Gene

KWMTBOMO13265  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004729

Annotation

PREDICTED:_twinfilin_[Amyelois_transitella]

Location

Bomo_Chr22(+):11902960-11914855      View in EpiBrowser

Full name

Twinfilin      

Location in the cell

Nuclear   Reliability : 3.405

CDS

ATGTCGCACCAAACAGGTATTCAAGCAAATGCTGAGTTAAAGAAGTACATCAGCAAATGCCGGGATAGTAAACTTCGTGTTTTAAAAGTCACTATTGAAAATGAACAGCTGACAATGGCTAAGCATTTTTCCACAAAAGGAACATGGGAGCATGATTTTGATAAATATGTACCATCATTGATTGAGGAAGATCAACCTTGTTATATATTATATAGGTTTGATTCAAAAAATTCCCTTGGTCACGAATGGTTGCTGTTGAGTTGGTCCCCAGATAGTGCACCCGTTAGGCAGAAAATGCTATATGCTTCAACGAAAGCCACATTGAAACAAGAATTTGGTTCCGCCCATATTAAGGATGAGATGCATGCAACTGTTAAGGAAGAAGTCTCTCTGAAAGGCTACAAGGCGCATTTGAGCGGAGTGAGTGCTCCCGCCCCCCTCACGGATAGAGAGGAAGCCTTGAAAGAGTTGCAAGAAAGCGAACATAACACCAACTATGGGGTTGATGCCAGGCAATCAACAATGGGTGGTGTAGCCTTTCCGATAACAGAAGCCGCTAAGCAAGGAATAGTTGATCTCCAAAGAGGTTCCTATAATTATTTACAATTTAGAATAGATTTAGAAGAAGAAAAGATTAACTTATCGAAAGCGTCAAAGATATTATTAGAAGAATTACCTCTCCAAGTTCCCAATGATCAAGCCAGATATCACCTTTACATATTCACACACACGCACGAGGGAGACCACATGGACAGTACAGTATTCATCTACTCAATGCCCGGCTACAACTGTAGTATAAAAGAGCGAATGATGTATTCAAGTTGCAAAGGACAGTTCTTAGAAATCATAGAGAAAATGGGCGTCGAAATAACAAAAAGATTGGAAATCGACGATGGCAAAGAACTGACCGAAGAATATCTATATGATGAAATACATCCGAAGAGAAACTTACACCGTCCAGCTTTTGCCAAACCTAAAGGCCCTCCGAATAGGGGTGCCAAACGTATCACAAAATCACAGACCTCTCAGTAG

Protein

MSHQTGIQANAELKKYISKCRDSKLRVLKVTIENEQLTMAKHFSTKGTWEHDFDKYVPSLIEEDQPCYILYRFDSKNSLGHEWLLLSWSPDSAPVRQKMLYASTKATLKQEFGSAHIKDEMHATVKEEVSLKGYKAHLSGVSAPAPLTDREEALKELQESEHNTNYGVDARQSTMGGVAFPITEAAKQGIVDLQRGSYNYLQFRIDLEEEKINLSKASKILLEELPLQVPNDQARYHLYIFTHTHEGDHMDSTVFIYSMPGYNCSIKERMMYSSCKGQFLEIIEKMGVEITKRLEIDDGKELTEEYLYDEIHPKRNLHRPAFAKPKGPPNRGAKRITKSQTSQ

Description

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.

Subunit

Interacts with G-actin; ADP-actin form.

Similarity

Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.

Keywords

Actin-binding   Complete proteome   Cytoplasm   Cytoskeleton   Reference proteome   Repeat  

Feature

chain  Twinfilin

Uniprot

H9J5D9   A0A1E1WHZ3   A0A2H1V2A1   A0A212FB15   A0A194PY90   D6X1X0   + More
A0A1W4XN17   V5FZ65   N6UMM1   A0A2K7P6A3   Q17A58   U5EWR4   A0A084WR20   A0A182ILQ4   A0A1I8QF06   A0A182F8F7   A0A1L8EFT1   A0A0M4ECX1   A0A232EXE2   K7IMD7   A0A2M3Z8C5   A0A2M4BSW9   A0A2M4ANR3   A0A2M4BSW1   A0A2M3Z8F6   A0A1L8EFN5   B3LYR5   T1P921   W5JGK4   A0A1Q3G2J7   A0A182WVD8   A0A182I919   Q7QG28   A0A3B0K1E0   A0A1I8MYE7   A0A182Q393   A0A182YJL7   Q7QG27   B4M038   B4KDW7   A0A182R8E3   B4G4T8   Q298X4   A0A1W4V6M2   B4PTC2   B3P0L8   Q9VFM9   A0A2A3E3L9   A0A182GMN2   B4N9I1   A0A151IGF9   W8B6J4   A0A182NCM0   B4HF54   A0A158P3N0   A0A182SNT1   E1ZUV4   A0A026W5Q6   A0A182PQQ6   A0A2P8Y0G9   A0A182JVP9   A0A1B0CNK4   A0A336KII4   B4R0H7   A0A2J7QVY3   A0A1Y1MDA8   A0A0K8VHN6   A0A1A9W7D2   A0A1Y1MDH8   A0A067R0P1   B4K013   A0A1B6J9Q9   A0A1B6EV85   F4WM54   A0A195FUP5   A0A0A1X472   A0A1B6LI65   E9IXZ1   A0A195BC80   A0A1B6KYF9   A0A0L7R0S3   A0A151WFJ1   A0A023END5   A0A195DCE8   A0A1L8E451   A0A182W311   A0A182LW59   A0A1S4ET28   A0A182VK19   A0A182U9M9   A0A2R5LGT2   A0A1A9VG04   A0A0P5IPN0   A0A0P6E8F9   A0A1B6CRZ5   A0A1J1HJG4   A0A1A9ZZ00   A0A0P5L7N5   A0A1Z5L4P8   A0A1A9YSU8  

Pubmed

19121390    22118469    26354079    18362917    19820115    23537049    + More
17510324    24438588    28648823    20075255    17994087    20920257    23761445    12364791    25315136    25244985    14747013    17210077    15632085    17550304    11724820    10731132    12537572    12537569    26483478    24495485    21347285    20798317    24508170    30249741    29403074    28004739    24845553    21719571    25830018    21282665    24945155    28528879   

EMBL

BABH01039193    BABH01039194    GDQN01007194    GDQN01006765    GDQN01004528    GDQN01001172    + More
JAT83860.1    JAT84289.1    JAT86526.1    JAT89882.1    ODYU01000346    SOQ34939.1    AGBW02009387    OWR50934.1    KQ459586    KPI97993.1    KQ971371    EFA09952.1    GALX01005486    JAB62980.1    APGK01017189    KB739998    KB631984    ENN81951.1    ERL87640.1    CH477340    GANO01001292    JAB58579.1    ATLV01025890    KE525402    KFB52664.1    GFDG01001324    JAV17475.1    CP012526    ALC45554.1    NNAY01001740    OXU23064.1    GGFM01004023    MBW24774.1    GGFJ01007034    MBW56175.1    GGFK01009098    MBW42419.1    GGFJ01007035    MBW56176.1    GGFM01004055    MBW24806.1    GFDG01001325    JAV17474.1    CH902617    EDV44031.1    KA645197    AFP59826.1    ADMH02001252    ETN63492.1    GFDL01001023    JAV34022.1    APCN01003158    AAAB01008844    OUUW01000013    SPP88087.1    AXCN02001183    EAA06061.3    CH940650    EDW68288.1    CH933806    EDW14964.1    CH479179    EDW24604.1    CM000070    CM000160    EDW97621.1    CH954181    EDV48844.1    AJ430055    AE014297    AY069613    KZ288439    PBC25739.1    JXUM01075106    JXUM01075107    JXUM01075108    KQ562869    KXJ74965.1    CH964232    EDW81657.1    KQ977726    KYN00314.1    GAMC01012333    JAB94222.1    CH480815    EDW42228.1    ADTU01001333    ADTU01001334    GL434297    EFN75046.1    KK107399    QOIP01000002    EZA51338.1    RLU26161.1    PYGN01001082    PSN37761.1    AJWK01020463    UFQS01000350    UFQT01000350    SSX03085.1    SSX23451.1    CM000364    EDX12992.1    NEVH01009770    PNF32736.1    GEZM01034446    JAV83792.1    GDHF01013941    JAI38373.1    GEZM01034445    JAV83794.1    KK852801    KDR16312.1    CH916384    EDV91615.1    GECU01011818    JAS95888.1    GECZ01027927    JAS41842.1    GL888217    EGI64698.1    KQ981264    KYN44012.1    GBXI01008732    JAD05560.1    GEBQ01016638    JAT23339.1    GL766836    EFZ14561.1    KQ976519    KYM82171.1    GEBQ01023517    JAT16460.1    KQ414670    KOC64443.1    KQ983219    KYQ46555.1    GAPW01002681    JAC10917.1    KQ980989    KYN10585.1    GFDF01000782    JAV13302.1    AXCM01003114    GGLE01004600    MBY08726.1    GDIP01216839    GDIQ01212156    GDIP01067212    GDIP01028613    GDIQ01072814    GDIQ01036887    JAJ06563.1    JAK39569.1    GDIQ01078110    JAN16627.1    GEDC01021203    JAS16095.1    CVRI01000006    CRK88175.1    GDIQ01173663    JAK78062.1    GFJQ02004587    JAW02383.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000007266    UP000192223    UP000019118    + More
UP000030742    UP000008820    UP000030765    UP000075880    UP000095300    UP000069272    UP000092553    UP000215335    UP000002358    UP000007801    UP000000673    UP000076407    UP000075840    UP000007062    UP000268350    UP000095301    UP000075886    UP000076408    UP000008792    UP000009192    UP000075900    UP000008744    UP000001819    UP000192221    UP000002282    UP000008711    UP000000803    UP000242457    UP000069940    UP000249989    UP000007798    UP000078542    UP000075884    UP000001292    UP000005205    UP000075901    UP000000311    UP000053097    UP000279307    UP000075885    UP000245037    UP000075881    UP000092461    UP000000304    UP000235965    UP000091820    UP000027135    UP000001070    UP000007755    UP000078541    UP000078540    UP000053825    UP000075809    UP000078492    UP000075920    UP000075883    UP000079169    UP000075903    UP000075902    UP000078200    UP000183832    UP000092445    UP000092443   

PRIDE

H9J5D9    Q17A58    Q9VFM9   

Pfam

PF00241   Cofilin_ADF

Interpro

IPR029006   ADF-H/Gelsolin-like_dom_sf        + More
IPR028458   Twinfilin       
IPR002108   ADF-H       

Gene 3D

3.40.20.10    

ProteinModelPortal

H9J5D9   A0A1E1WHZ3   A0A2H1V2A1   A0A212FB15   A0A194PY90   D6X1X0   + More
A0A1W4XN17   V5FZ65   N6UMM1   A0A2K7P6A3   Q17A58   U5EWR4   A0A084WR20   A0A182ILQ4   A0A1I8QF06   A0A182F8F7   A0A1L8EFT1   A0A0M4ECX1   A0A232EXE2   K7IMD7   A0A2M3Z8C5   A0A2M4BSW9   A0A2M4ANR3   A0A2M4BSW1   A0A2M3Z8F6   A0A1L8EFN5   B3LYR5   T1P921   W5JGK4   A0A1Q3G2J7   A0A182WVD8   A0A182I919   Q7QG28   A0A3B0K1E0   A0A1I8MYE7   A0A182Q393   A0A182YJL7   Q7QG27   B4M038   B4KDW7   A0A182R8E3   B4G4T8   Q298X4   A0A1W4V6M2   B4PTC2   B3P0L8   Q9VFM9   A0A2A3E3L9   A0A182GMN2   B4N9I1   A0A151IGF9   W8B6J4   A0A182NCM0   B4HF54   A0A158P3N0   A0A182SNT1   E1ZUV4   A0A026W5Q6   A0A182PQQ6   A0A2P8Y0G9   A0A182JVP9   A0A1B0CNK4   A0A336KII4   B4R0H7   A0A2J7QVY3   A0A1Y1MDA8   A0A0K8VHN6   A0A1A9W7D2   A0A1Y1MDH8   A0A067R0P1   B4K013   A0A1B6J9Q9   A0A1B6EV85   F4WM54   A0A195FUP5   A0A0A1X472   A0A1B6LI65   E9IXZ1   A0A195BC80   A0A1B6KYF9   A0A0L7R0S3   A0A151WFJ1   A0A023END5   A0A195DCE8   A0A1L8E451   A0A182W311   A0A182LW59   A0A1S4ET28   A0A182VK19   A0A182U9M9   A0A2R5LGT2   A0A1A9VG04   A0A0P5IPN0   A0A0P6E8F9   A0A1B6CRZ5   A0A1J1HJG4   A0A1A9ZZ00   A0A0P5L7N5   A0A1Z5L4P8   A0A1A9YSU8  

PDB

1M4J     E-value=4.30553e-42,     Score=430

KEGG

101740059    K08870 twinfilin | (RefSeq) twinfilin

GO

GO:0030837   GO:0003779   GO:0051016   GO:0005737   GO:0030016   GO:0010976   GO:0003785   GO:0005884   GO:0042989   GO:0010591   GO:0030042   GO:0051015   GO:0005856   GO:0005938   GO:0098793   GO:0005886   GO:0008407   GO:0007298   GO:0048488   GO:0007274   GO:0016319   GO:0030833   GO:0016787   GO:0005622   GO:0030976   GO:0008152   GO:0016624   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

PANTHER

PTHR13759  

Subcellular location

Cytoplasm  
Cytoskeleton  
Cell cortex  

Length:

343

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00266

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03981

outside

1  -  343

 

 

Pi

179.361243

Theta

160.454343

Tajima's D

0.593476

CLR

0.000001

CSRT

0.547322633868307

Interpretation

Uncertain