12740526    17554307    27762356    28528879    26334808    9215903    25329095    16339071    26555130    17495919    26108605    7607545    29240929    29451363    25476704    25186727    23025625    28087693    27129103   

EMBL

AB072306    BAB86851.1    NWSH01000459    PCG76254.1    ODYU01012310    SOQ58562.1    + More
RSAL01000125    RVE46588.1    BABH01039687    AGBW02013197    OWR43883.1    KQ460323    KPJ15855.1    KZ288287    PBC29425.1    KK107019    EZA62783.1    KQ414940    KOC59211.1    QOIP01000007    RLU20474.1    KQ978268    KYM95822.1    KQ434902    KZC11096.1    GL451499    EFN79177.1    LBMM01002880    KMQ94251.1    GEZM01021611    JAV88908.1    KQ435879    KOX69879.1    KQ981606    KYN39523.1    PYGN01000491    PSN45442.1    GL436239    EFN72192.1    APAU02000118    EUB56387.1    KQ979685    KYN19815.1    GEZM01021612    JAV88907.1    KE164532    EPQ18458.1    BC170862    BC171015    AAI70862.1    CR760170    AF082027    AAC97928.1    KB201263    ESO98168.1    GADI01005204    JAA68604.1    KB199905    ESP04035.1    AMQN01014879    KB311390    ELT89394.1    ABJB010009611    ABJB010251127    DS980981    EEC20578.1    AJ428050    BC077769    CM004482    AAH77769.1    OCT63377.1    AAGJ04114327    AYCK01016441    GGLE01006061    MBY10187.1    CCAG010023980    CCAG010023981    JXJN01024715    JXJN01024716    GFJQ02007027    JAV99942.1    GBGD01001440    JAC87449.1    UYRS01018887    VDK40999.1    AFYH01201289    AFYH01201290    AFYH01201291    MUJZ01000105    OTF84219.1    GEFM01005474    JAP70322.1    KJ690265    AIE13824.1    NCKU01001410    NCKU01001402    RWS12163.1    RWS12179.1    UZAE01015393    VDO15853.1    AHAT01034396    AHAT01034397    AY986760    AAX84656.1    LNIX01000002    OXA60971.1    KB200522    ESP01200.1    JXLN01002314    KPM02593.1    CM004468    OCT95640.1    RJVU01017312    ROL52161.1    JRES01000426    KNC31385.1    X71980    CM004469    OCT92773.1    GBSH01002947    JAG66080.1    JU176342    AFJ51865.1    CP026253    AWP10073.1    BC042319    BC165818    AAH42319.1    AAI65818.1    GFFW01001461    JAV43327.1    KB106857    ELK30543.1    GFTR01006330    JAW10096.1    GDKW01000590    JAI56005.1    GAHY01000452    JAA77058.1   

Proteomes

UP000218220    UP000283053    UP000005204    UP000007151    UP000053240    UP000005203    + More
UP000242457    UP000053097    UP000053825    UP000279307    UP000078542    UP000076502    UP000008237    UP000036403    UP000053105    UP000078541    UP000245037    UP000000311    UP000019149    UP000078492    UP000008143    UP000192220    UP000261660    UP000265100    UP000030746    UP000014760    UP000001555    UP000001038    UP000265200    UP000186698    UP000007110    UP000261480    UP000028760    UP000264800    UP000261500    UP000092444    UP000092443    UP000092460    UP000092445    UP000091820    UP000046400    UP000282613    UP000265040    UP000008672    UP000285301    UP000046398    UP000278807    UP000018468    UP000018467    UP000198287    UP000007635    UP000002280    UP000095300    UP000037069    UP000265000    UP000261540    UP000261560    UP000261420    UP000265160    UP000246464    UP000286640    UP000078200   

PRIDE

Q8T8B4    H9J591    Q28IX8    B7QP06    Q8WQ47    P36220    + More

Pfam

PF03953   Tubulin_C        + More
PF00091   Tubulin
PF04696   Pinin_SDK_memA
PF01813   ATP-synt_D
PF07986   TBCC
PF16752   TBCC_N
PF01778   Ribosomal_L28e

Interpro

IPR036525   Tubulin/FtsZ_GTPase_sf        + More
IPR023123   Tubulin_C       
IPR000217   Tubulin       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR003008   Tubulin_FtsZ_GTPase       
IPR008280   Tub_FtsZ_C       
IPR037103   Tubulin/FtsZ_C_sf       
IPR002452   Alpha_tubulin       
IPR017975   Tubulin_CS       
IPR017901   C-CAP_CF_C-like       
IPR006786   Pinin_SDK_MemA       
IPR012945   Tubulin-bd_cofactor_C_dom       
IPR031925   TBCC_N       
IPR016098   CAP/MinC_C       
IPR006599   CARP_motif       
IPR038397   TBCC_N_sf       
IPR002699   V_ATPase_D       
IPR029004   L28e/Mak16       

SUPFAM

SSF55307   SSF55307        + More
SSF52490   SSF52490       

Gene 3D

1.10.287.600     3.30.1330.20     3.40.50.1440     1.20.58.1250     2.160.20.70    

ProteinModelPortal

Q8T8B4   A0A2A4JX96   A0A2H1WZY3   A0A3S2NFZ3   H9J591   A0A212EQV5   + More
A0A194REY2   A0A088AEZ4   A0A2A3ECG0   A0A026X3W6   A0A0L7QL05   A0A3L8DJ67   A0A151I9S0   A0A154PGT8   E2BYM3   A0A0J7KVC1   A0A1Y1MUS0   A0A0M8ZUN7   A0A195FGK2   A0A2P8YMG0   E2A2Y4   W6UDI6   A0A195E3R3   A0A1Y1N000   S7Q4Z3   B7ZTG2   Q28IX8   Q9YHW2   A0A2I4D018   A0A3Q3L447   A0A3P8QCW6   V4A2S7   A0A0K8RDS4   V4CNQ5   R7T6Z8   B7QP06   Q8WQ47   A0A3Q3E9D2   A0A3B3ICA2   A0A3P9IA60   A0A3P8QDU8   Q6DD58   W4ZJ54   A0A3B3YZV5   A0A2I4D484   A0A096M087   A0A3Q3F4W5   A0A3B3VZH0   A0A2R5LLI8   A0A1A9YUF9   A0A1A9XMZ8   A0A1B0C2X1   A0A1Z5KXS7   A0A1B0A8T1   A0A069DZ13   A0A1A9W6N7   A0A0R3WDD2   A0A3Q1JWL4   A0A3P8QDI8   H3AGU2   A0A1Y3BTA3   A0A131XVH2   A0A068J741   A0A3S4R6E6   A0A0R3TZZ1   W5MXH5   A0A3B1JFU0   A0A3P9H4L4   H3AGU3   Q52PV9   A0A226EVU5   V4CGI5   A0A131ZV00   A0A1L8HHQ5   G3PCL3   A0A3N0Z1J9   F6U388   A0A068XPQ2   A0A1I8PKP1   A0A0L0CGN0   P36220   A0A1L8H9K3   A0A3Q2PC85   A0A3B3TDV4   G3PCE1   A0A3B3DK83   A0A3B4TNK3   A0A0B8RPP3   A0A3P9DDJ3   J3SDL3   A0A2U9C1Z1   Q8AWD6   H2MPB8   A0A250YI73   L5LYK7   A0A3Q7SMU8   A0A224XCE3   A0A0P4VZJ1   A0A1A9UJX4   R4G8S7  

PDB

6QTN     E-value=0,     Score=1878

KEGG

692430    K07374 tubulin alpha | (RefSeq) Tua3, bmtua3; alpha-tubulin

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0005200   GO:0005737   GO:0003924   GO:0005525   GO:0005874   GO:0007017   GO:0000902   GO:0042626   GO:0015631   GO:0000226   GO:0000278   GO:0019901   GO:0031386   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

PANTHER

PTHR11588  

Subcellular location

  

Length:

451

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.04265

Exp number, first 60 AAs:

0.09388

Total prob of N-in:

0.09499

outside

1  -  451

 

 

Pi

20.261909

Theta

29.906205

Tajima's D

-0.660757

CLR

0.084663

CSRT

0.203089845507725

Interpretation

Uncertain