Gene

KWMTBOMO13179  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008821

Annotation

fatty_alcohol_acetyltransferase_[Agrotis_segetum]

Location

Bomo_Chr22(+):9610697-9617092      View in EpiBrowser

Full name

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex       + More
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial      

Alternative Name

Branched-chain alpha-keto acid dehydrogenase complex component E2
Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
Dihydrolipoamide branched chain transacylase
Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

Location in the cell

Mitochondrial   Reliability : 2.384

CDS

ATGTCGATTCTTGTTCGTAGATCTGTATTCCAACTGAGAACCGTGAACCGGTGCCGGAAAATCAAGGTGACGACGCAAAGTGCGAGAAACGGATCACAGCTATCTTACAAAACGCCTTTGAATGAAAGCTTAAGCAAGGAGTTAAGGCATTTCCACACCAGTCATGCTGTCAACAAAATCGTCGCTTTCAAGCTTTCTGATATCGGTGAAGGGATACGAGAAGTCGTCATCAAGGAATGGTTCGTCAAAGTCGGTGATAATGTTCAACAATTCGACAACATTTGCGAAGTACAAAGCGACAAGGCAGCTGTCACCATCACTAGCCGATACGACGGTATCATAACACGACTGTACCATGATATTGATCAGACCGCTCTTGTAGGACAACCCCTAGTCGATATTGACGTGCAAGACTCTGAAAATGACGGGAAACCCACAGACGTTGCGCCTGATAAGCCTGTTGCTGAAATAGACGCTCCGAAAACGGAACAAAACCAAAAAATTAAAGTATTAACTACTCCGGCGGTGAGAAGAATCGCCGCTCAATTTAAAGTAGACTTGAGTGCCGTTAAAGCAACTGGCAGAAACGGAAGAGTTCTCAAGGAAGACATGTTGTCTCATTTAAACATTAACTCGGATGACTCGAACGAAGTCGTATTACCTGGTAGTGTCAGAGCTGTAGAAATACCAGTTACAAAAGCGCAGGCAAGAGTAGAATTAGCTCTCGAGGATAAAGTTGTCCCTGTTACCGGCTTCCAGAGAGCAATGGTTAAATCTATGACGGAGGCCATGAAAATTCCGCACTTTGTATTCAGTGACGAGTACAACGTCACAAAACTGGTTGAATCGCGTGCAGCACTCAAAAAGCAAGCGGAAGAACGTGGGGTTAGACTAACTTACATGCCGATCATCATCAAAGCGGCATCTTTAAGTTTGAGCTATCTACCCATTCTCAACAGTAGTCTCGATAGCTCCTGTGAAAATCTCATTTACAAAGCAAGTCATAACATAGGCGTTGCTATGGATACGCCCAACGGATTAGTCGTACCTGTTATCAAGAACATCCAAATTAAATCAATATTAGAAATTGCACAAGAGTTAAATACATTGCAAGAGAAAGGATCGAAGGGGCAACTTGGATTGAATGATCTCACCGGAGGGACATTTACAATATCAAATATCGGAATTGTTGGAGGTACTTACACGAAACCGGTGATATTCCCACCGCAAGTTGCAATTGGAGCATTAGGAAAAATACAGGTTAGTAGTGCGTAG

Protein

MSILVRRSVFQLRTVNRCRKIKVTTQSARNGSQLSYKTPLNESLSKELRHFHTSHAVNKIVAFKLSDIGEGIREVVIKEWFVKVGDNVQQFDNICEVQSDKAAVTITSRYDGIITRLYHDIDQTALVGQPLVDIDVQDSENDGKPTDVAPDKPVAEIDAPKTEQNQKIKVLTTPAVRRIAAQFKVDLSAVKATGRNGRVLKEDMLSHLNINSDDSNEVVLPGSVRAVEIPVTKAQARVELALEDKVVPVTGFQRAMVKSMTEAMKIPHFVFSDEYNVTKLVESRAALKKQAEERGVRLTYMPIIIKAASLSLSYLPILNSSLDSSCENLIYKASHNIGVAMDTPNGLVVPVIKNIQIKSILEIAQELNTLQEKGSKGQLGLNDLTGGTFTISNIGIVGGTYTKPVIFPPQVAIGALGKIQVSSA

Catalytic Activity

(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA

Cofactor

(R)-lipoate

Subunit

Forms a 24-polypeptide structural core with octahedral symmetry.

Similarity

Belongs to the 2-oxoacid dehydrogenase family.

Keywords

Acetylation   Acyltransferase   Complete proteome   Lipoyl   Mitochondrion   Phosphoprotein   Reference proteome   Transferase   Transit peptide  

Feature

chain  Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

Uniprot

H9JH24   A0A291P133   A0A291P181   A0A088ML95   A0A1V0M886   A0A0P0E5H1   + More
A0A2H1W075   A0A2A4IW66   A0A3S2KZ82   A0A212EV79   A0A1L8D6H5   A0A194R1E9   A0A194PX56   H0Z485   A0A093BWL8   A0A091KHD4   A0A091PIJ9   A0A093F9D0   A0A091QET6   A0A2I0MDV3   A0A091QHG9   A0A094KWW3   A0A091MLK6   A0A3L8SPN8   A0A093QPE4   A0A1V4JYG2   A0A091NI61   A0A091HGW8   G1N527   A0A091WEC9   A0A1V4JYN9   A0A087VGJ2   H0Z400   A0A1L8E0H2   A0A0A0AG34   A0A093I6X5   A0A093NB19   A0A093J441   A0A091VDF2   A0A2I0UID2   A0A099Z4G6   A0A1L8E0E2   A0A218VF26   A0A2D0RWA8   A0A091SJB9   R0JWK3   A0A091HU72   Q98UJ6   A0A091EHH1   A0A0Q3MCQ4   A0A1D5PWD8   A0A093GNZ4   A0A2C9JUM3   A0A091MJ87   A0A093S9S3   A0A3Q1D146   A0A091G9W2   A0A3B4EL58   A0A3P8S0J9   A0A091S7G3   A0A1I7TTQ4   A0A1I7YGF7   A0A1I7TTQ3   A0A1L8GN47   D2HFE5   A0A1B0C967   Q642P5   W5LJ32   A0A3Q0FZU5   A0A182YQ37   A0A151M4T6   A0A151M4T4   W5LW66   A0A1L8GGF6   A0A1W4Y2E9   A0A2D0RD28   G3SY24   A0A3B4D8C3   A0A3B4CZ64   A0A090LHD6   A0A3Q1F9B3   A0A182W4N9   A0A182JSU6   A0A0R4INZ8   W5LFA4   A0A182M3L0   A0A3P4S2X9   A0A3M0K5H9   Q5BKV3   Q7TND9   A0A3B4Y8P4   A0A1L8GGF4   A0A2Y9SB63   A0A2M4BLG5   A0A2Y9SIS1   P53395   E3LG82   Q28E15   A0A182FIU4   A0A182P7W6  

EC Number

2.3.1.-
2.3.1.168

Pubmed

19121390    28986331    26385554    28349297    26445454    22118469    + More
26354079    20360741    23371554    30282656    20838655    11168412    15592404    15562597    26392177    27762356    20010809    25329095    25244985    22293439    23594743    15489334    8605244    16141072    21183079    23806337    23576753    20431018   

EMBL

BABH01037515    BABH01037516    MF687658    ATJ44584.1    MF706187    ATJ44614.1    + More
KJ579234    AIN34710.1    KU755497    ARD71207.1    KT261719    ALJ30259.1    ODYU01005529    SOQ46468.1    NWSH01006136    PCG63638.1    RSAL01000387    RVE42026.1    AGBW02012225    OWR45408.1    GEYN01000162    JAV01967.1    KQ460883    KPJ11344.1    KQ459586    KPI97936.1    ABQF01035311    KL230344    KFV05254.1    KK502396    KFP23126.1    KK660240    KFQ07742.1    KK385525    KFV50846.1    KK674900    KFQ08034.1    AKCR02000018    PKK27859.1    KK797889    KFQ26653.1    KL269744    KFZ63633.1    KK829556    KFP75414.1    QUSF01000010    RLW05897.1    KL420106    KFW88235.1    LSYS01005497    OPJ77260.1    KL383079    KFP88697.1    KL536886    KFO94714.1    KK735283    KFR13455.1    OPJ77261.1    KL492575    KFO11734.1    ABQF01035305    ABQF01035306    GFDF01001883    JAV12201.1    KL871737    KGL93141.1    KL206922    KFV86882.1    KL224623    KFW62138.1    KK601813    KFW06652.1    KL410872    KFR00423.1    KZ505741    PKU45814.1    KL889294    KGL76616.1    GFDF01001884    JAV12200.1    MUZQ01000002    OWK64519.1    KK474025    KFQ58423.1    KB743021    EOB01911.1    KL217788    KFO98692.1    AB035085    BAB32667.1    KK718445    KFO56531.1    LMAW01002543    KQK80192.1    AADN05000647    KL216678    KFV71028.1    KK506687    KFP61620.1    KL670581    KFW79589.1    KL447874    KFO78131.1    KK944852    KFQ53522.1    CM004472    OCT85257.1    GL192786    EFB14675.1    AJWK01001964    BC081233    AAH81233.1    AKHW03006584    KYO19532.1    KYO19533.1    CM004473    OCT82929.1    LN609529    CEF67553.1    CR751228    CR936359    AXCM01001653    CYRY02045899    VCX41429.1    QRBI01000117    RMC08445.1    BC090917    BC165614    AAH90917.1    AAI65614.1    BC055890    AAH55890.1    OCT82930.1    GGFJ01004778    MBW53919.1    L42996    AK165959    CH466532    DS268408    EFO86267.1    AAMC01030687    CR848496    CAJ82272.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    + More
UP000007754    UP000053119    UP000053872    UP000276834    UP000190648    UP000001645    UP000053605    UP000053858    UP000053584    UP000054081    UP000053283    UP000053641    UP000197619    UP000221080    UP000054308    UP000052976    UP000051836    UP000000539    UP000053875    UP000076420    UP000053258    UP000257160    UP000053760    UP000261440    UP000265080    UP000095282    UP000095287    UP000186698    UP000092461    UP000018467    UP000189705    UP000076408    UP000050525    UP000018468    UP000192224    UP000007646    UP000035682    UP000257200    UP000075920    UP000075881    UP000000437    UP000075883    UP000269221    UP000261360    UP000248484    UP000000589    UP000008281    UP000008143    UP000069272    UP000075885   

PRIDE

H9JH24    Q7TND9    P53395   

Pfam

PF00364   Biotin_lipoyl        + More
PF00198   2-oxoacid_dh
PF02817   E3_binding

Interpro

IPR001078   2-oxoacid_DH_actylTfrase        + More
IPR011053   Single_hybrid_motif       
IPR036625   E3-bd_dom_sf       
IPR000089   Biotin_lipoyl       
IPR003016   2-oxoA_DH_lipoyl-BS       
IPR023213   CAT-like_dom_sf       
IPR004167   PSBD       

SUPFAM

SSF47005   SSF47005        + More
SSF51230   SSF51230       

Gene 3D

3.30.559.10     4.10.320.10    

ProteinModelPortal

H9JH24   A0A291P133   A0A291P181   A0A088ML95   A0A1V0M886   A0A0P0E5H1   + More
A0A2H1W075   A0A2A4IW66   A0A3S2KZ82   A0A212EV79   A0A1L8D6H5   A0A194R1E9   A0A194PX56   H0Z485   A0A093BWL8   A0A091KHD4   A0A091PIJ9   A0A093F9D0   A0A091QET6   A0A2I0MDV3   A0A091QHG9   A0A094KWW3   A0A091MLK6   A0A3L8SPN8   A0A093QPE4   A0A1V4JYG2   A0A091NI61   A0A091HGW8   G1N527   A0A091WEC9   A0A1V4JYN9   A0A087VGJ2   H0Z400   A0A1L8E0H2   A0A0A0AG34   A0A093I6X5   A0A093NB19   A0A093J441   A0A091VDF2   A0A2I0UID2   A0A099Z4G6   A0A1L8E0E2   A0A218VF26   A0A2D0RWA8   A0A091SJB9   R0JWK3   A0A091HU72   Q98UJ6   A0A091EHH1   A0A0Q3MCQ4   A0A1D5PWD8   A0A093GNZ4   A0A2C9JUM3   A0A091MJ87   A0A093S9S3   A0A3Q1D146   A0A091G9W2   A0A3B4EL58   A0A3P8S0J9   A0A091S7G3   A0A1I7TTQ4   A0A1I7YGF7   A0A1I7TTQ3   A0A1L8GN47   D2HFE5   A0A1B0C967   Q642P5   W5LJ32   A0A3Q0FZU5   A0A182YQ37   A0A151M4T6   A0A151M4T4   W5LW66   A0A1L8GGF6   A0A1W4Y2E9   A0A2D0RD28   G3SY24   A0A3B4D8C3   A0A3B4CZ64   A0A090LHD6   A0A3Q1F9B3   A0A182W4N9   A0A182JSU6   A0A0R4INZ8   W5LFA4   A0A182M3L0   A0A3P4S2X9   A0A3M0K5H9   Q5BKV3   Q7TND9   A0A3B4Y8P4   A0A1L8GGF4   A0A2Y9SB63   A0A2M4BLG5   A0A2Y9SIS1   P53395   E3LG82   Q28E15   A0A182FIU4   A0A182P7W6  

PDB

2II5     E-value=2.3125e-61,     Score=597

KEGG

101737060    K09699 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168] | (Re

PATHWAY

00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016746   GO:0042645   GO:0031625   GO:0009081   GO:0005929   GO:0061063   GO:0005829   GO:0045723   GO:1901046   GO:0040019   GO:0043005   GO:0031405   GO:0016407   GO:0005739   GO:0005737   GO:0043754   GO:0008152   GO:0016021   GO:0006812   GO:0016887   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Mitochondrion matrix  

Length:

424

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.18913

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00590

outside

1  -  424

 

 

Pi

220.840547

Theta

199.336007

Tajima's D

0.378305

CLR

1.329939

CSRT

0.479926003699815

Interpretation

Uncertain