Gene

KWMTBOMO13287  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004711

Annotation

PREDICTED:_ruvB-like_helicase_1_[Papilio_machaon]

Location

Bomo_Chr22(-):12907034-12912860      View in EpiBrowser

Full name

RuvB-like helicase       + More
RuvB-like helicase 1      
DNA helicase      

Alternative Name

Pontin

Location in the cell

Cytoplasmic   Reliability : 2.814

CDS

ATGAAAATTGAAGAAGTGAAAAGCACAGCTAAAACGCAAAGGATCTCTGCTCACAGTCATATAAAAGGCTTGGGGTTGGATGAAAATGGTGTTCCTATTCAAATGGCAGCCGGTCTCGTGGGTCAAGAGTCTGCACGTGAGGCTGCAGGGATAGTTGTAGATATGATAAGAAGTAAGAAAATGGCCGGGCGAGCTTTACTCTTGGCAGGGCCTCCTGGTACTGGCAAAACTGCTATAGCTCTTGCCATCGCTCAGGAACTTGGAACTAAGGTTCCTTTCTGTCCAATGGTTGGTAGTGAAGTTTACAGCACAGAGATCAAGAAAACAGAGGTATTAATGGAGAATTTTCGACGTGCTATAGGCCTGCGTATACGTGAAACCAAAGAAGTATATGAGGGTGAAGTAACTGAGTTAACACCTGTTGAAACAGAAAATCCTGCTGGAGGCTATGGAAAAACAGTATCTCATGTGATCATAGGACTAAAAACGGCCAAGGGTACCAAACAACTTAAACTTGATCCAACTATATATGAATCGTTACAAAAGGAAAAGGTTGAAGTTGGGGATGTCATTTACATTGAAGCTAATTCGGGGGCAGTGAAGAGACAGGGTAGGAGTGATACTTTTGCTACTGAATTTGACCTTGAGGCTGAAGAATATGTTCCGCTACCCAAAGGTGATGTACACAAAAAGAAAGAAGTTGTACAAGATGTAACCTTACACGATTTGGATTGTGCTAATGCAAGACCGCAGGGAGGTCATGACATTATGTCTATGATGGGACAACTCATGAAACCAAAGAAGACTGAAATAACAGATAAACTTCGAAAAGAGATCAATAAAGTTGTGAACAAATACATAGATCAAGGGATTGCAGAACTGGTTCCTGGTGTGCTATTCATTGATGAGGTACACATGCTGGACATTGAAACTTTCACATACCTACATCGAGCGTTGGAGTCCGCGATAGCACCAATTGTTATATTTGCTACAAACAGAGGGCGTTGTCAAATCAGAGGGACAGAAGACATTGTATCACCACACGGCATTCCACTAGATCTATTAGATAGGTTATTAATAATACGCACTCTCCCGTATAACAAAGCAGAACTTTTACAGATATTAAAGCTCCGTGCGGTCACAGAAGGAATTTCAATCGAGGACGAAGCTTTGTCGGCGCTCTCTGAGATTGGAGCTCACACGACGCTCAGGTACGCAGTTCAGCTGCTAACTCCGGCGATGTTGGCCGCGCGAGCCGACGGCTGCCAGCGCATATCGCCGGCGCACGTGTCCTCGGTCCACACGCTGTTCCTTGACGCTAAAGCTTCAGCCAAAATCCTCACTCAACATTCCGATAAATACATGCAGTAA

Protein

MKIEEVKSTAKTQRISAHSHIKGLGLDENGVPIQMAAGLVGQESAREAAGIVVDMIRSKKMAGRALLLAGPPGTGKTAIALAIAQELGTKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIRETKEVYEGEVTELTPVETENPAGGYGKTVSHVIIGLKTAKGTKQLKLDPTIYESLQKEKVEVGDVIYIEANSGAVKRQGRSDTFATEFDLEAEEYVPLPKGDVHKKKEVVQDVTLHDLDCANARPQGGHDIMSMMGQLMKPKKTEITDKLRKEINKVVNKYIDQGIAELVPGVLFIDEVHMLDIETFTYLHRALESAIAPIVIFATNRGRCQIRGTEDIVSPHGIPLDLLDRLLIIRTLPYNKAELLQILKLRAVTEGISIEDEALSALSEIGAHTTLRYAVQLLTPAMLAARADGCQRISPAHVSSVHTLFLDAKASAKILTQHSDKYMQ

Description

Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Acts as a transcriptional coactivator in Wg signaling.
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Forms homohexameric rings. May form a dodecamer with rept made of two stacked hexameric rings. Component of the chromatin remodeling Ino80 complex (By similarity).

Similarity

Belongs to the RuvB family.

Keywords

Activator   ATP-binding   Cell cycle   Cell division   Chromatin regulator   Complete proteome   DNA damage   DNA recombination   DNA repair   Helicase   Hydrolase   Nucleotide-binding   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  RuvB-like helicase 1

Uniprot

H9J5C1   A0A2A4IVP2   A0A194R1Z9   A0A194Q3L6   A0A3S2NZ56   S4NSQ2   + More
A0A212FAF2   A0A2H1WCW8   A0A067QQE5   A0A154PHZ2   A0A2J7QCA4   E9IDT2   E2B6Y7   A0A0J7NJC2   A0A195C2V5   A0A195BB51   A0A158NN53   A0A151IWH2   F4W8C7   A0A2A3E1P5   A0A087ZSJ5   A0A310SK01   A0A151X288   A0A195FAZ1   A0A1W4X1Z7   A0A1B6GJV2   A0A026WFT3   A0A1B6LL71   A0A1Y1LPU7   A0A232ESW5   A0A1B6HMU1   E0VMB1   K7J661   D6X0K0   A0A0C9QC64   A0A0N7Z9B2   R4FNT4   A0A0M8ZT85   A0A0V0G8C8   A0A069DU69   A0A210PMW5   A0A293MX40   A0A2R5LHA1   A0A1Z5LAI6   A0A182HCN0   U5EXK8   Q0IFL2   A0A2T7NVP9   T1IJL2   U4UF38   A0A1Q3F4B3   A0A1B0D5N8   A0A182XKF9   A0A182UB01   A0A2C9GQH2   A0A182VAW2   B0W8I1   W8CA62   W5JVX2   A0A0B7B8P4   L7MGZ0   A0A023FXK4   A0A084VTP9   A0A182XXI8   A0A131XCH3   A0A224Z0K8   A0A131Z1S1   A0A182PBG2   V4AYE4   A0A2R7X2A1   N6U3Y5   A0A023GNL1   G3MH90   A0A182IUZ6   A0A3F2Z113   A0A1B0CJ20   B7PYR8   A0A182MWY7   A0A2C9JD95   A0A1Y9HER1   A0A2M4ANB7   E9H9P0   A0A034WBU7   A0A224XQ29   A0A023FK87   T1FSY2   A0A131XXE0   A0A0K8W5T8   A0A182K3C8   A0A0P5XRN9   A0A267FV70   A0A1I8N241   A0A1J1HUP3   A0A182LCW5   A0A182FAX4   K4G9W9   A0A0T6B5H1   A0A0L0CDX9   A0A267F687   R7V1X6  

EC Number

3.6.4.12

Pubmed

19121390    26354079    23622113    22118469    24845553    21282665    + More
20798317    21347285    21719571    24508170    30249741    28004739    28648823    20566863    20075255    18362917    19820115    27129103    26334808    28812685    28528879    26483478    17510324    23537049    24495485    20920257    23761445    25576852    24438588    25244985    28049606    28797301    26830274    23254933    22216098    15562597    21292972    25348373    25315136    20966253    23056606    26108605   

EMBL

BABH01037043    NWSH01005962    PCG63791.1    KQ460883    KPJ11275.1    KQ459586    + More
KPI98005.1    RSAL01000018    RVE52812.1    GAIX01013977    JAA78583.1    AGBW02009486    OWR50708.1    ODYU01007822    SOQ50913.1    KK853050    KDR12040.1    KQ434912    KZC11417.1    NEVH01016290    PNF26215.1    GL762535    EFZ21241.1    GL446071    EFN88529.1    LBMM01004290    KMQ92600.1    KQ978344    KYM94925.1    KQ976537    KYM81419.1    ADTU01021054    KQ980854    KYN12179.1    GL887908    EGI69418.1    KZ288446    PBC25620.1    KQ765330    OAD53965.1    KQ982579    KYQ54545.1    KQ981693    KYN37598.1    GECZ01016759    GECZ01007037    JAS53010.1    JAS62732.1    KK107263    QOIP01000011    EZA53889.1    RLU16931.1    GEBQ01015554    JAT24423.1    GEZM01050187    JAV75682.1    NNAY01002380    OXU21407.1    GECU01031740    JAS75966.1    DS235306    EEB14517.1    KQ971371    EFA10722.1    GBYB01000864    JAG70631.1    GDKW01001035    JAI55560.1    ACPB03010982    GAHY01000448    JAA77062.1    KQ435903    KOX69059.1    GECL01001713    JAP04411.1    GBGD01001419    JAC87470.1    NEDP02005581    OWF37766.1    GFWV01019182    MAA43910.1    GGLE01004669    MBY08795.1    GFJQ02002527    JAW04443.1    JXUM01127766    KQ567233    KXJ69542.1    GANO01000904    JAB58967.1    CH477312    EAT43892.1    PZQS01000009    PVD25245.1    JH430315    KB632294    ERL91652.1    GFDL01012686    JAV22359.1    AJVK01011851    APCN01002169    DS231859    EDS39031.1    GAMC01001554    JAC05002.1    ADMH02000300    ETN67049.1    HACG01041826    CEK88691.1    GACK01002501    JAA62533.1    GBBL01001101    JAC26219.1    ATLV01016383    KE525080    KFB41343.1    GEFH01004756    JAP63825.1    GFPF01011559    MAA22705.1    GEDV01004151    JAP84406.1    KB201224    ESO98661.1    KK856508    PTY25924.1    APGK01050244    KB741169    ENN73292.1    GBBM01000943    JAC34475.1    JO841241    AEO32858.1    AJWK01013975    ABJB010179771    ABJB010262550    ABJB010671266    DS821669    EEC11740.1    AXCM01004705    GGFK01008954    MBW42275.1    GL732609    EFX71513.1    GAKP01007709    JAC51243.1    GFTR01006315    JAW10111.1    GBBK01002450    JAC22032.1    AMQM01003889    KB096365    ESO05157.1    GEFM01003872    JAP71924.1    GDHF01005895    JAI46419.1    GDIP01068291    JAM35424.1    NIVC01000731    PAA77636.1    CVRI01000021    CRK91792.1    JX053104    JX210316    AFK11332.1    AFM88630.1    LJIG01009677    KRT82601.1    JRES01000501    KNC30618.1    NIVC01001336    PAA69268.1    AMQN01005385    KB295903    ELU12497.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000283053    UP000007151    + More
UP000027135    UP000076502    UP000235965    UP000008237    UP000036403    UP000078542    UP000078540    UP000005205    UP000078492    UP000007755    UP000242457    UP000005203    UP000075809    UP000078541    UP000192223    UP000053097    UP000279307    UP000215335    UP000009046    UP000002358    UP000007266    UP000015103    UP000053105    UP000242188    UP000069940    UP000249989    UP000008820    UP000245119    UP000030742    UP000092462    UP000076407    UP000075902    UP000075840    UP000075903    UP000002320    UP000000673    UP000030765    UP000076408    UP000075885    UP000030746    UP000019118    UP000075880    UP000075920    UP000092461    UP000001555    UP000075883    UP000076420    UP000075900    UP000000305    UP000015101    UP000075881    UP000215902    UP000095301    UP000183832    UP000075882    UP000069272    UP000037069    UP000014760   

PRIDE

H9J5C1    Q0IFL2   

Pfam

PF17856   TIP49_C        + More
PF06068   TIP49
PF03435   Sacchrp_dh_NADP

Interpro

IPR027238   RuvB-like        + More
IPR010339   TIP49_P-loop       
IPR027417   P-loop_NTPase       
IPR041048   RuvB-like_C       
IPR003593   AAA+_ATPase       
IPR037938   RUVBL1       
IPR036291   NAD(P)-bd_dom_sf       
IPR005097   Sacchrp_dh_NADP       

SUPFAM

SSF52540   SSF52540        + More
SSF51735   SSF51735       

ProteinModelPortal

H9J5C1   A0A2A4IVP2   A0A194R1Z9   A0A194Q3L6   A0A3S2NZ56   S4NSQ2   + More
A0A212FAF2   A0A2H1WCW8   A0A067QQE5   A0A154PHZ2   A0A2J7QCA4   E9IDT2   E2B6Y7   A0A0J7NJC2   A0A195C2V5   A0A195BB51   A0A158NN53   A0A151IWH2   F4W8C7   A0A2A3E1P5   A0A087ZSJ5   A0A310SK01   A0A151X288   A0A195FAZ1   A0A1W4X1Z7   A0A1B6GJV2   A0A026WFT3   A0A1B6LL71   A0A1Y1LPU7   A0A232ESW5   A0A1B6HMU1   E0VMB1   K7J661   D6X0K0   A0A0C9QC64   A0A0N7Z9B2   R4FNT4   A0A0M8ZT85   A0A0V0G8C8   A0A069DU69   A0A210PMW5   A0A293MX40   A0A2R5LHA1   A0A1Z5LAI6   A0A182HCN0   U5EXK8   Q0IFL2   A0A2T7NVP9   T1IJL2   U4UF38   A0A1Q3F4B3   A0A1B0D5N8   A0A182XKF9   A0A182UB01   A0A2C9GQH2   A0A182VAW2   B0W8I1   W8CA62   W5JVX2   A0A0B7B8P4   L7MGZ0   A0A023FXK4   A0A084VTP9   A0A182XXI8   A0A131XCH3   A0A224Z0K8   A0A131Z1S1   A0A182PBG2   V4AYE4   A0A2R7X2A1   N6U3Y5   A0A023GNL1   G3MH90   A0A182IUZ6   A0A3F2Z113   A0A1B0CJ20   B7PYR8   A0A182MWY7   A0A2C9JD95   A0A1Y9HER1   A0A2M4ANB7   E9H9P0   A0A034WBU7   A0A224XQ29   A0A023FK87   T1FSY2   A0A131XXE0   A0A0K8W5T8   A0A182K3C8   A0A0P5XRN9   A0A267FV70   A0A1I8N241   A0A1J1HUP3   A0A182LCW5   A0A182FAX4   K4G9W9   A0A0T6B5H1   A0A0L0CDX9   A0A267F687   R7V1X6  

PDB

6QI9     E-value=0,     Score=1798

KEGG

101739823    K04499 RuvB-like protein 1 (pontin 52) | (RefSeq) ruvB-like helicase 1

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0031011   GO:0006325   GO:0005524   GO:0006281   GO:0035267   GO:0097255   GO:0043141   GO:0005634   GO:0004386   GO:0006338   GO:0006357   GO:0000492   GO:0016573   GO:0004003   GO:0000812   GO:0042127   GO:0006310   GO:0003713   GO:0051301   GO:0007049   GO:0090263   GO:0016021   GO:0016491   GO:0003678   GO:0006468   GO:0020037   GO:0006397   GO:0005737   GO:0048869   GO:0003676   GO:0015930  

PANTHER

PTHR11093:SF6   PTHR11093  

Subcellular location

Nucleus  

Length:

456

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.95908

Exp number, first 60 AAs:

0.00118

Total prob of N-in:

0.19222

outside

1  -  456

 

 

Pi

395.630188

Theta

213.628458

Tajima's D

1.794564

CLR

0.421185

CSRT

0.844757762111894

Interpretation

Uncertain