Gene

KWMTBOMO13305

Pre Gene Modal

BGIBMGA004701

Annotation

Dual_specificity_protein_phosphatase_Mpk3?_partial_[Papilio_machaon]

Location

Bomo_Chr22(-):13230961-13231730      View in EpiBrowser

Full name

Dual specificity protein phosphatase       + More
Dual specificity protein phosphatase Mpk3      

Alternative Name

Drosophila MKP3
Mitogen-activated protein kinase phosphatase 3

Location in the cell

Mitochondrial   Reliability : 2.647

CDS

ATGTCTGCGCGGTGCGGCGTGCTGGTGCACTGCGTGGCGGGCGTGTCCCGCTCCGTGACCGTGACGCTGGCGTACCTCATGCAGCGGCACCGGCTGTCCCTGCGCGACGCCTTCGAGCTGGTCCGCAGCCGCAAGACGGACATCGCGCCCAACTTCCACTTCATGCGGCAGCTGCACTCGTTCGAGCGCGACCTCGGCCTGCACGAGCACAGCGCCAGCTTGAGTAAGGTGCTGCACGAGACGGCGGGCGGCGGGCGCGCGCGCGGGGAGGGGGGCGCCGTGCCCTACGGCGTGTCGCCCGACTCCGGCATCGAGTTCGACCGCTGGAGCGCGCCCCGGGACACCCCGCAATGA

Protein

MSARCGVLVHCVAGVSRSVTVTLAYLMQRHRLSLRDAFELVRSRKTDIAPNFHFMRQLHSFERDLGLHEHSASLSKVLHETAGGGRARGEGGAVPYGVSPDSGIEFDRWSAPRDTPQ

Description

Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment. Has a specificity for the ERK family. Acts as negative regulator in a variety of developmental processes including cell differentiation and proliferation controlled by the Ras/ERK pathway. Suppresses the photoreceptor cell differentiation and wing vein formation. Required for proper oogenesis and early embryogenesis. Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks. Appears also to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation. Plays a role in the maintenance of epithelial integrity during tracheal development.

Catalytic Activity

H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate

Subunit

Interacts (via N-terminal region) with phosphorylated rl.

Similarity

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Hydrolase   Protein phosphatase   Reference proteome  

Feature

chain  Dual specificity protein phosphatase Mpk3
splice variant  In isoform A.

Uniprot

H9J5B1   A0A194R0E1   A0A3S2LAE9   A0A194PXE8   Q7PV94   A0A1Y1LXA8   + More
A0A026W176   A0A1B6BWD5   A0A2R7WUY6   B4IY47   V9IK86   E2A378   A0A1B6FUE7   E0VAX6   A0A195FKV8   B4LD28   A0A151I2K5   A0A158NUJ4   A0A151WKA1   F4WRD4   A0A195C9C7   A0A1B0D9R4   A0A1S3CW78   A0A2A3EGN0   A0A1B6I4H5   A0A087ZSQ5   E2C241   A0A2A3EFU8   A0A1B6F2Q1   T1GQ64   E9IRV1   A0A1Y1LWH0   A0A154PBF2   A0A151J325   A0A0M9A1T5   Q9VVW5-2   B4IU90   A0A0J9RXU4   V5GZC3   A0A1L8E2X3   T1PAJ6   A0A2P8Z4M5   A0A1I8N269   M9PFW0   Q9VVW5   B4IFZ3   M9PG13   A0A0A9YYM7   A0A0L7QSN8   B3NDX2   A0A1B0CKU5   B4PH00   B4QQC5   B4H6S8   A0A226E1L0   D6WZI5   A0A1I8QBA9   K7IM78   A0A2S2PFA5   A0A0L0C8K9   A0A3R7N808   A0A1A9UP83   A0A1A9XK34   A0A1B0ANP2   A0A0P4W8M2   A0A131YID7   A0A023F2P3   T1I5F2  

EC Number

3.1.3.16
3.1.3.48

Pubmed

19121390    26354079    12364791    28004739    24508170    30249741    + More
17994087    20798317    20566863    21347285    21719571    21282665    11742539    10731132    12537572    12537569    15033693    12810595    14701731    15704110    16831830    17550304    22936249    29403074    25315136    12537568    12537573    12537574    16110336    17569856    17569867    25401762    26823975    18362917    19820115    20075255    26108605    26830274    25474469   

EMBL

BABH01037009    BABH01037010    BABH01037011    KQ460883    KPJ11258.1    RSAL01000068    + More
RVE49293.1    KQ459586    KPI98021.1    AAAB01008986    EAA00236.5    GEZM01046139    GEZM01046138    GEZM01046137    GEZM01046133    JAV77488.1    KK107496    QOIP01000004    EZA49817.1    RLU24209.1    GEDC01031696    JAS05602.1    KK855638    PTY23377.1    CH916366    EDV97590.1    JR048647    AEY60719.1    GL436311    EFN72106.1    GECZ01016156    JAS53613.1    DS235019    EEB10532.1    KQ981522    KYN40629.1    CH940647    EDW69909.2    KQ976533    KYM81495.1    ADTU01026584    KQ983014    KYQ48240.1    GL888285    EGI63205.1    KQ978143    KYM96718.1    AJVK01013032    AJVK01013033    KZ288266    PBC30161.1    GECU01025870    JAS81836.1    GL452067    EFN77992.1    PBC30162.1    GECZ01025304    JAS44465.1    CAQQ02189220    GL765283    EFZ16686.1    GEZM01046136    JAV77491.1    KQ434868    KZC09182.1    KQ980368    KYN16326.1    KQ435760    KOX75570.1    AY043264    AE014296    AY060472    BT003536    AAF49192.2    AAF49193.2    AAO39540.1    CH891820    EDW99953.2    CM002912    KMZ00494.1    GALX01002623    JAB65843.1    GFDF01000991    JAV13093.1    KA645757    AFP60386.1    PYGN01000198    PSN51449.1    AGB94725.1    CH480834    EDW46580.1    AGB94724.1    GBHO01007408    GBHO01007406    GBRD01014408    GDHC01017980    GDHC01015251    JAG36196.1    JAG36198.1    JAG51418.1    JAQ00649.1    JAQ03378.1    KQ414756    KOC61645.1    CH954178    EDV52326.2    AJWK01016641    AJWK01016642    AJWK01016643    AJWK01016644    AJWK01016645    AJWK01016646    AJWK01016647    AJWK01016648    AJWK01016649    CM000159    EDW95370.2    CM000363    EDX11031.1    CH479215    EDW33516.1    LNIX01000009    OXA50356.1    KQ971372    EFA10433.2    GGMR01014987    MBY27606.1    JRES01000760    KNC28567.1    QCYY01001200    ROT79703.1    JXJN01000905    GDRN01081117    JAI62074.1    GEDV01010262    JAP78295.1    GBBI01003316    JAC15396.1    ACPB03011499    ACPB03011500   

Proteomes

UP000005204    UP000053240    UP000283053    UP000053268    UP000007062    UP000053097    + More
UP000279307    UP000001070    UP000000311    UP000009046    UP000078541    UP000008792    UP000078540    UP000005205    UP000075809    UP000007755    UP000078542    UP000092462    UP000079169    UP000242457    UP000005203    UP000008237    UP000015102    UP000076502    UP000078492    UP000053105    UP000000803    UP000002282    UP000245037    UP000095301    UP000001292    UP000053825    UP000008711    UP000092461    UP000000304    UP000008744    UP000198287    UP000007266    UP000095300    UP000002358    UP000037069    UP000283509    UP000078200    UP000092443    UP000092460    UP000015103   

PRIDE

H9J5B1    Q9VVW5   

Pfam

PF00782   DSPc        + More
PF00581   Rhodanese
PF02949   7tm_6

Interpro

IPR008343   MKP        + More
IPR029021   Prot-tyrosine_phosphatase-like       
IPR020417   Atypical_DUSP       
IPR020422   TYR_PHOSPHATASE_DUAL_dom       
IPR000340   Dual-sp_phosphatase_cat-dom       
IPR000387   TYR_PHOSPHATASE_dom       
IPR036873   Rhodanese-like_dom_sf       
IPR001763   Rhodanese-like_dom       
IPR003595   Tyr_Pase_cat       
IPR004117   7tm6_olfct_rcpt       

SUPFAM

SSF52799   SSF52799        + More
SSF52821   SSF52821       

Gene 3D

3.90.190.10     3.40.250.10    

CDD

cd00127  DSPc

ProteinModelPortal

H9J5B1   A0A194R0E1   A0A3S2LAE9   A0A194PXE8   Q7PV94   A0A1Y1LXA8   + More
A0A026W176   A0A1B6BWD5   A0A2R7WUY6   B4IY47   V9IK86   E2A378   A0A1B6FUE7   E0VAX6   A0A195FKV8   B4LD28   A0A151I2K5   A0A158NUJ4   A0A151WKA1   F4WRD4   A0A195C9C7   A0A1B0D9R4   A0A1S3CW78   A0A2A3EGN0   A0A1B6I4H5   A0A087ZSQ5   E2C241   A0A2A3EFU8   A0A1B6F2Q1   T1GQ64   E9IRV1   A0A1Y1LWH0   A0A154PBF2   A0A151J325   A0A0M9A1T5   Q9VVW5-2   B4IU90   A0A0J9RXU4   V5GZC3   A0A1L8E2X3   T1PAJ6   A0A2P8Z4M5   A0A1I8N269   M9PFW0   Q9VVW5   B4IFZ3   M9PG13   A0A0A9YYM7   A0A0L7QSN8   B3NDX2   A0A1B0CKU5   B4PH00   B4QQC5   B4H6S8   A0A226E1L0   D6WZI5   A0A1I8QBA9   K7IM78   A0A2S2PFA5   A0A0L0C8K9   A0A3R7N808   A0A1A9UP83   A0A1A9XK34   A0A1B0ANP2   A0A0P4W8M2   A0A131YID7   A0A023F2P3   T1I5F2  

PDB

3LJ8     E-value=2.56596e-20,     Score=236

KEGG

101740325    K04459 dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48] | (RefSeq) dual specificity pr

GO

GO:0017017   GO:0008138   GO:0005737   GO:0005829   GO:0004725   GO:0006470   GO:0007428   GO:0002385   GO:0042059   GO:0043409   GO:0042127   GO:0098609   GO:0016791   GO:0035160   GO:0007474   GO:0016301   GO:0005549   GO:0016021   GO:0004984   GO:0016311   GO:0008270   GO:0051287   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Cytoplasm  

Length:

117

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

11.13614

Exp number, first 60 AAs:

11.13614

Total prob of N-in:

0.55966

POSSIBLE N-term signal

sequence

outside

1  -  117

 

 

Pi

136.667842

Theta

143.917351

Tajima's D

-0.158314

CLR

0

CSRT

0.324233788310584

Interpretation

Uncertain