Gene

KWMTBOMO13236  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009953

Annotation

antitrypsin_isoform_2_[Bombyx_mori]

Location

Bomo_Chr22(-):11064126-11080564      View in EpiBrowser

Full name

Antichymotrypsin-2       + More
Antitrypsin      
Alaserpin      
Serine protease inhibitor 3/4      

Alternative Name

Antichymotrypsin II
Serpin-1

Location in the cell

Extracellular   Reliability : 2.619

CDS

ATGTTTACCGAAGTAGTGAAAAATAATCCAGGGAAAAGCGTTGTCCTCTCGGCATTTTCGGTGCTGCCTCCTCTCGCTCAGTTAGCTTTAGCTTCTGATGGTGAAACCCATGAAGAGCTTTTGAAAGCTATCGGCTTCCCTGACGACGATGCTATACGAACAGAATTCGCGAGTAAAAGCCGTGATCTTCGATCAATTAAAGGCGTTGAGCTTAAAATGGCGAATAAAGTATACGTTCATGATGGTGGAAAACTAGACGAGAATTTTGCAGTCGTTTCCAGGGACGTCTTCAATTCGGACGTCCAAAACATTGATTTCTCGAAGAATACAGTCGCAGCTAAGTCTATTAACGATTGGGTAGAAGAAAATACCAATAACCGCATTAAGGATTTAGTTAATCCGGACTCGCTCAGCTCAGCCACAGCGGCTGTTCTCGTCAACGCCATCTATTTCAAGGGAGCATGGAGTTCTAAATTTGACGAGCGACTGACCAGTGACCGTGACTTCTACGTGAGCAAAGACAAAACAATCAAAGTACCCATGATGTATAAACGCGGCGATTATAAATATGGAGAGAGCGCAGCACTTAATGCCCAACTAATTGAAATACCTTACAAGGGCGATCAATCGTCGCTGATCGTAGTGTTACCAAAAGACAAGGATGGCATTACACAACTTCAAGAAGCACTAAAAGACCCTAAGACGTTGGAAACGGCTCAGCAAAGCATGTATAGCACCGAAGTCGATTTGTATCTTCCCAAATTCAAAATTGAAACGGAGACGAATCTCAAAGATGTTTTAAGCAATATGAACGTTAATAAAATATTCAATAACGATGCTCAAATTACGCGCCTTCTAAAAGGAGAAAGCCTTTCTGTAAGTGAGGCTATTCAAAAAGCGTTCATTGAAATCAACGAGGAAGGCGCTGAAGCTGCTGCAGCTAACGCCTTCGCCGTAGTATTTATGAGTGCAGCTGTAAGTCAGCCGCTTGTATTCAAAGCGAACCATCCCTTCGTATTCTTCCTAAAAGGAGACGGTGTCACTCTTTTTAACGGAGTTTTCCACCCTTAG

Protein

MFTEVVKNNPGKSVVLSAFSVLPPLAQLALASDGETHEELLKAIGFPDDDAIRTEFASKSRDLRSIKGVELKMANKVYVHDGGKLDENFAVVSRDVFNSDVQNIDFSKNTVAAKSINDWVEENTNNRIKDLVNPDSLSSATAAVLVNAIYFKGAWSSKFDERLTSDRDFYVSKDKTIKVPMMYKRGDYKYGESAALNAQLIEIPYKGDQSSLIVVLPKDKDGITQLQEALKDPKTLETAQQSMYSTEVDLYLPKFKIETETNLKDVLSNMNVNKIFNNDAQITRLLKGESLSVSEAIQKAFIEINEEGAEAAAANAFAVVFMSAAVSQPLVFKANHPFVFFLKGDGVTLFNGVFHP

Miscellaneous

The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).

Similarity

Belongs to the serpin family.

Keywords

Complete proteome   Direct protein sequencing   Protease inhibitor   Reference proteome   Secreted   Serine protease inhibitor   Signal   3D-structure   Alternative splicing   Glycoprotein  

Feature

chain  Antichymotrypsin-2
splice variant  In isoform 2.

Uniprot

C7ASM7   C7ASM3   A0A0M4K7J2   P80034   C7ASM6   C7ASM4   + More
C7ASM9   C7ASM2   P22922   H9JKA2   C5I794   Q8IS86   Q25492   B0FZ61   A0A3G1T1E7   Q25498   Q25496   Q25495   B0FZ68   Q25497   Q8IS85   C5I795   Q25494   Q25500   B0FZ62   Q8IS84   K4P392   B0FZ67   Q25501   B0FZ66   Q25493   B0FZ65   B0FZ63   Q60FS0   B0FZ64   P14754   B0FZ60   Q25491   Q25526   Q25499   F5B4G8   A0A385XRT7   A0A385XRR7   A0A2H1VE36   Q5MGH0   I4DJC8   A0A3S2M7J7   A0A1L7B975   A0A194R1A3   A0A194PZ13   A3KEZ8   A3KEZ7   B4XH99   A0A212FD15   B4XHA0   B4XHA1   B4XH98   D9HQA1   G9D4T8   A0A0L7LMC8   Q5MGH0-2   D9HQ60   Q7JQ70   A0A3S2TR38   A0A194R217   G9F9J1   A0A212EIQ3   A0A194PY84   J7HI16   A0A3S2NC81   A0A0M4JBR8   E2GHX4   A0A1E1W071   A0A1E1W229   Q9NGS0   A0A1E1WB01   A0A2A4JR25   B2X122   C0J8H0   H9JDX3   A0A2H1VAC5   A0A212EXP2   A0A2A4JPH1   A0A2A4JQC6   A0A2A4JPB5   A0A2A4JQ63   A0A194PIN8   A0A1L7B974   A0A212ELH5   A0A1L7B973   A0A3G1T1R3  

Pubmed

21104446    1761030    2277028    1368515    19121390    19481148    + More
8910411    2463253    8276850    14728663    10368276    30237077    16023793    18342903    22651552    26354079    19524698    22118469    20375075    21967427    26227816    19150649   

EMBL

FJ613797    ACT36277.1    ACT36279.1    FJ613794    FJ613796    ACT36273.1    + More
ACT36275.1    KR003729    ALD62507.1    ACT36278.1    FJ613795    ACT36274.1    ACT36276.1    FJ613793    ACT36272.1    D00738    BABH01041150    FJ763763    ACR56864.1    AY148483    AAN71632.1    U58361    AAC47338.1    EU368832    ABY68562.1    MG992370    AXY94808.1    AAC47342.1    AAC47336.1    AAC47341.1    ABY68555.1    AAC47333.1    AY148484    AAN71633.1    FJ763764    ACR56865.1    AAC47332.1    AAC47335.1    ABY68561.1    AY148485    AAN71634.1    JX524148    AFV46312.1    ABY68556.1    AAC47339.1    ABY68557.1    AAC47337.1    ABY68558.1    ABY68560.1    AB189029    BAD52261.1    ABY68559.1    M23438    L20792    ABY68563.1    AAC47334.1    L20793    AAA29334.1    AAC47340.1    HQ615869    ADT63775.1    MG753798    AYC12555.1    MG753799    AYC12556.1    ODYU01002062    SOQ39103.1    AY829816    AY829817    AAV91430.1    AK401396    BAM18018.1    RSAL01000018    RVE52837.1    KY385635    APT69916.1    KQ460883    KPJ11294.1    KQ459586    KPI97989.1    AB295499    BAF48335.1    AB295498    BAF48334.1    EU040208    ABW17156.1    AGBW02009121    OWR51607.1    EU040209    ABW17157.1    EU040210    ABW17158.1    EU040207    ABW17155.1    HM023856    ADJ58589.2    JF777341    AEU11686.1    JTDY01000556    KOB76688.1    HM023815    JF777348    ADJ58548.1    AEU11693.1    L20790    AAA29328.1    RVE52836.1    KPJ11295.1    JN033736    AEW46889.1    AGBW02014593    OWR41373.1    KPI97988.1    JN400442    AFQ01141.1    RSAL01000236    RVE43711.1    KR003725    ALD62503.1    HM357255    ADN52338.1    GDQN01010691    JAT80363.1    GDQN01010075    GDQN01007015    JAT80979.1    JAT84039.1    AF242200    AAF61252.1    GDQN01006900    JAT84154.1    NWSH01000840    PCG73903.1    EF584499    ABU62829.1    EU935622    ACG61184.1    BABH01002639    BABH01002640    ODYU01001314    SOQ37342.1    AGBW02011729    OWR46227.1    PCG73901.1    PCG73908.1    PCG73905.1    PCG73906.1    KQ459602    KPI93286.1    KY385636    APT69917.1    AGBW02014057    OWR42342.1    KY094503    APT69915.1    MG770321    AXY94923.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000037510    + More
UP000218220   

PRIDE

C7ASM7    C7ASM3    P80034    C7ASM6    C7ASM4    C7ASM9    + More
P22922    H9JKA2    P14754    Q9NGS0    C0J8H0    H9JDX3   

Pfam

PF00079   Serpin        + More
PF01826   TIL

Interpro

IPR000215   Serpin_fam        + More
IPR023796   Serpin_dom       
IPR042178   Serpin_sf_1       
IPR023795   Serpin_CS       
IPR042185   Serpin_sf_2       
IPR036186   Serpin_sf       
IPR036084   Ser_inhib-like_sf       
IPR002919   TIL_dom       

SUPFAM

SSF56574   SSF56574        + More
SSF57567   SSF57567       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

C7ASM7   C7ASM3   A0A0M4K7J2   P80034   C7ASM6   C7ASM4   + More
C7ASM9   C7ASM2   P22922   H9JKA2   C5I794   Q8IS86   Q25492   B0FZ61   A0A3G1T1E7   Q25498   Q25496   Q25495   B0FZ68   Q25497   Q8IS85   C5I795   Q25494   Q25500   B0FZ62   Q8IS84   K4P392   B0FZ67   Q25501   B0FZ66   Q25493   B0FZ65   B0FZ63   Q60FS0   B0FZ64   P14754   B0FZ60   Q25491   Q25526   Q25499   F5B4G8   A0A385XRT7   A0A385XRR7   A0A2H1VE36   Q5MGH0   I4DJC8   A0A3S2M7J7   A0A1L7B975   A0A194R1A3   A0A194PZ13   A3KEZ8   A3KEZ7   B4XH99   A0A212FD15   B4XHA0   B4XHA1   B4XH98   D9HQA1   G9D4T8   A0A0L7LMC8   Q5MGH0-2   D9HQ60   Q7JQ70   A0A3S2TR38   A0A194R217   G9F9J1   A0A212EIQ3   A0A194PY84   J7HI16   A0A3S2NC81   A0A0M4JBR8   E2GHX4   A0A1E1W071   A0A1E1W229   Q9NGS0   A0A1E1WB01   A0A2A4JR25   B2X122   C0J8H0   H9JDX3   A0A2H1VAC5   A0A212EXP2   A0A2A4JPH1   A0A2A4JQC6   A0A2A4JPB5   A0A2A4JQ63   A0A194PIN8   A0A1L7B974   A0A212ELH5   A0A1L7B973   A0A3G1T1R3  

PDB

1K9O     E-value=1.19826e-93,     Score=875

KEGG

692739    no KO assigned | (RefSeq) serpin-1, AT, AchyII, BmSPN1, SPN1, sw-AchyII; antitrypsin

GO

GO:0005615   GO:0004867   GO:0008233   GO:0009617  

PANTHER

PTHR11461  

Subcellular location

Secreted  
  

Length:

356

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.44264

Exp number, first 60 AAs:

0.93315

Total prob of N-in:

0.07501

outside

1  -  356

 

 

Pi

262.43237

Theta

198.274646

Tajima's D

1.123163

CLR

0.212513

CSRT

0.693265336733163

Interpretation

Uncertain