Gene

KWMTBOMO13247

Annotation

serine_protease_inhibitor_26_[Bombyx_mori]

Location

Bomo_Chr22(+):11586255-11594380      View in EpiBrowser

Full name

Alaserpin       + More
Serine protease inhibitor 3/4      
Antichymotrypsin-2      
Antitrypsin      

Alternative Name

Serpin-1
Antichymotrypsin II

Location in the cell

Nuclear   Reliability : 1.956

CDS

ATGAAATACGCCACTTCAGGGTCTACAGTTCCTAAAGCTGAGTGTCCAGATGCACAGAAACGTTTTGAAGAGGCCGTTATTGCCTATAACGGAAAGTACTTAACTGAATTAGTATCTGAAAATACCGGTTTTTCGGTAGTAGGATCCAGTCTTTCAACATTCTACTTATTAGCGCAGCTAGCTTCTTATTCGAGTGGTCCGGCTTATAAAGAAATTATGACTTTCCTTAATTTACGGAACAAGGAAGAAATTGAGTGCGTCATCAGAAACATCGGTGTCAATAAACAATTTACGTTTGACAAGATATATGCGAAGCTATCTCCCGAACTCAGCGAGGACTTCAAAAAGGACACTAGAGTAATATTTAAGGACGAAGCTCAGAACATTGATTTCCGTAATCCATCTAGAGCAACGAGAGAAATAAATAATTATGCTGCTAAGCATTCAAACAAGAGGATTCAAAACTTCAACACCGGTATGATTGATCCTTCCACCAATCTACTGTCAGTCAACGGTAAATATTATCAGTTTTCGCTGAACGACTTCAGACCTAATGAGGTCAAAGACAAAGACTTCCGATCCGGACAAGGTAGAAGTGAAAAAGTACAAACATTAATCAAGAAAGATGCACTTACATACTTGGATAGCTCCTACTTAAAATCCAAGGTCGTGAGACTACCGAATGATAAATACAATCAATATCTCGTCCTAGTATTACCACATTCACACAAAGACATAAAGGACGTTATTAAGAAACTTGAAGACTCTAAAACGTTCAGGTCGACAGTAGTTAATTTAGAAGGAGGGCAGGTTTCTGCTGTTAATCTGCACATACCGATTGTAACCGAAGGTTATACCGAGGACATGAAGAGGACTCTGGATAAGACTGTGAAAGTAACTAAAGTATTCGACCCTAAAACATCTGGATTAAATAACGTATACAACAAGGATGAAACAACTTACGTGTCTAAAGCCTTATCGACGGTTATATTTGATATGAGCAGCTTCCAAATAGAACCGGAACCTTCAAGAGACGAACTGAAGAGACGGGCTGGTTACCCACACGTGCTACGTGACCATCATTTCAAAGCTGACCATCCTTTCATTTTCTACCTTATATCCGGGAACATTCCCGTGTTGAGCGGTGTTATAGCTTGA

Protein

MKYATSGSTVPKAECPDAQKRFEEAVIAYNGKYLTELVSENTGFSVVGSSLSTFYLLAQLASYSSGPAYKEIMTFLNLRNKEEIECVIRNIGVNKQFTFDKIYAKLSPELSEDFKKDTRVIFKDEAQNIDFRNPSRATREINNYAAKHSNKRIQNFNTGMIDPSTNLLSVNGKYYQFSLNDFRPNEVKDKDFRSGQGRSEKVQTLIKKDALTYLDSSYLKSKVVRLPNDKYNQYLVLVLPHSHKDIKDVIKKLEDSKTFRSTVVNLEGGQVSAVNLHIPIVTEGYTEDMKRTLDKTVKVTKVFDPKTSGLNNVYNKDETTYVSKALSTVIFDMSSFQIEPEPSRDELKRRAGYPHVLRDHHFKADHPFIFYLISGNIPVLSGVIA

Miscellaneous

The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).

Similarity

Belongs to the serpin family.

Keywords

3D-structure   Alternative splicing   Glycoprotein   Protease inhibitor   Secreted   Serine protease inhibitor   Signal   Direct protein sequencing   Complete proteome   Reference proteome  

Feature

chain  Alaserpin
splice variant  In isoform 2.

Uniprot

A0A212EGT4   B4XH99   B4XHA0   A0A194PXB8   B4XHA1   A0A3S2M6W8   + More
G9F9J3   Q25492   B4XH98   A0A2A4J7B9   Q25495   A0A3G1T1Q1   A0A194R0R3   A0A194PXE0   A0A2H1VE36   A0A3G1T1R3   G9F9J2   A0A385XRT7   Q25498   Q25497   A0A1E1WM18   A0A3S2NJW5   Q25500   P14754   A0A2A4J8D0   A0A1E1WCC9   A0A385XRR7   Q25496   Q25501   Q25499   Q25494   Q25526   Q25491   Q25493   F5B4G8   A3KEZ8   A3KEZ7   A0A2H1VAC5   B0FZ60   A0A1E1W9X2   Q60FS0   B0FZ61   Q8IS86   A0A194R217   A0A212FD15   C5I794   B0FZ68   C0J8H0   B0FZ64   A0A2A4JR25   C0J8H7   A0A194PZ13   B0FZ63   I4DJC8   A0A2A4JPH1   Q5MGH0   C7ASM3   P80034   A0A0L7LMC8   A0A0M4K7J2   C7ASM7   C7ASM4   B0FZ62   J7HI16   C7ASM6   B0FZ65   A0A3S2TR38   A0A3G1T1E7   B0FZ67   Q8IS85   B0FZ66   A0A2A4JQC6   A0A2A4JPB5   B2X122   K4P392   A0A194R1A3   Q8IS84   A0A2A4JQ63   A0A212EXP2   C5I795   Q7JQ70   A0A194PIN8   Q9NGS0   E2GHX4   A0A3S2NC81   A0A3S2M7J7   C7ASM2   P22922   A0A0M4JBR8   A0A2H1VQQ3   C7ASM9   H9JKA2   D9HQA1   G9D4T8   A0A1L7B975   A0A1E1W229   A0A139WD36   A0A1E1WB01  

Pubmed

22118469    19524698    26354079    8910411    30237077    2463253    + More
8276850    14728663    10368276    19481148    19150649    22651552    16023793    18342903    21104446    1761030    26227816    2277028    1368515    19121390    20375075    21967427    18362917    19820115   

EMBL

AGBW02015025    OWR40695.1    EU040208    ABW17156.1    EU040209    ABW17157.1    + More
KQ459586    KPI97991.1    EU040210    ABW17158.1    RSAL01000018    RVE52848.1    JN033738    AEW46891.2    U58361    AAC47338.1    EU040207    ABW17155.1    NWSH01002542    PCG68017.1    AAC47341.1    MG770320    AXY94922.1    KQ460883    KPJ11292.1    KPI97992.1    ODYU01002062    SOQ39103.1    MG770321    AXY94923.1    JN033737    AEW46890.2    MG753798    AYC12555.1    AAC47342.1    AAC47333.1    GDQN01003022    JAT88032.1    RVE52846.1    AAC47335.1    M23438    L20792    PCG68016.1    GDQN01006457    JAT84597.1    MG753799    AYC12556.1    AAC47336.1    AAC47339.1    AAC47340.1    AAC47332.1    L20793    AAA29334.1    AAC47334.1    AAC47337.1    HQ615869    ADT63775.1    AB295499    BAF48335.1    AB295498    BAF48334.1    ODYU01001314    SOQ37342.1    EU368832    ABY68563.1    GDQN01007288    JAT83766.1    AB189029    BAD52261.1    ABY68562.1    AY148483    AAN71632.1    KPJ11295.1    AGBW02009121    OWR51607.1    FJ763763    ACR56864.1    ABY68555.1    EU935622    ACG61184.1    ABY68559.1    NWSH01000840    PCG73903.1    EU935629    ACG61191.1    KPI97989.1    ABY68560.1    AK401396    BAM18018.1    PCG73901.1    AY829816    AY829817    AAV91430.1    FJ613794    FJ613796    ACT36273.1    ACT36275.1    JTDY01000556    KOB76688.1    KR003729    ALD62507.1    FJ613797    ACT36277.1    ACT36279.1    FJ613795    ACT36274.1    ABY68561.1    JN400442    AFQ01141.1    ACT36278.1    ABY68558.1    RVE52836.1    MG992370    AXY94808.1    ABY68556.1    AY148484    AAN71633.1    ABY68557.1    PCG73908.1    PCG73905.1    EF584499    ABU62829.1    JX524148    AFV46312.1    KPJ11294.1    AY148485    AAN71634.1    PCG73906.1    AGBW02011729    OWR46227.1    FJ763764    ACR56865.1    L20790    AAA29328.1    KQ459602    KPI93286.1    AF242200    AAF61252.1    HM357255    ADN52338.1    RSAL01000236    RVE43711.1    RVE52837.1    FJ613793    ACT36272.1    D00738    KR003725    ALD62503.1    ODYU01003852    SOQ43127.1    ACT36276.1    BABH01041150    HM023856    ADJ58589.2    JF777341    AEU11686.1    KY385635    APT69916.1    GDQN01010075    GDQN01007015    JAT80979.1    JAT84039.1    KQ971361    KYB25824.1    GDQN01006900    JAT84154.1   

Proteomes

UP000007151    UP000053268    UP000283053    UP000218220    UP000053240    UP000005204    + More
UP000037510    UP000007266   

PRIDE

P14754    C0J8H0    C0J8H7    C7ASM3    P80034    C7ASM7    + More
C7ASM4    C7ASM6    Q9NGS0    P22922    C7ASM9    H9JKA2   

Pfam

PF01826   TIL        + More
PF00079   Serpin

Interpro

IPR036084   Ser_inhib-like_sf        + More
IPR023796   Serpin_dom       
IPR042185   Serpin_sf_2       
IPR002919   TIL_dom       
IPR036186   Serpin_sf       
IPR042178   Serpin_sf_1       
IPR000215   Serpin_fam       
IPR023795   Serpin_CS       
IPR000742   EGF-like_dom       

SUPFAM

SSF56574   SSF56574        + More
SSF57567   SSF57567       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

A0A212EGT4   B4XH99   B4XHA0   A0A194PXB8   B4XHA1   A0A3S2M6W8   + More
G9F9J3   Q25492   B4XH98   A0A2A4J7B9   Q25495   A0A3G1T1Q1   A0A194R0R3   A0A194PXE0   A0A2H1VE36   A0A3G1T1R3   G9F9J2   A0A385XRT7   Q25498   Q25497   A0A1E1WM18   A0A3S2NJW5   Q25500   P14754   A0A2A4J8D0   A0A1E1WCC9   A0A385XRR7   Q25496   Q25501   Q25499   Q25494   Q25526   Q25491   Q25493   F5B4G8   A3KEZ8   A3KEZ7   A0A2H1VAC5   B0FZ60   A0A1E1W9X2   Q60FS0   B0FZ61   Q8IS86   A0A194R217   A0A212FD15   C5I794   B0FZ68   C0J8H0   B0FZ64   A0A2A4JR25   C0J8H7   A0A194PZ13   B0FZ63   I4DJC8   A0A2A4JPH1   Q5MGH0   C7ASM3   P80034   A0A0L7LMC8   A0A0M4K7J2   C7ASM7   C7ASM4   B0FZ62   J7HI16   C7ASM6   B0FZ65   A0A3S2TR38   A0A3G1T1E7   B0FZ67   Q8IS85   B0FZ66   A0A2A4JQC6   A0A2A4JPB5   B2X122   K4P392   A0A194R1A3   Q8IS84   A0A2A4JQ63   A0A212EXP2   C5I795   Q7JQ70   A0A194PIN8   Q9NGS0   E2GHX4   A0A3S2NC81   A0A3S2M7J7   C7ASM2   P22922   A0A0M4JBR8   A0A2H1VQQ3   C7ASM9   H9JKA2   D9HQA1   G9D4T8   A0A1L7B975   A0A1E1W229   A0A139WD36   A0A1E1WB01  

PDB

1SEK     E-value=9.28422e-25,     Score=281

KEGG

100272191    no KO assigned | (RefSeq) serpin-26; serine protease inhibitor 26

GO

GO:0005615   GO:0008233   GO:0004867   GO:0009617   GO:0010951  

PANTHER

PTHR11461  

Subcellular location

  
Secreted  

Length:

385

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.48589

Exp number, first 60 AAs:

1.10762

Total prob of N-in:

0.08204

outside

1  -  385

 

 

Pi

172.476415

Theta

140.550259

Tajima's D

0.250417

CLR

0.458575

CSRT

0.436278186090695

Interpretation

Uncertain