Gene
KWMTBOMO13283 Validated by peptides from experiments
Pre Gene Modal
BGIBMGA004688
Annotation
PREDICTED:_dipeptidyl_peptidase_3_isoform_X1_[Papilio_machaon]
Full name
Dipeptidyl peptidase 3
Alternative Name
Dipeptidyl aminopeptidase III
Dipeptidyl peptidase III
Dipeptidyl peptidase III
Location in the cell
Cytoplasmic Reliability : 2.895
Sequence
CDS
ATGGAAGACAAGTCAAATTTTTTACTGCCAAATAACCAAAGATTCGTGGAGTTGGATAGTTCGCAGGCTTTTGATAATCTAACAACGAATGAGAAATTATATGCTCATTATTTGAGTCAGGCTGCATGGAACGGTGGACTTATAGTATTGGTACAGACCAGTCCTGAGTCACCAAAGATATTCTCCTTGCTGCATAGAGTCTTTGTGGCTGAGCCATTAGAGAATCTTAAACAATCGGCTTTGAAATCTGGTGTATCTGAAGATGATTTTCAGGCTTTTCTCGTCTATGCAGGAGGTCTATTTGCCAACAGCGGTAACTATAAAGGTTTTGGTGATACAAAGTTCATTCCAAATTTACCAGCTGAATCATTAGAATTAATTTTAAAGGCATCTAAAGCATATGAAAATGACAATACGCACATACTAAAGTTATGGCAAAATACTAAAAATGCCATTTATGGGCTTGCACCCAGATTAACCAGTCTTGGTTTAGCTAATAAGGGGGTAACAACATATTTCTCAAGCAACTGTACCGAAGAAGATTCGAATCTCGTTAACGATTGGATGAAAACTAAACTCATAGAGGCGTACATTTGTCGTACGTTCAAAACTGTTGCTGATGACGGCTTACCCCTATACACCATTCATCTTGCCAGCGTCGAAACATCGTCAAAACCACCCCTAACGATGGATAAAGAATCGTACAAAGGCGCTTATTTCCAAGTGACACGCGGCGATTACTCACCCTTACTGAAGATTGTGAACGAACATCTAACCACAGCTCAGGAGTACGCAACAAATGATAATGAGAAGAACATGCTCTTGCATTATGTTAAAAGTTTTAAAGAAGGCGATCTTAGTGAGCATAAAGAGGGAAGCAGATTTTGGATAAGAGATAAGGGACCTATTATTGAGACATATCAAGGTTTCATTGAGACATATCGTGATCCAAGTGGTCAGCGGGGTGAGTTCGAGGGTTTCGTGGCGATGGTCAACAAGGAGATGTCCAAGAAGTTCGGCAGTCTCGTCGATGGCGCTGAGAGGTTCATTAAACTGTTGCCCTGGGGTGAAGACTTAGAAAAGGATTCGTTCCTGCGACCCGATTTCACGAGTCTGGACGTTCTAACGTTTTCCGGCAGTGGTATACCTGCGGGAATCAATATTCCTAATTATGACGAAATCCGTCAAAACGAAGGCTTCAAGAACGTGTCTCTGGGCAACGTGATCCCCGCCGCGTACAAGGAGTACACTATACCGTTCCTGTCTGATGCCGACAAGCAACTACTGGAGAAATACAGAGTTTCCGCCTTTGAGGTTCAAGTAGGACTTCACGAGCTATTAGGACACGGAAGCGGCAAGCTGTTGCGACAGAATGCAGATGGAACGTTCAATTTTGATAAAGAAAAAGTCAAAAACCCTCTGACTGATAAAGGTATAGAATCTTGGTACAGTGAAGGTGAGACCTACGACAGCAAGTTCACAACCCTGGGGTCCGCCTTCGAAGAGTGTCGCGCTGAAGCCGTCGGACTGTACCTCTCTTTGGTACCAGAGATACTTAAAATTTTCGGGTACGAAGGACAAGAAGCCGAAGACGTCACATACGTTAACTGGCTCAGCTTGTTGTGGAACGGAGCCGCTAAGGCGACCGAAATGTACCAACCCTCCACTAAGACTTGGTTGCAGGCGCACGCCCGCGCACGTTTCGTGATCATGCGTCTGTTGGAGCTGGAGGGGGGCGGCCTGCTCACCGTCGAGGAGTCCGAGCCCGGGAAGAATCTCCTGTTGACGCTACAAAAGGATCGTCTCGCTACCGACGGCAAGAAGATCATTGGCGATTTCTTGGTGAAACTTCAAACGATAAAGGCAACCGGTGACTTTAGTGCGGGCGAAAAACTATTCAATAAGTACAGCAGTCTCGACGAGCCCTGGGGCCGCTGGAGAGATATCGTTCTAATGCATAAACAGCCTAGAAACATCTTCGTTCAGCCCAACACCTTCCACAAGGGCGACGCGGTCGAGCTAAAGCGCTACCCGGCGACGGCTGAGGGCATGGTCGCGTCGTGGGTGGACAGGTTCCCCAACACGAAGGTCGACGACATTCTGGAGAAGTTAGCGAAAGAGAATAGCAAATATTTTGCTGATCTTGAACCTTTAACTGCTGCGTGA
Protein
MEDKSNFLLPNNQRFVELDSSQAFDNLTTNEKLYAHYLSQAAWNGGLIVLVQTSPESPKIFSLLHRVFVAEPLENLKQSALKSGVSEDDFQAFLVYAGGLFANSGNYKGFGDTKFIPNLPAESLELILKASKAYENDNTHILKLWQNTKNAIYGLAPRLTSLGLANKGVTTYFSSNCTEEDSNLVNDWMKTKLIEAYICRTFKTVADDGLPLYTIHLASVETSSKPPLTMDKESYKGAYFQVTRGDYSPLLKIVNEHLTTAQEYATNDNEKNMLLHYVKSFKEGDLSEHKEGSRFWIRDKGPIIETYQGFIETYRDPSGQRGEFEGFVAMVNKEMSKKFGSLVDGAERFIKLLPWGEDLEKDSFLRPDFTSLDVLTFSGSGIPAGINIPNYDEIRQNEGFKNVSLGNVIPAAYKEYTIPFLSDADKQLLEKYRVSAFEVQVGLHELLGHGSGKLLRQNADGTFNFDKEKVKNPLTDKGIESWYSEGETYDSKFTTLGSAFEECRAEAVGLYLSLVPEILKIFGYEGQEAEDVTYVNWLSLLWNGAAKATEMYQPSTKTWLQAHARARFVIMRLLELEGGGLLTVEESEPGKNLLLTLQKDRLATDGKKIIGDFLVKLQTIKATGDFSAGEKLFNKYSSLDEPWGRWRDIVLMHKQPRNIFVQPNTFHKGDAVELKRYPATAEGMVASWVDRFPNTKVDDILEKLAKENSKYFADLEPLTAA
Summary
Description
Degrades neuropeptide proctolin (RYLPT) by cleavage between Tyr and Leu residues.
Catalytic Activity
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
Cofactor
Zn(2+)
Similarity
Belongs to the peptidase M49 family.
Keywords
Alternative splicing
Aminopeptidase
Cell membrane
Complete proteome
Cytoplasm
Hydrolase
Membrane
Metal-binding
Metalloprotease
Protease
Reference proteome
Transmembrane
Transmembrane helix
Zinc
Feature
chain Dipeptidyl peptidase 3
splice variant In isoform 2.
splice variant In isoform 2.
Uniprot
H9J598
A0A1E1W925
A0A1E1VZ47
A0A3S2NPA0
A0A194R204
S4NQZ6
+ More
A0A194PXF0 A0A212EU88 A0A2H1V1R4 A0A1L8DTF9 A0A154P3S4 A0A088A023 Q17GV2 B4LYY4 A0A0Q9WS95 A0A2A3E497 A0A1Q3FFC5 K7J260 A0A232F3H0 A0A182QC05 A0A0Q9X0F2 B4K999 A0A182NCT3 A0A1I8MDN1 B0WDL4 A0A1I8MDN3 T1PA41 A0A182W368 A0A182IK67 A0A182LZ10 A0A310SJ36 E2B1G2 A0A026WW00 A0A182PLF5 A0A182HVM2 A0A182KZU3 A0A3L8DAK7 Q7PQ97 A0A182XF52 A0A182RI41 A0A182YQF4 E9IBJ6 A0A2J7R6R9 A0A182JQC2 A0A0R1E212 A0A067QWV6 A0A182TI80 B4PT52 A0A195F7C1 A0A2M4BFJ8 B4JV57 W5J8R3 A0A0C9RWS4 W8C2J3 A0A182FAD7 W8B4A6 I5ANW6 A0A0C9RU76 Q298R2 B4G4H0 A0A195EH24 W8BBB4 A0A1I8NZT2 Q9VHR8-2 A0A0A1X1M6 A0A151WJS3 Q9VHR8 B4QYL5 B3M0E9 B3P4Y4 A0A1I8NZP8 A0A0A1WX42 B4HLK9 A0A0P9ARK9 B4NLG4 A0A158NI09 A0A3B0JKS7 A0A195AWG2 A0A1W4VV59 A0A1W4VH36 A0A1B6DAV9 A0A1B6CVL8 A0A034V576 D3TMQ7 A0A0J7KTI8 A0A1A9UK01 A0A034VA64 F4WPT7 A0A1A9XMS1 A0A1B0BIR8 A0A182VHW7 A0A1B6LBX3 A0A1B6KD94 A0A084W3F1 A0A1B0FHA2 A0A1J1IZA2 A0A0M4EP37 A0A1B0CB27 A0A0M4EMA1 E2BZL5
A0A194PXF0 A0A212EU88 A0A2H1V1R4 A0A1L8DTF9 A0A154P3S4 A0A088A023 Q17GV2 B4LYY4 A0A0Q9WS95 A0A2A3E497 A0A1Q3FFC5 K7J260 A0A232F3H0 A0A182QC05 A0A0Q9X0F2 B4K999 A0A182NCT3 A0A1I8MDN1 B0WDL4 A0A1I8MDN3 T1PA41 A0A182W368 A0A182IK67 A0A182LZ10 A0A310SJ36 E2B1G2 A0A026WW00 A0A182PLF5 A0A182HVM2 A0A182KZU3 A0A3L8DAK7 Q7PQ97 A0A182XF52 A0A182RI41 A0A182YQF4 E9IBJ6 A0A2J7R6R9 A0A182JQC2 A0A0R1E212 A0A067QWV6 A0A182TI80 B4PT52 A0A195F7C1 A0A2M4BFJ8 B4JV57 W5J8R3 A0A0C9RWS4 W8C2J3 A0A182FAD7 W8B4A6 I5ANW6 A0A0C9RU76 Q298R2 B4G4H0 A0A195EH24 W8BBB4 A0A1I8NZT2 Q9VHR8-2 A0A0A1X1M6 A0A151WJS3 Q9VHR8 B4QYL5 B3M0E9 B3P4Y4 A0A1I8NZP8 A0A0A1WX42 B4HLK9 A0A0P9ARK9 B4NLG4 A0A158NI09 A0A3B0JKS7 A0A195AWG2 A0A1W4VV59 A0A1W4VH36 A0A1B6DAV9 A0A1B6CVL8 A0A034V576 D3TMQ7 A0A0J7KTI8 A0A1A9UK01 A0A034VA64 F4WPT7 A0A1A9XMS1 A0A1B0BIR8 A0A182VHW7 A0A1B6LBX3 A0A1B6KD94 A0A084W3F1 A0A1B0FHA2 A0A1J1IZA2 A0A0M4EP37 A0A1B0CB27 A0A0M4EMA1 E2BZL5
EC Number
3.4.14.4
Pubmed
19121390
26354079
23622113
22118469
17510324
17994087
+ More
20075255 28648823 25315136 20798317 24508170 20966253 30249741 12364791 14747013 17210077 25244985 21282665 17550304 24845553 20920257 23761445 24495485 15632085 10731132 12537572 12537569 11559363 12846841 25830018 21347285 25348373 20353571 21719571 24438588
20075255 28648823 25315136 20798317 24508170 20966253 30249741 12364791 14747013 17210077 25244985 21282665 17550304 24845553 20920257 23761445 24495485 15632085 10731132 12537572 12537569 11559363 12846841 25830018 21347285 25348373 20353571 21719571 24438588
EMBL
BABH01037048
GDQN01007578
JAT83476.1
GDQN01011051
JAT80003.1
RSAL01000018
+ More
RVE52815.1 KQ460883 KPJ11280.1 GAIX01014652 JAA77908.1 KQ459586 KPI98002.1 AGBW02012444 OWR45056.1 ODYU01000289 SOQ34783.1 GFDF01004341 JAV09743.1 KQ434809 KZC06472.1 CH477255 EAT45903.1 CH940650 EDW68087.2 KRF83636.1 KZ288379 PBC26583.1 GFDL01008786 JAV26259.1 NNAY01001059 OXU25304.1 AXCN02001582 CH933806 KRG01606.1 EDW15531.1 DS231898 EDS44623.1 KA644808 KA649140 AFP59437.1 AXCM01000899 KQ764717 OAD54432.1 GL444918 EFN60470.1 KK107078 EZA60250.1 APCN01005805 QOIP01000011 RLU16899.1 AAAB01008898 EAA09143.5 GL762111 EFZ22033.1 NEVH01006756 PNF36525.1 CM000160 KRK03177.1 KK853153 KDR10566.1 EDW96513.1 KQ981763 KYN36082.1 GGFJ01002590 MBW51731.1 CH916374 EDV91377.1 ADMH02001950 ETN60351.1 GBYB01012276 JAG82043.1 GAMC01010611 JAB95944.1 GAMC01010615 JAB95940.1 CM000070 EIM52651.1 GBYB01012300 JAG82067.1 EAL27893.3 CH479179 EDW24518.1 KQ978957 KYN27177.1 GAMC01010613 JAB95942.1 AE014297 AY051625 BT001283 BT001401 BT001402 BT001639 GBXI01009734 JAD04558.1 KQ983039 KYQ48086.1 CM000364 EDX13773.1 CH902617 EDV43155.1 CH954181 EDV49928.1 GBXI01011197 JAD03095.1 CH480815 EDW43036.1 KPU80103.1 CH964272 EDW84367.2 ADTU01016132 OUUW01000007 SPP82825.1 KQ976725 KYM76516.1 GEDC01014563 JAS22735.1 GEDC01019864 JAS17434.1 GAKP01020506 JAC38446.1 EZ422709 ADD18985.1 LBMM01003259 KMQ93737.1 GAKP01020504 JAC38448.1 GL888255 EGI63766.1 JXJN01015156 GEBQ01018794 JAT21183.1 GEBQ01030803 JAT09174.1 ATLV01019962 KE525286 KFB44745.1 CCAG010023021 CVRI01000064 CRL05541.1 CP012526 ALC46551.1 AJWK01004777 ALC46552.1 GL451634 EFN78866.1
RVE52815.1 KQ460883 KPJ11280.1 GAIX01014652 JAA77908.1 KQ459586 KPI98002.1 AGBW02012444 OWR45056.1 ODYU01000289 SOQ34783.1 GFDF01004341 JAV09743.1 KQ434809 KZC06472.1 CH477255 EAT45903.1 CH940650 EDW68087.2 KRF83636.1 KZ288379 PBC26583.1 GFDL01008786 JAV26259.1 NNAY01001059 OXU25304.1 AXCN02001582 CH933806 KRG01606.1 EDW15531.1 DS231898 EDS44623.1 KA644808 KA649140 AFP59437.1 AXCM01000899 KQ764717 OAD54432.1 GL444918 EFN60470.1 KK107078 EZA60250.1 APCN01005805 QOIP01000011 RLU16899.1 AAAB01008898 EAA09143.5 GL762111 EFZ22033.1 NEVH01006756 PNF36525.1 CM000160 KRK03177.1 KK853153 KDR10566.1 EDW96513.1 KQ981763 KYN36082.1 GGFJ01002590 MBW51731.1 CH916374 EDV91377.1 ADMH02001950 ETN60351.1 GBYB01012276 JAG82043.1 GAMC01010611 JAB95944.1 GAMC01010615 JAB95940.1 CM000070 EIM52651.1 GBYB01012300 JAG82067.1 EAL27893.3 CH479179 EDW24518.1 KQ978957 KYN27177.1 GAMC01010613 JAB95942.1 AE014297 AY051625 BT001283 BT001401 BT001402 BT001639 GBXI01009734 JAD04558.1 KQ983039 KYQ48086.1 CM000364 EDX13773.1 CH902617 EDV43155.1 CH954181 EDV49928.1 GBXI01011197 JAD03095.1 CH480815 EDW43036.1 KPU80103.1 CH964272 EDW84367.2 ADTU01016132 OUUW01000007 SPP82825.1 KQ976725 KYM76516.1 GEDC01014563 JAS22735.1 GEDC01019864 JAS17434.1 GAKP01020506 JAC38446.1 EZ422709 ADD18985.1 LBMM01003259 KMQ93737.1 GAKP01020504 JAC38448.1 GL888255 EGI63766.1 JXJN01015156 GEBQ01018794 JAT21183.1 GEBQ01030803 JAT09174.1 ATLV01019962 KE525286 KFB44745.1 CCAG010023021 CVRI01000064 CRL05541.1 CP012526 ALC46551.1 AJWK01004777 ALC46552.1 GL451634 EFN78866.1
Proteomes
UP000005204
UP000283053
UP000053240
UP000053268
UP000007151
UP000076502
+ More
UP000005203 UP000008820 UP000008792 UP000242457 UP000002358 UP000215335 UP000075886 UP000009192 UP000075884 UP000095301 UP000002320 UP000075920 UP000075880 UP000075883 UP000000311 UP000053097 UP000075885 UP000075840 UP000075882 UP000279307 UP000007062 UP000076407 UP000075900 UP000076408 UP000235965 UP000075881 UP000002282 UP000027135 UP000075902 UP000078541 UP000001070 UP000000673 UP000069272 UP000001819 UP000008744 UP000078492 UP000095300 UP000000803 UP000075809 UP000000304 UP000007801 UP000008711 UP000001292 UP000007798 UP000005205 UP000268350 UP000078540 UP000192221 UP000036403 UP000078200 UP000007755 UP000092443 UP000092460 UP000075903 UP000030765 UP000092444 UP000183832 UP000092553 UP000092461 UP000008237
UP000005203 UP000008820 UP000008792 UP000242457 UP000002358 UP000215335 UP000075886 UP000009192 UP000075884 UP000095301 UP000002320 UP000075920 UP000075880 UP000075883 UP000000311 UP000053097 UP000075885 UP000075840 UP000075882 UP000279307 UP000007062 UP000076407 UP000075900 UP000076408 UP000235965 UP000075881 UP000002282 UP000027135 UP000075902 UP000078541 UP000001070 UP000000673 UP000069272 UP000001819 UP000008744 UP000078492 UP000095300 UP000000803 UP000075809 UP000000304 UP000007801 UP000008711 UP000001292 UP000007798 UP000005205 UP000268350 UP000078540 UP000192221 UP000036403 UP000078200 UP000007755 UP000092443 UP000092460 UP000075903 UP000030765 UP000092444 UP000183832 UP000092553 UP000092461 UP000008237
PRIDE
ProteinModelPortal
H9J598
A0A1E1W925
A0A1E1VZ47
A0A3S2NPA0
A0A194R204
S4NQZ6
+ More
A0A194PXF0 A0A212EU88 A0A2H1V1R4 A0A1L8DTF9 A0A154P3S4 A0A088A023 Q17GV2 B4LYY4 A0A0Q9WS95 A0A2A3E497 A0A1Q3FFC5 K7J260 A0A232F3H0 A0A182QC05 A0A0Q9X0F2 B4K999 A0A182NCT3 A0A1I8MDN1 B0WDL4 A0A1I8MDN3 T1PA41 A0A182W368 A0A182IK67 A0A182LZ10 A0A310SJ36 E2B1G2 A0A026WW00 A0A182PLF5 A0A182HVM2 A0A182KZU3 A0A3L8DAK7 Q7PQ97 A0A182XF52 A0A182RI41 A0A182YQF4 E9IBJ6 A0A2J7R6R9 A0A182JQC2 A0A0R1E212 A0A067QWV6 A0A182TI80 B4PT52 A0A195F7C1 A0A2M4BFJ8 B4JV57 W5J8R3 A0A0C9RWS4 W8C2J3 A0A182FAD7 W8B4A6 I5ANW6 A0A0C9RU76 Q298R2 B4G4H0 A0A195EH24 W8BBB4 A0A1I8NZT2 Q9VHR8-2 A0A0A1X1M6 A0A151WJS3 Q9VHR8 B4QYL5 B3M0E9 B3P4Y4 A0A1I8NZP8 A0A0A1WX42 B4HLK9 A0A0P9ARK9 B4NLG4 A0A158NI09 A0A3B0JKS7 A0A195AWG2 A0A1W4VV59 A0A1W4VH36 A0A1B6DAV9 A0A1B6CVL8 A0A034V576 D3TMQ7 A0A0J7KTI8 A0A1A9UK01 A0A034VA64 F4WPT7 A0A1A9XMS1 A0A1B0BIR8 A0A182VHW7 A0A1B6LBX3 A0A1B6KD94 A0A084W3F1 A0A1B0FHA2 A0A1J1IZA2 A0A0M4EP37 A0A1B0CB27 A0A0M4EMA1 E2BZL5
A0A194PXF0 A0A212EU88 A0A2H1V1R4 A0A1L8DTF9 A0A154P3S4 A0A088A023 Q17GV2 B4LYY4 A0A0Q9WS95 A0A2A3E497 A0A1Q3FFC5 K7J260 A0A232F3H0 A0A182QC05 A0A0Q9X0F2 B4K999 A0A182NCT3 A0A1I8MDN1 B0WDL4 A0A1I8MDN3 T1PA41 A0A182W368 A0A182IK67 A0A182LZ10 A0A310SJ36 E2B1G2 A0A026WW00 A0A182PLF5 A0A182HVM2 A0A182KZU3 A0A3L8DAK7 Q7PQ97 A0A182XF52 A0A182RI41 A0A182YQF4 E9IBJ6 A0A2J7R6R9 A0A182JQC2 A0A0R1E212 A0A067QWV6 A0A182TI80 B4PT52 A0A195F7C1 A0A2M4BFJ8 B4JV57 W5J8R3 A0A0C9RWS4 W8C2J3 A0A182FAD7 W8B4A6 I5ANW6 A0A0C9RU76 Q298R2 B4G4H0 A0A195EH24 W8BBB4 A0A1I8NZT2 Q9VHR8-2 A0A0A1X1M6 A0A151WJS3 Q9VHR8 B4QYL5 B3M0E9 B3P4Y4 A0A1I8NZP8 A0A0A1WX42 B4HLK9 A0A0P9ARK9 B4NLG4 A0A158NI09 A0A3B0JKS7 A0A195AWG2 A0A1W4VV59 A0A1W4VH36 A0A1B6DAV9 A0A1B6CVL8 A0A034V576 D3TMQ7 A0A0J7KTI8 A0A1A9UK01 A0A034VA64 F4WPT7 A0A1A9XMS1 A0A1B0BIR8 A0A182VHW7 A0A1B6LBX3 A0A1B6KD94 A0A084W3F1 A0A1B0FHA2 A0A1J1IZA2 A0A0M4EP37 A0A1B0CB27 A0A0M4EMA1 E2BZL5
PDB
3FVY
E-value=0,
Score=1796
Ontologies
GO
PANTHER
Topology
Subcellular location
Membrane
Cell membrane
Cytoplasm
Cell membrane
Cytoplasm
Length:
721
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0330100000000001
Exp number, first 60 AAs:
0.02989
Total prob of N-in:
0.00152
outside
1 - 721
Population Genetic Test Statistics
Pi
203.028203
Theta
172.156546
Tajima's D
0.545702
CLR
0.000844
CSRT
0.529873506324684
Interpretation
Uncertain
