SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO13264
Pre Gene Modal
BGIBMGA004735
Annotation
serine_protease_inhibitor_19_precursor_[Bombyx_mori]
Full name
Alaserpin       + More
Antichymotrypsin-2      
Antitrypsin      
Serine protease inhibitor 3/4      
Alternative Name
Serpin-1
Antichymotrypsin II
Location in the cell
Cytoplasmic   Reliability : 1.882
 

Sequence

CDS
ATGAAGAAGTCCTTGTTGAGTTGTTTGTGTACCTTATTTGGGTTGCTAGCCGCCGGATTCATAGAAGATAAATATCCGAATTCAAATATAGGCAACTGGCTTGCTGAAAATAATAATGAGTTGACAAGGAACTTGTTTTATGAACTTCAAAAAGATTATCCAGGAAAATCTCTCGCTGTAACATCCGTGCCCATTTTGAACATTTTGGGGCAGCTTGCATTATATTCCAAAGGAGAAACTTTTGAAGCTATCACAGATACACTGGGAATTAGGAATAGTACTGAGGTGAAGAGGACTTTCCAAATGGCAAACGAAAAGACATTTGATGACAGTGAACTTCCACTCAGATATACATCGAAAATATACGCGGATGACGAAGATCAATTTTGTCCGACTTTCAAGAAAACCTATTCGAAGTACTTTAAAGGGCAAACAGGAAATGTAGACTTCGATAGACCACAGAAAGCGGCAAAAGAAATAAATAAGTGGCTCGAAGAAGATTTCGATCAATATGGAAACGCGGATTTAGTTGATACAAGCGTAATTAAGGAGGGCGATGGCTTCGTTGTAGTTGGTTCTCTCGAACTAGAGCTTGACTACAATACTGGGCTCAATCCAACGAAAGTGAAAACAATGGATTTCTATTTAAACGCTAAGAAAAAGGTAAAGACACCTGCTTTGGTCGGAAAGGCAATCGTAAAGTATGCCAAGGTTTCGGAATACGATGCACAGTTCATCAGCATATCGCTCAAGGGAGGTGACTTCACACTATTCGCAATTCTTCCCGATGAGGTCAATGGATTATATAAGCTCACACAGAAATTCAAAAGTTTGAAAACTGACGTTTACAATAAAATCAGTCCATACCTGGAATATAAATGCGTCGAACTACAAATGCCCCTTGGACAAATACTGACTCAAGGTGACATTACGGAGGCCCTCAAAAAGATACAGGACTTGGACATTTTGTTTGACAAAAAACGGGCCCAGCTCTGTGGTGTGACCAACAACTGTGAGCCCGGTGTAATCAAAAGTTTCTTGACCGAAACCTATCTTGTTGACAAAATAATTAAAGAAAATAGTTTCGCGTATTAA
Protein
MKKSLLSCLCTLFGLLAAGFIEDKYPNSNIGNWLAENNNELTRNLFYELQKDYPGKSLAVTSVPILNILGQLALYSKGETFEAITDTLGIRNSTEVKRTFQMANEKTFDDSELPLRYTSKIYADDEDQFCPTFKKTYSKYFKGQTGNVDFDRPQKAAKEINKWLEEDFDQYGNADLVDTSVIKEGDGFVVVGSLELELDYNTGLNPTKVKTMDFYLNAKKKVKTPALVGKAIVKYAKVSEYDAQFISISLKGGDFTLFAILPDEVNGLYKLTQKFKSLKTDVYNKISPYLEYKCVELQMPLGQILTQGDITEALKKIQDLDILFDKKRAQLCGVTNNCEPGVIKSFLTETYLVDKIIKENSFAY

Summary

Miscellaneous
The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).
Similarity
Belongs to the serpin family.
Keywords
3D-structure   Alternative splicing   Glycoprotein   Protease inhibitor   Secreted   Serine protease inhibitor   Signal   Complete proteome   Direct protein sequencing   Reference proteome  
Feature
chain  Alaserpin
splice variant  In isoform 2.
EMBL
BABH01039199    EU935620    ACG61182.1    EU935624    ACG61186.1    EU935631    + More
ACG61193.1    BABH01039200    EU935621    ACG61183.1    BABH01037565    EU935626    ACG61188.1    MG770321    AXY94923.1    MG770320    AXY94922.1    MG753799    AYC12556.1    MG753798    AYC12555.1    U58361    AAC47340.1    AAC47334.1    AAC47333.1    L20793    AAA29334.1    AAC47341.1    AAC47337.1    AAC47336.1    AAC47332.1    AAC47339.1    AAC47335.1    M23438    L20792    AAC47338.1    AAC47342.1    EU040208    ABW17156.1    EU040209    ABW17157.1    HQ615869    ADT63775.1    AB295499    BAF48335.1    EU040210    ABW17158.1    AB295498    BAF48334.1    AB189029    BAD52261.1    EU040207    ABW17155.1    EU368832    ABY68562.1    ABY68559.1    ABY68561.1    ABY68560.1    ABY68555.1    ABY68558.1    ABY68557.1    ABY68556.1    ABY68563.1    EU935625    ACG61187.1    AY148483    AAN71632.1    AY148484    AAN71633.1    BABH01041150    FJ613797    ACT36276.1    ACT36277.1    ACT36279.1    FJ763763    ACR56864.1    ACT36278.1    AY148485    AAN71634.1    FJ763764    ACR56865.1    AGBW02009121    OWR51607.1    FJ613794    FJ613796    ACT36273.1    ACT36275.1    FJ613795    ACT36274.1    FJ613793    ACT36272.1    D00738    KR003729    ALD62507.1    KY385635    APT69916.1    JX524148    AFV46312.1    KQ460883    KPJ11294.1    EU935616    ACG61178.1    BABH01037571    BABH01037572    ODYU01002062    SOQ39103.1    EU935618    ACG61180.1    RSAL01000018    RVE52836.1    BABH01037570    BABH01037558    JN033738    AEW46891.2    RVE52848.1    AK401396    BAM18018.1    KQ459586    KPI97989.1    HM023856    ADJ58589.2    JF777341    AEU11686.1    HM023815    JF777348    ADJ58548.1    AEU11693.1    RVE52837.1    KPJ11295.1    MG992370    AXY94808.1    JN033737    AEW46890.2    JR050992    AEY61403.1    KZ288499    PBC25171.1    AY829816    AY829817    AAV91430.1    JTDY01000556    KOB76688.1    GDQN01007288    JAT83766.1    GDQN01003022    JAT88032.1    KQ971361    EFA09177.1    CH902619    EDV35507.2    EDV36812.2    GFTR01005837    JAW10589.1    GDQN01006457    JAT84597.1    KPI97991.1    CM000158    EDW90055.1   
Pfam
PF00079   Serpin        + More
PF01826   TIL
Interpro
IPR000215   Serpin_fam        + More
IPR042185   Serpin_sf_2       
IPR042178   Serpin_sf_1       
IPR023796   Serpin_dom       
IPR036186   Serpin_sf       
IPR036084   Ser_inhib-like_sf       
IPR002919   TIL_dom       
IPR023795   Serpin_CS       
SUPFAM
SSF56574   SSF56574        + More
SSF57567   SSF57567       
Gene 3D
PDB
1SEK     E-value=1.81445e-29,     Score=322

Ontologies

Topology

Subcellular location
  
Secreted  
SignalP
Position:   1 - 19,         Likelihood:  0.984825
 
 
Length:
364
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
4.24809999999999
Exp number, first 60 AAs:
4.01533
Total prob of N-in:
0.22956
outside
1  -  364
 
 

Population Genetic Test Statistics

Pi
250.166824
Theta
181.828217
Tajima's D
0.910106
CLR
0
CSRT
0.63796810159492
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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