Gene

KWMTBOMO13224  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009981

Annotation

PREDICTED:_polyadenylate-binding_protein-interacting_protein_1_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr22(-):10802881-10810406      View in EpiBrowser

Full name

Dihydrolipoyl dehydrogenase      

Location in the cell

Cytoplasmic   Reliability : 1.913 Nuclear   Reliability : 2.557

CDS

ATGAATAACGGTGATATTAGTGCTCCAAAAGGACGAGGCCGGGGGTGGCAAATGAACAACCAGGCACGCGAGCTCCGGCGGCCTAAGGCAGTTTCAGACGAACCAAAGGTGGATACTTCTAAATCGAAGTTATCAGCAGATGCTAAAGAATGGTACCCTGCAAATTACACTTCTCAAGCGCTACCCGCTTACAACACTGAACCTGCCCCATATAGACCATCTCGCCCCTCTGTACAAGGTAGACTTCGTCAAGCTCAAGATCAAAATCCATACAATTTGGATGACATGTCTTATTCACTTGAAGAAGCTGAAAACATGGATCTACGGGAGAACATAGCAAACTTGATAACTGTTATGTGTGAGATAACCTTTGACCCGGGCAAGTTTGACACCTTGTGTGGTCCCTTGGTGGATTCATTTGCTTCAACACTTAATGATGAAAGCTATACCAGACCCTTGGTGGATGCCATTGTTAATCAGTCAATCGGCGAAGCTAATTTCCGGTACAATGGAGCTCGTTTGTGTTCAATGTACGATTCAGTGGCGCAACCTGAGGAGTCTGTATTCCGCGAGTGCCTGCTCGAGCGCTGTTCCGTTGAGGAAAACAAGATTATCAGCGGCTTGGAAACTTCAGAGGAGAATATGCGTGGATTTGCTATGTTCCTTGCCGAGATTTATACTCAGCTTGAGGATAGTCAAGGAGGAAGAATAAAGACTCTCGGTGAAAGTCTCTGCAAAGTTTTTCTGCATCTATTGGACACTGATAAGGAGTCAAACATCAAAGCTGTTTGTCAACTGCTCAAGTTGTCGGGTCTGGCCCTCGACGCGGACTGCCCGACGGGGATGCACGCGACGTTCGAGCGGCTCCGGCGGCGCGGGTCGCTGCCGCTCGTGCGCGCCGTGCTCGACCTGCGCGCGGCCCGCTGGGGGCTCGCCGACACCTCGCACCAACACGTTGGCGGCATGAACGGCGGGTCGGATTACGTAGAGGGCGGTTTCCTGGCGGACGGTCACTCGCTGACCGCCGAGGAGCGCGCCTTCCTGCAGAGCAACCTGCCGCCGCACAAGCACCAGCCCATAGACGACGATATACTGGAGGAGCTTGAGAACGACTCGTGGGAGACTGGAATGGATCCTGAAATGCAGGAGAGCTTCCTCGAGTTTCTCAAGATATCGAATCAGATAAAGCGATAA

Protein

MNNGDISAPKGRGRGWQMNNQARELRRPKAVSDEPKVDTSKSKLSADAKEWYPANYTSQALPAYNTEPAPYRPSRPSVQGRLRQAQDQNPYNLDDMSYSLEEAENMDLRENIANLITVMCEITFDPGKFDTLCGPLVDSFASTLNDESYTRPLVDAIVNQSIGEANFRYNGARLCSMYDSVAQPEESVFRECLLERCSVEENKIISGLETSEENMRGFAMFLAEIYTQLEDSQGGRIKTLGESLCKVFLHLLDTDKESNIKAVCQLLKLSGLALDADCPTGMHATFERLRRRGSLPLVRAVLDLRAARWGLADTSHQHVGGMNGGSDYVEGGFLADGHSLTAEERAFLQSNLPPHKHQPIDDDILEELENDSWETGMDPEMQESFLEFLKISNQIKR

Catalytic Activity

(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH

Cofactor

FAD

Miscellaneous

The active site is a redox-active disulfide bond.

Similarity

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Uniprot

H9JKD0   A0A2A4J7D0   A0A2H1V4X7   A0A194PXC0   A0A194R1B7   A0A0L7KU00   + More
S4PLL0   A0A212EWE3   A0A1E1WHP8   A0A067R9A3   A0A2J7RLM9   A0A2J7RLM2   A0A2J7RLM5   A0A182HN38   A0A182LNV5   A0A1S4H829   E9GHY6   A0A182WX68   A0A182QX68   A0A1L8DHV1   A0A182RQP3   T1DTY6   A0A2L2Y0V1   A0A182MXL8   K7JG92   A0A2M4BGS6   A0A2M4BHA8   A0A2M4CP36   W5JD24   A0A2M4BLI5   A0A2M4CP67   A0A2M4A8D6   A0A2M4A7V6   A0A182S5T7   A0A2M3Z0L3   A0A2M3YZF7   A0A0P6IL16   A0A0P6FMJ6   A0A0P5JMG0   A0A154PHQ5   A0A0N8DXM0   A0A0P5CYA8   A0A0P5TA19   A0A0P5GJU3   A0A182MWC9   A0A164YZC4   A0A0P6AMP8   A0A182FBF0   A0A087UCC0   A0A2P8XG69   U5EUL5   A0A0A1WK95   U4UEI9   A0A0K8WIV3   A0A034VUL8   A0A182WEM0   A0A0C9QZC8   A0A1B0G8U9   E2BA49   A0A1Z5KWT5   A0A1A9ZNT0   A0A1A9UET8   A0A1A9XT18   A0A1B0C177   A0A1J1ILN4   A0A1A9X4B9  

EC Number

1.8.1.4

Pubmed

19121390    26354079    26227816    23622113    22118469    24845553    + More
20966253    12364791    21292972    26561354    20075255    20920257    23761445    29403074    25830018    23537049    25348373    20798317    28528879   

EMBL

BABH01036766    BABH01036767    NWSH01002706    PCG67646.1    ODYU01000696    SOQ35900.1    + More
KQ459586    KPI97972.1    KQ460883    KPJ11309.1    JTDY01005816    KOB66590.1    GAIX01003975    JAA88585.1    AGBW02012012    OWR45799.1    GDQN01004534    JAT86520.1    KK852850    KDR15070.1    NEVH01002684    PNF41735.1    PNF41737.1    PNF41736.1    AAAB01008986    GL732545    EFX80968.1    AXCN02001065    GFDF01008093    JAV05991.1    GAMD01000639    JAB00952.1    IAAA01008794    IAAA01008795    IAAA01008796    IAAA01008797    LAA00900.1    GGFJ01003083    MBW52224.1    GGFJ01003047    MBW52188.1    GGFL01002918    MBW67096.1    ADMH02001870    ETN60724.1    GGFJ01004713    MBW53854.1    GGFL01002942    MBW67120.1    GGFK01003743    MBW37064.1    GGFK01003552    MBW36873.1    GGFM01001285    MBW22036.1    GGFM01000892    MBW21643.1    GDIQ01002730    JAN92007.1    GDIQ01062558    JAN32179.1    GDIQ01197672    JAK54053.1    KQ434912    KZC11385.1    GDIQ01081908    JAN12829.1    GDIP01179991    JAJ43411.1    GDIP01130494    JAL73220.1    GDIQ01239461    JAK12264.1    AXCM01001149    LRGB01000868    KZS15769.1    GDIP01028212    JAM75503.1    KK119182    KFM75009.1    PYGN01002262    PSN30972.1    GANO01003826    JAB56045.1    GBXI01015186    GBXI01011713    GBXI01004157    JAC99105.1    JAD02579.1    JAD10135.1    KB632325    ERL92374.1    GDHF01028183    GDHF01012715    GDHF01001325    JAI24131.1    JAI39599.1    JAI50989.1    GAKP01013177    GAKP01013176    GAKP01013175    JAC45777.1    GBYB01006072    JAG75839.1    CCAG010023840    GL446664    EFN87458.1    GFJQ02007719    JAV99250.1    JXJN01023892    JXJN01025435    CVRI01000055    CRL01072.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000007151    + More
UP000027135    UP000235965    UP000075882    UP000000305    UP000076407    UP000075886    UP000075900    UP000075884    UP000002358    UP000000673    UP000075901    UP000076502    UP000075883    UP000076858    UP000069272    UP000054359    UP000245037    UP000030742    UP000075920    UP000092444    UP000008237    UP000092445    UP000078200    UP000092443    UP000092460    UP000183832    UP000091820   

PRIDE

H9JKD0   

Pfam

PF01521   Fe-S_biosyn        + More
PF02854   MIF4G
PF02852   Pyr_redox_dim
PF03299   TF_AP-2
PF07992   Pyr_redox_2
PF07145   PAM2

Interpro

IPR016024   ARM-type_fold        + More
IPR016021   MIF4-like_sf       
IPR035903   HesB-like_dom_sf       
IPR000361   FeS_biogenesis       
IPR003890   MIF4G-like_typ-3       
IPR016156   FAD/NAD-linked_Rdtase_dimer_sf       
IPR012999   Pyr_OxRdtase_I_AS       
IPR006258   Lipoamide_DH       
IPR004099   Pyr_nucl-diS_OxRdtase_dimer       
IPR013854   TF_AP2_C       
IPR036188   FAD/NAD-bd_sf       
IPR023753   FAD/NAD-binding_dom       
IPR009818   Ataxin-2_C       

SUPFAM

SSF48371   SSF48371        + More
SSF89360   SSF89360       
SSF51905   SSF51905       
SSF55424   SSF55424       

Gene 3D

1.25.40.180     2.60.300.12     3.30.390.30     3.50.50.60    

ProteinModelPortal

H9JKD0   A0A2A4J7D0   A0A2H1V4X7   A0A194PXC0   A0A194R1B7   A0A0L7KU00   + More
S4PLL0   A0A212EWE3   A0A1E1WHP8   A0A067R9A3   A0A2J7RLM9   A0A2J7RLM2   A0A2J7RLM5   A0A182HN38   A0A182LNV5   A0A1S4H829   E9GHY6   A0A182WX68   A0A182QX68   A0A1L8DHV1   A0A182RQP3   T1DTY6   A0A2L2Y0V1   A0A182MXL8   K7JG92   A0A2M4BGS6   A0A2M4BHA8   A0A2M4CP36   W5JD24   A0A2M4BLI5   A0A2M4CP67   A0A2M4A8D6   A0A2M4A7V6   A0A182S5T7   A0A2M3Z0L3   A0A2M3YZF7   A0A0P6IL16   A0A0P6FMJ6   A0A0P5JMG0   A0A154PHQ5   A0A0N8DXM0   A0A0P5CYA8   A0A0P5TA19   A0A0P5GJU3   A0A182MWC9   A0A164YZC4   A0A0P6AMP8   A0A182FBF0   A0A087UCC0   A0A2P8XG69   U5EUL5   A0A0A1WK95   U4UEI9   A0A0K8WIV3   A0A034VUL8   A0A182WEM0   A0A0C9QZC8   A0A1B0G8U9   E2BA49   A0A1Z5KWT5   A0A1A9ZNT0   A0A1A9UET8   A0A1A9XT18   A0A1B0C177   A0A1J1ILN4   A0A1A9X4B9  

PDB

3RK6     E-value=1.28089e-11,     Score=168

KEGG

101739024    K14322 polyadenylate-binding protein-interacting protein 1 | (RefSeq) polyadenylate-binding protein-

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)

GO

GO:0003723   GO:0008494   GO:0006446   GO:0016301   GO:0005623   GO:0045454   GO:0050660   GO:0004148   GO:0005488   GO:0003824   GO:0016614   GO:0016491   GO:0016829   GO:0005737   GO:0048869   GO:0003676   GO:0015930  

Length:

397

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00012

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01573

outside

1  -  397

 

 

Pi

233.715626

Theta

176.451239

Tajima's D

1.232782

CLR

0.338423

CSRT

0.719914004299785

Interpretation

Uncertain