Gene

KWMTBOMO13294

Pre Gene Modal

BGIBMGA004692

Annotation

sphingomyelin_synthase-related_protein_[Chilo_suppressalis]

Location

Bomo_Chr22(+):12996471-13012416      View in EpiBrowser

Full name

Sphingomyelin synthase-related 1      

Alternative Name

Ceramide phosphoethanolamine synthase

Location in the cell

PlasmaMembrane   Reliability : 4.694

CDS

ATGGAGTCCGATATTCTAAATTGGGGTAACAAAGAAGTGGAAGAATTATTACATAAAGAGAATATTTCCAGTTGTTTAATAGAAATATGTAAAACGCACGATATAGACGGACCGTGCCTGCTATCGTTTGTTGATCGAGATTTCCATACGCATCCTTTCGATCAATTGAAACTTGGTGAAAGAAAAAGATTTATTTTACTCGTGAAGAAACTACAACGACACAATCGCTCCGCTATGATGGAGCTCGGTCTATGTGATGACCTAATAAATCCAGCTACTAACATTAATTTTCTTGGCACTAATTTGTCACATTTAAGTTATGATCTCCACAATAAAATTCCAAATGAATTATCATTTGCTGGGAATACCGAATGTGTATCAAGCTATCCTCCCGCTGACATAAAGGCTTCCAAGTTAAGGCCAGAGGTTTGGAAGACAGCTATAGCTTTGGGTTATGTCTTCCTAGTGACTTGGGTAACTGCAGTTGTGATGGTTATAGTACATGATAAGGTGCCGGACATGAAGAAATACCCTCCCCTGCCAGATTTGTTTTTGGATAATGTACCGCACATTCCATGGGCTTTTGACATGTGCGAGATTACAGGCTCCTTACTTATGGCAATATGGTTGATAGTGCTATTTTTCCATAAACACAGATTCATAATATTAAGGAGATTCTTCGCGCTCGCCGGGACGGTATTCCTGCTGCGTTGCTTCACGATGCTGATCACTTCGCTCTCGGTTCCCGGATCGCATCTCAAGTGCGAACCTCGTTCGTATCCGCCAGCCGACGAGATGACAGTGTGGGGCAGACGACTGGCACAAGCCTATGACATATGGAGCGGAGCCGGCATGTCTGTCAGGGGGGTCAGGACCTGCGGAGACTACATGTTCTCGGGACATACAGTCGCTTTAACGCTGTTGAATTTCTTCATCACTGAATACACATCGCGAAGTCTGTACCTCCTCCACATCCTGACGTGGGTCATGAACATGTTCGGTATATTCTTCATCTTGGCCGCCCACGAGCATTATTCCATCGACGTGTTCATCGCGTTCTACATAACCTCGCGTCTGTTCCTGTATTACCACACGCTGTCGAACAACCAGGCGCTTATGCAGAGCGATTCTTCCAGAACCAGAATATGGTTTCCACTGTTATCGTTCTTCGAGTCCGAAGTGGACGGTATCGTTCCCAATGAATATGAGGGACCGGTGACCATAATGCAGAACTTGAAGCAGTGGTGCGTGCAGATGGTGGCCGACGTCAAAGAGTCCTCTGTGGCCAAGATCGCCGGCTCGAAACTGCAGGAGGGCGCCGCTATGGGGGAGTACTCCGTCGTCAGGATCGTCGACGGCATCAAGAGGAACCTGAGCCTCGTCGAAGAGTTCAAAAACTCCCGGCCGCGACTGGTCACGCTCGACAAGAACATACAGGCTTGTTTACTGGACGAGTGCTCTGACCACGAATTACGTCACAGAAACATTGAACTTCCAAAGGATTCGCTCCGAAAAGAATTCGGCGATCCGCCGTCGCCAATTTTGAAAAAAAGTATATGA

Protein

MESDILNWGNKEVEELLHKENISSCLIEICKTHDIDGPCLLSFVDRDFHTHPFDQLKLGERKRFILLVKKLQRHNRSAMMELGLCDDLINPATNINFLGTNLSHLSYDLHNKIPNELSFAGNTECVSSYPPADIKASKLRPEVWKTAIALGYVFLVTWVTAVVMVIVHDKVPDMKKYPPLPDLFLDNVPHIPWAFDMCEITGSLLMAIWLIVLFFHKHRFIILRRFFALAGTVFLLRCFTMLITSLSVPGSHLKCEPRSYPPADEMTVWGRRLAQAYDIWSGAGMSVRGVRTCGDYMFSGHTVALTLLNFFITEYTSRSLYLLHILTWVMNMFGIFFILAAHEHYSIDVFIAFYITSRLFLYYHTLSNNQALMQSDSSRTRIWFPLLSFFESEVDGIVPNEYEGPVTIMQNLKQWCVQMVADVKESSVAKIAGSKLQEGAAMGEYSVVRIVDGIKRNLSLVEEFKNSRPRLVTLDKNIQACLLDECSDHELRHRNIELPKDSLRKEFGDPPSPILKKSI

Description

Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.

Similarity

Belongs to the sphingomyelin synthase family.

Keywords

Complete proteome   Endoplasmic reticulum   Lipid metabolism   Membrane   Phosphoprotein   Reference proteome   Sphingolipid metabolism   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Sphingomyelin synthase-related 1

Uniprot

H9J5A2   H9T838   A0A1E1WC80   A0A212F0M6   A0A194PZ33   A0A0L7LTF6   + More
A0A194R1Z2   S4P9C6   A0A067R4L6   A0A0C9R8Y1   A0A026WJ92   A0A088ABC0   A0A2A3E0Y2   A0A195EUF5   A0A0L7QW29   A0A195CW92   A0A2J7PEY5   A0A195E5R9   A0A195B0Z3   A0A158NQY4   A0A232EJT6   A0A1W4XKN7   D6WKU2   E2ADP2   A0A154PGP5   E2BR39   K7IVM3   N6TGQ6   A0A1Y1LU78   A0A0M9ABB6   F4WPD0   A0A0T6B540   T1I5E9   A0A1J1I7R3   A0A023F5F8   V5GRA6   U5ERV1   A0A2S2NKG4   A0A182HBX6   A0A1B6KKU3   A0A2H8TM68   A0A2M4CGM3   A0A2M4CGR1   A0A1L4A1S7   A0A1S4EYL4   A0A146LKQ5   A0A2M4CGR9   A0A0A9WX00   A0A182FCM8   A0A2P8Y1E4   A0A084W2S0   A0A182R6S3   A0A2R7WBT5   B4LDW7   A0A151WME3   Q2M141   A0A182Y2Y3   A0A3B0JUY5   B4GUP5   E9ISP2   A0A182JAU6   A0A182VMX3   A0A182QMC4   A0A1L8DYD8   A7UTX5   B3M5R3   B4ML71   B4QKD8   A0A336LH56   B4PK69   Q5TRB3   A0A0J9RRZ0   A0A0A1XHZ0   B3NFE1   A0A1Q3FXE3   A0A1W4UBS9   B4J2H0   B4HV60   Q9VS60   A0A1Q3FWY9   A0A0K8UPK5   B4H0C5   B5DMY1   W8AZR3   A0A1I8PT36   C3YL71   A0A1E1X5U8   A0A1A9Y9Z3   A0A2R5LMT0   A0A1B0G3V7   V4C592   A0A293LG08   A0A131XBD2   A0A3S3PM50   A0A1A9WCW3  

Pubmed

19121390    22118469    26354079    26227816    23622113    24845553    + More
24508170    30249741    21347285    28648823    18362917    19820115    20798317    20075255    23537049    28004739    21719571    25474469    26483478    26823975    25401762    29403074    24438588    17994087    15632085    25244985    21282665    12364791    17550304    22936249    25830018    10731132    12537572    12537569    14685263    18327897    19506037    24495485    18563158    28503490    23254933    28049606   

EMBL

BABH01037029    BABH01037030    BABH01037031    BABH01037032    BABH01037033    JQ664739    + More
RSAL01000018    AFG17058.1    RVE52807.1    GDQN01010406    GDQN01009546    GDQN01006485    JAT80648.1    JAT81508.1    JAT84569.1    AGBW02011073    OWR47254.1    KQ459586    KPI98009.1    JTDY01000159    KOB78526.1    KQ460883    KPJ11270.1    GAIX01005556    JAA87004.1    KK852982    KDR12905.1    GBYB01003251    JAG73018.1    KK107189    QOIP01000003    EZA55731.1    RLU24600.1    KZ288469    PBC25358.1    KQ981965    KYN31885.1    KQ414716    KOC62817.1    KQ977220    KYN04807.1    NEVH01026087    PNF14888.1    KQ979608    KYN20431.1    KQ976691    KYM77962.1    ADTU01023703    NNAY01003955    OXU18588.1    KQ971342    EFA03044.1    GL438820    EFN68404.1    KQ434900    KZC11056.1    GL449898    EFN81845.1    APGK01028388    KB740686    KB631879    ENN79574.1    ERL86906.1    GEZM01046461    JAV77223.1    KQ435692    KOX81037.1    GL888243    EGI64025.1    LJIG01009714    KRT82528.1    ACPB03017243    CVRI01000043    CRK96351.1    GBBI01002333    JAC16379.1    GALX01005673    JAB62793.1    GANO01003554    JAB56317.1    GGMR01005061    MBY17680.1    JXUM01125934    JXUM01125935    JXUM01125936    KQ567004    KXJ69673.1    GEBQ01027908    JAT12069.1    GFXV01003420    MBW15225.1    GGFL01000324    MBW64502.1    GGFL01000325    MBW64503.1    KU182488    API61863.1    GDHC01010081    JAQ08548.1    GGFL01000326    MBW64504.1    GBHO01031331    GBHO01031330    GBRD01003604    JAG12273.1    JAG12274.1    JAG62217.1    PYGN01001050    PSN38078.1    ATLV01019687    ATLV01019688    ATLV01019689    KE525277    KFB44514.1    KK854420    PTY15725.1    CH940647    EDW68990.1    KQ982944    KYQ48971.1    CH379069    EAL30735.1    OUUW01000002    SPP77176.1    CH479191    EDW26328.1    GL765434    EFZ16318.1    AXCN02000923    GFDF01002613    JAV11471.1    AAAB01008960    EDO63750.1    CH902618    EDV40697.1    CH963847    EDW73129.1    CM000363    EDX09561.1    UFQT01000003    SSX17156.1    CM000159    EDW93749.1    EAL39951.3    CM002912    KMY98084.1    GBXI01003313    GBXI01003067    JAD10979.1    JAD11225.1    CH954178    EDV50483.1    GFDL01002923    JAV32122.1    CH916366    EDV97055.1    CH480817    EDW50831.1    AE014296    AY051605    BT003174    AAO24929.1    GFDL01002921    JAV32124.1    GDHF01023876    GDHF01016424    JAI28438.1    JAI35890.1    CH479200    EDW29720.1    CH379064    EDY72788.2    GAMC01014808    JAB91747.1    GG666526    EEN58941.1    GFAC01004563    JAT94625.1    GGLE01006688    MBY10814.1    CCAG010020666    KB201376    ESO96759.1    GFWV01002069    MAA26799.1    GEFH01005186    JAP63395.1    NCKU01001279    NCKU01001276    NCKU01001020    NCKU01001018    RWS12548.1    RWS12559.1    RWS13344.1    RWS13348.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053268    UP000037510    UP000053240    + More
UP000027135    UP000053097    UP000279307    UP000005203    UP000242457    UP000078541    UP000053825    UP000078542    UP000235965    UP000078492    UP000078540    UP000005205    UP000215335    UP000192223    UP000007266    UP000000311    UP000076502    UP000008237    UP000002358    UP000019118    UP000030742    UP000053105    UP000007755    UP000015103    UP000183832    UP000069940    UP000249989    UP000069272    UP000245037    UP000030765    UP000075900    UP000008792    UP000075809    UP000001819    UP000076408    UP000268350    UP000008744    UP000075880    UP000075903    UP000075886    UP000007062    UP000007801    UP000007798    UP000000304    UP000002282    UP000008711    UP000192221    UP000001070    UP000001292    UP000000803    UP000095300    UP000001554    UP000092443    UP000092444    UP000030746    UP000285301    UP000091820   

PRIDE

H9J5A2    Q9VS60   

Pfam

PF14360   PAP2_C        + More
PF00536   SAM_1
PF07647   SAM_2

Interpro

IPR025749   Sphingomyelin_synth-like_dom        + More
IPR013761   SAM/pointed_sf       
IPR001660   SAM       

SUPFAM

SSF47769   SSF47769       

Gene 3D

1.10.150.50    

ProteinModelPortal

H9J5A2   H9T838   A0A1E1WC80   A0A212F0M6   A0A194PZ33   A0A0L7LTF6   + More
A0A194R1Z2   S4P9C6   A0A067R4L6   A0A0C9R8Y1   A0A026WJ92   A0A088ABC0   A0A2A3E0Y2   A0A195EUF5   A0A0L7QW29   A0A195CW92   A0A2J7PEY5   A0A195E5R9   A0A195B0Z3   A0A158NQY4   A0A232EJT6   A0A1W4XKN7   D6WKU2   E2ADP2   A0A154PGP5   E2BR39   K7IVM3   N6TGQ6   A0A1Y1LU78   A0A0M9ABB6   F4WPD0   A0A0T6B540   T1I5E9   A0A1J1I7R3   A0A023F5F8   V5GRA6   U5ERV1   A0A2S2NKG4   A0A182HBX6   A0A1B6KKU3   A0A2H8TM68   A0A2M4CGM3   A0A2M4CGR1   A0A1L4A1S7   A0A1S4EYL4   A0A146LKQ5   A0A2M4CGR9   A0A0A9WX00   A0A182FCM8   A0A2P8Y1E4   A0A084W2S0   A0A182R6S3   A0A2R7WBT5   B4LDW7   A0A151WME3   Q2M141   A0A182Y2Y3   A0A3B0JUY5   B4GUP5   E9ISP2   A0A182JAU6   A0A182VMX3   A0A182QMC4   A0A1L8DYD8   A7UTX5   B3M5R3   B4ML71   B4QKD8   A0A336LH56   B4PK69   Q5TRB3   A0A0J9RRZ0   A0A0A1XHZ0   B3NFE1   A0A1Q3FXE3   A0A1W4UBS9   B4J2H0   B4HV60   Q9VS60   A0A1Q3FWY9   A0A0K8UPK5   B4H0C5   B5DMY1   W8AZR3   A0A1I8PT36   C3YL71   A0A1E1X5U8   A0A1A9Y9Z3   A0A2R5LMT0   A0A1B0G3V7   V4C592   A0A293LG08   A0A131XBD2   A0A3S3PM50   A0A1A9WCW3  

KEGG

101739124    K22697 sphingomyelin synthase-related protein 1 | (RefSeq) sphingomyelin synthase-related 1-like

GO

GO:0016021   GO:0046513   GO:0030173   GO:0030176   GO:0047493   GO:0005887   GO:0030148   GO:0033188   GO:0060305   GO:2000303   GO:0007030   GO:0006686  

Subcellular location

Endoplasmic reticulum membrane  

Length:

519

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

123.73294

Exp number, first 60 AAs:

0

Total prob of N-in:

0.99894

inside

1  -  147

TMhelix

148  -  167

outside

168  -  192

TMhelix

193  -  215

inside

216  -  221

TMhelix

222  -  244

outside

245  -  295

TMhelix

296  -  313

inside

314  -  319

TMhelix

320  -  342

outside

343  -  519

 

 

Pi

221.92306

Theta

158.355152

Tajima's D

1.578934

CLR

0.020047

CSRT

0.803509824508775

Interpretation

Uncertain