Gene

KWMTBOMO13188  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000357

Annotation

preproPTTH_[Bombyx_mori]

Location

Bomo_Chr22(+):9699557-9701682      View in EpiBrowser

Full name

Prothoracicotropic hormone      

Location in the cell

Nuclear   Reliability : 2.53

CDS

ATGATTACTCGACCGATTATATTAGTCATTTTGTGTTACGCTATTCTTATGATAGTGCAGTCATTCGTGCCTAAAGCGGTAGCGCTGAAAAGAAAACCAGACGTGGGTGGTTTTATGGTAGAAGACCAAAGCACACATAAAAGTCACAACTACATGATGAAAAGAGCAAGAAATGACGTTTTGGGAGATAAAGAAAACGTCAGGCCGAATCCTTACTACACGGAGCCTTTTGACCCAGACACGAGCCCAGAAGAATTGTCCGCTTTAATAGTTGATTACGCCAATATGATTAGGAATGATGTTATTCTGTTGGATAATTCCGTTGAAACGAGAACGCGAAAAAGGGGAAACATTCAAGTTGAAAACCAAGCTATTCCGGACCCACCTTGCACTTGCAAATACAAGAAAGAAATAGAAGACTTGGGCGAAAACTCTGTTCCACGCTTCATTGAAACCAGAAACTGCAATAAAACACAACAGCCGACCTGTCGACCCCCGTACATTTGCAAAGAAAGTTTATACAGTATAACTATTTTAAAAAGAAGGGAGACTAAATCGCAGGAGTCTCTCGAGATACCGAATGAATTGAAATATCGATGGGTGGCGGAATCTCACCCCGTCAGCGTGGCGTGTTTGTGTACAAGAGACTACCAACTACGATATAATAATAATTAA

Protein

MITRPIILVILCYAILMIVQSFVPKAVALKRKPDVGGFMVEDQSTHKSHNYMMKRARNDVLGDKENVRPNPYYTEPFDPDTSPEELSALIVDYANMIRNDVILLDNSVETRTRKRGNIQVENQAIPDPPCTCKYKKEIEDLGENSVPRFIETRNCNKTQQPTCRPPYICKESLYSITILKRRETKSQESLEIPNELKYRWVAESHPVSVACLCTRDYQLRYNNN

Subunit

Homodimer; disulfide-linked.

Keywords

3D-structure   Cleavage on pair of basic residues   Complete proteome   Direct protein sequencing   Disulfide bond   Glycoprotein   Hormone   Neuropeptide   Reference proteome   Signal  

Feature

peptide  P2K
chain  Prothoracicotropic hormone

Uniprot

Q17238   P17219   A0A088MVI9   H9ISX9   Q6E0C8   Q7Z1Z6   + More
Q86QR2   Q5U818   G8E4B3   Q95UY8   Q86QR1   Q17079   Q6SA72   Q9GSY8   A0A0S1MMC2   A0A385H8Z2   Q26482   A0A0S1U2D0   A0A2H1V6F6   N0DQH2   A0A1Z2RRJ8   A0A212EVA1   A0A0C5BQ63   A0A0L7KZ90   A0A336JY68   A0A336K1K1   B4KFG3  

Pubmed

8125124    2315701    1368675    8180220    19121390    17653666    + More
15869761    14706546    12878226    12974956    8812139    11755069    30171635    23577167    28605547    22118469    25640113    26227816    17994087   

EMBL

X75941    CAA53542.1    D90082    D90083    X75942    KJ941087    + More
AIN40498.1    BABH01013022    AY628763    AAT64423.2    AY286543    AY780527    AAP41131.1    AAV41398.1    AY172670    AAO18190.1    AY780526    AAV41397.1    JF731347    AER59749.1    AY007724    AAG14368.1    AY172671    AAO18191.1    U62535    AAB05259.1    AY461435    AAR23822.1    AF288695    AAG10517.1    KT225461    ALL42053.1    MH028125    AXY04294.1    L25668    AAA29964.1    KT005989    RSAL01000618    ALM30340.1    RVE41301.1    ODYU01000908    SOQ36379.1    AB748456    BAN16739.1    KY938824    ASA46465.1    AGBW02012225    OWR45416.1    KJ783488    AJM76777.1    JTDY01004119    KOB68578.1    UFQS01000015    UFQT01000015    SSW97389.1    SSX17775.1    SSW97388.1    SSX17774.1    CH933807    EDW13078.2   

Proteomes

UP000005204    UP000283053    UP000007151    UP000037510    UP000009192   

PRIDE

Q17238    P17219    H9ISX9   

Interpro

IPR029034   Cystine-knot_cytokine       

SUPFAM

SSF57501   SSF57501       

Gene 3D

2.10.90.10    

ProteinModelPortal

Q17238   P17219   A0A088MVI9   H9ISX9   Q6E0C8   Q7Z1Z6   + More
Q86QR2   Q5U818   G8E4B3   Q95UY8   Q86QR1   Q17079   Q6SA72   Q9GSY8   A0A0S1MMC2   A0A385H8Z2   Q26482   A0A0S1U2D0   A0A2H1V6F6   N0DQH2   A0A1Z2RRJ8   A0A212EVA1   A0A0C5BQ63   A0A0L7KZ90   A0A336JY68   A0A336K1K1   B4KFG3  

PDB

5AOQ     E-value=2.04472e-52,     Score=517

KEGG

692767    no KO assigned | (RefSeq) PTTH, PTTH-KS; prothoracicotropic hormone

GO

GO:0016021   GO:0007218   GO:0005179   GO:0018445   GO:0044060   GO:0007552   GO:0008293   GO:0045998   GO:0043196   GO:0046957  

SignalP

Position:   1 - 21,         Likelihood:  0.735906

 

 

Length:

224

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

21.13831

Exp number, first 60 AAs:

21.13647

Total prob of N-in:

0.93095

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  224

 

 

Pi

189.630968

Theta

150.525552

Tajima's D

0.637981

CLR

0.420759

CSRT

0.555772211389431

Interpretation

Uncertain