Gene

KWMTBOMO13263

Pre Gene Modal

BGIBMGA004735

Annotation

serine_protease_inhibitor_23_precursor_[Bombyx_mori]

Location

Bomo_Chr22(-):11843638-11846039      View in EpiBrowser

Full name

Antichymotrypsin-2       + More
Antitrypsin      
Alaserpin      

Alternative Name

Antichymotrypsin II
Serpin-1

Location in the cell

Extracellular   Reliability : 2.258

CDS

ATGAAGAAGTCCTTGTTGAGTTGTTTGTGTTCCTTATTTGGGTTGTTAACTGCCGCATTCATAGAAGATAAGAATCCAAACGCAAATATAAGCAACTGGCTTGCTGCAAATAGTAATGAGTTAACGAGGAACCTGTTTTTTGAACTTCAAAAATATTATCCAGGAAAATCTCTCGCTGTAACATCCGTGCCCATTTTCAACATTTTGGGGCAGCTTGTTTTATATTCCAAAGGAGAAACTTTTGAAACTATCACAGATATAGTGGGATTGAAGAATAGTACTGATGTGAAGAGGAGTTTCAAAATAGGAAACGAAAGGACATTTGACAGTGATATTCCACTCAGGTACACATCGAAAATATACGCCGATGACGAAGACCAATTTTGTCCGGCTTTCAAGAAAACCTATTCGCAGTACTTCAAAGGGAAAACAGGAAATGTAGACTTCGATAGACCACAGAAAGCGGCCAAAGAAATAAATGAGTGGGTATGTATCTTCCAGCAGATAAGTTCCTAA

Protein

MKKSLLSCLCSLFGLLTAAFIEDKNPNANISNWLAANSNELTRNLFFELQKYYPGKSLAVTSVPIFNILGQLVLYSKGETFETITDIVGLKNSTDVKRSFKIGNERTFDSDIPLRYTSKIYADDEDQFCPAFKKTYSQYFKGKTGNVDFDRPQKAAKEINEWVCIFQQISS

Miscellaneous

The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).

Similarity

Belongs to the serpin family.

Keywords

Complete proteome   Direct protein sequencing   Protease inhibitor   Reference proteome   Secreted   Serine protease inhibitor   Signal   3D-structure   Alternative splicing   Glycoprotein  

Feature

chain  Antichymotrypsin-2

Uniprot

C0J8H2   C0J8G8   H9J5E5   H9J5E6   C0J8H9   H9JH30   + More
C0J8G9   H9JH29   H9JH31   C0J8H4   F5B4G8   B4XH99   B4XH98   B4XHA1   C0J8H3   B4XHA0   A0A2H1VE36   H9JKA2   C7ASM7   C7ASM6   C7ASM9   A0A194R1A3   P80034   C7ASM3   C7ASM4   C7ASM2   P22922   A0A0M4K7J2   H9JH33   B0FZ60   B0FZ63   B0FZ61   Q8IS86   B0FZ62   C5I794   B0FZ68   B0FZ64   Q8IS84   B0FZ65   B0FZ66   B0FZ67   Q8IS85   C5I795   C0J8G6   C0J8G4   A0A212FD15   H9JH34   A3KEZ8   A3KEZ7   Q60FS0   I4DJC8   A0A194PZ13   A0A3S2TR38   A0A1L7B975   A0A3S2M7J7   K4P392   A0A3S2NJW5   A0A2K8JL73   A0A2K8JKZ6   G9D4T8   D9HQA1   A0A212FD30   G9F9J3   A0A3S2M6W8   A0A194R217   A0A385XRT7   A0A3G1T1Q1   D9HQ60   A0A3L7HV82   G3GWY0   Q25497   Q25496   Q25499   A0A3G1T1R3   Q25493   Q25500   Q25526   Q25494   Q25492   Q25491   Q25501   Q25495   Q25498   P14754   G3X2D8   G3X2D7   A0A385XRR7   A0A3B6LTZ4   R7W1R1   I7HJI5   Q9D6A7   A0A3B4D8M5   A0A1W4V212  

Pubmed

19150649    19121390    19524698    26354079    1761030    21104446    + More
2277028    1368515    19481148    22118469    22651552    21967427    20375075    30237077    29704459    21804562    8910411    8276850    10368276    2463253    14728663    21709235    19468303    10349636    11042159    11076861    11217851    12466851    12040188    16141073   

EMBL

EU935624    ACG61186.1    EU935620    ACG61182.1    BABH01039199    BABH01039200    + More
EU935631    ACG61193.1    BABH01037565    EU935621    ACG61183.1    BABH01037558    BABH01037566    EU935626    ACG61188.1    HQ615869    ADT63775.1    EU040208    ABW17156.1    EU040207    ABW17155.1    EU040210    ABW17158.1    EU935625    ACG61187.1    EU040209    ABW17157.1    ODYU01002062    SOQ39103.1    BABH01041150    FJ613797    ACT36277.1    ACT36279.1    ACT36278.1    ACT36276.1    KQ460883    KPJ11294.1    FJ613794    FJ613796    ACT36273.1    ACT36275.1    FJ613795    ACT36274.1    FJ613793    ACT36272.1    D00738    KR003729    ALD62507.1    BABH01037570    EU368832    ABY68563.1    ABY68560.1    ABY68562.1    AY148483    AAN71632.1    ABY68561.1    FJ763763    ACR56864.1    ABY68555.1    ABY68559.1    AY148485    AAN71634.1    ABY68558.1    ABY68557.1    ABY68556.1    AY148484    AAN71633.1    FJ763764    ACR56865.1    EU935618    ACG61180.1    EU935616    ACG61178.1    AGBW02009121    OWR51607.1    BABH01037571    BABH01037572    AB295499    BAF48335.1    AB295498    BAF48334.1    AB189029    BAD52261.1    AK401396    BAM18018.1    KQ459586    KPI97989.1    RSAL01000018    RVE52836.1    KY385635    APT69916.1    RVE52837.1    JX524148    AFV46312.1    RVE52846.1    MF683301    ATU82442.1    MF683260    ATU82401.1    JF777341    AEU11686.1    HM023856    ADJ58589.2    OWR51608.1    JN033738    AEW46891.2    RVE52848.1    KPJ11295.1    MG753798    AYC12555.1    MG770320    AXY94922.1    HM023815    JF777348    ADJ58548.1    AEU11693.1    RAZU01000140    RLQ69826.1    JH000056    EGV99243.1    U58361    AAC47333.1    AAC47336.1    AAC47340.1    MG770321    AXY94923.1    AAC47337.1    AAC47335.1    L20793    AAA29334.1    AAC47332.1    AAC47338.1    AAC47334.1    AAC47339.1    AAC47341.1    AAC47342.1    M23438    L20792    AEFK01055100    MG753799    AYC12556.1    KD698463    EMT00737.1    AL645704    AK014448    CH466561    BAB29358.1    EDL32347.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000283053    UP000273346    + More
UP000001075    UP000007648    UP000019116    UP000000589    UP000261440    UP000192221   

PRIDE

C0J8H2    C0J8G8    H9J5E5    H9J5E6    C0J8H9    H9JH30    + More
C0J8G9    H9JH29    H9JH31    C0J8H4    C0J8H3    H9JKA2    C7ASM7    C7ASM6    C7ASM9    P80034    C7ASM3    C7ASM4    P22922    H9JH33    C0J8G6    C0J8G4    H9JH34    G3GWY0    P14754    I7HJI5   

Pfam

PF00079   Serpin        + More
PF01826   TIL

Interpro

IPR000215   Serpin_fam        + More
IPR036186   Serpin_sf       
IPR042178   Serpin_sf_1       
IPR042185   Serpin_sf_2       
IPR023796   Serpin_dom       
IPR023795   Serpin_CS       
IPR002919   TIL_dom       
IPR036084   Ser_inhib-like_sf       
IPR000240   Serpin_B9/Maspin       

SUPFAM

SSF56574   SSF56574        + More
SSF57567   SSF57567       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

C0J8H2   C0J8G8   H9J5E5   H9J5E6   C0J8H9   H9JH30   + More
C0J8G9   H9JH29   H9JH31   C0J8H4   F5B4G8   B4XH99   B4XH98   B4XHA1   C0J8H3   B4XHA0   A0A2H1VE36   H9JKA2   C7ASM7   C7ASM6   C7ASM9   A0A194R1A3   P80034   C7ASM3   C7ASM4   C7ASM2   P22922   A0A0M4K7J2   H9JH33   B0FZ60   B0FZ63   B0FZ61   Q8IS86   B0FZ62   C5I794   B0FZ68   B0FZ64   Q8IS84   B0FZ65   B0FZ66   B0FZ67   Q8IS85   C5I795   C0J8G6   C0J8G4   A0A212FD15   H9JH34   A3KEZ8   A3KEZ7   Q60FS0   I4DJC8   A0A194PZ13   A0A3S2TR38   A0A1L7B975   A0A3S2M7J7   K4P392   A0A3S2NJW5   A0A2K8JL73   A0A2K8JKZ6   G9D4T8   D9HQA1   A0A212FD30   G9F9J3   A0A3S2M6W8   A0A194R217   A0A385XRT7   A0A3G1T1Q1   D9HQ60   A0A3L7HV82   G3GWY0   Q25497   Q25496   Q25499   A0A3G1T1R3   Q25493   Q25500   Q25526   Q25494   Q25492   Q25491   Q25501   Q25495   Q25498   P14754   G3X2D8   G3X2D7   A0A385XRR7   A0A3B6LTZ4   R7W1R1   I7HJI5   Q9D6A7   A0A3B4D8M5   A0A1W4V212  

PDB

5CDZ     E-value=1.39744e-07,     Score=128

KEGG

100272188    no KO assigned | (RefSeq) serpin-23, BmSPN13, SPN13; serine protease inhibitor 23

GO

GO:0005615   GO:0008233   GO:0004867   GO:0009617   GO:0005737   GO:0010951   GO:0010757  

PANTHER

PTHR11461  

Subcellular location

Secreted  
  

SignalP

Position:   1 - 19,         Likelihood:  0.986636

 

 

Length:

171

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

7.13002

Exp number, first 60 AAs:

4.68264

Total prob of N-in:

0.28798

outside

1  -  171

 

 

Pi

133.06496

Theta

190.761954

Tajima's D

0.098899

CLR

0.953884

CSRT

0.397530123493825

Interpretation

Uncertain