Gene

KWMTBOMO13169  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000349

Annotation

PREDICTED:_probable_tRNA_N6-adenosine_threonylcarbamoyltransferase?_mitochondrial?_partial_[Papilio_machaon]

Location

Bomo_Chr22(+):9488403-9489729      View in EpiBrowser

Full name

Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial      

Alternative Name

N6-L-threonylcarbamoyladenine synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein
tRNA threonylcarbamoyladenosine biosynthesis protein
t(6)A37 threonylcarbamoyladenosine biosynthesis protein HaOG216964
tRNA threonylcarbamoyladenosine biosynthesis protein HaOG216964
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC108734774
tRNA threonylcarbamoyladenosine biosynthesis protein LOC108734774
t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgepl1
tRNA threonylcarbamoyladenosine biosynthesis protein osgepl1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON014481
tRNA threonylcarbamoyladenosine biosynthesis protein CSON014481
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON010212
tRNA threonylcarbamoyladenosine biosynthesis protein CSON010212
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1_1
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1_1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1_0
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1_0
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 5565046
tRNA threonylcarbamoyladenosine biosynthesis protein 5565046
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 6044601
tRNA threonylcarbamoyladenosine biosynthesis protein 6044601
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 105627815
tRNA threonylcarbamoyladenosine biosynthesis protein 105627815
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 106084148
tRNA threonylcarbamoyladenosine biosynthesis protein 106084148
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 100118784
tRNA threonylcarbamoyladenosine biosynthesis protein 100118784
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 100168791
tRNA threonylcarbamoyladenosine biosynthesis protein 100168791
t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGP2
tRNA threonylcarbamoyladenosine biosynthesis protein OSGP2
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 101899321
tRNA threonylcarbamoyladenosine biosynthesis protein 101899321
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC106173665
tRNA threonylcarbamoyladenosine biosynthesis protein LOC106173665
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DanaGF20469
tRNA threonylcarbamoyladenosine biosynthesis protein DanaGF20469
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC106158878
tRNA threonylcarbamoyladenosine biosynthesis protein LOC106158878
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DvirGJ15615
tRNA threonylcarbamoyladenosine biosynthesis protein DvirGJ15615
O-sialoglycoprotein endopeptidase-like protein 1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1
tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DgriGH12256
tRNA threonylcarbamoyladenosine biosynthesis protein DgriGH12256
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC108097636
tRNA threonylcarbamoyladenosine biosynthesis protein LOC108097636
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DmojGI11016
tRNA threonylcarbamoyladenosine biosynthesis protein DmojGI11016

Location in the cell

Cytoplasmic   Reliability : 1.151 Mitochondrial   Reliability : 1.249

CDS

ATGCCAGGAATACTTTGCAGAAGTGCTATGAATACGTTTCAAAAATTAAGACCTTTAACGAATTCTAAATGTAATTCTACTTTAATATTCGGAATAGAAACATCGTGTGATGATACTGGATGTGCCATAATCAACGAGGAAGGGAATATCATTGCGGAGTCCTTAAAATCCCAAAATTTAGTACATTTAAGAAATGGCGGAATTATACCTGATGTTGCTCAAGATCTTCATCGGAAATATATTGAACCGACAGTCACAGAAACATTACTAAAAGCTAATCTGTTGATGAAAGACATAAGCGCAATAGCTGTTACAGTAAAACCTGGTTTACCATTAAGTCTGGCTGTCGGCATGAAGTATGCCAAACATTTAGCACGAGTTAATGCTAAACCTATAATTCCTATTCACCATATGGAAGCACATGCATTGACAGTCAGAATGGAACACAATGTTAATTTCCCATATTTAGTGTTACTCATTTCTGGTGGTCATTGCTTATTGGCTGTGGTCCAAAATATAAACAAGTTCCTCCTTCTAGGTAAAAGTATAGACATGGCACCAGGTGAACTATTTGATAAAATTGCTAGGAGAATGAAACTTAGGAATGTACCTGAACTCTCCACTATGTGTGGAGGACAAGCTGTAGAAACAGCGGCATTAAGAGCCACCAATCCAGAGATGTTTAACCTTCCAATACCACTGGTACAAGTTAAAGATTGCAATTTTAGTTTTAATGGATTAAAAACTTCAGTTTTGTATCACCTGCGTAAGAAAGAAAAGGAACACAAAGTAGTTGCTGATGCATTAATACCTGAAATAAGTAATTTATGTTGTGCTGCATTGATAGCAACTACAAAACATCTTGTTCACAGGACACAACGTGCAATGCAATTCTGTTCTATCAATAATTTAATTCCAGAAAATAATAAACGGTTAGTTGTATCTGGAGGTGTAGCATGTAATAATTACATTTTCAATGCCTTAAAAGCTGCAAGTGTTGATTATGGCTATAATGTATATAGACCATCAATGAAACTGTGCACCGATAATGGTATTATGATAGCATGGAATGGCTTAGAAAAATGGAGAAAAAATTTGGATATTATGACAAATTTCAACACATTAGACTTGGAAGCAACAAGTCAATTAGGTGAAAGCTTAATTGACCAAGTTGCAAGTGCAAAAATAAAAACGAAAATTTTTAAATTTCAGAAAGCTGTTCAATAA

Protein

MPGILCRSAMNTFQKLRPLTNSKCNSTLIFGIETSCDDTGCAIINEEGNIIAESLKSQNLVHLRNGGIIPDVAQDLHRKYIEPTVTETLLKANLLMKDISAIAVTVKPGLPLSLAVGMKYAKHLARVNAKPIIPIHHMEAHALTVRMEHNVNFPYLVLLISGGHCLLAVVQNINKFLLLGKSIDMAPGELFDKIARRMKLRNVPELSTMCGGQAVETAALRATNPEMFNLPIPLVQVKDCNFSFNGLKTSVLYHLRKKEKEHKVVADALIPEISNLCCAALIATTKHLVHRTQRAMQFCSINNLIPENNKRLVVSGGVACNNYIFNALKAASVDYGYNVYRPSMKLCTDNGIMIAWNGLEKWRKNLDIMTNFNTLDLEATSQLGESLIDQVASAKIKTKIFKFQKAVQ

Description

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

Catalytic Activity

adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA

Cofactor

a divalent metal cation

Subunit

Homodimer.

Similarity

Belongs to the KAE1 / TsaD family.

Uniprot

H9ISX1   A0A0L7L6I4   A0A194PY26   A0A2H1X3N5   A0A194R0X3   A0A2W1C4D0   + More
A0A2H1X347   A0A2A4IW70   A0A1W4WPA9   A0A2J7RR99   A0A1Y1M9Q3   A0A194PWQ9   D6WLE6   A0A2P8XPP6   A0A0N0BBB1   A0A0L7L9T2   A0A154P9X6   N6U739   A0A194QW36   E2APZ2   A0A182WK23   A0A336MN16   A0A2A3E3K4   A0A1B0D067   A0A0L7RDD4   A0A336M6N1   A0A0C9RNQ0   A0A146LH26   A0A0A9Z2B8   A0A0A9Z3T9   A0A182LU65   A0A1B6DRA7   A0A026WW60   A0A1S4F805   Q17CG3   A0A1Z5L8P8   A0A182K7W4   B0WXG7   A0A0N7ZD09   A0A182IVK4   A0A195BC70   A0A195DCF8   A0A158P3X8   A0A195FUQ5   A0A151XA22   F4WM44   A0A195C832   A0A182FCX8   A0A182QZQ6   A0A0T6AYM3   A0A067R256   A0A182HNX9   A0A1I8Q329   A0A182XEV3   A0A0P6CZV0   K7J6Z0   A0A182TQ06   A0A0N8A705   A0A182UVT3   Q7Q9I8   A0A293MWU7   A0A0N8AP11   A0A0P4XHK2   J9K955   A0A182LBN1   A0A232FFV1   E9J2L7   S4PEC3   A0A0L0CNC3   A0A1A9WDQ9   A0A1A9USV1   A0A1D2MBU8   W8ARE0   A0A1I8NB88   E9HIS5   A0A1B0BB71   A0A1A9ZQH8   A0A2R2MRT2   B3MQN2   A0A182RKV9   A0A0K8TTA4   A0A1S3HY11   A0A2R2MKR0   A0A2R7W0S0   A0A1A9XCV2   A0A2J7RR93   A0A1B0FI42   A0A212EXC0   E2BX47   B4MAR3   A0A0L8G310   A0A3L8SGN8   B4JJH6   A0A1W4VH02   A0A3Q2PAL8   A0A3B0JXC8   A0A3N0YW70   A0A034WMF0   A0A023F2T3   B4L800  

EC Number

2.3.1.234

Pubmed

19121390    26227816    26354079    28756777    28004739    18362917    + More
19820115    29403074    23537049    20798317    26823975    25401762    24508170    17510324    28528879    21347285    21719571    24845553    20075255    12364791    20966253    28648823    21282665    23622113    26108605    27289101    24495485    25315136    21292972    17994087    26369729    22118469    18057021    30282656    25348373    25474469   

EMBL

BABH01013035    JTDY01002647    KOB71010.1    KQ459586    KPI97928.1    ODYU01013257    + More
SOQ59960.1    KQ460883    KPJ11352.1    KZ149892    PZC79013.1    ODYU01013074    SOQ59751.1    NWSH01005435    PCG64217.1    NEVH01000611    PNF43359.1    GEZM01036651    JAV82542.1    KPI97801.1    KQ971343    EFA04757.2    PYGN01001570    PSN33976.1    KQ438551    KOX67162.1    JTDY01002054    KOB72227.1    KQ434856    KZC08709.1    APGK01046725    KB741067    ENN74407.1    KQ461073    KPJ09748.1    GL441645    EFN64479.1    UFQT01000821    SSX27378.1    KZ288427    PBC25872.1    AJVK01009849    KQ414614    KOC68834.1    UFQS01000410    UFQT01000410    SSX03672.1    SSX24037.1    GBYB01010050    JAG79817.1    GDHC01011218    GDHC01006384    JAQ07411.1    JAQ12245.1    GBHO01005598    GBHO01005597    GBHO01005596    GBHO01005595    GBHO01005594    GBHO01005593    JAG38006.1    JAG38007.1    JAG38008.1    JAG38009.1    JAG38010.1    JAG38011.1    GBHO01005592    GBHO01005591    GBHO01005590    GBRD01004962    JAG38012.1    JAG38013.1    JAG38014.1    JAG60859.1    AXCM01001015    GEDC01009109    JAS28189.1    KK107109    EZA59359.1    CH477308    EAT44058.1    GFJQ02003649    JAW03321.1    DS232164    EDS36497.1    GDRN01055717    JAI65936.1    KQ976519    KYM82161.1    KQ980989    KYN10595.1    ADTU01001343    KQ981264    KYN44022.1    KQ982353    KYQ57211.1    GL888217    EGI64688.1    KQ978220    KYM96298.1    AXCN02001020    LJIG01022502    KRT80233.1    KK853074    KDR11760.1    APCN01002811    GDIQ01085103    JAN09634.1    GDIP01176297    JAJ47105.1    AAAB01008900    EAA09387.4    GFWV01019841    MAA44569.1    GDIQ01256971    JAJ94753.1    GDIP01241709    JAI81692.1    ABLF02027799    NNAY01000271    OXU29582.1    GL767895    EFZ12937.1    GAIX01003246    JAA89314.1    JRES01000256    KNC32919.1    LJIJ01002009    ODM90364.1    GAMC01019414    GAMC01019412    JAB87143.1    GL732657    EFX68328.1    JXJN01011310    CH902621    EDV44658.1    GDAI01000458    JAI17145.1    KK854184    PTY12771.1    PNF43358.1    CCAG010004713    AGBW02011787    OWR46139.1    GL451202    EFN79766.1    CH940655    EDW66322.1    KRF82634.1    KQ424182    KOF71411.1    QUSF01000024    RLW01050.1    CH916370    EDV99728.1    OUUW01000011    SPP86714.1    RJVU01020258    ROL50423.1    GAKP01002256    JAC56696.1    GBBI01003281    JAC15431.1    CH933814    EDW05575.1   

Proteomes

UP000005204    UP000037510    UP000053268    UP000053240    UP000218220    UP000192223    + More
UP000235965    UP000007266    UP000245037    UP000053105    UP000076502    UP000019118    UP000000311    UP000075920    UP000242457    UP000092462    UP000053825    UP000075883    UP000053097    UP000008820    UP000075881    UP000002320    UP000075880    UP000078540    UP000078492    UP000005205    UP000078541    UP000075809    UP000007755    UP000078542    UP000069272    UP000075886    UP000027135    UP000075840    UP000095300    UP000076407    UP000002358    UP000075902    UP000075903    UP000007062    UP000007819    UP000075882    UP000215335    UP000037069    UP000091820    UP000078200    UP000094527    UP000095301    UP000000305    UP000092460    UP000092445    UP000085678    UP000007801    UP000075900    UP000092443    UP000092444    UP000007151    UP000008237    UP000008792    UP000053454    UP000276834    UP000001070    UP000192221    UP000265000    UP000268350    UP000009192   

PRIDE

H9ISX1   

Pfam

PF00814   Peptidase_M22

Interpro

IPR000905   Gcp-like_dom        + More
IPR022450   TsaD       
IPR017861   KAE1/TsaD       
IPR017860   Peptidase_M22_CS       

ProteinModelPortal

H9ISX1   A0A0L7L6I4   A0A194PY26   A0A2H1X3N5   A0A194R0X3   A0A2W1C4D0   + More
A0A2H1X347   A0A2A4IW70   A0A1W4WPA9   A0A2J7RR99   A0A1Y1M9Q3   A0A194PWQ9   D6WLE6   A0A2P8XPP6   A0A0N0BBB1   A0A0L7L9T2   A0A154P9X6   N6U739   A0A194QW36   E2APZ2   A0A182WK23   A0A336MN16   A0A2A3E3K4   A0A1B0D067   A0A0L7RDD4   A0A336M6N1   A0A0C9RNQ0   A0A146LH26   A0A0A9Z2B8   A0A0A9Z3T9   A0A182LU65   A0A1B6DRA7   A0A026WW60   A0A1S4F805   Q17CG3   A0A1Z5L8P8   A0A182K7W4   B0WXG7   A0A0N7ZD09   A0A182IVK4   A0A195BC70   A0A195DCF8   A0A158P3X8   A0A195FUQ5   A0A151XA22   F4WM44   A0A195C832   A0A182FCX8   A0A182QZQ6   A0A0T6AYM3   A0A067R256   A0A182HNX9   A0A1I8Q329   A0A182XEV3   A0A0P6CZV0   K7J6Z0   A0A182TQ06   A0A0N8A705   A0A182UVT3   Q7Q9I8   A0A293MWU7   A0A0N8AP11   A0A0P4XHK2   J9K955   A0A182LBN1   A0A232FFV1   E9J2L7   S4PEC3   A0A0L0CNC3   A0A1A9WDQ9   A0A1A9USV1   A0A1D2MBU8   W8ARE0   A0A1I8NB88   E9HIS5   A0A1B0BB71   A0A1A9ZQH8   A0A2R2MRT2   B3MQN2   A0A182RKV9   A0A0K8TTA4   A0A1S3HY11   A0A2R2MKR0   A0A2R7W0S0   A0A1A9XCV2   A0A2J7RR93   A0A1B0FI42   A0A212EXC0   E2BX47   B4MAR3   A0A0L8G310   A0A3L8SGN8   B4JJH6   A0A1W4VH02   A0A3Q2PAL8   A0A3B0JXC8   A0A3N0YW70   A0A034WMF0   A0A023F2T3   B4L800  

PDB

3ZEU     E-value=1.94797e-40,     Score=417

KEGG

101743560    no KO assigned | (RefSeq) probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial pse

GO

GO:0004222   GO:0046872   GO:0005739   GO:0002949   GO:0061711   GO:0000408   GO:0016740   GO:0016705   GO:0020037   GO:0004497   GO:0005634   GO:0005737   GO:0048869   GO:0003676   GO:0016491   GO:0015930  

PANTHER

PTHR11735   PTHR11735:SF6  

Subcellular location

Mitochondrion  

Length:

408

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

12.2404

Exp number, first 60 AAs:

0

Total prob of N-in:

0.29083

outside

1  -  408

 

 

Pi

169.562956

Theta

169.552002

Tajima's D

0.000203

CLR

0.03327

CSRT

0.370881455927204

Interpretation

Uncertain