Gene

KWMTBOMO13233

Pre Gene Modal

BGIBMGA009975

Annotation

PREDICTED:_calcium_uptake_protein_1?_mitochondrial-like_isoform_X2_[Papilio_polytes]

Location

Bomo_Chr22(-):10967147-10977644      View in EpiBrowser

Full name

Calcium uptake protein 1 homolog, mitochondrial      

Alternative Name

Mitochondrial calcium uptake 1

Location in the cell

Mitochondrial   Reliability : 1.741 Nuclear   Reliability : 1.179

CDS

ATGTTAACTTTAAGCACAAGTGTTGTTAAGATATCAGGACAATTGACAACATTAAGGAAAATTACAGTATTAGGAAGTAATAAAATTATTCCTAAAGCTTTTAATAATTCCACTAAACGCAACTTTAACTATCAAAATAATGTTGACTACAAAACGAGGAAGAATCCCTTTTGGCTCTATTCGCTGTTAACTGGAGCAACCGCTTATGTTACTTACAAATTCTGGATAAATTACAACGTAATTCCGTCAATAGTTGCTGCTGAAGAAATATCACAACAATCCAATTCTGATAGTGATGTTGAAACAAAGAAAAAAAGATACAGAAAGGAGAAAATTGGCTTTAGAGATCGTAAGATCATAGAGTATGAAAATCGAATGAGGTCTTATTCAACTCCTGATAAAATATTTAGATACTTTGCTACTGTAAAATTGACTCATGGGGATCATACAGAAATTCTCATGACACCTGATGATTTTTTACGAGCTATTACTCCTGGCATGAAGCAACCAGATGGTTTGGGCTTAGATCAGTACCGTAGATATGACCCAAAGAGCATCACTCAACGTTTGAATCTCGACTTGGATGAAGATTCAATATTCTACAAACTTGGATCATCGGGCCTCATTACTTTCAGTGACTACATCTTTTTGCTTACCGTGCTATCAACATCACGTCGCCATTTCGAGATCGCCTTTCGAATGTTCGACCTGAATGGGGACGGAGATGTGGACTGCGAGGAGTTCGAGAAGGTGGCCGCACTGATCCGACAGCAGAGTAGCATCGGTTCCAGGCACAGAGACCACGCTAATACCGGAAACACTTTTAAGGGCATAAACTCGGCTCTGACAACTTATTTCTTCGGTTCTAAACTCGACGAAAAATTGACTATAGAAAAGTTCCTGGACTTCCAGCATCAACTGCAAAAAGAGATATTGTCTCTTGAATTCCAGAGGAAACAACCCGATGAAGTTGGTCACATCACCGAAGCGGATTTCGCAGAGCTGCTACTGGCGTATGCCGGGTACCCTGCTAAGAAGAAGGCTAGAATGTTGAAACGCGTTAAAAAAACCTTCCGCGACCACGGCGTGGGCATCACGAAAGACGACTACCTCAAGTTCTTCCACTTCCTGAACAACATTAACGACGTAGACACGGCACTGACGTTCTACCACATCGCGGGCGCGTCCATCGACCAGCCCACGCTGCGGCACGTGGCGCGGACGGTCGCGCACGTCGACCTCGACCCGCACGTCATCAATGTCGTCTTCACTATTTTCGATGAGAATATGGACGGACAACTGAGCAACCGAGAATTTGTGGCAGTGATGAAGAACAGGCTGCTCCGAGGTCTGGAGAAACCGAAGGACACAGGTTTCGTAAAACTAATGTACTCGCTTATAAAATGCGCCAGAGATACGAAACCGGCAATCTTAGATTTTTAA

Protein

MLTLSTSVVKISGQLTTLRKITVLGSNKIIPKAFNNSTKRNFNYQNNVDYKTRKNPFWLYSLLTGATAYVTYKFWINYNVIPSIVAAEEISQQSNSDSDVETKKKRYRKEKIGFRDRKIIEYENRMRSYSTPDKIFRYFATVKLTHGDHTEILMTPDDFLRAITPGMKQPDGLGLDQYRRYDPKSITQRLNLDLDEDSIFYKLGSSGLITFSDYIFLLTVLSTSRRHFEIAFRMFDLNGDGDVDCEEFEKVAALIRQQSSIGSRHRDHANTGNTFKGINSALTTYFFGSKLDEKLTIEKFLDFQHQLQKEILSLEFQRKQPDEVGHITEADFAELLLAYAGYPAKKKARMLKRVKKTFRDHGVGITKDDYLKFFHFLNNINDVDTALTFYHIAGASIDQPTLRHVARTVAHVDLDPHVINVVFTIFDENMDGQLSNREFVAVMKNRLLRGLEKPKDTGFVKLMYSLIKCARDTKPAILDF

Description

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult (PubMed:27568554).

Similarity

Belongs to the MICU1 family. MICU1 subfamily.

Keywords

Alternative splicing   Calcium   Calcium transport   Complete proteome   Ion transport   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Reference proteome   Repeat   Transit peptide   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Calcium uptake protein 1 homolog, mitochondrial
splice variant  In isoform A.

Uniprot

A0A3S2NPA9   A0A194R0R8   A0A212ER41   A0A194PZ09   A0A2H1VJR7   D6WJK2   + More
A0A0K8TSV9   A0A1Y1KVW6   A0A2M4AGY3   A0A2M4BJV4   A0A2M4AGV4   A0A2M4BJT4   A0A2M4CSR8   Q16TU9   Q16TU7   A0A2M3Z5W0   A0A084VG84   A0A023EUR5   A0A2M3Z5W9   Q7PW20   Q16TU8   A0A1Q3FL75   A0A1B6CP78   A0A1Q3FM30   A0A1Q3FM47   A0A1Q3FM00   A0A1Y1KUZ9   A0A1Q3FLV5   A0A336LVV2   A0A1B6CI45   A0A1S4H0X5   U5EQU9   A0A1B6E3W6   A0A1J1I005   B0W1J6   A0A1Q3FM59   A0A1B6EJ52   A0A1B6IDT9   A0A1J1I1Y7   A0A1B6KUC6   A0A2J7Q7U9   A0A1B6CAQ2   A0A069DZ12   A0A1B6F0H6   A0A1B6L5P9   A0A1B6L269   A0A1I8QC31   A0A1I8M6R1   A0A2J7Q7W8   A0A336K9V9   T1PDL6   A0A2J7Q7V8   A0A1B6M4G1   A0A1B6D1W9   A0A0A9XW38   A0A1B6L002   A0A1I8QC28   A0A195FQ26   A0A067RCC6   U4U1L3   A0A0L0C9S9   N6U6M4   A0A151WT11   A0A151JR36   A0A158NUX5   A0A0P4VJ93   A0A1B6BZ01   A0A224XIQ0   A0A336K7K3   A0A0A9YGL3   V9IHX8   A0A146M9M0   A0A1I8QC20   A0A1I8QC44   A0A023F4A5   A0A1B6CA02   A0A026W8R8   B4NZV5   A0A1W4VAY5   A0A0J9QXH6   A2VEI2-2   A0A0Q9WRE1   E2AEI7   A0A0Q9WL02   E2BT28   A0A1I8QC74   A0A0N8NZJ2   A0A1S3DHE7   A0A1I8QC15   B3N699   A0A0J9QXK4   A0A0R1DJL3   A0A0J9QYB5   A0A0R3NXR7   A0A0R1DR14   A0A0M5J955   A0A1W4VBU8   A0A0Q9WNA8   A0A0Q9X5E7   K7J7U1  

Pubmed

26354079    22118469    18362917    19820115    26369729    28004739    + More
17510324    24438588    24945155    12364791    14747013    17210077    26334808    25315136    25401762    26823975    24845553    23537049    26108605    21347285    27129103    25474469    24508170    17994087    17550304    22936249    10731132    12537572    12537569    27568554    28198506    20798317    15632085    20075255   

EMBL

RSAL01000018    RVE52833.1    KQ460883    KPJ11297.1    AGBW02013113    OWR43960.1    + More
KQ459586    KPI97984.1    ODYU01002682    SOQ40494.1    KQ971342    EFA03908.2    GDAI01000144    JAI17459.1    GEZM01076919    JAV63546.1    GGFK01006676    MBW39997.1    GGFJ01004122    MBW53263.1    GGFK01006695    MBW40016.1    GGFJ01004123    MBW53264.1    GGFL01004127    MBW68305.1    CH477639    EAT37944.1    EAT37946.1    GGFM01003160    MBW23911.1    ATLV01012698    ATLV01012699    KE524808    KFB36978.1    GAPW01000887    JAC12711.1    GGFM01003165    MBW23916.1    AAAB01008984    EAA43380.3    EAT37945.1    GFDL01006694    JAV28351.1    GEDC01022048    JAS15250.1    GFDL01006492    JAV28553.1    GFDL01006472    JAV28573.1    GFDL01006406    JAV28639.1    GEZM01076920    JAV63545.1    GFDL01006518    JAV28527.1    UFQS01000144    UFQT01000144    SSX00459.1    SSX20839.1    GEDC01024154    JAS13144.1    GANO01003113    JAB56758.1    GEDC01004693    JAS32605.1    CVRI01000037    CRK93605.1    DS231822    EDS25794.1    GFDL01006433    JAV28612.1    GECZ01031834    JAS37935.1    GECU01036051    GECU01022611    JAS71655.1    JAS85095.1    CRK93604.1    GEBQ01024921    JAT15056.1    NEVH01017000    PNF24666.1    GEDC01026755    JAS10543.1    GBGD01001445    JAC87444.1    GECZ01026416    JAS43353.1    GEBQ01020924    JAT19053.1    GEBQ01022189    JAT17788.1    PNF24669.1    SSX00458.1    SSX20838.1    KA646851    AFP61480.1    PNF24667.1    GEBQ01009162    JAT30815.1    GEDC01017606    JAS19692.1    GBHO01034381    GBHO01029182    GBHO01024616    GBHO01024614    GBHO01024613    GBHO01024612    GBHO01019505    GBHO01019504    GBRD01017130    GDHC01003442    GDHC01001023    JAG09223.1    JAG14422.1    JAG18988.1    JAG18990.1    JAG18991.1    JAG18992.1    JAG24099.1    JAG24100.1    JAG48697.1    JAQ15187.1    JAQ17606.1    GEBQ01022941    JAT17036.1    KQ981335    KYN42583.1    KK852601    KDR20509.1    KB631899    ERL86947.1    JRES01000714    KNC29007.1    APGK01040851    KB740984    ENN76301.1    KQ982769    KYQ50927.1    KQ978622    KYN29734.1    ADTU01026811    ADTU01026812    GDKW01002389    JAI54206.1    GEDC01030796    JAS06502.1    GFTR01005502    JAW10924.1    SSX00457.1    SSX20837.1    GBHO01034288    GBHO01024619    GBHO01024618    GBHO01024617    GBHO01019503    GBHO01011407    GBHO01005873    GBHO01005870    GBHO01005867    GBRD01011508    JAG09316.1    JAG18985.1    JAG18986.1    JAG18987.1    JAG24101.1    JAG32197.1    JAG37731.1    JAG37734.1    JAG37737.1    JAG54316.1    JR046830    AEY60262.1    GDHC01003153    JAQ15476.1    GBBI01002357    JAC16355.1    GEDC01027044    JAS10254.1    KK107356    EZA52031.1    CM000157    EDW87782.1    CM002910    KMY88711.1    AE014134    AY051995    BT030151    CH963920    KRF98762.1    GL438862    EFN68144.1    CH940649    KRF81839.1    GL450325    EFN81158.1    CH902624    KPU74476.1    CH954177    EDV59186.1    KMY88713.1    KRJ97402.1    KMY88714.1    CH379059    KRT03744.1    KRJ97401.1    CP012523    ALC39356.1    KRF81840.1    CH933807    KRG03376.1   

Proteomes

UP000283053    UP000053240    UP000007151    UP000053268    UP000007266    UP000008820    + More
UP000030765    UP000007062    UP000183832    UP000002320    UP000235965    UP000095300    UP000095301    UP000078541    UP000027135    UP000030742    UP000037069    UP000019118    UP000075809    UP000078492    UP000005205    UP000053097    UP000002282    UP000192221    UP000000803    UP000007798    UP000000311    UP000008792    UP000008237    UP000007801    UP000079169    UP000008711    UP000001819    UP000092553    UP000009192    UP000002358   

PRIDE

A2VEI2   

Pfam

PF13833   EF-hand_8        + More
PF13202   EF-hand_5

Interpro

IPR002048   EF_hand_dom        + More
IPR039800   MICU1/2/3       
IPR011992   EF-hand-dom_pair       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF47473   SSF47473       

ProteinModelPortal

A0A3S2NPA9   A0A194R0R8   A0A212ER41   A0A194PZ09   A0A2H1VJR7   D6WJK2   + More
A0A0K8TSV9   A0A1Y1KVW6   A0A2M4AGY3   A0A2M4BJV4   A0A2M4AGV4   A0A2M4BJT4   A0A2M4CSR8   Q16TU9   Q16TU7   A0A2M3Z5W0   A0A084VG84   A0A023EUR5   A0A2M3Z5W9   Q7PW20   Q16TU8   A0A1Q3FL75   A0A1B6CP78   A0A1Q3FM30   A0A1Q3FM47   A0A1Q3FM00   A0A1Y1KUZ9   A0A1Q3FLV5   A0A336LVV2   A0A1B6CI45   A0A1S4H0X5   U5EQU9   A0A1B6E3W6   A0A1J1I005   B0W1J6   A0A1Q3FM59   A0A1B6EJ52   A0A1B6IDT9   A0A1J1I1Y7   A0A1B6KUC6   A0A2J7Q7U9   A0A1B6CAQ2   A0A069DZ12   A0A1B6F0H6   A0A1B6L5P9   A0A1B6L269   A0A1I8QC31   A0A1I8M6R1   A0A2J7Q7W8   A0A336K9V9   T1PDL6   A0A2J7Q7V8   A0A1B6M4G1   A0A1B6D1W9   A0A0A9XW38   A0A1B6L002   A0A1I8QC28   A0A195FQ26   A0A067RCC6   U4U1L3   A0A0L0C9S9   N6U6M4   A0A151WT11   A0A151JR36   A0A158NUX5   A0A0P4VJ93   A0A1B6BZ01   A0A224XIQ0   A0A336K7K3   A0A0A9YGL3   V9IHX8   A0A146M9M0   A0A1I8QC20   A0A1I8QC44   A0A023F4A5   A0A1B6CA02   A0A026W8R8   B4NZV5   A0A1W4VAY5   A0A0J9QXH6   A2VEI2-2   A0A0Q9WRE1   E2AEI7   A0A0Q9WL02   E2BT28   A0A1I8QC74   A0A0N8NZJ2   A0A1S3DHE7   A0A1I8QC15   B3N699   A0A0J9QXK4   A0A0R1DJL3   A0A0J9QYB5   A0A0R3NXR7   A0A0R1DR14   A0A0M5J955   A0A1W4VBU8   A0A0Q9WNA8   A0A0Q9X5E7   K7J7U1  

PDB

4NSC     E-value=4.2734e-117,     Score=1079

KEGG

101741664    K22827 calcium uptake protein 1, mitochondrial | (RefSeq) calcium uptake protein 1 homolog, mitochon

GO

GO:0006851   GO:0005509   GO:0016021   GO:0005758   GO:0007615   GO:0051561   GO:0072375   GO:1990246   GO:0036444   GO:0005515   GO:0051536   GO:0016491   GO:0016829   GO:0005737   GO:0048869   GO:0003676   GO:0015930  

PANTHER

PTHR12294  

Subcellular location

Mitochondrion inner membrane   The topology is subject to debate.   With evidence from 1 publications.
Mitochondrion intermembrane space   The topology is subject to debate.   With evidence from 1 publications.

Length:

480

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

13.30836

Exp number, first 60 AAs:

2.46134

Total prob of N-in:

0.51423

outside

1  -  480

 

 

Pi

204.114379

Theta

149.535388

Tajima's D

0.901475

CLR

0.015606

CSRT

0.634118294085296

Interpretation

Uncertain