Gene

KWMTBOMO13293  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004691

Annotation

parp_[Bombyx_mori]

Location

Bomo_Chr22(+):12968641-12989883      View in EpiBrowser

Full name

Poly [ADP-ribose] polymerase      

Alternative Name

NAD(+) ADP-ribosyltransferase
Poly[ADP-ribose] synthase
Protein ADP-ribosyltransferase
Protein ADP-ribosyltransferase Parp

Location in the cell

Nuclear   Reliability : 2.709

CDS

ATGGCAGACTTGCCATATCAAGTTGAATACGCAAAGACAGGTAGAGCAGCCTGTAAGGGTTGTAAACAAAAAATTGATCAAGGCTCACTGCGCATTGCTGTGATGGTACAGTCAGCTTTCTTTGATGGAAAACAACCAAACTGGCATCATGAAGATTGTTTTTTTAAAAAGCGACGTTTAAACAGTTTCACTGAAATTGCAAACTTCAATGTACTTAAAAATGAAGACCAGAAAAGAATAAAAACTACTATAGAAAACAGTGCTGGTGCTGTTGTAATGCCCATTCAAGAAACCAAAACCAAAGGCAAAGGTAAACGTAACAAGAGAGCCGCCCCAGAATCAGATAACTCTGCGCTGAAGGACTTCAAAGTTGAATATTCAAAAAGCAGTAGGGCCACGTGTCCTGAATGTGAAATTAAAATTTGTAAGGATGAAATTAGAATATGTAAGATTTTATATGATACAGAAGTTGGTATGAAATATGGTGGACAACCAAGATGGCACCACTTGCCTTGTTTCGTTAAATGCAGAAATGAACTTCTGTACTTCGCTGGAGGAGAGAATCTACCAGGATTTGATGATCTTAAGAAAGCAGATCAGATAATTGTGAAAACGGAGATAAAACCATTTGAAAGCCCTGACATTCCAATAAAAAAATTGAAGAACGAAGTAAAAGACGAAAAAGAGTTGAAAGAGGACAAAGCACTTGAAAACAAAATTGAAAAACAAAACAAATTGTTTGATAAACATAGAAATGCTTTAATGAATACAAATAAAAATGATGTAGAAAAAATTTTGGAGTACAATTTACAGGGAATCCCAACAGGAAAGACTGAGTGTTTTGATCGTTTAGCAGATTGTATGACATTCGGAGCTCTCGAGGCCTGTCCTGAATGTAAACAAGGGCAGTTAGTTTTAGATACCCTTGGCTATAAATGCACAGGTAATTTGAGCGAGTGGACCAAATGTACCTATCAAACTGATAAACCGAAGAGGAGGGCTCTGAAAATACCAGAAAAATACAAAGAGCTTGATTGTTTCCGCTCGTTTAAGCCCACGGTCCGCACTCGTTTGTTCCACGCTCCACTTCCATCACAAAACTTTGTTGTGAAACAAGAAGAGACAGAAGTAAAAAAAGAAATCCGTGTGCCGCCTTTGAAAAACTTGAAATTCTTCATTTACGGAACATTGAAGAAGAATGAAAAGGAGAATATCAAGAATCGCATTATCAAGCTCGGAGGAGACCCCGTCAGTAAACTGTCTGAAGCTACGGTCGCAGTCATCTCTACTAAAGCGGATGTCGAGAAAATGTCTTCTAAAATGCAATCCATACAATATCTAGATATTGTAGTTCTAGATGAAAGTTTTCTAAATTCGATTGACCCTGAGACCGGAACTGTAGCCAGATCCCTGGAGTTAATGAAAGAATATAATATCGCCGATTGGGGTGTTGATCCTGCCTCTAAGCTGCCCCAAGATATTATTGATGGAAAATCGATACCCAAGAGTAAAAGCATGTATGTCAAGTCTGAAAAATCAGCAGTCAAACTCAAGATCCGCGACGGCAACGCTGTGGACCCGGCATCGGAACTGGACGAGGAGTGCCACGTGTACACGGACCGCTACAAAACAACGTATTCGGTCGTGCTCTCGCTCACTGATGTTGTCGCTCAGAAGAACTCCTTCTACAAACTGCAGATCTTGAAACATAATAAAGAGAACAGATACTGGTTGTTCCGTTCGTGGGGTCGGATCGGCACAACGATCGGCGGCAGTAAAGTCGAGAAGATGAAAGATCTCGATAACGCTTTGGACAGATTCCAAGCGCTGTACGAAGAAAAAACTGAGAACCGTTGGAAAGACAGGAATAACTTTGTCAAGATTCCGGGGCGATACTTCCCGCTGGAAATAGACTACGGTGACAATGAGACGAAAACACTCACTGTCGACCCCAAGTGTGAGCTCGCCGAGCCCGTGCAGCGACTCATCGTCACCATCTTTGACATCCACTACATGAAGCAGACCTTGCTCGAATTCGAGTTGGACACAGAGAAAATGCCTCTCGGAAAGTTGTCTAAGAAACAAATAAAAGCAGGCTACAAAGTATTATCTGAACTGCAGAATCTCATAAAAAGCGGAGATGCGAGTCGAAATAAAATTGTGGATGCCACTAATAGATTTTTCACTTTAATACCCCACGACTTCGGGGTAAATAACGCACCGCTGTTGGATAATAATGAAATTATAAAGACGAAGACCGATATGATGGATAACCTGTTGGAAATTGAAATTGCGTATGGTCTATTACAATCAGACACTGACGACACGGTGAGCCCCATCGAAGGCCACTACAAGAAGCTGAAGGCGGAGATAGCGCCGCTCGACAAAACCACCGACGAGTTCGAAATGATCCTGGAGTACGTGCGGAACACGCACGGAAAAACGCACAACTTCTACACGCTCAATGTGGAAGAGGTGTTCAAAGTTATCCGCGAGGGAGAAGATAAGCGTTACAAGCCCTTCAAGAAACTCCACAACCGCCGCCTCTTGTGGCACGGCTCCCGCACCACCAACTTCGCCGGCATTATTTCACAAGGTCTTCGTATTGCGCCGCCCGAAGCGCCGGTCACGGGCTACATGTTCGGCAAGGGCATATACTTTGCGGACATGGTCTCCAAGTCCGCCAACTACTGCTGCACCACCAGAAACAACCCCGTCGGCCTCATGTTGCTGTGTGAGGTCGCTCTCGGGAATATGAAGGAGTGTGTCAATGCTGAAGGTTTCTCTAAAGCCCCGTCCGGCACGCATTCCGTGTGGGGCGTCGGTCGAACTGAGCCGGACCCGAAAATGAATAAGGAATTGCCCGACGGACTCATTGTGCCGCTCGGGACGCCCGTCGACAGGGCGGAGAACAGCACGCTGCTGTACAACGAGTTCATCGTGTACGACGTGGCTCAGGTCAAAGTGAAATACCTGATTGAAATGAGATTCGATTACAGATAA

Protein

MADLPYQVEYAKTGRAACKGCKQKIDQGSLRIAVMVQSAFFDGKQPNWHHEDCFFKKRRLNSFTEIANFNVLKNEDQKRIKTTIENSAGAVVMPIQETKTKGKGKRNKRAAPESDNSALKDFKVEYSKSSRATCPECEIKICKDEIRICKILYDTEVGMKYGGQPRWHHLPCFVKCRNELLYFAGGENLPGFDDLKKADQIIVKTEIKPFESPDIPIKKLKNEVKDEKELKEDKALENKIEKQNKLFDKHRNALMNTNKNDVEKILEYNLQGIPTGKTECFDRLADCMTFGALEACPECKQGQLVLDTLGYKCTGNLSEWTKCTYQTDKPKRRALKIPEKYKELDCFRSFKPTVRTRLFHAPLPSQNFVVKQEETEVKKEIRVPPLKNLKFFIYGTLKKNEKENIKNRIIKLGGDPVSKLSEATVAVISTKADVEKMSSKMQSIQYLDIVVLDESFLNSIDPETGTVARSLELMKEYNIADWGVDPASKLPQDIIDGKSIPKSKSMYVKSEKSAVKLKIRDGNAVDPASELDEECHVYTDRYKTTYSVVLSLTDVVAQKNSFYKLQILKHNKENRYWLFRSWGRIGTTIGGSKVEKMKDLDNALDRFQALYEEKTENRWKDRNNFVKIPGRYFPLEIDYGDNETKTLTVDPKCELAEPVQRLIVTIFDIHYMKQTLLEFELDTEKMPLGKLSKKQIKAGYKVLSELQNLIKSGDASRNKIVDATNRFFTLIPHDFGVNNAPLLDNNEIIKTKTDMMDNLLEIEIAYGLLQSDTDDTVSPIEGHYKKLKAEIAPLDKTTDEFEMILEYVRNTHGKTHNFYTLNVEEVFKVIREGEDKRYKPFKKLHNRRLLWHGSRTTNFAGIISQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCCTTRNNPVGLMLLCEVALGNMKECVNAEGFSKAPSGTHSVWGVGRTEPDPKMNKELPDGLIVPLGTPVDRAENSTLLYNEFIVYDVAQVKVKYLIEMRFDYR

Description

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
Isoform e: Plays a fundamental role in organizing chromatin on a global scale. Autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment.

Catalytic Activity

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide

Miscellaneous

The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

Keywords

ADP-ribosylation   Direct protein sequencing   DNA-binding   Glycosyltransferase   Metal-binding   NAD   Nucleus   Repeat   Transferase   Zinc   Zinc-finger   Alternative splicing   Chromatin regulator   Complete proteome   Reference proteome  

Feature

chain  Poly [ADP-ribose] polymerase
splice variant  In isoform I.

Uniprot

E9JEI6   A0A212F0J8   A0A2H1VJQ4   A0A194PYA6   A0A2H1VI59   A0A2J7PXX8   + More
A0A2J7PXW9   A0A336MUR8   A0A2Z5U1X2   U5EZI1   A0A1L8DH70   A0A1A9XX79   A0A194PHW5   A0A1Y1KWX6   A0A1W4XRS2   A0A1B0BYD9   A0A1I8PWS2   A0A1A9WQP6   B4K4G8   A0A1B0GBV0   A0A1A9Z7M1   A0A154P952   A0A034V6Q0   Q11208   A0A1I8NDN9   A0A0A1X5Z5   A0A069DZP0   A0A0A9YXP0   Q16NZ4   B4JYU1   W5J9L6   T1IQQ9   A0A0M9A7Q7   A0A0T6B3Q7   A0A088A5D3   A0A182G2R9   A0A0K8U6G2   A0A182YM37   A0A0V0G612   A0A182FSK4   A0A3B0KIL8   B4GMA4   A0A2A3E5X0   E2AAA6   E2BH34   A0A232EXK9   A0A1S3JN87   A0A182JNU7   B0WYS5   A0A084WSM5   E9IXR5   A0A0Q5U9S9   A0A1Q3EXW2   K7IV59   B4MC98   W8BF08   F4X1H8   A0A0L7R840   A0A0P4W0D4   W8BJP9   A0A182R0F8   A0A195DLT0   A0A182VQR6   A0A195FRQ8   A0A194QPL8   A0A182N598   A0A151X7L1   P35875   A0A0C9REF5   A0A182RIX6   A0A182MGH8   A0A0J7L6S8   A0A158NA68   A0A195BKD2   A0A182PE54   A0A310S7N4   A0A0P9BT56   B4NZE0   A0A182HJB0   A0A026WPG3   A0A3L8D5Q5   A0A182V5X3   A0A182LCH6   T1P821   A0A182TIM5   K1QLU6   C8CCN1   T1HMS8   A0A0K2SYF4   A0A182XE12   Q7QBC7   A0A1B6DFG5   A0A0P8Y6K9   A0A0P5HT38   A0A2P8ZDR5   A0A0P6G395   A0A0P6EZW2   A0A0P5R332   A0A0P5IJS6   A0A164YKT3  

EC Number

2.4.2.-
2.4.2.30

Pubmed

19121390    21040523    22118469    26354079    26760975    28004739    + More
17994087    25348373    8125121    25315136    25830018    26334808    25401762    26823975    17510324    20920257    23761445    26483478    25244985    20798317    28648823    24438588    21282665    20075255    24495485    21719571    8475096    9565614    12183365    10731132    12537572    12537569    21347285    17550304    24508170    30249741    20966253    22992520    19641118    12364791    29403074   

EMBL

BABH01037034    BABH01037035    GQ426303    ADM32529.1    AGBW02011073    OWR47253.1    + More
ODYU01002680    SOQ40484.1    KQ459586    KPI98008.1    SOQ40486.1    NEVH01020852    PNF21176.1    PNF21175.1    UFQT01001256    SSX29698.1    FX985744    BBA93631.1    GANO01000754    JAB59117.1    GFDF01008347    JAV05737.1    KQ459603    KPI92907.1    GEZM01071263    GEZM01071262    JAV65923.1    JXJN01022594    CH933806    EDW13920.1    CCAG010005890    KQ434846    KZC08363.1    GAKP01019946    JAC39006.1    D16482    GBXI01008132    JAD06160.1    GBGD01000305    JAC88584.1    GBHO01005832    GDHC01000572    JAG37772.1    JAQ18057.1    CH477801    EAT36080.1    CH916378    EDV98556.1    ADMH02002074    ETN59550.1    JH431312    KQ435729    KOX77633.1    LJIG01015963    KRT82026.1    JXUM01140010    KQ568989    KXJ68804.1    GDHF01030092    GDHF01003396    JAI22222.1    JAI48918.1    GECL01002996    JAP03128.1    OUUW01000014    SPP88360.1    CH479185    EDW37978.1    KZ288364    PBC26884.1    GL438057    EFN69632.1    GL448268    EFN84955.1    NNAY01001734    OXU23091.1    DS232197    EDS37185.1    ATLV01026624    KE525415    KFB53219.1    GL766762    EFZ14625.1    CH954178    KQS44468.1    GFDL01014896    JAV20149.1    AAZX01008502    CH940657    EDW63180.2    GAMC01009298    JAB97257.1    GL888529    EGI59706.1    KQ414633    KOC67050.1    GDRN01082474    GDRN01082473    JAI61826.1    GAMC01009297    JAB97258.1    AXCN02000148    KQ980734    KYN13833.1    KQ981305    KYN42972.1    KQ461194    KPJ06925.1    KQ982446    KYQ56319.1    D13806    AF051548    AF051544    AF051545    AF051546    AF051547    AF533701    AE014297    BT015238    AY118947    GBYB01005341    JAG75108.1    AXCM01001496    LBMM01000492    KMQ98224.1    ADTU01010050    KQ976455    KYM85147.1    KQ777311    OAD52149.1    CH902627    KPU74869.1    CM000157    EDW89853.1    APCN01002135    KK107153    EZA56984.1    QOIP01000012    RLU15812.1    KA644786    AFP59415.1    JH816283    EKC34863.1    GQ389638    ACU83597.1    ACPB03017427    HACA01001209    CDW18570.1    AAAB01008879    EAA08394.4    GEDC01012869    JAS24429.1    KPU74867.1    GDIQ01246178    JAK05547.1    PYGN01000086    PSN54639.1    GDIQ01041403    JAN53334.1    GDIQ01056248    JAN38489.1    GDIQ01108431    JAL43295.1    GDIQ01211538    JAK40187.1    LRGB01000872    KZS15355.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000235965    UP000092443    UP000192223    + More
UP000092460    UP000095300    UP000091820    UP000009192    UP000092444    UP000092445    UP000076502    UP000095301    UP000008820    UP000001070    UP000000673    UP000053105    UP000005203    UP000069940    UP000249989    UP000076408    UP000069272    UP000268350    UP000008744    UP000242457    UP000000311    UP000008237    UP000215335    UP000085678    UP000075881    UP000002320    UP000030765    UP000008711    UP000002358    UP000008792    UP000007755    UP000053825    UP000075886    UP000078492    UP000075920    UP000078541    UP000053240    UP000075884    UP000075809    UP000000803    UP000075900    UP000075883    UP000036403    UP000005205    UP000078540    UP000075885    UP000007801    UP000002282    UP000075840    UP000053097    UP000279307    UP000075903    UP000075882    UP000075902    UP000005408    UP000015103    UP000076407    UP000007062    UP000245037    UP000076858   

PRIDE

E9JEI6    Q11208    P35875   

Pfam

PF00533   BRCT        + More
PF00645   zf-PARP
PF02877   PARP_reg
PF05406   WGR
PF00644   PARP
PF08063   PADR1
PF16589   BRCT_2

Interpro

IPR008893   WGR_domain        + More
IPR001510   Znf_PARP       
IPR004102   Poly(ADP-ribose)pol_reg_dom       
IPR036420   BRCT_dom_sf       
IPR001357   BRCT_dom       
IPR012982   PADR1       
IPR036616   Poly(ADP-ribose)pol_reg_dom_sf       
IPR036957   Znf_PARP_sf       
IPR038650   PADR1_dom_sf       
IPR012317   Poly(ADP-ribose)pol_cat_dom       
IPR036930   WGR_dom_sf       
IPR008288   PARP       

SUPFAM

SSF142921   SSF142921        + More
SSF47587   SSF47587       
SSF52113   SSF52113       

Gene 3D

1.20.142.10     2.20.140.10     2.20.25.630     3.30.1740.10     3.40.50.10190    

CDD

cd00027  BRCT

ProteinModelPortal

E9JEI6   A0A212F0J8   A0A2H1VJQ4   A0A194PYA6   A0A2H1VI59   A0A2J7PXX8   + More
A0A2J7PXW9   A0A336MUR8   A0A2Z5U1X2   U5EZI1   A0A1L8DH70   A0A1A9XX79   A0A194PHW5   A0A1Y1KWX6   A0A1W4XRS2   A0A1B0BYD9   A0A1I8PWS2   A0A1A9WQP6   B4K4G8   A0A1B0GBV0   A0A1A9Z7M1   A0A154P952   A0A034V6Q0   Q11208   A0A1I8NDN9   A0A0A1X5Z5   A0A069DZP0   A0A0A9YXP0   Q16NZ4   B4JYU1   W5J9L6   T1IQQ9   A0A0M9A7Q7   A0A0T6B3Q7   A0A088A5D3   A0A182G2R9   A0A0K8U6G2   A0A182YM37   A0A0V0G612   A0A182FSK4   A0A3B0KIL8   B4GMA4   A0A2A3E5X0   E2AAA6   E2BH34   A0A232EXK9   A0A1S3JN87   A0A182JNU7   B0WYS5   A0A084WSM5   E9IXR5   A0A0Q5U9S9   A0A1Q3EXW2   K7IV59   B4MC98   W8BF08   F4X1H8   A0A0L7R840   A0A0P4W0D4   W8BJP9   A0A182R0F8   A0A195DLT0   A0A182VQR6   A0A195FRQ8   A0A194QPL8   A0A182N598   A0A151X7L1   P35875   A0A0C9REF5   A0A182RIX6   A0A182MGH8   A0A0J7L6S8   A0A158NA68   A0A195BKD2   A0A182PE54   A0A310S7N4   A0A0P9BT56   B4NZE0   A0A182HJB0   A0A026WPG3   A0A3L8D5Q5   A0A182V5X3   A0A182LCH6   T1P821   A0A182TIM5   K1QLU6   C8CCN1   T1HMS8   A0A0K2SYF4   A0A182XE12   Q7QBC7   A0A1B6DFG5   A0A0P8Y6K9   A0A0P5HT38   A0A2P8ZDR5   A0A0P6G395   A0A0P6EZW2   A0A0P5R332   A0A0P5IJS6   A0A164YKT3  

PDB

4DQY     E-value=2.79124e-161,     Score=1463

KEGG

100862754    K10798 poly [ADP-ribose] polymerase [EC:2.4.2.30] | (RefSeq) poly [ADP-ribose] polymerase

PATHWAY

03410    Base excision repair - Bombyx mori (domestic silkworm)
04214    Apoptosis - fly - Bombyx mori (domestic silkworm)

GO

GO:0008270   GO:0006471   GO:0051287   GO:0005634   GO:0003677   GO:0003950   GO:0043484   GO:0051276   GO:1900182   GO:0015030   GO:0035080   GO:0042393   GO:0005694   GO:0006325   GO:0051457   GO:0045087   GO:0005730   GO:0009303   GO:0006355   GO:0008069   GO:0035363   GO:0030576   GO:0005703   GO:0035079   GO:0007000   GO:0006963   GO:0005719   GO:0005700   GO:0007552   GO:0070212   GO:0006302   GO:1990404   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Nucleus  
Nucleolus  

Length:

1000

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00985

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00002

outside

1  -  1000

 

 

Pi

293.153927

Theta

198.496977

Tajima's D

3.419136

CLR

0.594162

CSRT

0.992200389980501

Interpretation

Uncertain