Gene

KWMTBOMO13184

Pre Gene Modal

BGIBMGA000354

Annotation

HOP_precursor_[Bombyx_mori]

Location

Bomo_Chr22(+):9643767-9644741      View in EpiBrowser

Full name

Tyrosine-protein kinase transmembrane receptor Ror2      

Alternative Name

Neurospecific receptor tyrosine kinase

Location in the cell

Cytoplasmic   Reliability : 1.829 Nuclear   Reliability : 1.41

CDS

ATGCTTAAAGATGAAGCTTCTCATGATTTACAATTGGATTTTGAAAGAGAAGCTTGCCTACTTGCAGACTTTGACCATCCAAATATTGTTAAATTACTTGGAGTTTGTGCTATAGGACGTCCAATGTGTTTGCTTTTTGAGTACATGGGAAAAGGTGATCTAAATGAATACTTAAGAGCATGCAGTACTGTTACTAGTTTTGCACCAGTAGAACACCGTGAAGATCTACGATTGCTTGCTGCACCATTAAGTCACTTAGATCTTCTTCACATTGCCAGACAGATTGCATCAGGAATGCTGTACTTATCGGACAGGAAGTTTGTACATCGTGACCTTGCAACTAGAAATTGTTTAATAAATGATGACATGGTTGTAAAGATTGCAGACTTTGGACTCTCACACAAAATTTATTTACAAGACTATTATAAGGGTGATGAACATGATGCAATCCCAGTAAGGTGGATGCCGCTTGAAAGTATACTCTACAATAAGTACACGTTAGAATCTGATGTTTGGGCATACGGAGTATGCTTGTGGGAGATATTTTCATTTGCCTTACAACCATACTTTGGTATGACCCATGAGGAAGTTGTTAGATTTTTGAAGGATGAAAATGTGTTAGCTTGCCCAGATAATACCCCTAGATGTGTCTATGATTTAATGAAGCAATGCTGGAATCATAATCCAAGTGATCGTCCAAATTTTAGAGTAATTTATCAAACACTAGATAACATTCAGCTAATTTTAGAAAGAGGTCGAACACATTAA

Protein

MLKDEASHDLQLDFEREACLLADFDHPNIVKLLGVCAIGRPMCLLFEYMGKGDLNEYLRACSTVTSFAPVEHREDLRLLAAPLSHLDLLHIARQIASGMLYLSDRKFVHRDLATRNCLINDDMVVKIADFGLSHKIYLQDYYKGDEHDAIPVRWMPLESILYNKYTLESDVWAYGVCLWEIFSFALQPYFGMTHEEVVRFLKDENVLACPDNTPRCVYDLMKQCWNHNPSDRPNFRVIYQTLDNIQLILERGRTH

Description

Tyrosine-protein kinase receptor that functions during early stages of neuronal development.

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Keywords

ATP-binding   Cell membrane   Complete proteome   Developmental protein   Disulfide bond   Glycoprotein   Kinase   Kringle   Membrane   Nucleotide-binding   Phosphoprotein   Receptor   Reference proteome   Signal   Transferase   Transmembrane   Transmembrane helix   Tyrosine-protein kinase  

Feature

chain  Tyrosine-protein kinase transmembrane receptor Ror2

Uniprot

H9ISX6   E3VLC1   A0A194Q3F2   A0A194R261   A0A0L7LD30   A0A2H1W1S3   + More
A0A2J7R939   A0A2R7X2I0   A0A1B6MPL4   A0A2R4G8U4   A0A1B6HHW8   A0A067QVX9   A0A2S2QWY1   A0A1B6D852   J9JLC2   A0A2S2PBN5   A0A2H8TMW3   E2B3S0   A0A1Y1KRZ0   A0A182GGH5   A0A182GDH7   A0A158NM65   A0A0A9X0C7   A0A151JTN3   F4WYP9   W5J551   A0A182T9S5   A0A151J563   Q17LF1   A0A1S4EYK0   D6W6W4   E0VZ21   A0A182Q647   A0A182V0U1   A0A1J1IM76   A0A151WGV5   Q7QIP0   A0A026WF73   A0A182LUU4   A0A0M8ZZI8   A0A195BYS6   A0A084WRP3   A0A182R9T9   A0A182UIM7   A0A232FEP8   K7IPS7   B0W5C6   A0A1Q3F697   A0A1Q3F5K3   A0A088A1T8   A0A0L7QU28   A0A151IE51   A0A2A3ELS0   T1J9X7   A0A224XL87   A0A154P709   A0A336LRK2   A0A182J8Y2   A0A182JSW9   A0A182WWL6   A0A182P128   A0A182L3G9   A0A182NLS5   A0A182FGB6   A0A1W4X124   A0A1S3D1J9   A0A146L7Q9   B7PU79   A0A0A9WRV3   A0A034W7Z4   B4QDY4   A0A1I8MBY2   A0A1I8PW20   A0A2P6L7P1   A0A147BJR6   Q9V6K3   B3MDE2   A0A0J9RBJ8   A0A0A1WE69   B4P4U6   B4HQ08   B3NRR2   A0A1W4VCC8   A0A0M3QUK9   A0A0L0BP40   A0A1A9X3J4   A0A0K8UB71   A0A2R5L9U6   B4LMI7   A0A1V9XN87   A0A1Z5L997   A0A1A9X969   A0A1B0BU08   B4KSX1   A0A0U3SIE7   A0A087TXG6   B4J4Z5   A0A1A9V0S4   A0A1B0A8K9   B4MPC1  

EC Number

2.7.10.1

Pubmed

19121390    26354079    26227816    24845553    20798317    28004739    + More
26483478    21347285    25401762    21719571    20920257    23761445    17510324    18362917    19820115    20566863    12364791    14747013    17210077    24508170    30249741    24438588    28648823    20075255    20966253    26823975    25348373    17994087    25315136    29652888    10731132    12537572    9115253    9731193    22936249    25830018    17550304    26108605    28327890    28528879   

EMBL

BABH01013027    HQ020332    ADO51635.1    KQ459586    KPI97940.1    KQ460883    + More
KPJ11340.1    JTDY01001609    KOB73377.1    ODYU01005529    SOQ46464.1    NEVH01006693    PNF37351.1    KK856554    PTY26007.1    GEBQ01002172    GEBQ01001877    JAT37805.1    JAT38100.1    MF620045    AVT56267.1    GECU01033438    JAS74268.1    KK853308    KDR08682.1    GGMS01012439    MBY81642.1    GEDC01015543    JAS21755.1    ABLF02038436    GGMR01014196    MBY26815.1    GFXV01003698    GFXV01006406    MBW15503.1    MBW18211.1    GL445398    EFN89657.1    GEZM01075257    JAV64172.1    JXUM01011068    JXUM01011069    JXUM01011070    KQ560323    KXJ83048.1    JXUM01009960    JXUM01009961    KQ560295    KXJ83204.1    ADTU01020307    GBHO01033054    JAG10550.1    KQ981960    KYN31914.1    GL888455    EGI60684.1    ADMH02002070    ETN59607.1    KQ980039    KYN18126.1    CH477216    EAT47511.1    KQ971307    EFA11471.2    DS235849    EEB18627.1    AXCN02000966    CVRI01000054    CRL00182.1    KQ983145    KYQ47061.1    AAAB01008807    EAA04776.2    KK107238    QOIP01000007    EZA54770.1    RLU21085.1    AXCM01000490    KQ435800    KOX73286.1    KQ976395    KYM93081.1    ATLV01026173    KE525407    KFB52887.1    NNAY01000347    OXU29023.1    DS231842    EDS35246.1    GFDL01011954    JAV23091.1    GFDL01012209    JAV22836.1    KQ414735    KOC62153.1    KQ977890    KYM98993.1    KZ288215    PBC32705.1    JH431979    GFTR01007637    JAW08789.1    KQ434819    KZC06910.1    UFQT01000067    SSX19343.1    GDHC01015929    JAQ02700.1    ABJB010221755    DS791111    EEC10151.1    GBHO01033055    GBRD01011301    JAG10549.1    JAG54523.1    GAKP01008717    JAC50235.1    CM000362    EDX06878.1    MWRG01001161    PRD34598.1    GEGO01004371    JAR91033.1    AF037164    AE013599    BT033065    AB001420    AJ002920    CH902619    EDV36390.2    CM002911    KMY93403.1    GBXI01017579    JAC96712.1    CM000158    EDW90667.1    CH480816    EDW47671.1    CH954179    EDV56214.1    CP012524    ALC40803.1    JRES01001578    KNC21827.1    GDHF01028498    GDHF01005943    JAI23816.1    JAI46371.1    GGLE01002133    MBY06259.1    CH940648    EDW59974.2    MNPL01007263    OQR74852.1    GFJQ02003066    GFJQ02003021    JAW03949.1    JXJN01020437    CH933808    EDW08468.2    KT355582    ALV82501.1    KK117201    KFM69805.1    CH916367    EDW01701.1    CH963849    EDW73960.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000037510    UP000235965    UP000027135    + More
UP000007819    UP000008237    UP000069940    UP000249989    UP000005205    UP000078541    UP000007755    UP000000673    UP000075901    UP000078492    UP000008820    UP000007266    UP000009046    UP000075886    UP000075903    UP000183832    UP000075809    UP000007062    UP000053097    UP000279307    UP000075883    UP000053105    UP000078540    UP000030765    UP000075900    UP000075902    UP000215335    UP000002358    UP000002320    UP000005203    UP000053825    UP000078542    UP000242457    UP000076502    UP000075880    UP000075881    UP000076407    UP000075885    UP000075882    UP000075884    UP000069272    UP000192223    UP000079169    UP000001555    UP000000304    UP000095301    UP000095300    UP000000803    UP000007801    UP000002282    UP000001292    UP000008711    UP000192221    UP000092553    UP000037069    UP000091820    UP000008792    UP000192247    UP000092443    UP000092460    UP000009192    UP000054359    UP000001070    UP000078200    UP000092445    UP000007798   

PRIDE

H9ISX6    E3VLC1    Q9V6K3   

Pfam

PF07714   Pkinase_Tyr        + More
PF01392   Fz
PF00051   Kringle
PF02002   TFIIE_alpha
PF00225   Kinesin
PF15879   MWFE

Interpro

IPR020635   Tyr_kinase_cat_dom        + More
IPR008266   Tyr_kinase_AS       
IPR036790   Frizzled_dom_sf       
IPR000719   Prot_kinase_dom       
IPR013806   Kringle-like       
IPR011009   Kinase-like_dom_sf       
IPR038178   Kringle_sf       
IPR000001   Kringle       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR018056   Kringle_CS       
IPR020067   Frizzled_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR002853   TFIIE_asu       
IPR024550   TFIIEa/SarR/Rpc3_HTH_dom       
IPR017919   TFIIE/TFIIEa_HTH       
IPR013083   Znf_RING/FYVE/PHD       
IPR019821   Kinesin_motor_CS       
IPR036961   Kinesin_motor_dom_sf       
IPR027417   P-loop_NTPase       
IPR001752   Kinesin_motor_dom       
IPR016247   Tyr_kinase_rcpt_ROR       
IPR013783   Ig-like_fold       
IPR007110   Ig-like_dom       
IPR036179   Ig-like_dom_sf       
IPR017384   NADH_Ub_cplx-1_asu_su-1       

SUPFAM

SSF57440   SSF57440        + More
SSF56112   SSF56112       
SSF63501   SSF63501       
SSF52540   SSF52540       
SSF48726   SSF48726       

Gene 3D

1.10.2000.10     2.40.20.10     3.30.40.10     3.40.850.10     2.60.40.10    

CDD

cd00108  KR

ProteinModelPortal

H9ISX6   E3VLC1   A0A194Q3F2   A0A194R261   A0A0L7LD30   A0A2H1W1S3   + More
A0A2J7R939   A0A2R7X2I0   A0A1B6MPL4   A0A2R4G8U4   A0A1B6HHW8   A0A067QVX9   A0A2S2QWY1   A0A1B6D852   J9JLC2   A0A2S2PBN5   A0A2H8TMW3   E2B3S0   A0A1Y1KRZ0   A0A182GGH5   A0A182GDH7   A0A158NM65   A0A0A9X0C7   A0A151JTN3   F4WYP9   W5J551   A0A182T9S5   A0A151J563   Q17LF1   A0A1S4EYK0   D6W6W4   E0VZ21   A0A182Q647   A0A182V0U1   A0A1J1IM76   A0A151WGV5   Q7QIP0   A0A026WF73   A0A182LUU4   A0A0M8ZZI8   A0A195BYS6   A0A084WRP3   A0A182R9T9   A0A182UIM7   A0A232FEP8   K7IPS7   B0W5C6   A0A1Q3F697   A0A1Q3F5K3   A0A088A1T8   A0A0L7QU28   A0A151IE51   A0A2A3ELS0   T1J9X7   A0A224XL87   A0A154P709   A0A336LRK2   A0A182J8Y2   A0A182JSW9   A0A182WWL6   A0A182P128   A0A182L3G9   A0A182NLS5   A0A182FGB6   A0A1W4X124   A0A1S3D1J9   A0A146L7Q9   B7PU79   A0A0A9WRV3   A0A034W7Z4   B4QDY4   A0A1I8MBY2   A0A1I8PW20   A0A2P6L7P1   A0A147BJR6   Q9V6K3   B3MDE2   A0A0J9RBJ8   A0A0A1WE69   B4P4U6   B4HQ08   B3NRR2   A0A1W4VCC8   A0A0M3QUK9   A0A0L0BP40   A0A1A9X3J4   A0A0K8UB71   A0A2R5L9U6   B4LMI7   A0A1V9XN87   A0A1Z5L997   A0A1A9X969   A0A1B0BU08   B4KSX1   A0A0U3SIE7   A0A087TXG6   B4J4Z5   A0A1A9V0S4   A0A1B0A8K9   B4MPC1  

KEGG

100527944    K05129 muscle, skeletal, receptor tyrosine kinase [EC:2.7.10.1] | (RefSeq) HOP

GO

GO:0005524   GO:0004713   GO:0016021   GO:0006367   GO:0043565   GO:0005887   GO:0043235   GO:0017147   GO:0048856   GO:0004714   GO:0007169   GO:0016787   GO:0007018   GO:0003777   GO:0008017   GO:0072499   GO:0006468   GO:0007165   GO:0042052   GO:0005886   GO:0046716   GO:0005623   GO:0004672   GO:0016887   GO:0005737   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Cell membrane  

Length:

255

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.04921

Exp number, first 60 AAs:

0.09385

Total prob of N-in:

0.05865

outside

1  -  255

 

 

Pi

272.20243

Theta

234.57984

Tajima's D

0.489418

CLR

0

CSRT

0.505974701264937

Interpretation

Uncertain