Gene

KWMTBOMO13216  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009963

Annotation

PREDICTED:_methionine_aminopeptidase_2_[Papilio_polytes]

Location

Bomo_Chr22(+):10729297-10736849      View in EpiBrowser

Full name

Methionine aminopeptidase 2       + More
Methionine aminopeptidase      

Alternative Name

Peptidase M

Location in the cell

Cytoplasmic   Reliability : 2.142 Nuclear   Reliability : 2.495

CDS

ATGGCTGCAGTTGTAACAGAAAATGATGTTACCGAAAATGTAGTGGAAAATGGAGAAGATGACGATGTAGAGGTTATCGATGAAGGTGACACAAAAGATCCCGCAAAGAAGAAGAAAAAGAAAAAAAAGAAGAAGAAGGCAGAAGGTGAAACTGCTAAAGAAAGTCCGACAGAAGTGACTGCAACAACAGAAAAATTAGAGGCATTATCTCTTGGAGAGAATGCTGGTGAAGGTGATGAGAAAAAGAAAAAGAAGAAGAATAAGAGTAAATCTGGAAAAGGATCTTCTAAGGAGCAGACCGTCCCACCTACTATACCAGTAGCGGAACTATTTCCTGATGGAAACTTTCCTGAGGGTCAAATTATGGACCATGGTCCTGCTGAGGGTATTGATGAGAGAACTGCAAAAAATCGTTTTACAAGTGAGGAGAAAAGAGCTCTTGATAGATTACATAAAGATATTTATCAGGAAATCAGACATGCTGCTGAAGCCCACAGGCAGACAAGAAAACACATCCGCAATTGGATCAAGCCTGGCATGACTATGATAGATATTTGTGAAGAGTTAGAGAAGACTGCGAGACGTCTTATTGGTGAAGATGGGCTCAAAGCAGGTCTGGCTTTCCCCACAGGATGCAGCCGCAACCACTGTGCAGCGCATTATACTCCTAACACAGGTGATACAACAGTTCTCGAATATGATGATGTAGTGAAGATCGACTTTGGTACTCACATAAATGGTCGCATTATTGACTGCGCCTTCACACTACACTTTAACCCACGCTATGATCCCCTTGTGAAGGGCGTTCAAGAGGCTACAGAAGCTGGCATTAAGGCGTCAGGGGTCGATGTAAGGCTTTGCGATGTAGGTGCTGCTGTACAAGAGGTAATGGAGTCACATGAAGTTGAACTCGACGGGCAGATGTACCAGGTGAAACCAATCCGTAATCTTAATGGACATTCAATTGAACCTTATAAAATCCACGCCGGTAAGACAGTCCCGATAGTGAAAGGTGGCGAGACAACGCGCATGGAGGAGAACGAAATCTACGCTATAGAAACTTTCGGATCCACTGGACGTGGTCAAGTTCACGACGACATGGACTGCTCTCACTACATGAAAAACTTCGATCAGCAATTTGTTCCGTTGAGATTGCAATCGTCGAAACAGCTTCTGAACGTGATCAACAAGAACTTTGGTACACTCGCGTTTTGCAAGCGCTGGCTGGAACGCGCCGGGGCCTCTCGTTACGCGATGGCGCTGAAGGACCTCTGCGACAAGGGGGTGGTGGACGCCTACCCGCCCCTCTGCGACATCAAGGGGTGCTACACCGCACAGTTCGAACACACCATCCTGCTCAGACCCACCTGCAAGGAAGTCGTGTCCCGTGGCGATGACTACTAA

Protein

MAAVVTENDVTENVVENGEDDDVEVIDEGDTKDPAKKKKKKKKKKKAEGETAKESPTEVTATTEKLEALSLGENAGEGDEKKKKKKNKSKSGKGSSKEQTVPPTIPVAELFPDGNFPEGQIMDHGPAEGIDERTAKNRFTSEEKRALDRLHKDIYQEIRHAAEAHRQTRKHIRNWIKPGMTMIDICEELEKTARRLIGEDGLKAGLAFPTGCSRNHCAAHYTPNTGDTTVLEYDDVVKIDFGTHINGRIIDCAFTLHFNPRYDPLVKGVQEATEAGIKASGVDVRLCDVGAAVQEVMESHEVELDGQMYQVKPIRNLNGHSIEPYKIHAGKTVPIVKGGETTRMEENEIYAIETFGSTGRGQVHDDMDCSHYMKNFDQQFVPLRLQSSKQLLNVINKNFGTLAFCKRWLERAGASRYAMALKDLCDKGVVDAYPPLCDIKGCYTAQFEHTILLRPTCKEVVSRGDDY

Description

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

Catalytic Activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Cofactor

Fe(2+)
Mn(2+)
Zn(2+)

Similarity

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Belongs to the peptidase M24A family.

Feature

chain  Methionine aminopeptidase

Uniprot

H9JKB2   A0A194R624   A0A194PYZ1   A0A3S2M4U6   A0A212FFE1   S4PY04   + More
A0A0C9RYN8   A0A026WWC4   A0A088AII8   A0A0M9A3B4   A0A1B0CYD4   A0A0K8TSP2   E2A544   A0A0J7P060   T1PE21   A0A310SIJ3   F4WLJ2   A0A151XA76   A0A195EEY1   A0A195FWE3   A0A195AUF4   A0A158NN97   A0A336MD95   A0A0A1XJP4   A0A154PA63   W8BYY6   E2BEK4   E9IVN5   B3N8H7   A0A1W4VXS0   A0A1B0FHJ4   A0A034WMG8   A0A336K161   A0A1L8E2V7   A0A1L8E3B0   B4KID0   A0A182JDT8   B4NYL5   A0A2A3EK17   A0A0T6B0S9   B4HWA0   B4Q872   Q9VL89   O61540   D7EI35   A0A1Q3F0L8   A0A1A9Y514   A0A1B0AWZ7   A0A1I8PIH9   A0A1A9V8A1   A0A1W4XAZ9   A0A0M3QTL8   B3MUY8   A0A182P8N0   A0A1B6DCQ7   A0A1A9WK95   U5EZS9   A0A1A9Z9F5   Q17BZ1   A0A195CRD2   A0A182V826   A0A0L0CNK1   A0A3B0JU82   A0A182Y3A5   A0A182L0P6   A0A182TZK6   A0A182XLC0   Q7Q4D3   B4LQC3   A0A182ICA2   A0A084W5S5   A0A182K6I5   B4N1A5   A0A182QLJ7   A0A1Y1NJW2   A0A182MKW9   A0A2J7PPY4   A0A182W6J0   A0A1B6CYV4   Q29NC1   A0A023EUF7   B0XLC9   A0A182RM88   K7J6V4   A0A2M3Z043   A0A2M3Z041   A0A2M4A6M8   B0WXC2   A0A2M3Z072   A0A2M4A6I7   A0A182F1X5   A0A232F6K0   B4JZH5   A0A2M4BKS8   A0A2M4BKQ9   A0A1B6EQ98   W5JTD6   V5GR86   J3JZJ0   A0A1B6M8T9  

EC Number

3.4.11.18

Pubmed

19121390    26354079    22118469    23622113    24508170    30249741    + More
26369729    20798317    25315136    21719571    21347285    25830018    24495485    21282665    17994087    25348373    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10354468    18362917    19820115    17510324    26108605    25244985    20966253    12364791    14747013    17210077    24438588    28004739    15632085    24945155    20075255    28648823    20920257    23761445    22516182    23537049   

EMBL

BABH01036772    KQ460883    KPJ11316.1    KQ459586    KPI97964.1    RSAL01000040    + More
RVE50955.1    AGBW02008829    OWR52449.1    GAIX01004133    JAA88427.1    GBYB01013086    GBYB01013087    JAG82853.1    JAG82854.1    KK107085    QOIP01000008    EZA60036.1    RLU19437.1    KQ435774    KOX75083.1    AJVK01000020    AJVK01000021    AJVK01000022    GDAI01000460    JAI17143.1    GL436803    EFN71450.1    LBMM01000584    KMQ98030.1    KA646390    AFP61019.1    KQ760869    OAD58776.1    GL888208    EGI64928.1    KQ982351    KYQ57272.1    KQ979039    KYN23362.1    KQ981208    KYN44746.1    KQ976738    KYM75868.1    ADTU01021183    UFQT01000672    SSX26367.1    GBXI01003554    JAD10738.1    KQ434856    KZC08742.1    GAMC01002028    JAC04528.1    GL447817    EFN85894.1    GL766328    EFZ15357.1    CH954177    EDV58400.1    CCAG010020379    GAKP01003587    JAC55365.1    UFQS01000055    UFQT01000055    SSW98694.1    SSX19080.1    GFDF01001098    JAV12986.1    GFDF01001099    JAV12985.1    CH933807    EDW13427.1    CM000157    EDW88679.1    KZ288222    PBC32040.1    LJIG01016285    KRT81059.1    CH480818    EDW52295.1    CM000361    CM002910    EDX04394.1    KMY89326.1    AE014134    AY047525    AAF52807.1    AAK77257.1    AHN54297.1    AF049912    AAC05144.1    DS497671    EFA13129.1    GFDL01013945    JAV21100.1    JXJN01004965    CP012523    ALC39109.1    CH902624    EDV33053.1    GEDC01013811    JAS23487.1    GANO01000219    JAB59652.1    CH477314    EAT43828.1    KQ977372    KYN03266.1    JRES01000147    KNC33807.1    OUUW01000010    SPP85665.1    AAAB01008964    EAA12286.3    CH940649    EDW63373.1    APCN01000789    ATLV01020692    KE525305    KFB45569.1    CH963920    EDW78098.1    AXCN02000807    GEZM01005716    GEZM01005715    JAV95977.1    AXCM01009376    NEVH01022641    PNF18389.1    GEDC01018636    JAS18662.1    CH379060    EAL33421.1    GAPW01001037    JAC12561.1    DS234417    EDS33934.1    AAZX01008634    GGFM01001138    MBW21889.1    GGFM01001139    MBW21890.1    GGFK01003126    MBW36447.1    DS232162    EDS36452.1    GGFM01001135    MBW21886.1    GGFK01003086    MBW36407.1    NNAY01000795    OXU26461.1    CH916379    EDV94097.1    GGFJ01004514    MBW53655.1    GGFJ01004516    MBW53657.1    GECZ01029660    GECZ01018527    JAS40109.1    JAS51242.1    ADMH02000138    ETN67637.1    GALX01004359    JAB64107.1    APGK01058936    BT128672    KB741292    KB631727    AEE63629.1    ENN70350.1    ERL85616.1    GEBQ01007649    JAT32328.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    UP000053097    + More
UP000279307    UP000005203    UP000053105    UP000092462    UP000000311    UP000036403    UP000095301    UP000007755    UP000075809    UP000078492    UP000078541    UP000078540    UP000005205    UP000076502    UP000008237    UP000008711    UP000192221    UP000092444    UP000009192    UP000075880    UP000002282    UP000242457    UP000001292    UP000000304    UP000000803    UP000007266    UP000092443    UP000092460    UP000095300    UP000078200    UP000192223    UP000092553    UP000007801    UP000075885    UP000091820    UP000092445    UP000008820    UP000078542    UP000075903    UP000037069    UP000268350    UP000076408    UP000075882    UP000075902    UP000076407    UP000007062    UP000008792    UP000075840    UP000030765    UP000075881    UP000007798    UP000075886    UP000075883    UP000235965    UP000075920    UP000001819    UP000002320    UP000075900    UP000002358    UP000069272    UP000215335    UP000001070    UP000000673    UP000019118    UP000030742   

PRIDE

H9JKB2    Q9VL89    O61540   

Pfam

PF00557   Peptidase_M24        + More
PF04719   TAFII28

Interpro

IPR001714   Pept_M24_MAP        + More
IPR036005   Creatinase/aminopeptidase-like       
IPR002468   Pept_M24A_MAP2       
IPR000994   Pept_M24       
IPR036390   WH_DNA-bd_sf       
IPR018349   Pept_M24A_MAP2_BS       
IPR036388   WH-like_DNA-bd_sf       
IPR009072   Histone-fold       
IPR006809   TAFII28       

SUPFAM

SSF46785   SSF46785        + More
SSF55920   SSF55920       
SSF47113   SSF47113       

Gene 3D

1.10.10.10     1.10.20.10    

CDD

cd01088  MetAP2
cd08048  TAF11

ProteinModelPortal

H9JKB2   A0A194R624   A0A194PYZ1   A0A3S2M4U6   A0A212FFE1   S4PY04   + More
A0A0C9RYN8   A0A026WWC4   A0A088AII8   A0A0M9A3B4   A0A1B0CYD4   A0A0K8TSP2   E2A544   A0A0J7P060   T1PE21   A0A310SIJ3   F4WLJ2   A0A151XA76   A0A195EEY1   A0A195FWE3   A0A195AUF4   A0A158NN97   A0A336MD95   A0A0A1XJP4   A0A154PA63   W8BYY6   E2BEK4   E9IVN5   B3N8H7   A0A1W4VXS0   A0A1B0FHJ4   A0A034WMG8   A0A336K161   A0A1L8E2V7   A0A1L8E3B0   B4KID0   A0A182JDT8   B4NYL5   A0A2A3EK17   A0A0T6B0S9   B4HWA0   B4Q872   Q9VL89   O61540   D7EI35   A0A1Q3F0L8   A0A1A9Y514   A0A1B0AWZ7   A0A1I8PIH9   A0A1A9V8A1   A0A1W4XAZ9   A0A0M3QTL8   B3MUY8   A0A182P8N0   A0A1B6DCQ7   A0A1A9WK95   U5EZS9   A0A1A9Z9F5   Q17BZ1   A0A195CRD2   A0A182V826   A0A0L0CNK1   A0A3B0JU82   A0A182Y3A5   A0A182L0P6   A0A182TZK6   A0A182XLC0   Q7Q4D3   B4LQC3   A0A182ICA2   A0A084W5S5   A0A182K6I5   B4N1A5   A0A182QLJ7   A0A1Y1NJW2   A0A182MKW9   A0A2J7PPY4   A0A182W6J0   A0A1B6CYV4   Q29NC1   A0A023EUF7   B0XLC9   A0A182RM88   K7J6V4   A0A2M3Z043   A0A2M3Z041   A0A2M4A6M8   B0WXC2   A0A2M3Z072   A0A2M4A6I7   A0A182F1X5   A0A232F6K0   B4JZH5   A0A2M4BKS8   A0A2M4BKQ9   A0A1B6EQ98   W5JTD6   V5GR86   J3JZJ0   A0A1B6M8T9  

PDB

6QEJ     E-value=2.70117e-165,     Score=1494

KEGG

101740408    K01265 methionyl aminopeptidase [EC:3.4.11.18] | (RefSeq) methionine aminopeptidase 2

GO

GO:0070084   GO:0070006   GO:0046872   GO:0005737   GO:0004177   GO:0008235   GO:0005634   GO:0006367   GO:0046982   GO:0006508   GO:0003824   GO:0016829   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Cytoplasm  

Length:

467

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00038

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00593

outside

1  -  467

 

 

Pi

245.840136

Theta

188.411092

Tajima's D

0.37034

CLR

132.810306

CSRT

0.47757612119394

Interpretation

Uncertain