Silkworm Genome Informatics Database

Gene

KWMTBOMO13173

Pre Gene Modal

BGIBMGA000351

Annotation

PREDICTED:_adenylate_kinase_7-like_[Amyelois_transitella]

Location

Bomo_Chr22(+):9509733-9516754 View in EpiBrowser

Full name

Adenylate kinase 7

Alternative Name

ATP-AMP transphosphorylase 7

Location in the cell

Cytoplasmic Reliability : 3.83

CDS

ATGCTCGCGCATTTACCTTTCTTAGAAAGTGATTTCCGCAAAAGGAAGCCACATCCTAATTACAAAATTCACTATGACATTGAAAATGATGTGATTGCTATTGCTAGAAAATATAAATCCCAAATCAGGGCTACAGTGATTGCGTCTGGTATAACTTACGGTGGTCGTGAGGATGTGCTATTTTATTGGTTTCAAAAAGCTTGGGAATGTGAACGTCTTTTACCAACAGTCGGACGTGGTGGCAATATAATTCCCCTGATTAATATTATCGATTTAGCACAAATTGTGTATAACTTGGTGACGGATTTCCCCAAGAAACTCTACATACTTGCTGTGGAACAAAACATTTCCAAACAAAGAGAGATTGTGAAAGCTTTAGGAAGAATCGTTGGTTCGGGTATGTTCACATGCATACCACCTGAAGATGCTTTTTTAATTCCCGAGATAGACCAAAGAATTTACGATTCCATAACACTAAATTTGACAATGGAGCCTACTTTTATCGTTGAGACAATGGGTCTTCAGTGGGTTTCGGAGCAAACATTCGCAGAAAACGTTCCGATGTTAATGAATCAATTTAAAAAAGAGAGAGGTTTGAAATCTTTCAAGGTCATTGTTTACGGACCTCCGCTGGTTGGGAAGACGACTCTGTCAAACCTCATATGCGAATCTTACGGATTATTGTATATTTCTCCAGAGACAATAGTTCAGGATACTATAGATGATTTGACATGGCGAGTAAACCATTGGGAGAAAGGGGAAACCGCAGCTTTAGGCCCTATAATGGGTGAGGAGGCCGAACCAAGTGAAGTCGACGATGATTTTGGTGAGGAAGAGGGCTTTCAAGAATCGGCGAAGCACACTTTGGCCATGCTCCAGACTGGGCGCCCCCTCGACGATGAAGAAATTCTAGGATACATAAGACAACGATTACTGTGCCGTGCGGCAACAAATAGAGGATGGGTACTTGATGGTTTCCCGACCTCTCTAGGACAATGTTCTTCATTATTTGAAAAAGGCGACGAACAAGATTCAGAGACCGGGGAAGAGCGCAATGAAGATGATTTTGATGAAGATATTGATTTGTACAGTAATGTTTTGAAAAAGTTATTACCAGATATTGTGGTATCTCTGGAAGCATCCGACGATTTCATCTGTGAAAAAGCCATGCGGCAACCCGAAGGTGATGAGCGTCTGGATGAAGAAATAGTTCTTAAAAGGTTAAATGAATTTCGAGCAGGAGACATGAGAGATATAACTCCGCTGAATTTTTTTGATGAGCTTGACATACACCCGCTTGTGGTGCCCGTGAAAGAACATTGTGATTATGCTATGAAAAGCATATATACCACTGTGGCCCTCCGAATGGGAAGGCCATGTCTTTATGGGAAACTTATTGCCATAGCAGAAGCTACGAAAAAAAGAGAGAAAGAGGAATTAGAGACATTAAGGTCTAAGGAAGCAAAACTGATGAAAGAAATGGAAAATAAAATGAGGACTGATCGGGAGGAAAAAATGGAATATTGGTCCGAACTGTACGCTTTGCTGCGTGAAGAGGAAGAAGCCGCTCTAGCTGCTGCCAGTGAACCGATGAGGAACTATTTAGTACAATACATATTTCCTACTCTTACAAAAGGGTTATTAGAAGTTGCCAAACTTCGCCCGAACGATCCAATAGATTTTCTCGCCGAATATCTTTTTAAACAGAACCCCACTGGGAAAATGTTGGAGCCCGGTTATAACTTGCAAGCGGAAAAATTATTGGGTAAAATAAAAATCCTAGATGATGCTATAAGGGATCTGAACATCCAATTGGAGCCATTACTGCCAGATGATGCGAAAGCGGACGAGGAATCGACTTCAAAAAAGAAAATATATAGCATGACTGCATTTTAA

Protein

MLAHLPFLESDFRKRKPHPNYKIHYDIENDVIAIARKYKSQIRATVIASGITYGGREDVLFYWFQKAWECERLLPTVGRGGNIIPLINIIDLAQIVYNLVTDFPKKLYILAVEQNISKQREIVKALGRIVGSGMFTCIPPEDAFLIPEIDQRIYDSITLNLTMEPTFIVETMGLQWVSEQTFAENVPMLMNQFKKERGLKSFKVIVYGPPLVGKTTLSNLICESYGLLYISPETIVQDTIDDLTWRVNHWEKGETAALGPIMGEEAEPSEVDDDFGEEEGFQESAKHTLAMLQTGRPLDDEEILGYIRQRLLCRAATNRGWVLDGFPTSLGQCSSLFEKGDEQDSETGEERNEDDFDEDIDLYSNVLKKLLPDIVVSLEASDDFICEKAMRQPEGDERLDEEIVLKRLNEFRAGDMRDITPLNFFDELDIHPLVVPVKEHCDYAMKSIYTTVALRMGRPCLYGKLIAIAEATKKREKEELETLRSKEAKLMKEMENKMRTDREEKMEYWSELYALLREEEEAALAAASEPMRNYLVQYIFPTLTKGLLEVAKLRPNDPIDFLAEYLFKQNPTGKMLEPGYNLQAEKLLGKIKILDDAIRDLNIQLEPLLPDDAKADEESTSKKKIYSMTAF

Description

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.

Catalytic Activity

AMP + ATP = 2 ADP
a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

Similarity

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
In the central section; belongs to the adenylate kinase family.
In the C-terminal section; belongs to the dpy-30 family.

Keywords

Alternative splicing ATP-binding Cell projection Cilium Coiled coil Complete proteome Cytoplasm Flagellum Kinase Nucleotide-binding Reference proteome Transferase

Feature

chain Adenylate kinase 7
splice variant In isoform 2.

Uniprot

H9ISX3 A0A3S2NWC4 A0A212EV96 A0A2H1VLY8 A0A194R1F3 A0A2A4IX25 + More
A0A194PX51 A0A0L7LGD2 D6WT90 E0VG29 A0A088AMU8 A0A195BGN8 A0A154PSZ0 A0A1X7V6X0 A0A026WH19 A0A1W4WS61 A0A151JZB8 V4B4B1 H2YJ59 W5MQ21 A0A1W5BKQ3 A0A1S3IK42 A0A1S3I4J7 A0A1W4XU26 A0A060W3S7 A0A3P8ZBQ9 A0A210Q4I7 A0A1W4Y3P6 F6U2V6 A0A1S3RDQ1 A0A1U7REI7 H2YJ58 A0A0B7ANA9 A0A1V4KAK6 T2M6R4 A0A151P9M2 R7UQN9 F1NDU6 A0A3B3R7T4 W5JZ47 A0A0L8GGK1 A0A2B4SEE2 A0A0N0BHW2 G1NKK5 K1QJQ6 A0A1W3JG50 G1NKK6 A0A3B3R785 A7SIC3 A0A2I0MPU1 A0A091XH35 A0A0L0HHX4 C3Z2C9 A0A093GXW6 W4Y4X2 A0A1S8W7I7 A0A1S3M7Q9 G1KNT6 A0A3B4VGY4 K7G5Z6 A0A3B4BWP8 A0A3B4XPV5 A0A093DUI3 A0A267F0T8 A0A2U9CLZ7 Q5FWX2 A0A267FNY3 A0A099Z9C2 A0A3B4BTA7 A0A093RA87 A0A1Y2CMP3 A0A267EVK4 A0A3M7QPL4 Q7ZWJ0 A0A1L8F0E2 A0A2Y9T9C6 Q5M7Q2 F7C9L8 E2RHM6 A0A3Q1JWM8 A0A3Q3MJB0 A0A091TI40 A0A093J4D5 R0JSR4 Q9D2H2 D2HWZ6 G1M6C5 A0A2K5CQT5 A0A384CMV6 A0A091V822 A0A2D0RL81 F7DCK4 A0A2T7NYR8 A0A091PKI7 A0A337SWY9 F8WIC0 A0A384CMU6 A0A0G2JZ71 F7DQB3 A0A383ZV52

EC Number

2.7.4.3
2.7.4.6

Pubmed

19121390 22118469 26354079 26227816 18362917 19820115 + More
20566863 24508170 23254933 24755649 25069045 28812685 12481130 15114417 24065732 22293439 15592404 29240929 25329095 20838655 22992520 17615350 23371554 18563158 17381049 30375419 27762356 20431018 16341006 16141072 18776131 21183079 29365104 20010809 24813606 17495919 17975172 19468303 15057822 19892987

EMBL

BABH01013035 RSAL01000133 RVE46311.1 AGBW02012225 OWR45403.1 ODYU01003023 + More
SOQ41264.1 KQ460883 KPJ11349.1 NWSH01006083 PCG63680.1 KQ459586 KPI97931.1 JTDY01001231 KOB74470.1 KQ971354 EFA05847.1 DS235131 EEB12335.1 KQ976476 KYM83836.1 KQ435066 KZC14378.1 KK107214 EZA55243.1 KQ981404 KYN41946.1 KB200294 ESP02316.1 AHAT01003930 FR904392 CDQ61948.1 NEDP02005034 OWF43656.1 HACG01035252 CEK82117.1 LSYS01003973 OPJ81499.1 HAAD01001746 CDG67978.1 AKHW03000563 KYO45445.1 AMQN01006576 KB298689 ELU08844.1 AADN05000303 KQ421897 KOF76009.1 LSMT01000109 PFX27190.1 KQ435740 KOX76788.1 JH818403 EKC31394.1 DS469667 EDO36546.1 AKCR02000005 PKK31712.1 KK735116 KFR12531.1 KQ257456 KND00419.1 GG666574 EEN53180.1 KL217157 KFV74231.1 AAGJ04112705 LYON01000059 OON10426.1 AGCU01156344 AGCU01156345 AGCU01156346 AGCU01156347 AGCU01156348 AGCU01156349 AGCU01156350 AGCU01156351 AGCU01156352 AGCU01156353 KL231213 KFV05826.1 NIVC01001540 PAA66699.1 CP026259 AWP16859.1 BC089169 AAH89169.1 NIVC01000914 PAA74914.1 KL890064 KGL77395.1 KL446083 KFW95465.1 MCGO01000012 ORY48290.1 NIVC01001639 PAA65553.1 REGN01005571 RNA12888.1 BC049290 AAH49290.1 CM004481 OCT65035.1 BC088514 AAH88514.1 AAMC01053217 AAMC01053218 AAMC01053219 AAMC01053220 AAEX03005968 AAEX03005969 KK454365 KFQ75431.1 KK607141 KFW09825.1 KB743197 EOB00466.1 AK019664 AK078221 GL193582 EFB20783.1 ACTA01076129 ACTA01084129 ACTA01092129 ACTA01100129 KL410770 KFQ99441.1 PZQS01000008 PVD26309.1 KK674589 KFQ07783.1 AANG04004659 AC158526 AC125847

Proteomes

UP000005204 UP000283053 UP000007151 UP000053240 UP000218220 UP000053268 + More
UP000037510 UP000007266 UP000009046 UP000005203 UP000078540 UP000076502 UP000007879 UP000053097 UP000192223 UP000078541 UP000030746 UP000007875 UP000018468 UP000085678 UP000192224 UP000193380 UP000265140 UP000242188 UP000008144 UP000087266 UP000189705 UP000190648 UP000050525 UP000014760 UP000000539 UP000261540 UP000018467 UP000053454 UP000225706 UP000053105 UP000001645 UP000005408 UP000001593 UP000053872 UP000053605 UP000053201 UP000001554 UP000053875 UP000007110 UP000189906 UP000001646 UP000261420 UP000007267 UP000261440 UP000261360 UP000215902 UP000246464 UP000053641 UP000193642 UP000276133 UP000186698 UP000248484 UP000008143 UP000002254 UP000265040 UP000261640 UP000000589 UP000008912 UP000233020 UP000261680 UP000291021 UP000053283 UP000221080 UP000002280 UP000245119 UP000011712 UP000002494 UP000002281 UP000261681

PRIDE

H9ISX3 Q9D2H2 F8WIC0

Pfam

PF09380   FERM_C        + More
PF09379   FERM_N
PF00373   FERM_M
PF08736   FA
PF05186   Dpy-30
PF00858   ASC
PF17213   Hydin_ADK
PF00004   AAA
PF00400   WD40
PF02138   Beach

Interpro

IPR019747   FERM_CS        + More
IPR018979   FERM_N
IPR011993   PH-like_dom_sf
IPR019748   FERM_central
IPR018980   FERM_PH-like_C
IPR029071   Ubiquitin-like_domsf
IPR000299   FERM_domain
IPR014352   FERM/acyl-CoA-bd_prot_sf
IPR007858   Dpy-30_motif
IPR019749   Band_41_domain
IPR014847   FERM-adjacent
IPR036291   NAD(P)-bd_dom_sf
IPR035963   FERM_2
IPR027417   P-loop_NTPase
IPR026867   AK7
IPR000850   Adenylat/UMP-CMP_kin
IPR001873   ENaC
IPR003593   AAA+_ATPase
IPR033768   Hydin_ADK
IPR003959   ATPase_AAA_core
IPR015943   WD40/YVTN_repeat-like_dom_sf
IPR036372   BEACH_dom_sf
IPR017986   WD40_repeat_dom
IPR001680   WD40_repeat
IPR000409   BEACH_dom
IPR036322   WD40_repeat_dom_sf

SUPFAM

SSF54236   SSF54236        + More
SSF47031   SSF47031
SSF51735   SSF51735
SSF52540   SSF52540
SSF81837   SSF81837
SSF50978   SSF50978

Gene 3D

1.20.80.10 2.30.29.30 1.10.1540.10 2.130.10.10

CDD

cd14473  FERM_B-lobe
cd01428  ADK
cd06071  Beach

ProteinModelPortal

H9ISX3 A0A3S2NWC4 A0A212EV96 A0A2H1VLY8 A0A194R1F3 A0A2A4IX25 + More
A0A194PX51 A0A0L7LGD2 D6WT90 E0VG29 A0A088AMU8 A0A195BGN8 A0A154PSZ0 A0A1X7V6X0 A0A026WH19 A0A1W4WS61 A0A151JZB8 V4B4B1 H2YJ59 W5MQ21 A0A1W5BKQ3 A0A1S3IK42 A0A1S3I4J7 A0A1W4XU26 A0A060W3S7 A0A3P8ZBQ9 A0A210Q4I7 A0A1W4Y3P6 F6U2V6 A0A1S3RDQ1 A0A1U7REI7 H2YJ58 A0A0B7ANA9 A0A1V4KAK6 T2M6R4 A0A151P9M2 R7UQN9 F1NDU6 A0A3B3R7T4 W5JZ47 A0A0L8GGK1 A0A2B4SEE2 A0A0N0BHW2 G1NKK5 K1QJQ6 A0A1W3JG50 G1NKK6 A0A3B3R785 A7SIC3 A0A2I0MPU1 A0A091XH35 A0A0L0HHX4 C3Z2C9 A0A093GXW6 W4Y4X2 A0A1S8W7I7 A0A1S3M7Q9 G1KNT6 A0A3B4VGY4 K7G5Z6 A0A3B4BWP8 A0A3B4XPV5 A0A093DUI3 A0A267F0T8 A0A2U9CLZ7 Q5FWX2 A0A267FNY3 A0A099Z9C2 A0A3B4BTA7 A0A093RA87 A0A1Y2CMP3 A0A267EVK4 A0A3M7QPL4 Q7ZWJ0 A0A1L8F0E2 A0A2Y9T9C6 Q5M7Q2 F7C9L8 E2RHM6 A0A3Q1JWM8 A0A3Q3MJB0 A0A091TI40 A0A093J4D5 R0JSR4 Q9D2H2 D2HWZ6 G1M6C5 A0A2K5CQT5 A0A384CMV6 A0A091V822 A0A2D0RL81 F7DCK4 A0A2T7NYR8 A0A091PKI7 A0A337SWY9 F8WIC0 A0A384CMU6 A0A0G2JZ71 F7DQB3 A0A383ZV52

PDB

4RIQ E-value=0.00101719, Score=102

KEGG

101738098 K00939 adenylate kinase [EC:2.7.4.3] | (RefSeq) adenylate kinase 7-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005856 GO:0004017 GO:0004127 GO:0005524 GO:0016021 GO:0005272 GO:0019205 GO:0006139 GO:0009142 GO:0004550 GO:0016787 GO:0016301 GO:0007420 GO:0005829 GO:0003351 GO:0035082 GO:0006165 GO:0031514 GO:0007283 GO:0002437

PANTHER

PTHR23359:SF105 PTHR23359 PTHR11690

Subcellular location

Cytoplasm   Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin.   With evidence from 2 publications.
Cytosol   Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin.   With evidence from 2 publications.
Cell projection   Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin.   With evidence from 2 publications.
Cilium   Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin.   With evidence from 2 publications.
Flagellum   Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin.   With evidence from 2 publications.

Length:

631

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01645

Exp number, first 60 AAs:

0.00267

Total prob of N-in:

0.00052

outside

1 - 631

Pi

237.376058

Theta

184.861283

Tajima's D

0.842172

CLR

0

CSRT

0.607419629018549

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics