Silkworm Genome Informatics Database

Gene

KWMTBOMO13291

Pre Gene Modal

BGIBMGA004710

Annotation

PREDICTED:_uncharacterized_protein_LOC101741008_[Bombyx_mori]

Location

Bomo_Chr22(-):12943862-12955150 View in EpiBrowser

Full name

E3 ubiquitin-protein ligase

Location in the cell

Nuclear Reliability : 4.51

CDS

ATGGGTAGTAGAAAAGAGAGCTTGAAAAAGTCCTTAGGAATTACAGAATACCCTTGGAGCTCCGATGAGGAAGAAAACAGTAGTAATCTTATGAGGAGATCATCCACAGAACCTAGAACCAGTATAGCTGACACACCTGGGACTAGTGGGGTAACAACACAAAACCCATTCGTTCCGGTGCCGCCACGTCGCAACGTTGTTGGTGGCATGAATGGACCAGAAAATAATTGGTTCTGGTCTAATAATAGGAATAACCATCACGAGAGTCTCATTAATGGCTCCAGCCGTCCCAGGTTATGCGTTCAAGAGGGATCGATGCCTCTCCCGTATCTGCGTCCGGCCAATCACGTTCCCGCAGCCGAGCTCCACGAGAGGAACACCGAGGCTGCGATGACGGCCAACGCGGACATTCAACGGATAATCGCCTTCAAGAAATTCGCCAGGAACTACAATAATGTTCGTGACAGACGCAGAGTCAACACGCTGTACGCTATTTCGTCACGAGTTGCAGGTAATTTGGGATCGGATCGAATACCATTTTTTCCGATGCCGTCAACATCGGAGGCCTCCAACGCTACGTGTGATCAGAGAGCAATGAAAATGAATAACCCGAGACAGAACCACATGCGTCAATACCGCCCCTTATATTGTAGAGTGGGGGACCCGTCGACGTCGAGCCTGGCGCTGGAGGACGGTCCGCCGGACATCGGCTGCGTGTCGCAGATCCGGCTGATGCGGTCCAACACCGCTGTGGACCTGAGCAACACCGCGCCCGCCAACGCCACCGCCGAGCTCAACGTCGACATCGGCCGCTCGGACGACGAAGCGGAAGCGGAGTCCGAGCCCACCCTGATGCTCGTCAACAACGATCAGAACGATGGACAAGAACAAAGTGCTGAACCGAGTACGTCACACGATCCGACGCCCGGTGGGGCCATGGAGGAAGAGATCGTGGAACTGGACGCGCCCGACGACGACACCAACGAGGAAGGCGAGAACAATGTTGCCAATGACGTGGTCATGACAAACGCGGCTACTGCCAGTAATGAAGATGATACTCCAGAGTCTCCCGAAGCTGAGGCCGAAGGATCAGCCCCGGAGCCGCAACCGCACGGAGTGAAGAGGAAGAAGAGTGGTAACGATGAAGCCGGATTCTTCTCTGTTAAAGATTTTAACCAGGGTCTGCTGCGGCTGCTGGAGTGCCCGGTGTGCCTGGAGTGGATGGAGCCGCCCATCGCGCAGTGCCGGCGCGGGCACCTGGTGTGCGTGCGCTGCCGCTCGCGACTCAACGCGTGCCCCGTGTGCCGCACCGTGTTCTCCAGCGTGCGGAACCGAGCCATGGAAGGGGTTAGTCCTGGCCTCAACGTGTACTCGAACTGA

Protein

MGSRKESLKKSLGITEYPWSSDEEENSSNLMRRSSTEPRTSIADTPGTSGVTTQNPFVPVPPRRNVVGGMNGPENNWFWSNNRNNHHESLINGSSRPRLCVQEGSMPLPYLRPANHVPAAELHERNTEAAMTANADIQRIIAFKKFARNYNNVRDRRRVNTLYAISSRVAGNLGSDRIPFFPMPSTSEASNATCDQRAMKMNNPRQNHMRQYRPLYCRVGDPSTSSLALEDGPPDIGCVSQIRLMRSNTAVDLSNTAPANATAELNVDIGRSDDEAEAESEPTLMLVNNDQNDGQEQSAEPSTSHDPTPGGAMEEEIVELDAPDDDTNEEGENNVANDVVMTNAATASNEDDTPESPEAEAEGSAPEPQPHGVKRKKSGNDEAGFFSVKDFNQGLLRLLECPVCLEWMEPPIAQCRRGHLVCVRCRSRLNACPVCRTVFSSVRNRAMEGVSPGLNVYSN

Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Similarity

Belongs to the SINA (Seven in absentia) family.

Uniprot

A0A2A4IZX5 A0A3S2NJU9

EC Number

2.3.2.27

EMBL

NWSH01004365 PCG65179.1 RSAL01000018 RVE52810.1

Proteomes

UP000218220 UP000283053

Pfam

PF03145 Sina

Interpro

IPR001841   Znf_RING        + More
IPR004162   SINA-like
IPR013083   Znf_RING/FYVE/PHD
IPR008974   TRAF-like
IPR018121   7-in-absentia-prot_TRAF-dom

SUPFAM

SSF49599 SSF49599

Gene 3D

3.30.40.10

ProteinModelPortal

A0A2A4IZX5 A0A3S2NJU9

KEGG

101741008 no KO assigned | (RefSeq) uncharacterized LOC101741008

GO

GO:0006511 GO:0016567 GO:0007275 GO:0005634 GO:0046872 GO:0005515 GO:0008270 GO:0006397 GO:0005737 GO:0048869 GO:0003676 GO:0016491 GO:0015930

PANTHER

PTHR45877

Length:

459

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0051

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00910

outside

1 - 459

Pi

27.14921

Theta

159.53465

Tajima's D

2.163095

CLR

0.17217

CSRT

0.905754712264387

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics