Gene

KWMTBOMO13126

Pre Gene Modal

BGIBMGA000375

Annotation

PREDICTED:_tRNA-dihydrouridine(20a/20b)_synthase_[NAD(P)+]-like_[Papilio_machaon]

Location

Bomo_Chr22(-):8882547-8884270      View in EpiBrowser

Full name

tRNA-dihydrouridine synthase      

Location in the cell

Cytoplasmic   Reliability : 2.303 Extracellular   Reliability : 1.825

CDS

ATGAAAGAAATCTGCGATATTATGGAAAAATTTGCTGATGCCAAAATAAATAAAACATATTTGAAAGTATGTGCCCCGATGGTCAGATACAGCAAAGTTCATTTTAGAACTTTAGTAAGAAATTTTAATGCAGATCTATGTTTCACTCCAATGATTTTGGCAGATTCTTTTTGTCAAAATTCTAAAGCTAGAGCTAATGAGTTTATGACAACAACAACAGACTTTCCTGTGATAGCCCAATTTGCGGCTAATAATCGAGACGATTTCGTGGATGCTTCAAAACTAGTTTATCCATATGTCGACGGGGTGGACTTAAATTGTGGGTGTCCTCAGAAATGGGCAATGAAAGATGGCTATGGATGTTCCTTATTATCTAAACCAGAAATAATTTATGACATTGTAAAAGGACTAAGAAATGTTTTGCCCAACAAATTTAGTATATCTGTGAAAATAAGACTTTTGAATGATATAAAAAAAACTGTTATTTTGTGCCAGCAGCTAGAGAAATGCGGAGTAACATTTTTGACAATACATGGAAGAACAATTGCACAAAAAAGCAGTGGTCCTGTAGATATAAATGGATTAAAAGAGGTCAGAGAGGCCTTATCTGTCCCAATGGTAGCAAATGGTGGTGTCAAGAATCTTAATGATGCCAACCACTTATATGAAGTAGTAAAGTGTAGTGGTGTAATGGCGGCTGGGGGTCTTTTGTCTAATCCTGCTTTATTCAGTGGTATTACAAAAACTCCACTTAGTTGTGTGAAAATGTGGATGGAATTAAAGAATAAAAACATTGAAAGAATAACATTTCAGTGCTATCATCATCATTTAGTCTTTATGTTAGAAAAAGTATTGACCAAGCAGCAAAAACAAATTTTCAACCATTTAAGTACATTTGAAAGTGTTGATGATTTTATACTGAATAACTTATTTGAGAATTCAATAGTTGATTTTCATTATAAACATGAATTAGGAAACTTTACAGAATGTCAGTTTCCTGATCAAATTACTATGAAACATTGTACTAAATGTAGAACCTGTGGCAAAAGTGTACATTACTGTGTGTGTAATAAATATGACTATAGTACTACCCACGGAAACTTTTTTATCTCGCACATTAATGCAGATGATGGTCTTGATTACATGGACAGTAATATATTTGATGAACCAATATGA

Protein

MKEICDIMEKFADAKINKTYLKVCAPMVRYSKVHFRTLVRNFNADLCFTPMILADSFCQNSKARANEFMTTTTDFPVIAQFAANNRDDFVDASKLVYPYVDGVDLNCGCPQKWAMKDGYGCSLLSKPEIIYDIVKGLRNVLPNKFSISVKIRLLNDIKKTVILCQQLEKCGVTFLTIHGRTIAQKSSGPVDINGLKEVREALSVPMVANGGVKNLNDANHLYEVVKCSGVMAAGGLLSNPALFSGITKTPLSCVKMWMELKNKNIERITFQCYHHHLVFMLEKVLTKQQKQIFNHLSTFESVDDFILNNLFENSIVDFHYKHELGNFTECQFPDQITMKHCTKCRTCGKSVHYCVCNKYDYSTTHGNFFISHINADDGLDYMDSNIFDEPI

Description

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Cofactor

FMN

Similarity

Belongs to the dus family.

Uniprot

A0A2H1VLL8   A0A3S2TCN7   A0A212EV25   A0A0L7LJX8   A0A182VRV9   A0A182QKF6   + More
A0A182XVY7   A0A182MTU5   A0A182J8W2   A0A182XIQ9   A0A182KGG2   A0A182HTK6   Q7QCT0   W5JVD0   A0A182LBV0   A0A0K8TLI0   A0A182RGZ9   A0A182H7N5   A0A1B6K4D1   A0A182UH47   Q0IFC6   A0A1B6FT87   A0A182PDY5   A0A182UNV6   A0A182F733   A0A026W4F5   A0A182N799   A0A2M4BR34   A0A1Q3EZA5   A0A1B6M4W7   D6WQ25   A0A0A9YWV7   E9IND1   A0A0C9R4H0   A0A195C7K4   A0A1W4WTJ9   K7IMR7   A0A151WHI5   A0A158NMV5   E2BEE4   A0A232FHI1   A0A023F3T4   A0A195EXU5   A0A154PKR8   A0A2A3EDJ2   A0A0L7QQZ2   E0VKA2   T1HX61   A0A088ASJ4   A0A2M4CLH5   A0A0M9ABK9   J9K6J4   A0A1J1J092   A0A0A9Y6K9   A0A146KV37   A0A2H8TRL2   A0A0K8UY66   A0A2H8TYY1   A0A067R3W9   A0A0A1XBG4   A0A034WG31   A0A1A9WKD7   B0X4B0   A0A1I8M4T1   A0A0B7A037   A0A2J7QMZ2   A0A091NC64   W8C6Q0   A0A087RKP8   E9GJN7   A0A093PC64   A0A093BQG7   A0A091FSM8   K1R069   A0A091HYK6   A0A147BPV2   A0A093PD29   A0A2Y9DX04   A0A091PQY8   A0A131Y2I3   A0A093J7C4   A0A093HBG9   A0A1I8PM34   A0A091K338   A0A3P8WUS4   A0A091IZ79   A0A2I0MH73   A0A091W0D6   A0A093G7E0   A0A0L0CE11   A0A091X9J0   A0A195BC07   G3WHV9   Q29PI6   A0A091NXZ3   A0A0A0ATQ2  

EC Number

1.3.1.-

Pubmed

22118469    26227816    25244985    12364791    14747013    17210077    + More
20920257    23761445    20966253    26369729    26483478    17510324    24508170    30249741    18362917    19820115    25401762    21282665    20075255    21347285    20798317    28648823    25474469    20566863    26823975    24845553    25830018    25348373    25315136    24495485    21292972    22992520    29652888    24487278    23371554    26108605    21709235    15632085    17994087   

EMBL

ODYU01003232    SOQ41725.1    RSAL01000365    RVE42182.1    AGBW02012251    OWR45350.1    + More
JTDY01000826    KOB75752.1    AXCN02000147    AXCM01000985    APCN01000539    AAAB01008859    EAA07861.4    ADMH02000237    ETN67283.1    GDAI01002391    JAI15212.1    JXUM01028964    KQ560836    KXJ80677.1    GECU01001442    JAT06265.1    CH477364    EAT42566.1    GECZ01016374    JAS53395.1    KK107432    QOIP01000001    EZA50898.1    RLU27499.1    GGFJ01006404    MBW55545.1    GFDL01014421    JAV20624.1    GEBQ01026423    GEBQ01009010    JAT13554.1    JAT30967.1    KQ971354    EFA06141.2    GBHO01006925    JAG36679.1    GL764295    EFZ17930.1    GBYB01011194    JAG80961.1    KQ978231    KYM96133.1    KQ983115    KYQ47284.1    ADTU01020820    GL447768    EFN85989.1    NNAY01000238    OXU29797.1    GBBI01003133    JAC15579.1    KQ981940    KYN32717.1    KQ434948    KZC12471.1    KZ288271    PBC29778.1    KQ414785    KOC60979.1    AAZO01003005    DS235241    EEB13808.1    ACPB03000369    GGFL01002008    MBW66186.1    KQ435710    KOX79923.1    ABLF02020829    CVRI01000066    CRL05939.1    GBHO01015780    JAG27824.1    GDHC01018471    JAQ00158.1    GFXV01004063    MBW15868.1    GDHF01021054    JAI31260.1    GFXV01007294    MBW19099.1    KK852715    KDR17862.1    GBXI01006489    JAD07803.1    GAKP01005685    JAC53267.1    DS232335    EDS40263.1    HACG01027414    CEK74279.1    NEVH01013202    PNF29947.1    KK828715    KFP74792.1    GAMC01001002    JAC05554.1    KL226413    KFM14052.1    GL732548    EFX80145.1    KL668891    KFW74508.1    KL451477    KFV05990.1    KL447430    KFO73515.1    JH816384    EKC27051.1    KL217905    KFP00265.1    GEGO01003039    JAR92365.1    KL225260    KFW70127.1    KK676997    KFQ09731.1    GEFM01002709    JAP73087.1    KK575025    KFW09838.1    KL205899    KFV76332.1    KK540417    KFP30711.1    KK501259    KFP13667.1    AKCR02000012    PKK29031.1    KL410275    KFQ95293.1    KL214981    KFV62689.1    JRES01000523    KNC30437.1    KK734681    KFR10046.1    KQ976529    KYM81752.1    AEFK01195698    CH379058    EAL34307.1    KK644148    KFP97797.1    KL873146    KGL97939.1   

Proteomes

UP000283053    UP000007151    UP000037510    UP000075920    UP000075886    UP000076408    + More
UP000075883    UP000075880    UP000076407    UP000075881    UP000075840    UP000007062    UP000000673    UP000075882    UP000075900    UP000069940    UP000249989    UP000075902    UP000008820    UP000075885    UP000075903    UP000069272    UP000053097    UP000279307    UP000075884    UP000007266    UP000078542    UP000192223    UP000002358    UP000075809    UP000005205    UP000008237    UP000215335    UP000078541    UP000076502    UP000242457    UP000053825    UP000009046    UP000015103    UP000005203    UP000053105    UP000007819    UP000183832    UP000027135    UP000091820    UP000002320    UP000095301    UP000235965    UP000053286    UP000000305    UP000053258    UP000053760    UP000005408    UP000054308    UP000054081    UP000248480    UP000053584    UP000095300    UP000265120    UP000053119    UP000053872    UP000053283    UP000053875    UP000037069    UP000053605    UP000078540    UP000007648    UP000001819    UP000053858   

Pfam

PF01207   Dus

Interpro

IPR018517   tRNA_hU_synthase_CS        + More
IPR001269   tRNA_hU_synthase       
IPR035587   DUS-like_FMN-bd       
IPR013785   Aldolase_TIM       
IPR029055   Ntn_hydrolases_N       

SUPFAM

SSF56235   SSF56235       

Gene 3D

3.20.20.70    

CDD

cd02801  DUS_like_FMN

ProteinModelPortal

A0A2H1VLL8   A0A3S2TCN7   A0A212EV25   A0A0L7LJX8   A0A182VRV9   A0A182QKF6   + More
A0A182XVY7   A0A182MTU5   A0A182J8W2   A0A182XIQ9   A0A182KGG2   A0A182HTK6   Q7QCT0   W5JVD0   A0A182LBV0   A0A0K8TLI0   A0A182RGZ9   A0A182H7N5   A0A1B6K4D1   A0A182UH47   Q0IFC6   A0A1B6FT87   A0A182PDY5   A0A182UNV6   A0A182F733   A0A026W4F5   A0A182N799   A0A2M4BR34   A0A1Q3EZA5   A0A1B6M4W7   D6WQ25   A0A0A9YWV7   E9IND1   A0A0C9R4H0   A0A195C7K4   A0A1W4WTJ9   K7IMR7   A0A151WHI5   A0A158NMV5   E2BEE4   A0A232FHI1   A0A023F3T4   A0A195EXU5   A0A154PKR8   A0A2A3EDJ2   A0A0L7QQZ2   E0VKA2   T1HX61   A0A088ASJ4   A0A2M4CLH5   A0A0M9ABK9   J9K6J4   A0A1J1J092   A0A0A9Y6K9   A0A146KV37   A0A2H8TRL2   A0A0K8UY66   A0A2H8TYY1   A0A067R3W9   A0A0A1XBG4   A0A034WG31   A0A1A9WKD7   B0X4B0   A0A1I8M4T1   A0A0B7A037   A0A2J7QMZ2   A0A091NC64   W8C6Q0   A0A087RKP8   E9GJN7   A0A093PC64   A0A093BQG7   A0A091FSM8   K1R069   A0A091HYK6   A0A147BPV2   A0A093PD29   A0A2Y9DX04   A0A091PQY8   A0A131Y2I3   A0A093J7C4   A0A093HBG9   A0A1I8PM34   A0A091K338   A0A3P8WUS4   A0A091IZ79   A0A2I0MH73   A0A091W0D6   A0A093G7E0   A0A0L0CE11   A0A091X9J0   A0A195BC07   G3WHV9   Q29PI6   A0A091NXZ3   A0A0A0ATQ2  

PDB

6EZC     E-value=7.14564e-24,     Score=274

KEGG

101745883    K05545 tRNA-dihydrouridine synthase 4 [EC:1.3.1.90] | (RefSeq) tRNA-dihydrouridine(20a/20b) synthase

GO

GO:0017150   GO:0050660   GO:0016491   GO:0008033   GO:0016021   GO:0003824   GO:0005634   GO:0005737   GO:0048869   GO:0003676   GO:0015930  

Length:

391

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1165

Exp number, first 60 AAs:

0.05621

Total prob of N-in:

0.02487

outside

1  -  391

 

 

Pi

238.248688

Theta

203.303407

Tajima's D

0.803017

CLR

0.720346

CSRT

0.608369581520924

Interpretation

Uncertain