Gene

KWMTBOMO13264

Pre Gene Modal

BGIBMGA004735

Annotation

serine_protease_inhibitor_19_precursor_[Bombyx_mori]

Location

Bomo_Chr22(-):11851464-11857619      View in EpiBrowser

Full name

Alaserpin       + More
Antichymotrypsin-2      
Antitrypsin      
Serine protease inhibitor 3/4      

Alternative Name

Serpin-1
Antichymotrypsin II

Location in the cell

Cytoplasmic   Reliability : 1.882

CDS

ATGAAGAAGTCCTTGTTGAGTTGTTTGTGTACCTTATTTGGGTTGCTAGCCGCCGGATTCATAGAAGATAAATATCCGAATTCAAATATAGGCAACTGGCTTGCTGAAAATAATAATGAGTTGACAAGGAACTTGTTTTATGAACTTCAAAAAGATTATCCAGGAAAATCTCTCGCTGTAACATCCGTGCCCATTTTGAACATTTTGGGGCAGCTTGCATTATATTCCAAAGGAGAAACTTTTGAAGCTATCACAGATACACTGGGAATTAGGAATAGTACTGAGGTGAAGAGGACTTTCCAAATGGCAAACGAAAAGACATTTGATGACAGTGAACTTCCACTCAGATATACATCGAAAATATACGCGGATGACGAAGATCAATTTTGTCCGACTTTCAAGAAAACCTATTCGAAGTACTTTAAAGGGCAAACAGGAAATGTAGACTTCGATAGACCACAGAAAGCGGCAAAAGAAATAAATAAGTGGCTCGAAGAAGATTTCGATCAATATGGAAACGCGGATTTAGTTGATACAAGCGTAATTAAGGAGGGCGATGGCTTCGTTGTAGTTGGTTCTCTCGAACTAGAGCTTGACTACAATACTGGGCTCAATCCAACGAAAGTGAAAACAATGGATTTCTATTTAAACGCTAAGAAAAAGGTAAAGACACCTGCTTTGGTCGGAAAGGCAATCGTAAAGTATGCCAAGGTTTCGGAATACGATGCACAGTTCATCAGCATATCGCTCAAGGGAGGTGACTTCACACTATTCGCAATTCTTCCCGATGAGGTCAATGGATTATATAAGCTCACACAGAAATTCAAAAGTTTGAAAACTGACGTTTACAATAAAATCAGTCCATACCTGGAATATAAATGCGTCGAACTACAAATGCCCCTTGGACAAATACTGACTCAAGGTGACATTACGGAGGCCCTCAAAAAGATACAGGACTTGGACATTTTGTTTGACAAAAAACGGGCCCAGCTCTGTGGTGTGACCAACAACTGTGAGCCCGGTGTAATCAAAAGTTTCTTGACCGAAACCTATCTTGTTGACAAAATAATTAAAGAAAATAGTTTCGCGTATTAA

Protein

MKKSLLSCLCTLFGLLAAGFIEDKYPNSNIGNWLAENNNELTRNLFYELQKDYPGKSLAVTSVPILNILGQLALYSKGETFEAITDTLGIRNSTEVKRTFQMANEKTFDDSELPLRYTSKIYADDEDQFCPTFKKTYSKYFKGQTGNVDFDRPQKAAKEINKWLEEDFDQYGNADLVDTSVIKEGDGFVVVGSLELELDYNTGLNPTKVKTMDFYLNAKKKVKTPALVGKAIVKYAKVSEYDAQFISISLKGGDFTLFAILPDEVNGLYKLTQKFKSLKTDVYNKISPYLEYKCVELQMPLGQILTQGDITEALKKIQDLDILFDKKRAQLCGVTNNCEPGVIKSFLTETYLVDKIIKENSFAY

Miscellaneous

The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).

Similarity

Belongs to the serpin family.

Keywords

3D-structure   Alternative splicing   Glycoprotein   Protease inhibitor   Secreted   Serine protease inhibitor   Signal   Complete proteome   Direct protein sequencing   Reference proteome  

Feature

chain  Alaserpin
splice variant  In isoform 2.

Uniprot

H9J5E5   C0J8G8   C0J8H2   C0J8H9   H9J5E6   C0J8G9   + More
H9JH30   C0J8H4   A0A3G1T1R3   A0A3G1T1Q1   A0A385XRR7   A0A385XRT7   Q25499   Q25491   Q25497   Q25526   Q25495   Q25493   Q25496   Q25494   Q25501   Q25500   P14754   Q25492   Q25498   B4XH99   B4XHA0   F5B4G8   A3KEZ8   B4XHA1   A3KEZ7   Q60FS0   B4XH98   B0FZ61   B0FZ64   B0FZ62   B0FZ63   B0FZ68   B0FZ65   B0FZ66   B0FZ67   B0FZ60   C0J8H3   Q8IS86   Q8IS85   H9JKA2   C7ASM9   C7ASM7   C5I794   C7ASM6   Q8IS84   C5I795   A0A212FD15   C7ASM3   P80034   C7ASM4   C7ASM2   P22922   A0A0M4K7J2   A0A1L7B975   K4P392   A0A194R1A3   C0J8G4   H9JH34   A0A2H1VE36   C0J8G6   A0A3S2TR38   H9JH33   H9JH29   G9F9J3   A0A3S2M6W8   I4DJC8   A0A194PZ13   D9HQA1   G9D4T8   D9HQ60   A0A3S2M7J7   A0A194R217   A0A3G1T1E7   G9F9J2   V9IJT7   A0A2A3E250   Q5MGH0   A0A0L7LMC8   A0A1E1W9X2   A0A1E1WM18   A0A1W4U5N2   D6WWI0   B3MEP3   B3MGQ4   A0A224XRJ3   A0A1E1WCC9   A0A194PXB8   B4P7M0  

Pubmed

19121390    19150649    30237077    8910411    8276850    10368276    + More
2463253    14728663    19524698    19481148    22118469    21104446    1761030    2277028    1368515    26354079    22651552    20375075    21967427    16023793    18342903    26227816    18362917    19820115    17994087    17550304   

EMBL

BABH01039199    EU935620    ACG61182.1    EU935624    ACG61186.1    EU935631    + More
ACG61193.1    BABH01039200    EU935621    ACG61183.1    BABH01037565    EU935626    ACG61188.1    MG770321    AXY94923.1    MG770320    AXY94922.1    MG753799    AYC12556.1    MG753798    AYC12555.1    U58361    AAC47340.1    AAC47334.1    AAC47333.1    L20793    AAA29334.1    AAC47341.1    AAC47337.1    AAC47336.1    AAC47332.1    AAC47339.1    AAC47335.1    M23438    L20792    AAC47338.1    AAC47342.1    EU040208    ABW17156.1    EU040209    ABW17157.1    HQ615869    ADT63775.1    AB295499    BAF48335.1    EU040210    ABW17158.1    AB295498    BAF48334.1    AB189029    BAD52261.1    EU040207    ABW17155.1    EU368832    ABY68562.1    ABY68559.1    ABY68561.1    ABY68560.1    ABY68555.1    ABY68558.1    ABY68557.1    ABY68556.1    ABY68563.1    EU935625    ACG61187.1    AY148483    AAN71632.1    AY148484    AAN71633.1    BABH01041150    FJ613797    ACT36276.1    ACT36277.1    ACT36279.1    FJ763763    ACR56864.1    ACT36278.1    AY148485    AAN71634.1    FJ763764    ACR56865.1    AGBW02009121    OWR51607.1    FJ613794    FJ613796    ACT36273.1    ACT36275.1    FJ613795    ACT36274.1    FJ613793    ACT36272.1    D00738    KR003729    ALD62507.1    KY385635    APT69916.1    JX524148    AFV46312.1    KQ460883    KPJ11294.1    EU935616    ACG61178.1    BABH01037571    BABH01037572    ODYU01002062    SOQ39103.1    EU935618    ACG61180.1    RSAL01000018    RVE52836.1    BABH01037570    BABH01037558    JN033738    AEW46891.2    RVE52848.1    AK401396    BAM18018.1    KQ459586    KPI97989.1    HM023856    ADJ58589.2    JF777341    AEU11686.1    HM023815    JF777348    ADJ58548.1    AEU11693.1    RVE52837.1    KPJ11295.1    MG992370    AXY94808.1    JN033737    AEW46890.2    JR050992    AEY61403.1    KZ288499    PBC25171.1    AY829816    AY829817    AAV91430.1    JTDY01000556    KOB76688.1    GDQN01007288    JAT83766.1    GDQN01003022    JAT88032.1    KQ971361    EFA09177.1    CH902619    EDV35507.2    EDV36812.2    GFTR01005837    JAW10589.1    GDQN01006457    JAT84597.1    KPI97991.1    CM000158    EDW90055.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000283053    UP000053268    UP000242457    + More
UP000037510    UP000192221    UP000007266    UP000007801    UP000002282   

PRIDE

H9J5E5    C0J8G8    C0J8H2    C0J8H9    H9J5E6    C0J8G9    + More
H9JH30    C0J8H4    P14754    C0J8H3    H9JKA2    C7ASM9    C7ASM7    C7ASM6    C7ASM3    P80034    C7ASM4    P22922    C0J8G4    H9JH34    C0J8G6    H9JH33    H9JH29   

Pfam

PF00079   Serpin        + More
PF01826   TIL

Interpro

IPR000215   Serpin_fam        + More
IPR042185   Serpin_sf_2       
IPR042178   Serpin_sf_1       
IPR023796   Serpin_dom       
IPR036186   Serpin_sf       
IPR036084   Ser_inhib-like_sf       
IPR002919   TIL_dom       
IPR023795   Serpin_CS       

SUPFAM

SSF56574   SSF56574        + More
SSF57567   SSF57567       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

H9J5E5   C0J8G8   C0J8H2   C0J8H9   H9J5E6   C0J8G9   + More
H9JH30   C0J8H4   A0A3G1T1R3   A0A3G1T1Q1   A0A385XRR7   A0A385XRT7   Q25499   Q25491   Q25497   Q25526   Q25495   Q25493   Q25496   Q25494   Q25501   Q25500   P14754   Q25492   Q25498   B4XH99   B4XHA0   F5B4G8   A3KEZ8   B4XHA1   A3KEZ7   Q60FS0   B4XH98   B0FZ61   B0FZ64   B0FZ62   B0FZ63   B0FZ68   B0FZ65   B0FZ66   B0FZ67   B0FZ60   C0J8H3   Q8IS86   Q8IS85   H9JKA2   C7ASM9   C7ASM7   C5I794   C7ASM6   Q8IS84   C5I795   A0A212FD15   C7ASM3   P80034   C7ASM4   C7ASM2   P22922   A0A0M4K7J2   A0A1L7B975   K4P392   A0A194R1A3   C0J8G4   H9JH34   A0A2H1VE36   C0J8G6   A0A3S2TR38   H9JH33   H9JH29   G9F9J3   A0A3S2M6W8   I4DJC8   A0A194PZ13   D9HQA1   G9D4T8   D9HQ60   A0A3S2M7J7   A0A194R217   A0A3G1T1E7   G9F9J2   V9IJT7   A0A2A3E250   Q5MGH0   A0A0L7LMC8   A0A1E1W9X2   A0A1E1WM18   A0A1W4U5N2   D6WWI0   B3MEP3   B3MGQ4   A0A224XRJ3   A0A1E1WCC9   A0A194PXB8   B4P7M0  

PDB

1SEK     E-value=1.81445e-29,     Score=322

KEGG

100272184    no KO assigned | (RefSeq) serpin-19, BmSPN12, SPN12; serine protease inhibitor 19

GO

GO:0005615   GO:0008233   GO:0004867   GO:0009617   GO:0010951   GO:0032504  

PANTHER

PTHR11461  

Subcellular location

  
Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.984825

 

 

Length:

364

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.24809999999999

Exp number, first 60 AAs:

4.01533

Total prob of N-in:

0.22956

outside

1  -  364

 

 

Pi

250.166824

Theta

181.828217

Tajima's D

0.910106

CLR

0

CSRT

0.63796810159492

Interpretation

Uncertain