Gene

KWMTBOMO13306

Pre Gene Modal

BGIBMGA004700

Annotation

PREDICTED:_dual_specificity_protein_phosphatase_7_[Bombyx_mori]

Location

Bomo_Chr22(-):13234082-13264180      View in EpiBrowser

Full name

Dual specificity protein phosphatase       + More
Dual specificity protein phosphatase Mpk3      

Alternative Name

Drosophila MKP3
Mitogen-activated protein kinase phosphatase 3

Location in the cell

Extracellular   Reliability : 1.229 Nuclear   Reliability : 1.696 PlasmaMembrane   Reliability : 1.045

CDS

ATGCTTAGGCGGTTAGCTGCTGGGAAGATTGAGTTGTCATCAACAGTGCAGTGCAAAGAGTTGAAGGCGAGGATAAACCACTGTCGAACCCGTGGTATATTCGTGTTGTACGGTGATGGACCTCCCAGAGACCCTGACTCTGTCCACGGTATACTCCTCAAGAGGCTGAAGCAAGACAGCGTGCAAGTCGTTTGTCTTGAAGGTGACTTCGATGACTTCCGTCGCGCATACCCCGAATGGTGCAGCGAAGCTGGCGCCCAACATGTACCCCACCTGCCGCTAATGGGATTACGGTCGCTGCGTATTTCGGGTTCGGGTTGCGAGGAGACCCTGTCCTCTGGCTCGTCGTCGGAGTGCGAGGAGGTGCACAGCCACGTCCAGCAGGACTTCCCTATCGAGATCCTGCCGAATCTGTACCTCGGTAACTCCACCAACAGCGAGGATTGCGAAGCTCTCGCCAGGCATAATATTAAGGTGATTATTCTATTCTGTGTGCTTAGTGCGAGTTTCTTAACGTTTTCGATAACGTAA

Protein

MLRRLAAGKIELSSTVQCKELKARINHCRTRGIFVLYGDGPPRDPDSVHGILLKRLKQDSVQVVCLEGDFDDFRRAYPEWCSEAGAQHVPHLPLMGLRSLRISGSGCEETLSSGSSSECEEVHSHVQQDFPIEILPNLYLGNSTNSEDCEALARHNIKVIILFCVLSASFLTFSIT

Description

Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment. Has a specificity for the ERK family. Acts as negative regulator in a variety of developmental processes including cell differentiation and proliferation controlled by the Ras/ERK pathway. Suppresses the photoreceptor cell differentiation and wing vein formation. Required for proper oogenesis and early embryogenesis. Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks. Appears also to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation. Plays a role in the maintenance of epithelial integrity during tracheal development.

Catalytic Activity

H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate

Subunit

Interacts (via N-terminal region) with phosphorylated rl.

Similarity

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Hydrolase   Protein phosphatase   Reference proteome  

Feature

chain  Dual specificity protein phosphatase Mpk3
splice variant  In isoform A.

Uniprot

A0A0L7LQ89   S4P960   A0A2W1BE91   A0A212F0I3   A0A3S2LAE9   A0A067R934   + More
A0A1B6L609   A0A1B6I4H5   A0A1B6F2Q1   A0A023F2P3   A0A1B6BWD5   E0VAX6   T1I5F2   A0A1B0CKU5   A0A1L8E2X3   D6WZI5   A0A026W176   V5GZC3   A0A1Y1LV60   A0A1Y1LWH0   E2A378   K7IM78   E2C241   A0A0A9YX42   A0A0A9YYM7   F4WRD4   A0A151J325   A0A151I2K5   A0A158NUJ4   A0A195C9C7   A0A087ZSQ5   A0A2A3EGN0   A0A2A3EFU8   A0A151WKA1   A0A1S4G7S1   A0A195FKV8   A0A0L7QSN8   E9IRV1   A0A2M4CM13   A0A1Q3FUD0   Q7PV94   A0A0M4EMY2   T1PAJ6   A0A154PBF2   A0A2M4APE5   A0A2S2Q8S1   A0A0M9A1T5   A0A0K8WK77   A0A2M4AAE0   A0A2H8TPQ7   A0A084WB53   A0A034VQ01   A0A1I8N269   U5EXJ8   A0A0A1WL42   M9PFW0   Q9VVW5   A0A2C9GQA1   B3NDX2   B4IFZ3   B4KZ97   M9PG13   W8ADW6   B4LD28   B4PH00   B4QQC5   A0A1B0FBR6   A0A1J1HUD1   B4IY47   A0A0L0C8K9   J9K9N6   A0A1S3IT30   B3M7P3   A0A336M0Y7   A0A1W4UP65   A0A1I8QBA9   B4H6S8   Q29DI8   A0A087UFB5   A0A3B0JM89   B4N4R1   A0A3B0JS64   A0A0P4W116   T1GQ64   A0A2L2YBF8   A0A2T7NUM3   T1JDA7   A0A0B6ZWL2   A0A2C9JCT1   R7TQ03  

EC Number

3.1.3.16
3.1.3.48

Pubmed

26227816    23622113    28756777    22118469    24845553    25474469    + More
20566863    18362917    19820115    24508170    30249741    28004739    20798317    20075255    25401762    26823975    21719571    21347285    17510324    21282665    12364791    24438588    25348373    25315136    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    11742539    12537569    15033693    12810595    14701731    15704110    16831830    17994087    24495485    17550304    26108605    15632085    26561354    15562597    23254933   

EMBL

JTDY01000398    KOB77366.1    GAIX01005661    JAA86899.1    KZ150103    PZC73472.1    + More
AGBW02011073    OWR47268.1    RSAL01000068    RVE49293.1    KK852616    KDR20183.1    GEBQ01020828    JAT19149.1    GECU01025870    JAS81836.1    GECZ01025304    JAS44465.1    GBBI01003316    JAC15396.1    GEDC01031696    JAS05602.1    DS235019    EEB10532.1    ACPB03011499    ACPB03011500    AJWK01016641    AJWK01016642    AJWK01016643    AJWK01016644    AJWK01016645    AJWK01016646    AJWK01016647    AJWK01016648    AJWK01016649    GFDF01000991    JAV13093.1    KQ971372    EFA10433.2    KK107496    QOIP01000004    EZA49817.1    RLU24209.1    GALX01002623    JAB65843.1    GEZM01046135    GEZM01046134    JAV77492.1    GEZM01046136    JAV77491.1    GL436311    EFN72106.1    GL452067    EFN77992.1    GBHO01007407    GBHO01007403    GDHC01012020    JAG36197.1    JAG36201.1    JAQ06609.1    GBHO01007408    GBHO01007406    GBRD01014408    GDHC01017980    GDHC01015251    JAG36196.1    JAG36198.1    JAG51418.1    JAQ00649.1    JAQ03378.1    GL888285    EGI63205.1    KQ980368    KYN16326.1    KQ976533    KYM81495.1    ADTU01026584    KQ978143    KYM96718.1    KZ288266    PBC30161.1    PBC30162.1    KQ983014    KYQ48240.1    KQ981522    KYN40629.1    KQ414756    KOC61645.1    GL765283    EFZ16686.1    GGFL01001750    MBW65928.1    GFDL01003959    JAV31086.1    AAAB01008986    EAA00236.5    CP012525    ALC45147.1    KA645757    AFP60386.1    KQ434868    KZC09182.1    GGFK01009157    MBW42478.1    GGMS01004926    MBY74129.1    KQ435760    KOX75570.1    GDHF01028712    GDHF01017961    GDHF01016312    GDHF01000850    JAI23602.1    JAI34353.1    JAI36002.1    JAI51464.1    GGFK01004442    MBW37763.1    GFXV01003423    MBW15228.1    ATLV01022313    ATLV01022314    KE525331    KFB47447.1    GAKP01013576    JAC45376.1    GANO01000051    JAB59820.1    GBXI01015057    JAC99234.1    AE014296    AGB94725.1    AY043264    AY060472    BT003536    AAF49192.2    AAF49193.2    AAO39540.1    APCN01003283    APCN01003284    CH954178    EDV52326.2    CH480834    EDW46580.1    CH933809    EDW18923.2    AGB94724.1    GAMC01020218    GAMC01020215    JAB86340.1    CH940647    EDW69909.2    CM000159    EDW95370.2    CM000363    EDX11031.1    CCAG010004107    CVRI01000021    CRK91679.1    CH916366    EDV97590.1    JRES01000760    KNC28567.1    ABLF02027754    ABLF02027755    CH902618    EDV40971.2    UFQT01000391    SSX23892.1    CH479215    EDW33516.1    CH379070    EAL30426.3    KK119571    KFM76054.1    OUUW01000002    SPP76550.1    CH964095    EDW79135.2    SPP76549.1    GDRN01081109    JAI62078.1    CAQQ02189220    IAAA01010301    LAA05496.1    PZQS01000009    PVD24854.1    JH432102    HACG01026074    HACG01026075    CEK72939.1    CEK72940.1    AMQN01011685    KB309028    ELT95734.1   

Proteomes

UP000037510    UP000007151    UP000283053    UP000027135    UP000009046    UP000015103    + More
UP000092461    UP000007266    UP000053097    UP000279307    UP000000311    UP000002358    UP000008237    UP000007755    UP000078492    UP000078540    UP000005205    UP000078542    UP000005203    UP000242457    UP000075809    UP000078541    UP000053825    UP000007062    UP000092553    UP000076502    UP000053105    UP000030765    UP000095301    UP000000803    UP000075840    UP000008711    UP000001292    UP000009192    UP000008792    UP000002282    UP000000304    UP000092444    UP000183832    UP000001070    UP000037069    UP000007819    UP000085678    UP000007801    UP000192221    UP000095300    UP000008744    UP000001819    UP000054359    UP000268350    UP000007798    UP000015102    UP000245119    UP000076420    UP000014760   

PRIDE

Q9VVW5   

Pfam

PF00581   Rhodanese        + More
PF00782   DSPc
PF02949   7tm_6

Interpro

IPR000340   Dual-sp_phosphatase_cat-dom        + More
IPR001763   Rhodanese-like_dom       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR020422   TYR_PHOSPHATASE_DUAL_dom       
IPR000387   TYR_PHOSPHATASE_dom       
IPR036873   Rhodanese-like_dom_sf       
IPR020417   Atypical_DUSP       
IPR008343   MKP       
IPR003595   Tyr_Pase_cat       
IPR004117   7tm6_olfct_rcpt       

SUPFAM

SSF52799   SSF52799        + More
SSF52821   SSF52821       

Gene 3D

3.40.250.10     3.90.190.10    

CDD

cd00127  DSPc

ProteinModelPortal

A0A0L7LQ89   S4P960   A0A2W1BE91   A0A212F0I3   A0A3S2LAE9   A0A067R934   + More
A0A1B6L609   A0A1B6I4H5   A0A1B6F2Q1   A0A023F2P3   A0A1B6BWD5   E0VAX6   T1I5F2   A0A1B0CKU5   A0A1L8E2X3   D6WZI5   A0A026W176   V5GZC3   A0A1Y1LV60   A0A1Y1LWH0   E2A378   K7IM78   E2C241   A0A0A9YX42   A0A0A9YYM7   F4WRD4   A0A151J325   A0A151I2K5   A0A158NUJ4   A0A195C9C7   A0A087ZSQ5   A0A2A3EGN0   A0A2A3EFU8   A0A151WKA1   A0A1S4G7S1   A0A195FKV8   A0A0L7QSN8   E9IRV1   A0A2M4CM13   A0A1Q3FUD0   Q7PV94   A0A0M4EMY2   T1PAJ6   A0A154PBF2   A0A2M4APE5   A0A2S2Q8S1   A0A0M9A1T5   A0A0K8WK77   A0A2M4AAE0   A0A2H8TPQ7   A0A084WB53   A0A034VQ01   A0A1I8N269   U5EXJ8   A0A0A1WL42   M9PFW0   Q9VVW5   A0A2C9GQA1   B3NDX2   B4IFZ3   B4KZ97   M9PG13   W8ADW6   B4LD28   B4PH00   B4QQC5   A0A1B0FBR6   A0A1J1HUD1   B4IY47   A0A0L0C8K9   J9K9N6   A0A1S3IT30   B3M7P3   A0A336M0Y7   A0A1W4UP65   A0A1I8QBA9   B4H6S8   Q29DI8   A0A087UFB5   A0A3B0JM89   B4N4R1   A0A3B0JS64   A0A0P4W116   T1GQ64   A0A2L2YBF8   A0A2T7NUM3   T1JDA7   A0A0B6ZWL2   A0A2C9JCT1   R7TQ03  

PDB

2HXP     E-value=0.00164308,     Score=93

KEGG

101740325    K04459 dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48] | (RefSeq) dual specificity pr

GO

GO:0008138   GO:0017017   GO:0004725   GO:0005737   GO:0005829   GO:0006470   GO:0005549   GO:0016021   GO:0004984   GO:0016301   GO:0035160   GO:0007474   GO:0042059   GO:0043409   GO:0042127   GO:0098609   GO:0016791   GO:0002385   GO:0007428  

Subcellular location

Cytoplasm  

Length:

176

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

9.05561

Exp number, first 60 AAs:

0

Total prob of N-in:

0.49528

outside

1  -  176

 

 

Pi

193.694506

Theta

179.099342

Tajima's D

0.504529

CLR

0.113905

CSRT

0.520173991300435

Interpretation

Uncertain