Gene

KWMTBOMO13215

Pre Gene Modal

BGIBMGA009962

Annotation

PREDICTED:_cAMP-specific_3'?5'-cyclic_phosphodiesterase?_isoforms_N/G_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr22(+):10660817-10724623      View in EpiBrowser

Full name

Phosphodiesterase       + More
cAMP-specific 3',5'-cyclic phosphodiesterase      
cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G      
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I      
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F      

Alternative Name

Learning/memory process protein
Protein dunce

Location in the cell

Nuclear   Reliability : 2.599

CDS

ATGAAGCTGGCTTTGGAAACCGTTGAGGAACTCGACTGGTGCCTGGACCAATTGGAGACGATACAGACACATCGATCGGTCTCCGACATGGCTTCGCTTAAGTTCAAGAGGATGCTGAACAAGGAGCTGAGCCACTTCTCAGAGTCCAGCAAGTCCGGCAATCAGATCTCCGAGTATATCTGCTCCACATTTTTGGACAAACAACAGGAGCTTGACTTACCATCCTTACAAGTCGAAGAAACTTCGGAACGCGGCGCCAAGAAAAAGGAAAAACCACGTCATGGCGGACCAGCGACTACGATGTCACAAATATCGGGTGTTAAGAGGACTTTGACACACACAAATAGCTTCACCGGCGAACGCGTGCCGAGGTATGGAGTTGAAACACCGCATGAGGAAGAGCTCGGCCTTCTTCTCAGCGATCTAGACCGGTGGGGAGTGAATATATTCCGCATCGGTGATCTGTCATGCGGTAGACCACTCACTGCTGTCGCGTACACAGCGTTCACATCACGGGAGCTGTTGACTACTCTTCAGATACCGGCGCGTACTTTCTTGGCGTTCGCAGTTACCTTAGAGGAGCACTATATTCGAGACAATCCTTTCCACAACTCTCTCCACGCTGCCGATGTCACACAGTCTACAAACGTACTGTTGAATACACCTGCGCTTAATGCTGTCTTCACACCACTAGAAGTTTGCGCTGCTCTTTTCGCTGCCTGCGTCCACGACGTCGATCACCCGGGCCTCACCAATCAATTCCTCGTCAACTCCAGTTCCGAACTCGCACTAATGTACAACGACGAGTCAGTCCTCGAGAACCACCACCTTGCAGTCGCATTCAAGCTGCTGCAGAATGATGGATGTGATATTTTCGTGAATCTTCACAAGAAACAAAGACAGACCCTCAGGAAAATGGTTATCGACATGGTCCTCTCGACAGATATGTCGAAACACATGAGTCTGCTGGCGGATCTGAAGACGATGGTCGAAACGAAGAAAGTCGCGGGTAGCGGTGTCTTATTGCTAGACAACTACACTGATAGAATTCAAGTATTAGAGAATCTCGTACACTGTGCCGATCTGAGCAATCCTACTAAGCCGTTGCCACTGTATAAACGATGGGTGGCATTACTGATGGAAGAGTTCTTCCAGCAAGGCGATCGTGAACGTGAACATGGCATGGATATCAGTCCAATGTGTGACAGACATAATGCTACTATAGAAAAATCTCAAGTCGGTTTCATTGACTATATCGTGCATCCTCTGTGGGAAACTTGGGCAGATTTGGTACATCCTGACGCTCAAGATATTTTGGACACCTTAGAAGAAAACCGAGACTATTACCAAAGTATGATTCCACCGTCACCGCCACCAGCACCGATACAATCCTCACACGCCTCTGATGATGATCGCCCTGAACAAATACGATTTCAAGTCACCCTAGAGGAGGGAGAAGGATCAGAAGATTGCGAGGGCGAAGGTGATGGTGGAATGTGA

Protein

MKLALETVEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSKSGNQISEYICSTFLDKQQELDLPSLQVEETSERGAKKKEKPRHGGPATTMSQISGVKRTLTHTNSFTGERVPRYGVETPHEEELGLLLSDLDRWGVNIFRIGDLSCGRPLTAVAYTAFTSRELLTTLQIPARTFLAFAVTLEEHYIRDNPFHNSLHAADVTQSTNVLLNTPALNAVFTPLEVCAALFAACVHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNDGCDIFVNLHKKQRQTLRKMVIDMVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFQQGDREREHGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPAPIQSSHASDDDRPEQIRFQVTLEEGEGSEDCEGEGDGGM

Description

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory (By similarity).

Catalytic Activity

3',5'-cyclic AMP + H2O = AMP + H(+)

Cofactor

a divalent metal cation

Subunit

Monomer.

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Keywords

Alternative initiation   Alternative splicing   cAMP   Complete proteome   Hydrolase   Metal-binding   Reference proteome  

Feature

chain  Phosphodiesterase
splice variant  In isoform VII.

Uniprot

A0A1E1W0K8   H9JKB1   A0A1E1W093   A0A194R246   A0A2H1W3R2   A0A194Q3G7   + More
A0A212ENZ6   A0A1B0CBX1   A0A2A3E5J0   V9I967   B4JMU1   A0A3B0K0B8   V9IAZ4   A0A0Q9W6Z7   A0A0Q9WB84   A0A0M4F9F4   A0A0Q9VZ20   A0A1I8QDE8   A0A1I8QD96   A0A1I8QD92   A0A1L8DLH8   A0A1B6ERJ9   A0A1I8QDE4   A0A1I8QDA1   A0A1A9ZLK7   A0A1L8DLL1   A0A0Q9WZA2   A0A0Q9WNL3   A0A1B6FHL2   A0A1L8DL56   P12252-5   A0A1I8MIT5   E2QD73   A0A0Q9VZ02   A0A1I8QD76   P12252   P12252-4   A0A0Q9VZB9   A0A1I8QDA8   B4MJA8   E2AWF4   A0A1L8DLD7   A0A195FWK9   B4MCU3   A0A0Q9WBB8   A0A1A9WIK4   A0A1W4W882   A0A0Q9WNT8   A0A1W4WIJ3   A0A0Q5TGS1   A0A0Q5T381   A0A1W4VSN5   A0A0Q9VZ07   A0A1W4WJS5   A0A1W4VEP6   A0A1W4VEE2   A0A0Q9WAJ9   A0A1W4W883   A0A0T6AVH7   A0A0Q5TG56   Q9W4S9-2   A0A154P7D8   D0IQA0   K7J1X9   A0A1I8QD97   A0A1I8QDB2   B4IA32   A0A1B6E622   A0A0Q9WNR7   A0A151WH39   Q9W4S9   A0A1I8QD91   Q8MS17   T1PME5   H8F4P8   Q9W4T4   A0A1W4WJI5   A0A1W4WIJ8   A0A1B6DRH6   A0A1W4VRE9   A0A1W4VS49   A0A1W4WJJ1   A0A1W4W887   A0A1B6CIC6   A0A1B6CZC8   P12252-7   A0A232FBZ1   A0A1W4W888   M9PDN2   P12252-9   A0A1W4WJT5   C9QPC1   A0A0L0C0L2   Q8IRU4   A0A1W4W891   A0A0C9PRG4   B3N1U9   A0A0Q5T2H8   A0A195C111   P12252-8  

EC Number

3.1.4.-
3.1.4.53

Pubmed

19121390    26354079    22118469    17994087    1660926    3025834    + More
10731132    12537572    10731137    12537569    25315136    12537568    12537573    12537574    16110336    17569856    17569867    18057021    20798317    20075255    26109357    26109356    28648823    26108605   

EMBL

GDQN01010548    JAT80506.1    BABH01036773    GDQN01010644    JAT80410.1    KQ460883    + More
KPJ11325.1    ODYU01005845    SOQ47134.1    KQ459586    KPI97955.1    AGBW02013576    OWR43204.1    AJWK01005928    AJWK01005929    AJWK01005930    AJWK01005931    KZ288361    PBC26965.1    JR037164    JR037167    AEY57620.1    AEY57622.1    CH916371    EDV92034.1    OUUW01000003    SPP78451.1    JR037165    JR037168    AEY57621.1    AEY57623.1    CH940660    KRF78071.1    KRF78075.1    CP012528    ALC48832.1    KRF78074.1    GFDF01006884    JAV07200.1    GECZ01029271    JAS40498.1    GFDF01006829    JAV07255.1    CH963738    KRF97512.1    KRF97513.1    GECZ01020080    GECZ01000476    JAS49689.1    JAS69293.1    GFDF01006885    JAV07199.1    X55167    X55168    X55169    X55170    X55171    X55172    X55173    X55174    X55175    M14982    M14978    M14979    M14980    M14981    AE014298    AL121800    AY119511    AAN09603.2    KRF78076.1    KRF78077.1    EDW72197.2    GL443286    EFN62254.1    GFDF01006899    JAV07185.1    KQ981208    KYN44697.1    EDW58015.1    KRF78078.1    KRF97511.1    CH954180    KQS29675.1    KQS29679.1    KRF78073.1    KRF78079.1    LJIG01022741    KRT78957.1    KQS29678.1    AAF45863.2    KQ434832    KZC07855.1    BT100138    ACX94163.1    CH480825    EDW44063.1    GEDC01003926    JAS33372.1    KRF97510.1    KQ983136    KYQ47128.1    AY119147    AAM51007.1    KA644518    KA649083    AFP63712.1    BT133288    AAN09599.1    AFC88877.1    AL024484    AAF45858.3    GEDC01023956    GEDC01009028    JAS13342.1    JAS28270.1    GEDC01024213    JAS13085.1    GEDC01018496    JAS18802.1    NNAY01000471    OXU28142.1    AGB95047.1    BT100003    ACX54887.1    JRES01001065    KNC25848.1    AAN09606.1    GBYB01003893    JAG73660.1    CH902663    EDV29990.1    KQS29673.1    KQ978457    KYM93858.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000092461    UP000242457    + More
UP000001070    UP000268350    UP000008792    UP000092553    UP000095300    UP000092445    UP000007798    UP000000803    UP000095301    UP000000311    UP000078541    UP000091820    UP000192223    UP000008711    UP000192221    UP000076502    UP000002358    UP000001292    UP000075809    UP000215335    UP000037069    UP000007801    UP000078542   

PRIDE

H9JKB1    P12252    E2QD73    Q9W4S9    D0IQA0    Q8MS17    + More
H8F4P8    Q9W4T4    C9QPC1    Q8IRU4   

Pfam

PF00233   PDEase_I        + More
PF18100   PDE4_UCR

Interpro

IPR040844   PDE4_UCR        + More
IPR003607   HD/PDEase_dom       
IPR036971   PDEase_catalytic_dom_sf       
IPR002073   PDEase_catalytic_dom       
IPR023088   PDEase       
IPR023174   PDEase_CS       

Gene 3D

1.10.1300.10    

CDD

cd00077  HDc

ProteinModelPortal

A0A1E1W0K8   H9JKB1   A0A1E1W093   A0A194R246   A0A2H1W3R2   A0A194Q3G7   + More
A0A212ENZ6   A0A1B0CBX1   A0A2A3E5J0   V9I967   B4JMU1   A0A3B0K0B8   V9IAZ4   A0A0Q9W6Z7   A0A0Q9WB84   A0A0M4F9F4   A0A0Q9VZ20   A0A1I8QDE8   A0A1I8QD96   A0A1I8QD92   A0A1L8DLH8   A0A1B6ERJ9   A0A1I8QDE4   A0A1I8QDA1   A0A1A9ZLK7   A0A1L8DLL1   A0A0Q9WZA2   A0A0Q9WNL3   A0A1B6FHL2   A0A1L8DL56   P12252-5   A0A1I8MIT5   E2QD73   A0A0Q9VZ02   A0A1I8QD76   P12252   P12252-4   A0A0Q9VZB9   A0A1I8QDA8   B4MJA8   E2AWF4   A0A1L8DLD7   A0A195FWK9   B4MCU3   A0A0Q9WBB8   A0A1A9WIK4   A0A1W4W882   A0A0Q9WNT8   A0A1W4WIJ3   A0A0Q5TGS1   A0A0Q5T381   A0A1W4VSN5   A0A0Q9VZ07   A0A1W4WJS5   A0A1W4VEP6   A0A1W4VEE2   A0A0Q9WAJ9   A0A1W4W883   A0A0T6AVH7   A0A0Q5TG56   Q9W4S9-2   A0A154P7D8   D0IQA0   K7J1X9   A0A1I8QD97   A0A1I8QDB2   B4IA32   A0A1B6E622   A0A0Q9WNR7   A0A151WH39   Q9W4S9   A0A1I8QD91   Q8MS17   T1PME5   H8F4P8   Q9W4T4   A0A1W4WJI5   A0A1W4WIJ8   A0A1B6DRH6   A0A1W4VRE9   A0A1W4VS49   A0A1W4WJJ1   A0A1W4W887   A0A1B6CIC6   A0A1B6CZC8   P12252-7   A0A232FBZ1   A0A1W4W888   M9PDN2   P12252-9   A0A1W4WJT5   C9QPC1   A0A0L0C0L2   Q8IRU4   A0A1W4W891   A0A0C9PRG4   B3N1U9   A0A0Q5T2H8   A0A195C111   P12252-8  

PDB

4X0F     E-value=7.0757e-163,     Score=1474

KEGG

101742254    K13293 cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] | (RefSeq) cAMP-specific 3',5'-cyclic phospho

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0004114   GO:0007165   GO:0040040   GO:0048149   GO:0010738   GO:0072375   GO:0019933   GO:0048675   GO:0007614   GO:0005634   GO:0007268   GO:0005829   GO:0007615   GO:0001661   GO:0006198   GO:0007612   GO:0046958   GO:0007613   GO:0007619   GO:0004115   GO:0007623   GO:0007617   GO:0045475   GO:0000003   GO:0008306   GO:0008355   GO:0007611   GO:0008081   GO:0003824   GO:0016829   GO:0005737   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Length:

499

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00722

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00146

outside

1  -  499

 

 

Pi

245.507637

Theta

185.100581

Tajima's D

0.700527

CLR

0.381695

CSRT

0.572821358932053

Interpretation

Uncertain