Gene

KWMTBOMO13256  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004726

Annotation

PREDICTED:_antichymotrypsin-2-like_[Bombyx_mori]

Location

Bomo_Chr22(+):11706410-11715155      View in EpiBrowser

Full name

Antitrypsin       + More
Antichymotrypsin-2      
Alaserpin      

Alternative Name

Antichymotrypsin II
Serpin-1

Location in the cell

Extracellular   Reliability : 1.794

CDS

ATGTATCCCGAAGACAGAGTGCCAATTGATCCTAAATACTGTAAAGGAGGCTGTCTCTGTGAAGACGGCTATGTAAAAGCTAAGAATGGTACTTGCATACCAGAGAAAGAATGTCCATCATGTGGCGGTGATCCGAATGCCGAAGCTGGTTGTGGGATAAATTGTAACAGGCGTTGTTCAGATGTTGGCAAGGACCCTGGAGTGTGCGAGGACGATATATGTGCTGTAAACGGTTGTGATTGTAAACAAGGATATTACTATGATTACGTCTCATCGAAATGTGTTCTACCAGATCGATGTCCTACTACCAATTCATCGGGAAATGTCGACCAATCCTTGGAAAAACTCCGCAGAGGAAACATGGCATTAGTTGGCCAGTTTCTTTGGGAATTATACAAAATGAATCCAGGACAAAGTTTCGTTACATCACCCGTATCTGTACTCATTCCTTACGGTCAACTAGCGCTATACGCCGTTGGAGAAACTTTAGATCAACTATTAAAGTTTATAAACCTCGACAATAAGGATCAGATCAAGAAAGCTTTCCCCGCGTTGCTTAAGAATTATCGGTCTCAAACCTCAGTTCTTTTGACGGTGGCAGTTAAATGCTACGGCAACATAAATTATCCTTTTACGGACCAGTTTAAGAACGACGCTGTAACTTATTTTGACTCAGAAGGAGAAAATATTGATTTTAAATATGCGAAACAAGCTGCAGACACAATAAACGGATGGGTCGCAAACAAAACCAATAACTTAATTCAAAATCTTGTCAGCGAAGATTTGTTCAGCGATGACACTAGATTGGTTCTAGTTGACGCCATTTATTTGCATGGAATTTGGCAAAATCAGTTCAATCCTAATAACACTCACGACAGAGACTTCTACATCACACCAAACAAAACTAAGTCCATAAAGACTATGTATCAAGAAAACTTCTTTAATTATGGAGAAAACGAGATTCTTGATGCACAGATCTTAGAATTGTTCTACAAAGGCGGCAATTCTAGTTTAGTAATCTTGTTACCAAAGAAAAAAGATGGCCTACCCCAGATGTCACATAAATTACGAAATTCAGATGAATTTTTTAATAGCATTAAATCACTTAGGCGAGAGAAAGTCAAATGTTTCCTACCTAAGATGGATATAAAAACGAACATCGATATGGCAGACCTTTCCCAGAAGATGAACGTAACCAAAATGTTCGATCCACAATCAAATGATTTCGAAGGAATTTTATTAAATTCGGACCCCGTATATGTTTCTGCTGCAATACAGAAAGCTCAAATCATAGTTGATGAAACTGGAACCGAGGCAGCGGTCGCAACTGCCGTCGTACTCACGAAAAGAAGTAGAACAGATATGTATTCTTTTGAAGCAGATCATCCGTTTGTATACGCAATCAAAGTTCAAGATGACATTATATTTAGTGGGGTTTTCGTCGGATAA

Protein

MYPEDRVPIDPKYCKGGCLCEDGYVKAKNGTCIPEKECPSCGGDPNAEAGCGINCNRRCSDVGKDPGVCEDDICAVNGCDCKQGYYYDYVSSKCVLPDRCPTTNSSGNVDQSLEKLRRGNMALVGQFLWELYKMNPGQSFVTSPVSVLIPYGQLALYAVGETLDQLLKFINLDNKDQIKKAFPALLKNYRSQTSVLLTVAVKCYGNINYPFTDQFKNDAVTYFDSEGENIDFKYAKQAADTINGWVANKTNNLIQNLVSEDLFSDDTRLVLVDAIYLHGIWQNQFNPNNTHDRDFYITPNKTKSIKTMYQENFFNYGENEILDAQILELFYKGGNSSLVILLPKKKDGLPQMSHKLRNSDEFFNSIKSLRREKVKCFLPKMDIKTNIDMADLSQKMNVTKMFDPQSNDFEGILLNSDPVYVSAAIQKAQIIVDETGTEAAVATAVVLTKRSRTDMYSFEADHPFVYAIKVQDDIIFSGVFVG

Miscellaneous

The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).

Similarity

Belongs to the serpin family.

Keywords

Complete proteome   Direct protein sequencing   Protease inhibitor   Reference proteome   Secreted   Serine protease inhibitor   Signal   3D-structure   Alternative splicing   Glycoprotein  

Feature

chain  Antitrypsin

Uniprot

C0J8H7   A0A3G1T1R3   A0A3S2M6W8   G9F9J3   A0A3G1T1Q1   A0A194R0R3   + More
A0A2A4J7B9   A0A194PXE0   G9F9J2   A0A212EGT4   A0A1E1WCC9   A0A194PXB8   A0A1E1WM18   A0A1E1W9X2   K4P392   Q25498   B4XH99   F5B4G8   B4XHA0   Q25495   B4XHA1   Q25492   A0A385XRR7   A0A3S2NJW5   Q25500   C7ASM2   P22922   Q25499   Q25526   Q25497   A3KEZ7   B4XH98   Q25491   A0A194PZ13   C7ASM3   C7ASM9   P80034   I4DJC8   Q25494   P14754   C7ASM7   A0A0M4K7J2   Q60FS0   C7ASM4   A0A3G1T1E7   A3KEZ8   C7ASM6   A0A194R1A3   A0A212FD15   B0FZ68   B0FZ61   C5I794   B0FZ67   J7HI16   B0FZ65   Q8IS84   Q8IS86   Q9NGS0   A0A194PIN8   B0FZ66   Q8IS85   A0A3S2NC81   E2GHX4   B0FZ60   A0A0M4JBR8   A0A212EXP2   B0FZ63   C5I795   B0FZ62   A0A2H1VE36   A0A2A4JPH1   B2X122   C0J8H0   A0A3S2TR38   Q5MGH1   A0A2A4JQ63   A0A0L7LMC8   A0A2H1VAC5   Q8IS50   Q5MGH2  

Pubmed

19150649    26354079    22118469    8910411    19524698    30237077    + More
2277028    1368515    8276850    10368276    21104446    1761030    22651552    2463253    14728663    19481148    16023793    26227816    15027074   

EMBL

EU935629    ACG61191.1    MG770321    AXY94923.1    RSAL01000018    RVE52848.1    + More
JN033738    AEW46891.2    MG770320    AXY94922.1    KQ460883    KPJ11292.1    NWSH01002542    PCG68017.1    KQ459586    KPI97992.1    JN033737    AEW46890.2    AGBW02015025    OWR40695.1    GDQN01006457    JAT84597.1    KPI97991.1    GDQN01003022    JAT88032.1    GDQN01007288    JAT83766.1    JX524148    AFV46312.1    U58361    AAC47342.1    EU040208    ABW17156.1    HQ615869    ADT63775.1    EU040209    ABW17157.1    AAC47341.1    EU040210    ABW17158.1    AAC47338.1    MG753799    AYC12556.1    RVE52846.1    AAC47335.1    FJ613793    ACT36272.1    D00738    AAC47340.1    L20793    AAA29334.1    AAC47333.1    AB295498    BAF48334.1    EU040207    ABW17155.1    AAC47334.1    KPI97989.1    FJ613794    FJ613796    ACT36273.1    ACT36275.1    FJ613797    ACT36276.1    AK401396    BAM18018.1    AAC47332.1    M23438    L20792    ACT36277.1    ACT36279.1    KR003729    ALD62507.1    AB189029    BAD52261.1    FJ613795    ACT36274.1    MG992370    AXY94808.1    AB295499    BAF48335.1    ACT36278.1    KPJ11294.1    AGBW02009121    OWR51607.1    EU368832    ABY68555.1    ABY68562.1    FJ763763    ACR56864.1    ABY68556.1    JN400442    AFQ01141.1    ABY68558.1    AY148485    AAN71634.1    AY148483    AAN71632.1    AF242200    AAF61252.1    KQ459602    KPI93286.1    ABY68557.1    AY148484    AAN71633.1    RSAL01000236    RVE43711.1    HM357255    ADN52338.1    ABY68563.1    KR003725    ALD62503.1    AGBW02011729    OWR46227.1    ABY68560.1    FJ763764    ACR56865.1    ABY68561.1    ODYU01002062    SOQ39103.1    NWSH01000840    PCG73901.1    EF584499    ABU62829.1    EU935622    ACG61184.1    RVE52836.1    AY829815    AAV91429.1    PCG73906.1    JTDY01000556    KOB76688.1    ODYU01001314    SOQ37342.1    AY150533    AAN73322.1    AY829814    AAV91428.1   

Proteomes

UP000283053    UP000053240    UP000218220    UP000053268    UP000007151    UP000005204    + More
UP000037510   

PRIDE

C0J8H7    P22922    C7ASM3    C7ASM9    P80034    P14754    + More
C7ASM7    C7ASM4    C7ASM6    Q9NGS0    C0J8H0   

Pfam

PF00079   Serpin        + More
PF01826   TIL

Interpro

IPR023796   Serpin_dom        + More
IPR042185   Serpin_sf_2       
IPR042178   Serpin_sf_1       
IPR000215   Serpin_fam       
IPR036186   Serpin_sf       
IPR036084   Ser_inhib-like_sf       
IPR002919   TIL_dom       
IPR023795   Serpin_CS       
IPR000742   EGF-like_dom       

SUPFAM

SSF56574   SSF56574        + More
SSF57567   SSF57567       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

C0J8H7   A0A3G1T1R3   A0A3S2M6W8   G9F9J3   A0A3G1T1Q1   A0A194R0R3   + More
A0A2A4J7B9   A0A194PXE0   G9F9J2   A0A212EGT4   A0A1E1WCC9   A0A194PXB8   A0A1E1WM18   A0A1E1W9X2   K4P392   Q25498   B4XH99   F5B4G8   B4XHA0   Q25495   B4XHA1   Q25492   A0A385XRR7   A0A3S2NJW5   Q25500   C7ASM2   P22922   Q25499   Q25526   Q25497   A3KEZ7   B4XH98   Q25491   A0A194PZ13   C7ASM3   C7ASM9   P80034   I4DJC8   Q25494   P14754   C7ASM7   A0A0M4K7J2   Q60FS0   C7ASM4   A0A3G1T1E7   A3KEZ8   C7ASM6   A0A194R1A3   A0A212FD15   B0FZ68   B0FZ61   C5I794   B0FZ67   J7HI16   B0FZ65   Q8IS84   Q8IS86   Q9NGS0   A0A194PIN8   B0FZ66   Q8IS85   A0A3S2NC81   E2GHX4   B0FZ60   A0A0M4JBR8   A0A212EXP2   B0FZ63   C5I795   B0FZ62   A0A2H1VE36   A0A2A4JPH1   B2X122   C0J8H0   A0A3S2TR38   Q5MGH1   A0A2A4JQ63   A0A0L7LMC8   A0A2H1VAC5   Q8IS50   Q5MGH2  

PDB

1SEK     E-value=3.79165e-59,     Score=579

KEGG

100272192    no KO assigned | (RefSeq) serpin-28, BmSPN11, SPN11; serine protease inhibitor 28

GO

GO:0005615   GO:0008233   GO:0004867   GO:0009617  

PANTHER

PTHR11461  

Subcellular location

Secreted  
  

Length:

482

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.15592

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00857

outside

1  -  482

 

 

Pi

179.7112

Theta

165.043365

Tajima's D

-1.069082

CLR

3.583155

CSRT

0.127243637818109

Interpretation

Uncertain