Gene

KWMTBOMO13122

Pre Gene Modal

BGIBMGA000378

Annotation

PREDICTED:_protein_still_life?_isoform_SIF_type_1_[Bombyx_mori]

Location

Bomo_Chr22(-):8720307-8764535      View in EpiBrowser

Full name

Protein still life, isoform SIF type 1      

Location in the cell

Nuclear   Reliability : 4.686

CDS

ATGGGCAATAAGCTCTCATCTTGTTCTTGCGCGCCCATACTGCGCAAGGCGTACCGCTATGAAGACAGCCCGTGGCAGAACTCTCGCCGCCGTGATGGTCACTTATTGAGATTATGGGCTGAAGTATTCCATGTGTCAGCTAGTGGCGCTGGTACAGTGAAATGGCAGCAGGTATCCGAAGATCTGGTACCGGTCAATATCACATGCATTCAAGATTCTCCGGAATGCGTATTTCATATCACGGCGTACAATTCTCAAGTTGATAAAATACTAGATGTGAGACTACTTCAACCAGGTACTCGTATTGGTCAAGCCTCGGAATGTTTTGTGTACTGGAAGGATCCAATGACTAACGACACTTGGGGACTAAATTTTACTTCCCCAATAGATGCCAAACAATTTAGAGAGTGTTGTTCCCCATCTTTCAAATTTTCCCGCAAAGCTTCGTCGAGTTATAGTTTAAAATTGGAACCTCCTGGAAGTAAGCAAAAGTTTAAGGCTAAAAGGAAACCCGTGTCTACACCAGCAAGTCCTAATCGATCTAGCTTAACCTATGGCCGTGAAGCACAATGTACTTGTATGACTCAAGAACAATATGCTCGATTAAGAGCTCAAGACCCAAGATACAGGTCATCAACTCTGCCAAGAACTACAACTCGCGCTATAGAAACAGAGGCCGCTGCGGCCGCCGCTACTAATGCAGCCCGTTCTGACAAAGTCGCTGCTGCCACATCTTCCACTTCCTTGTACGACAATGTCACAAATTCACAGGCCACACATCAACCGCCACCGAAACCGGTCGCGCGTCAATCGGAATCTCAGCCACCATCGAGACCTCCGAAATCTCAGGAGACATCTACAATGACAACTAATACTTCTACTGCGCCCAAAACCGTAACCGCATCTGTTGGCACACATGGAACTAATACTTCTGAGGAATCACAAGCAACAGCGGGTTCGACTCAACATGGTCAAGATTTAAAGTCTGAAGGTGTGCAGGCTGGAGGAACCCTTACCTCATCCAAATCTTCTGCAACTTCGACTCGCTCTGGGAAGGAATGTTCCTTGCAGCACATGCCAAAGAGCATCGACTATGGTGACGGGAATGAATCGTCCCGTGAGTCAGAGCGTCATGCCGCGCATCATCACAACCACAACGTGGTTAATAACAACACGTCTGGTTCGCGTCGTACAAAATCGAAGAGCACTGAGGATATGAATATGGATTCGAGTACACTAAAGCGCATGCTGAAGCCGATGCCGTCGACGGAGAGTCCGGTGACCTCTCCCGAGATGGGTCGGCGGCGGTACGGGGGCGCGGGCCCGTGTCCACCGGCGTGCGGCGCGCACGGACACCGCCCGCCGCACCTGCACCACGGACACTACGCGCACGTCGTGAACAACAATAGCCGCCAGAGTTCACAGAGACGCGGCGTGGGCGTGGGCGCCGCTCCGAGCGGGTACCCGGGGCGCGGACTGTACCTCGAGCTGGGCGGCGGAGAGCGCGACCTCTCCCCGCCCTCCGACAACGTCATGTTCGATAACCAGTGCTACGCCACCACGCCGTCTTCCTCCAACGGCAACTCCGACCAGGAGCCGTGTCAACGTCGGGACCCCAGGCAACATCATCATCCGAAGCCGTGCCTCAGTCGCCAGGCGTCGCAGTCGAGCGCGACGCCCGCGCCCGGCTCGCCCACCTCGCGCCTCTTGCTCGAGTACGAGATGCATCTCCGCAACACCCTCGCCAAGGGCATGGACGCCGAGAGCTACAGTCTGCACACGTTCGAGGCCTTGTTGAGCCAGAGCATGGAGGACTTAGAAATGAATGACAAAATGCCGTCTTCGAACCAACGCAGTCCATACCCCTCACGTCGACGGCCGACCCAAGAATCCATTCTACAATCTTTGAGACACCTCAAGGAAGCTGCAATAAGGGAGCGAGGTCCATCGTCACAATGTTCTGGGGGCGGCAGTCGGTCGTCGACCCTGCCCCTCCCGCACCGGCTCGGGGTCGAACGTCAGCACAGCGCCCGCTCCGATCGCGACGGATACTACAGCCCGCGGGCGCCTGATGGAATCCCGGAAATGCCAGAGTTAGAGCACCACATCGATCGCAATGAACTCATGCGCGAGAGGGAGCGTGAGCGCGACAGGGGATACCTCAGTGACCACAATACGAGGGACAGAGTGCGGGATCGTGATCAAGGGTACCTCAGCGACCATCAATCTAGCTTCGTGAGTACATCTCGGTGCGCGTCGTGTATTGGCGAGTCGGCCCGCGCGGCCTGGTATAGACACTCGGACGGCTGGCGCGGCGCTGCACCGCCGGGCCCCCGCCGCTCGCCCTGGGACTCACTGCCCAGTCTCCGACACGAGGGCAGTCTCAACGACTCCGGCTATAGGAGCAACAGAGCGGACAGCTTCGAACAAAGGGGTGTGTTTGATCGGCAAGACAGTGTGCGCTCCGAATACACAAGTGACCGGGAGTCTTCGCGCTACGGGATCGTGCAACAAGCTTCCATCGACAGTACCGACTCTAGGATCTGCTACTTGACATCGAGCGAGGTAAGCCATGTTAAATATTACGTCAATTATTCATAA

Protein

MGNKLSSCSCAPILRKAYRYEDSPWQNSRRRDGHLLRLWAEVFHVSASGAGTVKWQQVSEDLVPVNITCIQDSPECVFHITAYNSQVDKILDVRLLQPGTRIGQASECFVYWKDPMTNDTWGLNFTSPIDAKQFRECCSPSFKFSRKASSSYSLKLEPPGSKQKFKAKRKPVSTPASPNRSSLTYGREAQCTCMTQEQYARLRAQDPRYRSSTLPRTTTRAIETEAAAAAATNAARSDKVAAATSSTSLYDNVTNSQATHQPPPKPVARQSESQPPSRPPKSQETSTMTTNTSTAPKTVTASVGTHGTNTSEESQATAGSTQHGQDLKSEGVQAGGTLTSSKSSATSTRSGKECSLQHMPKSIDYGDGNESSRESERHAAHHHNHNVVNNNTSGSRRTKSKSTEDMNMDSSTLKRMLKPMPSTESPVTSPEMGRRRYGGAGPCPPACGAHGHRPPHLHHGHYAHVVNNNSRQSSQRRGVGVGAAPSGYPGRGLYLELGGGERDLSPPSDNVMFDNQCYATTPSSSNGNSDQEPCQRRDPRQHHHPKPCLSRQASQSSATPAPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMEDLEMNDKMPSSNQRSPYPSRRRPTQESILQSLRHLKEAAIRERGPSSQCSGGGSRSSTLPLPHRLGVERQHSARSDRDGYYSPRAPDGIPEMPELEHHIDRNELMRERERERDRGYLSDHNTRDRVRDRDQGYLSDHQSSFVSTSRCASCIGESARAAWYRHSDGWRGAAPPGPRRSPWDSLPSLRHEGSLNDSGYRSNRADSFEQRGVFDRQDSVRSEYTSDRESSRYGIVQQASIDSTDSRICYLTSSEVSHVKYYVNYS

Description

Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons (PubMed:8999801). May play a role in maintaining proper septate junction functions. Required for eye development and most likely affects corneal lens-formation (PubMed:30290152).

Keywords

Alternative splicing   Cell junction   Complete proteome   Developmental protein   Guanine-nucleotide releasing factor   Lipoprotein   Myristate   Reference proteome   Repeat   Synapse  

Feature

chain  Protein still life, isoform SIF type 1

Uniprot

A0A3S2LR85   A0A212EV20   A0A194PX37   H9ISZ9   A0A2A4J2C2   A0A2A4J0S1   + More
A0A2H1VFE2   A0A139WH59   A0A336M3G6   A0A139WH02   A0A087YXX8   W5JUF3   Q7PI66   Q7PNS8   A0A336LZQ4   A0A182LKF7   A0A1J1J554   A0A336LZQ6   A0A0R1DWE2   A0A182X4H0   A0A182Q6Y8   A0A0S0WGZ0   M9PHI5   A0A182MHV1   E2ARF0   A0A1B0BIM1   A0A182FEX2   A0A088ANW2   A0A1B0FDU5   V9I688   A0A2A3EQP6   V9I687   X2JC30   V9I797   M9PE98   A0A0L7R0F1   A8JNL4   Q8IQ62   A8JNL6   P91621   B4QRN0   A0A195EWX3   A0A195D6J7   A0A182NIS2   F4WWJ1   A0A182Y2L6   V9I792   V9I787   V9I7M4   A0A182I4G7   A0A1B6DPG3   A0A1A9Z976   A0A1W4WXX1   N6TKC9   A0A1A9VHD5   A0A182KAQ8  

Pubmed

22118469    26354079    19121390    18362917    19820115    20920257    + More
12364791    14747013    17210077    20966253    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    20798317    8999801    9072802    30290152    21719571    25244985    23537049   

EMBL

RSAL01000365    RVE42177.1    AGBW02012251    OWR45345.1    KQ459586    KPI97887.1    + More
BABH01013110    BABH01013111    BABH01013112    NWSH01003926    PCG65674.1    PCG65675.1    ODYU01002278    SOQ39545.1    KQ971343    KYB27185.1    UFQT01000356    SSX23473.1    KYB27186.1    ADMH02000462    ETN66384.1    AAAB01008960    EAA44262.4    EAA11675.5    SSX23474.1    CVRI01000067    CRL06598.1    SSX23475.1    CM000159    KRK01247.1    AXCN02000421    AE014296    ALI30454.1    AGB94141.1    AXCM01007421    GL442063    EFN63959.1    JXJN01014994    CCAG010018874    CCAG010018875    JR035365    AEY56355.1    KZ288193    PBC34058.1    JR035360    AEY56350.1    AHN57971.1    JR035371    AEY56361.1    AGB94143.1    KQ414670    KOC64322.1    ABW08473.2    AAN12103.2    ABW08474.2    D86547    CM000363    EDX09341.1    KQ981953    KYN32397.1    KQ976760    KYN08498.1    GL888408    EGI61422.1    JR035366    AEY56356.1    JR035361    AEY56351.1    JR035369    AEY56359.1    APCN01002309    GEDC01009738    JAS27560.1    APGK01021345    APGK01021346    KB740314    ENN80909.1   

Proteomes

UP000283053    UP000007151    UP000053268    UP000005204    UP000218220    UP000007266    + More
UP000000673    UP000007062    UP000075882    UP000183832    UP000002282    UP000076407    UP000075886    UP000000803    UP000075883    UP000000311    UP000092460    UP000069272    UP000005203    UP000092444    UP000242457    UP000053825    UP000000304    UP000078541    UP000078542    UP000075884    UP000007755    UP000076408    UP000075840    UP000092445    UP000192223    UP000019118    UP000078200    UP000075881   

PRIDE

H9ISZ9    M9PHI5    X2JC30    M9PE98    A8JNL4    Q8IQ62    + More
P91621   

Pfam

PF00169   PH        + More
PF18385   Tiam_CC_Ex
PF02196   RBD
PF00621   RhoGEF
PF00568   WH1

Interpro

IPR011993   PH-like_dom_sf        + More
IPR001849   PH_domain       
IPR000697   WH1/EVH1_dom       
IPR040655   TIAM1_CC-Ex       
IPR003116   RBD_dom       
IPR035899   DBL_dom_sf       
IPR000219   DH-domain       
IPR001478   PDZ       
IPR036034   PDZ_sf       
IPR001331   GDS_CDC24_CS       

SUPFAM

SSF48065   SSF48065        + More
SSF50156   SSF50156       

Gene 3D

2.30.29.30     1.20.900.10    

CDD

cd00160  RhoGEF

ProteinModelPortal

A0A3S2LR85   A0A212EV20   A0A194PX37   H9ISZ9   A0A2A4J2C2   A0A2A4J0S1   + More
A0A2H1VFE2   A0A139WH59   A0A336M3G6   A0A139WH02   A0A087YXX8   W5JUF3   Q7PI66   Q7PNS8   A0A336LZQ4   A0A182LKF7   A0A1J1J554   A0A336LZQ6   A0A0R1DWE2   A0A182X4H0   A0A182Q6Y8   A0A0S0WGZ0   M9PHI5   A0A182MHV1   E2ARF0   A0A1B0BIM1   A0A182FEX2   A0A088ANW2   A0A1B0FDU5   V9I688   A0A2A3EQP6   V9I687   X2JC30   V9I797   M9PE98   A0A0L7R0F1   A8JNL4   Q8IQ62   A8JNL6   P91621   B4QRN0   A0A195EWX3   A0A195D6J7   A0A182NIS2   F4WWJ1   A0A182Y2L6   V9I792   V9I787   V9I7M4   A0A182I4G7   A0A1B6DPG3   A0A1A9Z976   A0A1W4WXX1   N6TKC9   A0A1A9VHD5   A0A182KAQ8  

KEGG

101739475    K05731 T-lymphoma invasion and metastasis-inducing protein 1 | (RefSeq) protein still life, isoform

GO

GO:0007165   GO:0005089   GO:0035023   GO:0035556   GO:0007601   GO:0030054   GO:0045202   GO:0051491   GO:0030676   GO:0050803   GO:0001654   GO:0030036   GO:0050770   GO:0043087  

Subcellular location

   Localizes to the submembranous region of synaptic terminals.   With evidence from 8 publications.

Length:

866

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00843

Exp number, first 60 AAs:

0.00843

Total prob of N-in:

0.00046

outside

1  -  866

 

 

Pi

182.564588

Theta

179.557463

Tajima's D

0.106492

CLR

1.151865

CSRT

0.40037998100095

Interpretation

Uncertain