Gene

KWMTBOMO13214

Pre Gene Modal

BGIBMGA009960

Annotation

cAMP-specific_3'?5'-cyclic_phosphodiesterase?_isoform_M_[Papilio_machaon]

Location

Bomo_Chr22(+):10652657-10656509      View in EpiBrowser

Full name

Phosphodiesterase       + More
cAMP-specific 3',5'-cyclic phosphodiesterase      
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I      
cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G      

Alternative Name

Learning/memory process protein
Protein dunce

Location in the cell

Mitochondrial   Reliability : 1.015 Nuclear   Reliability : 1.468

CDS

ATGACCGTGGTTCTAAGTTTCGATGTGGAGAATGGGGGTGGAGCGGGAGTTGCCGGAGGCGCAAGATCTCCCCTCGAGGGCGGATCTCCGTCAGCCGCTCTCGTCCTGCAGGCCATGCCGCAGCGCCGCGAGTCTTTCCTATACCGCTCAGACTCCGATTTCGAAATGTCACCGAAATCCATGTCCAGGAACAGTTCGATCGCCAGCGAAAGATTCAAGGAGGCTGAGGCAGCACAACTGGACAGAGCGTACGTATTATCAACTCCGCACGACTAA

Protein

MTVVLSFDVENGGGAGVAGGARSPLEGGSPSAALVLQAMPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEAEAAQLDRAYVLSTPHD

Description

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory (By similarity).

Catalytic Activity

3',5'-cyclic AMP + H2O = AMP + H(+)

Cofactor

a divalent metal cation

Subunit

Monomer.

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Keywords

Alternative initiation   Alternative splicing   cAMP   Complete proteome   Hydrolase   Metal-binding   Reference proteome  

Feature

chain  cAMP-specific 3',5'-cyclic phosphodiesterase
splice variant  In isoform VII.

Uniprot

H9JKA9   A0A194R0K5   A0A194PXA7   A0A2H1VX82   A0A212ENX4   A0A1B0ALX2   + More
A0A1B0G270   A0A1I8QD96   A0A1I8QD92   W8BDX9   A0A0R1E9J5   A0A0R1E9H8   A0A1I8QD91   A0A0K8UJ55   A0A0Q9WNR7   A0A2A4J6X4   A0A1I8QDE8   P12252-8   A0A1I8QDE4   A0A0Q5T2U2   G7H7Y9   A0A1I8MIT5   B4JMU1   A0A1I8QD76   A0A0R1EA71   A0A3B0K0B8   P12252-5   E2QD73   P12252   A0A0R1EB95   A0A0Q9WZA2   A0A0R1EFS3   A0A0Q9VZ07   A0A1W4VRE9   A0A0Q5TG56   A0A0Q5T381   A0A1W4VEP6   A0A1W4VSN5   P12252-3   P12252-9   A0A1L8DLL1   B4L8C2   B4Q0K6   H8F4P8   Q9W4T4   A0A0L0C0L2   A0A0Q9WB84   A0A0Q9VZ02   A0A0Q9W6Z7   Q8MS17   B4IA32   A0A1A9WIK1   A0A1A9XKD2   A0A1W4WIJ3   A0A1B6IAM9   A0A1A9UU53   A0A1B6CIC6   A0A1W4WJI5   A0A1W4W887   A0A1W4W883   A0A1I8QDA1   A0A1B6ERJ9   A0A1W4WJJ1   A0A1W4W888   A0A1W4WIJ8   A0A1W4W882   A0A1B6M2N3   A0A1B6E622   A0A1B0DC95   A0A2S2P3L7   A0A0R1E9T9   A0A034VFR6   A0A0K8V1F2   J9K4M8   A0A1J1HUF2   A0A0N8NYW4   A0A2S2QGR0   A0A1S4EZB4   A0A1B0CBX1   Q9W4S9-2   D0IQA0   A0A1I8QDA8   A0A1L8DL56   A0A0M4F9F4   A0A1L8DLH8   A0A0R1EA14   A0A0Q9VZ20   A0A0Q9VZB9   B4MJA8   P12252-4   B3N1U9   A0A0Q9WNL3   A0A1W4VS49   Q9W4S9   A0A0Q5TGS1   A0A0Q5T2H8   A0A1W4VEE2   A0A1L8DLD7   A0A0B6Y888   A0A1B6K9H5  

EC Number

3.1.4.-
3.1.4.53

Pubmed

19121390    26354079    22118469    24495485    17994087    17550304    + More
1660926    3025834    10731132    12537572    10731137    12537569    25315136    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26108605    18057021    25348373    17510324   

EMBL

BABH01036775    KQ460883    KPJ11323.1    KQ459586    KPI97957.1    ODYU01004827    + More
SOQ45112.1    AGBW02013576    OWR43202.1    JXJN01000181    CCAG010008749    CCAG010008750    GAMC01011357    JAB95198.1    CM000162    KRK06058.1    KRK06060.1    KRK06061.1    KRK06054.1    GDHF01025954    JAI26360.1    CH963738    KRF97510.1    NWSH01002823    PCG67476.1    X55167    X55168    X55169    X55170    X55171    X55172    X55173    X55174    X55175    M14982    M14978    M14979    M14980    M14981    AE014298    AL121800    AY119511    CH954180    KQS29677.1    BT132711    AEQ94065.1    CH916371    EDV92034.1    KRK06053.1    OUUW01000003    SPP78451.1    AAN09603.2    KRK06062.1    KRF97512.1    KRK06052.1    CH940660    KRF78073.1    KQS29678.1    KQS29679.1    GFDF01006829    JAV07255.1    CH933814    EDW05697.2    EDX01290.2    BT133288    AAN09599.1    AFC88877.1    AL024484    AAF45858.3    JRES01001065    KNC25848.1    KRF78075.1    KRF78076.1    KRF78071.1    AY119147    AAM51007.1    CH480825    EDW44063.1    GECU01023712    JAS83994.1    GEDC01024213    JAS13085.1    GECZ01029271    JAS40498.1    GEBQ01009792    JAT30185.1    GEDC01003926    JAS33372.1    AJVK01030686    AJVK01030687    GGMR01011440    MBY24059.1    KRK06059.1    GAKP01017995    JAC40957.1    GDHF01019884    JAI32430.1    ABLF02034432    ABLF02034433    ABLF02034439    ABLF02034441    ABLF02034442    CVRI01000020    CRK91178.1    CH902663    KPU72652.1    GGMS01007746    MBY76949.1    AJWK01005928    AJWK01005929    AJWK01005930    AJWK01005931    AAF45863.2    BT100138    ACX94163.1    GFDF01006885    JAV07199.1    CP012528    ALC48832.1    GFDF01006884    JAV07200.1    KRK06057.1    KRF78074.1    KRF78077.1    EDW72197.2    EDV29990.1    KRF97513.1    KQS29675.1    KQS29673.1    GFDF01006899    JAV07185.1    HACG01004815    CEK51680.1    GEBQ01031868    JAT08109.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000092460    UP000092444    + More
UP000095300    UP000002282    UP000007798    UP000218220    UP000000803    UP000008711    UP000095301    UP000001070    UP000268350    UP000008792    UP000192221    UP000009192    UP000037069    UP000001292    UP000091820    UP000092443    UP000192223    UP000078200    UP000092462    UP000007819    UP000183832    UP000007801    UP000092461    UP000092553   

PRIDE

H9JKA9    P12252    G7H7Y9    E2QD73    H8F4P8    Q9W4T4    + More
Q8MS17    Q9W4S9    D0IQA0   

Pfam

PF18100   PDE4_UCR        + More
PF00233   PDEase_I

Interpro

IPR040844   PDE4_UCR        + More
IPR002073   PDEase_catalytic_dom       
IPR003607   HD/PDEase_dom       
IPR036971   PDEase_catalytic_dom_sf       
IPR023174   PDEase_CS       
IPR023088   PDEase       

Gene 3D

1.10.1300.10    

CDD

cd00077  HDc

ProteinModelPortal

H9JKA9   A0A194R0K5   A0A194PXA7   A0A2H1VX82   A0A212ENX4   A0A1B0ALX2   + More
A0A1B0G270   A0A1I8QD96   A0A1I8QD92   W8BDX9   A0A0R1E9J5   A0A0R1E9H8   A0A1I8QD91   A0A0K8UJ55   A0A0Q9WNR7   A0A2A4J6X4   A0A1I8QDE8   P12252-8   A0A1I8QDE4   A0A0Q5T2U2   G7H7Y9   A0A1I8MIT5   B4JMU1   A0A1I8QD76   A0A0R1EA71   A0A3B0K0B8   P12252-5   E2QD73   P12252   A0A0R1EB95   A0A0Q9WZA2   A0A0R1EFS3   A0A0Q9VZ07   A0A1W4VRE9   A0A0Q5TG56   A0A0Q5T381   A0A1W4VEP6   A0A1W4VSN5   P12252-3   P12252-9   A0A1L8DLL1   B4L8C2   B4Q0K6   H8F4P8   Q9W4T4   A0A0L0C0L2   A0A0Q9WB84   A0A0Q9VZ02   A0A0Q9W6Z7   Q8MS17   B4IA32   A0A1A9WIK1   A0A1A9XKD2   A0A1W4WIJ3   A0A1B6IAM9   A0A1A9UU53   A0A1B6CIC6   A0A1W4WJI5   A0A1W4W887   A0A1W4W883   A0A1I8QDA1   A0A1B6ERJ9   A0A1W4WJJ1   A0A1W4W888   A0A1W4WIJ8   A0A1W4W882   A0A1B6M2N3   A0A1B6E622   A0A1B0DC95   A0A2S2P3L7   A0A0R1E9T9   A0A034VFR6   A0A0K8V1F2   J9K4M8   A0A1J1HUF2   A0A0N8NYW4   A0A2S2QGR0   A0A1S4EZB4   A0A1B0CBX1   Q9W4S9-2   D0IQA0   A0A1I8QDA8   A0A1L8DL56   A0A0M4F9F4   A0A1L8DLH8   A0A0R1EA14   A0A0Q9VZ20   A0A0Q9VZB9   B4MJA8   P12252-4   B3N1U9   A0A0Q9WNL3   A0A1W4VS49   Q9W4S9   A0A0Q5TGS1   A0A0Q5T2H8   A0A1W4VEE2   A0A1L8DLD7   A0A0B6Y888   A0A1B6K9H5  

PDB

4X0F     E-value=4.95646e-07,     Score=122

KEGG

101742254    K13293 cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] | (RefSeq) cAMP-specific 3',5'-cyclic phospho

GO

GO:0046872   GO:0004114   GO:0007165   GO:0007619   GO:0004115   GO:0007268   GO:0007623   GO:0006198   GO:0007612   GO:0007614   GO:0048675   GO:0007613   GO:0046958   GO:0019933   GO:0048149   GO:0040040   GO:0010738   GO:0008355   GO:0008306   GO:0045475   GO:0000003   GO:0007611   GO:0001661   GO:0007617   GO:0007615   GO:0072375   GO:0005829   GO:0005634  

Length:

91

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00683

Exp number, first 60 AAs:

0.00683

Total prob of N-in:

0.10781

outside

1  -  91

 

 

Pi

325.855597

Theta

219.792994

Tajima's D

1.500817

CLR

0.05381

CSRT

0.785310734463277

Interpretation

Uncertain