Silkworm Genome Informatics Database

Gene

KWMTBOMO13290

Pre Gene Modal

BGIBMGA004710

Annotation

PREDICTED:_uncharacterized_protein_LOC101741008_[Bombyx_mori]

Location

Bomo_Chr22(-):12941114-12942350 View in EpiBrowser

Full name

E3 ubiquitin-protein ligase

Location in the cell

Nuclear Reliability : 2.794

CDS

ATGTCGATGCTGAAGATGGGTCGCAAGCATCAGTTCTCGATCAAAGTGAACGTGGAACAGCACGAGGACTGCGTCATCATGGCGCTGGACCAGCTGTTTCATCTGAAGGTCGACGTCGACATCCGCACGTGGGGCATCATCATCTACGTCGCATTCATCGGACCTAAGTCGAAAGCCAGCAATTATACTTACGAGGTGGTTGTGAACGGGCAGCACAACTCGAGGAAGCTAGTGTACACGAGGGTGACCCACAGCGACTTGGAGAGCTCGTCCGTGAACGTGAGCCGCCAGGACTGCTTCCACCTGACCCTCGACCAGGCCCTCAACTTCCTCAGGGTCAAGAACAAGCAGTGCGAGCCGGATAAATACTTGGAGTTCAATTTGGAGATCGCTCATCTGATCAAGAAGCGGCTCGCGAAGGCCATGAGGCTCGCCAAGCGGCCGCTCATGAACAGGAGCTGGAGCTTGATGATCAGGGACGTGTTGGACAATAAGTAG

Protein

MSMLKMGRKHQFSIKVNVEQHEDCVIMALDQLFHLKVDVDIRTWGIIIYVAFIGPKSKASNYTYEVVVNGQHNSRKLVYTRVTHSDLESSSVNVSRQDCFHLTLDQALNFLRVKNKQCEPDKYLEFNLEIAHLIKKRLAKAMRLAKRPLMNRSWSLMIRDVLDNK

Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Similarity

Belongs to the SINA (Seven in absentia) family.

Uniprot

H9J5C0 A0A1E1W3W3 A0A212F0J6 A0A2A4IZX5 A0A2H1VKZ7 A0A3S2NJU9 + More
S4NSM2 A0A194R0F6 A0A194PXF5 A0A0L7L816 A0A2P8XFC6 A0A067RBI7

EC Number

2.3.2.27

Pubmed

19121390 22118469 23622113 26354079 26227816 29403074 + More
24845553

EMBL

BABH01037039 BABH01037040 GDQN01009377 JAT81677.1 AGBW02011073 OWR47252.1 + More
NWSH01004365 PCG65179.1 ODYU01003145 SOQ41529.1 RSAL01000018 RVE52810.1 GAIX01014022 JAA78538.1 KQ460883 KPJ11273.1 KQ459586 KPI98007.1 JTDY01002428 KOB71436.1 PYGN01002346 PSN30707.1 KK852751 KDR17164.1

Proteomes

UP000005204 UP000007151 UP000218220 UP000283053 UP000053240 UP000053268 + More
UP000037510 UP000245037 UP000027135

PRIDE

H9J5C0

Pfam

PF03145 Sina

Interpro

IPR013083   Znf_RING/FYVE/PHD        + More
IPR004162   SINA-like
IPR001841   Znf_RING
IPR018121   7-in-absentia-prot_TRAF-dom
IPR008974   TRAF-like

SUPFAM

SSF49599 SSF49599

Gene 3D

3.30.40.10 2.60.210.10

ProteinModelPortal

H9J5C0 A0A1E1W3W3 A0A212F0J6 A0A2A4IZX5 A0A2H1VKZ7 A0A3S2NJU9 + More
S4NSM2 A0A194R0F6 A0A194PXF5 A0A0L7L816 A0A2P8XFC6 A0A067RBI7

KEGG

101741008 no KO assigned | (RefSeq) uncharacterized LOC101741008

GO

GO:0046872 GO:0007275 GO:0016567 GO:0005634 GO:0006511 GO:0016874 GO:0005515 GO:0006397 GO:0005737 GO:0048869 GO:0003676 GO:0016491 GO:0015930

PANTHER

PTHR45877

Length:

165

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13674

Exp number, first 60 AAs:

0.12963

Total prob of N-in:

0.24933

outside

1 - 165

Pi

395.150343

Theta

204.430097

Tajima's D

2.936821

CLR

0.308959

CSRT

0.976351182440878

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics