SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO13169  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA000349
Annotation
PREDICTED:_probable_tRNA_N6-adenosine_threonylcarbamoyltransferase?_mitochondrial?_partial_[Papilio_machaon]
Full name
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial      
Alternative Name
N6-L-threonylcarbamoyladenine synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein
tRNA threonylcarbamoyladenosine biosynthesis protein
t(6)A37 threonylcarbamoyladenosine biosynthesis protein HaOG216964
tRNA threonylcarbamoyladenosine biosynthesis protein HaOG216964
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC108734774
tRNA threonylcarbamoyladenosine biosynthesis protein LOC108734774
t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgepl1
tRNA threonylcarbamoyladenosine biosynthesis protein osgepl1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON014481
tRNA threonylcarbamoyladenosine biosynthesis protein CSON014481
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON010212
tRNA threonylcarbamoyladenosine biosynthesis protein CSON010212
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1_1
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1_1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1_0
tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1_0
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 5565046
tRNA threonylcarbamoyladenosine biosynthesis protein 5565046
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 6044601
tRNA threonylcarbamoyladenosine biosynthesis protein 6044601
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 105627815
tRNA threonylcarbamoyladenosine biosynthesis protein 105627815
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 106084148
tRNA threonylcarbamoyladenosine biosynthesis protein 106084148
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 100118784
tRNA threonylcarbamoyladenosine biosynthesis protein 100118784
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 100168791
tRNA threonylcarbamoyladenosine biosynthesis protein 100168791
t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGP2
tRNA threonylcarbamoyladenosine biosynthesis protein OSGP2
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 101899321
tRNA threonylcarbamoyladenosine biosynthesis protein 101899321
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC106173665
tRNA threonylcarbamoyladenosine biosynthesis protein LOC106173665
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DanaGF20469
tRNA threonylcarbamoyladenosine biosynthesis protein DanaGF20469
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC106158878
tRNA threonylcarbamoyladenosine biosynthesis protein LOC106158878
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DvirGJ15615
tRNA threonylcarbamoyladenosine biosynthesis protein DvirGJ15615
O-sialoglycoprotein endopeptidase-like protein 1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1
tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DgriGH12256
tRNA threonylcarbamoyladenosine biosynthesis protein DgriGH12256
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC108097636
tRNA threonylcarbamoyladenosine biosynthesis protein LOC108097636
t(6)A37 threonylcarbamoyladenosine biosynthesis protein DmojGI11016
tRNA threonylcarbamoyladenosine biosynthesis protein DmojGI11016
Location in the cell
Cytoplasmic   Reliability : 1.151 Mitochondrial   Reliability : 1.249
 

Sequence

CDS
ATGCCAGGAATACTTTGCAGAAGTGCTATGAATACGTTTCAAAAATTAAGACCTTTAACGAATTCTAAATGTAATTCTACTTTAATATTCGGAATAGAAACATCGTGTGATGATACTGGATGTGCCATAATCAACGAGGAAGGGAATATCATTGCGGAGTCCTTAAAATCCCAAAATTTAGTACATTTAAGAAATGGCGGAATTATACCTGATGTTGCTCAAGATCTTCATCGGAAATATATTGAACCGACAGTCACAGAAACATTACTAAAAGCTAATCTGTTGATGAAAGACATAAGCGCAATAGCTGTTACAGTAAAACCTGGTTTACCATTAAGTCTGGCTGTCGGCATGAAGTATGCCAAACATTTAGCACGAGTTAATGCTAAACCTATAATTCCTATTCACCATATGGAAGCACATGCATTGACAGTCAGAATGGAACACAATGTTAATTTCCCATATTTAGTGTTACTCATTTCTGGTGGTCATTGCTTATTGGCTGTGGTCCAAAATATAAACAAGTTCCTCCTTCTAGGTAAAAGTATAGACATGGCACCAGGTGAACTATTTGATAAAATTGCTAGGAGAATGAAACTTAGGAATGTACCTGAACTCTCCACTATGTGTGGAGGACAAGCTGTAGAAACAGCGGCATTAAGAGCCACCAATCCAGAGATGTTTAACCTTCCAATACCACTGGTACAAGTTAAAGATTGCAATTTTAGTTTTAATGGATTAAAAACTTCAGTTTTGTATCACCTGCGTAAGAAAGAAAAGGAACACAAAGTAGTTGCTGATGCATTAATACCTGAAATAAGTAATTTATGTTGTGCTGCATTGATAGCAACTACAAAACATCTTGTTCACAGGACACAACGTGCAATGCAATTCTGTTCTATCAATAATTTAATTCCAGAAAATAATAAACGGTTAGTTGTATCTGGAGGTGTAGCATGTAATAATTACATTTTCAATGCCTTAAAAGCTGCAAGTGTTGATTATGGCTATAATGTATATAGACCATCAATGAAACTGTGCACCGATAATGGTATTATGATAGCATGGAATGGCTTAGAAAAATGGAGAAAAAATTTGGATATTATGACAAATTTCAACACATTAGACTTGGAAGCAACAAGTCAATTAGGTGAAAGCTTAATTGACCAAGTTGCAAGTGCAAAAATAAAAACGAAAATTTTTAAATTTCAGAAAGCTGTTCAATAA
Protein
MPGILCRSAMNTFQKLRPLTNSKCNSTLIFGIETSCDDTGCAIINEEGNIIAESLKSQNLVHLRNGGIIPDVAQDLHRKYIEPTVTETLLKANLLMKDISAIAVTVKPGLPLSLAVGMKYAKHLARVNAKPIIPIHHMEAHALTVRMEHNVNFPYLVLLISGGHCLLAVVQNINKFLLLGKSIDMAPGELFDKIARRMKLRNVPELSTMCGGQAVETAALRATNPEMFNLPIPLVQVKDCNFSFNGLKTSVLYHLRKKEKEHKVVADALIPEISNLCCAALIATTKHLVHRTQRAMQFCSINNLIPENNKRLVVSGGVACNNYIFNALKAASVDYGYNVYRPSMKLCTDNGIMIAWNGLEKWRKNLDIMTNFNTLDLEATSQLGESLIDQVASAKIKTKIFKFQKAVQ

Summary

Description
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Catalytic Activity
adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA
Cofactor
a divalent metal cation
Subunit
Homodimer.
Similarity
Belongs to the KAE1 / TsaD family.
EC Number
2.3.1.234
EMBL
BABH01013035    JTDY01002647    KOB71010.1    KQ459586    KPI97928.1    ODYU01013257    + More
SOQ59960.1    KQ460883    KPJ11352.1    KZ149892    PZC79013.1    ODYU01013074    SOQ59751.1    NWSH01005435    PCG64217.1    NEVH01000611    PNF43359.1    GEZM01036651    JAV82542.1    KPI97801.1    KQ971343    EFA04757.2    PYGN01001570    PSN33976.1    KQ438551    KOX67162.1    JTDY01002054    KOB72227.1    KQ434856    KZC08709.1    APGK01046725    KB741067    ENN74407.1    KQ461073    KPJ09748.1    GL441645    EFN64479.1    UFQT01000821    SSX27378.1    KZ288427    PBC25872.1    AJVK01009849    KQ414614    KOC68834.1    UFQS01000410    UFQT01000410    SSX03672.1    SSX24037.1    GBYB01010050    JAG79817.1    GDHC01011218    GDHC01006384    JAQ07411.1    JAQ12245.1    GBHO01005598    GBHO01005597    GBHO01005596    GBHO01005595    GBHO01005594    GBHO01005593    JAG38006.1    JAG38007.1    JAG38008.1    JAG38009.1    JAG38010.1    JAG38011.1    GBHO01005592    GBHO01005591    GBHO01005590    GBRD01004962    JAG38012.1    JAG38013.1    JAG38014.1    JAG60859.1    AXCM01001015    GEDC01009109    JAS28189.1    KK107109    EZA59359.1    CH477308    EAT44058.1    GFJQ02003649    JAW03321.1    DS232164    EDS36497.1    GDRN01055717    JAI65936.1    KQ976519    KYM82161.1    KQ980989    KYN10595.1    ADTU01001343    KQ981264    KYN44022.1    KQ982353    KYQ57211.1    GL888217    EGI64688.1    KQ978220    KYM96298.1    AXCN02001020    LJIG01022502    KRT80233.1    KK853074    KDR11760.1    APCN01002811    GDIQ01085103    JAN09634.1    GDIP01176297    JAJ47105.1    AAAB01008900    EAA09387.4    GFWV01019841    MAA44569.1    GDIQ01256971    JAJ94753.1    GDIP01241709    JAI81692.1    ABLF02027799    NNAY01000271    OXU29582.1    GL767895    EFZ12937.1    GAIX01003246    JAA89314.1    JRES01000256    KNC32919.1    LJIJ01002009    ODM90364.1    GAMC01019414    GAMC01019412    JAB87143.1    GL732657    EFX68328.1    JXJN01011310    CH902621    EDV44658.1    GDAI01000458    JAI17145.1    KK854184    PTY12771.1    PNF43358.1    CCAG010004713    AGBW02011787    OWR46139.1    GL451202    EFN79766.1    CH940655    EDW66322.1    KRF82634.1    KQ424182    KOF71411.1    QUSF01000024    RLW01050.1    CH916370    EDV99728.1    OUUW01000011    SPP86714.1    RJVU01020258    ROL50423.1    GAKP01002256    JAC56696.1    GBBI01003281    JAC15431.1    CH933814    EDW05575.1   
Pfam
PF00814   Peptidase_M22
Interpro
IPR000905   Gcp-like_dom        + More
IPR022450   TsaD       
IPR017861   KAE1/TsaD       
IPR017860   Peptidase_M22_CS       
PDB
3ZEU     E-value=1.94797e-40,     Score=417

Ontologies

Topology

Subcellular location
Mitochondrion  
Length:
408
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
12.2404
Exp number, first 60 AAs:
0
Total prob of N-in:
0.29083
outside
1  -  408
 
 

Population Genetic Test Statistics

Pi
169.562956
Theta
169.552002
Tajima's D
0.000203
CLR
0.03327
CSRT
0.370881455927204
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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