Gene

KWMTBOMO13121

Pre Gene Modal

BGIBMGA000379

Annotation

PREDICTED:_protein_still_life?_isoforms_C/SIF_type_2_isoform_X2_[Papilio_machaon]

Location

Bomo_Chr22(-):8654375-8697755      View in EpiBrowser

Full name

Protein still life, isoforms C/SIF type 2      

Location in the cell

Nuclear   Reliability : 3.929

CDS

ATGGTGGAGACGCATCGTGCGCCGCCACCCAGATGTGCGCGTGCGCCAGAGTCACGGGTCAAGCCTGCTTCAGCCTCGGCACCGCCCTCTCTAGCCGGCAGCGGGACCATGATGCACTTGCGCCGGCGGCGACACAAGACTGTGCACTTCGGGGAAAATCTGCTTATGCAAGTCTGCGCCGACAGAGCCCACTTAGCGGCGTTAGGAGCGCGTATTCCCGATATCTCTTTTTGTCATAAGGCACGCACTGGTCTTCGACAAGGTGATGCTCGCTTCTGTTGTGTTGCTCATCACTGTTGTTTAGCTGCTGGAGAACTTGTAGCACTAACATCAAATGGGCGGCCAAAGCCAAGAAGAGAACGTAGTGCCGACTCACATTCGAGTGGCGGCGAAGCAGCTGAAGGAAGTAGAGGAGAGAGTAGTAGCGGTTCAGCGAATAAGGAACCAAAACGGAAATCAAAGCATCATCATCATCACCATCATCACCACCATAAAATACACAGCTGTCCTTACCACGATGCTGTACCTCCACCAGAAGATGAACCCGACGAGAAAGCAATTATTCCCAAAAAAACTGTTTCGCCATACCTCTACATACCTAGTAAGTTAGAGCCCAATGTGCAACAGTTATTTAGTTTCATTGAAAGCGTCTTAAGCGCATGGGCTGCCGAAGAGGGTCTTACCAGTACGGGAGAATATTCAGAGCCCGATGAACGTATAGTCCGAAGACGTAAACTAATTAAATATAAGAAACGTACCGACATACTGAATATACGACGGATCGTGTATGATGTTTCAATTTTACGGGGAACAAAGTTGCTTGGAAACGTTAGATACCGGCATTATCACTGGAAAGGCACTGCGCAGTCATGCAATGAAACGTTTCTACGAAAGATATCTGATGATGATCGAATGTCATTGACGACGGCGGTGTCGGATGAAGAAGATCCTGGTGAAAGCGCAATGAATTCTCCTTACAAAGGCAAGCAGACTGGTGCAGCCGCAGCATCTTTCAACTGCACCGGCGCAGTCAGGAAGGCAGGATTTCTAAGCGTTAAGAAATGGCTTCTTCGTAAAAAACATCAGATAGAGCTAGCACGCAAACGTGGTTGGAAGGGTTACTGGGTGTGCCTCAAAGGCACTACTTTACTCTTTTACCCGTGTGATTCGCGAGAAGGACGATCAGTAGAGGCTGCTCCTAAGCATCTCATAATAGTCGACGGCGCCATTATGCAGCCCATACCAGAACATCCGAAGCGAGATTATATATTTTGTCTCAGTACTGCTTTTGGAGACGCATACTTATTCCAAGCTCCGTGCCAAATTGAGCTCGAAAACTGGGTGAATAGTATACACAGTGCTTGCGCCGCGGCTTTCGCTCGTCACCGCGGCAAAACCGGCACCCTCCATTTATTGCAGGAAGAAATTTACCGTCTCGAGAAAGCCATTGAATCTGATCACAAATTGAAGCACATGGCAGACCTACAGCAGTCTGTTGTTTCGGATCCGGAAACTCGAGATCAACTAGCAGCCCAGATGCTTCAATGGGATGAAAATCTTGAACGCTTACACTGCGAGCAGTTCCGTCTACGCTGCTATATGGCGAGCCTCCAGAGCGGTGAACTACCCAACCCAAAGTCCCTGTTGACGCACGTGTCTCGCGGCACGAAGAGCACGCTGAACAAGCTGGGCGTGTTCACGGTGTCGTCCTTCCACGCGTTCATCTGCGCGCGCTCGCCGTCGCTTCTCAACAACCTGCTGGCGGGCCGCGGCGCCACCAAGCGGCGCCCGCCCAACCTCTCGCGCTCCAACTCGGCCTCCAGCAGGCGCTCCATGCAGATGTCCCGCGAGGATGGGGAGGCGGCCGTGCGTGTGTCGCTCCCGGAGGGCACGACCGCGACGGTGGGGGTCCGCGAGGGCATGTCGGTCGAGGAGTTCCTGGCCGCGGCCTGCGTCCGCCGCTCGCTCAACCCTCTGGAACATTTCGTGAGGGTCAAGAAACGACGCGACATGGAGGATCACAACTACTTTGTGCCGCACAGAAGCGATCTCATAGAAACTTACCTGCACACACACGAAGTTGTCGAAGTTTGTGCTAAAATCCTGTACCAAGTAGAGCTGCAACGTAATACTCTCGAGCAAATGTGGGGCTTCAGTGTTGAGGCAGAGCTTATTGAGAACGCCGAACGTCAAGACGAACTGTGCTGCTACGTAAGTCGGGTCGAGGACAAGAGCGTCGCCATGCAAAACGGTATCATCAAAGGCGACGAAATAATGGTGATCAACGGAGCGATCGTATCCGACCTCGACATGATGTACTTGGAAAGCGTATTGCAAGAGGAACTCTCCCTGGTCATGATGATGAGGTCGTCGCGCACGGAGCCGCCGGAGGTGTCGGGCGTGCTGCGCGGCGCCACCGACGACATCATCGACTCGCTGGTGTGCCCCCCGCCCCCCACCGACCCGCCCGTCATCTCCGACGACATGATCTCCGGACTCATCGTACCCGCGCCTGCCTGGAGTAAGGAGTTGTACAGCCCGGAGGCAGAGGCGCACGGTGGGGACTCGGTCAACACCGGCCCGCCCAAAGTTAGCTCGCGAACTAACTCCTTCGAAATTGAAAATCTTTTAAAGAGCGCGGAGCAGGTGACGGGGTGGTGCCGCTCGCCCGCCGAGACGCGGCGCGGGAGTCCCACCGGGAGCGTGGCCAGCGCCGCCGCCGGGACTCCCTCGCGACACCTCTCCGACGCCGACAAGCTCAGGAAGGTGCTGCTCGAAGTGGTCGACACTGAACGTGCCTACGTCAAGCACTTGAACAACTTGCTGGAGAACTATTTGGAGCCGCTGAAGAAGGAAACTTTTTTATCAAATGCCGAGATCAATGCTTTGTTTGGGAACATTCAGGAGATAGTGACTTTCCAAAGACAGTTCCTGCAGAACTTAGAGGAAGCGCTCGAGGCTGAACCTAACTTCAACCACTTTGAATTCTCGAATCAATTCAAGAACGTGCTCTTCGCCGTCGGGAACGCTTTCCTTTACTACGTCAATCATTTCAAGTTGTACAGCTCCTTCTGCGCCAGTCACAGTAAGGCACAGAAAGTTCTTCATCCAAATGAGGGTAATCAAGCTCTTCAAGAATTTTTGTCGGCAAGGAATCCGAAACAGCAACATTCATCGACGTTGGAGTCGTATTTGATTAAGCCGATACAGAGAATACTTAAGTACCCGTTGTTGTTGCAACAGCTTAGGAATTTAACCGACGTGAACTCTGAGGAACACCTTCATTTAGTTGAGTCTCTCAAGGGCATGGAGAAAGTCGCAGAACACATCAACGAGATGCAAAGAATCCACGAAGAGTACGGTGCTATATTCGATCACTTGTTTAGGCAACATCAAAAGTCTTGCAAACAGCCAATCGATCTCAGTCCCGGCGACCTGTTGTATTACGGCGGCGTTGAATGGCTGAATATATCAGACTTTTTAGGTAAAATAAAAAAGGGCTTAGAGCTGCATGCGATGTGCTTCGTGTTTAAATCCGCCGTTGTCTTCCTCTGTAAAGAAAGACTGAGACAAAAGAAGAAATTGATGGGGGTTTCTTCGAAAAATAATTCAAACGAAGTAGAGATAATTAGATACCAAGTATTGATTCCGGTCACCGAAGTGCAAGTGCGGGCTTCATCCGCTAAGGACATGGACAGTCACTTCCTCTGGGAGCTCATTCATCTCCGCAGCCAGCTCCAACGGCGCTCTGAGAAAGTCTACGTCCTCTCGAACAGCACTGCCGACTTCCGCAACGCCTTCTTGAAGACGATCCGTCAGATCATCCGCGAGTCGGTGCGCAACATGTCGCTGCCGAGCGCTCGGCCCGCGCCGCTCCCCCCGCGCGCCCCGCACACCCTCGACCGCCCCAAGCACCAGGTGCATGTGATGCAGGGATCCCAAACTCTTGGTAAAACGAAGAAACCAAAAACCACCGGCCAACGTCTCTCGGCTGGAAACATCGAAGTTGGAAACATATCTCGTGAGAATTCCCAGGATGCAGAAGAAACCCAAGACTCTGGCCCCGAAGAACCCTTCAGGCAGCGAAGTAAAACCATAGGCGATGTTGTGGAGAACGGAGGCAAGCGCGTGGCGTCGTCGGCCGCCGCGCCGGTGGAGTCCGACAAGGAGCCGGCGGGGTCGCGCTCCGAGGGCGAGGACGAACCCCCGCCGCCTCCCGTCAAACGCAGCCTAGGACGAACCCCCAACCATCTCACGCTAAGCACGACATCGACTCTGAGCGCTGGAAGTACAGGCAGCCAGGCCAGACTCATCCAGTCCTCCCACCAGCCGACCCATTACCAACCCGTCATGGTCAAGGAGCTAGGTAAGCAAGAATCTCTTTCGTTGAAGTCTTCGCCCGAGAAGAAATCATCCGAAAAGAAGATAAAAGTGATCCGATCGTGCAGCGGCAGCAGCATTAACAGAGACAGATCCCCGAACCGCTCTCTCGACCGCGCCTCCCCGGACCGCGACCGCGTAACGAAGGTTATCGTGTGCAAATCTCCGAATAAATCTAGCCTAAAACAAACTAAAACGCTACACCGATCTCCCCGTGGGAGCTTCGACCAGTCCAGATCTCCCCGAGGCTCCATCGACAAGTCCAAGTCACCGCAGCAAAGCTTCGACGGCTCCAGGTCCCCGCGCGGTAGCATCATGAAGTCCCGCGAGAACAGCGTTGATAGATCTCGCTCCCCCAAGCCGGCCCCCAAGAAGGGCATAATGCGCACACCGCAGGCCAGCTTCGATAGGTCCCCCTGCAAGTCGCCGGGCGCGAGCCGCCGCTCGTCTAAGTCCGGCGGCGAGAAGCTGGCGCGTCTGGGAACCAACTCGCTCGACAGAGCGACGCACTACTCGCAACTCGCGAAGGTCGAAGATAAAGCGATGAAAATGGGCATCGTGGTGTCGAAGTCTACAGAGTCCATCGCCAAGGCGATCGAGCACACGACCTGCGTGCAGTGCTACCTCTCTGGGAAAAGGCAGAGTAAAAGTTCCTAG

Protein

MVETHRAPPPRCARAPESRVKPASASAPPSLAGSGTMMHLRRRRHKTVHFGENLLMQVCADRAHLAALGARIPDISFCHKARTGLRQGDARFCCVAHHCCLAAGELVALTSNGRPKPRRERSADSHSSGGEAAEGSRGESSSGSANKEPKRKSKHHHHHHHHHHKIHSCPYHDAVPPPEDEPDEKAIIPKKTVSPYLYIPSKLEPNVQQLFSFIESVLSAWAAEEGLTSTGEYSEPDERIVRRRKLIKYKKRTDILNIRRIVYDVSILRGTKLLGNVRYRHYHWKGTAQSCNETFLRKISDDDRMSLTTAVSDEEDPGESAMNSPYKGKQTGAAAASFNCTGAVRKAGFLSVKKWLLRKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIPEHPKRDYIFCLSTAFGDAYLFQAPCQIELENWVNSIHSACAAAFARHRGKTGTLHLLQEEIYRLEKAIESDHKLKHMADLQQSVVSDPETRDQLAAQMLQWDENLERLHCEQFRLRCYMASLQSGELPNPKSLLTHVSRGTKSTLNKLGVFTVSSFHAFICARSPSLLNNLLAGRGATKRRPPNLSRSNSASSRRSMQMSREDGEAAVRVSLPEGTTATVGVREGMSVEEFLAAACVRRSLNPLEHFVRVKKRRDMEDHNYFVPHRSDLIETYLHTHEVVEVCAKILYQVELQRNTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMQNGIIKGDEIMVINGAIVSDLDMMYLESVLQEELSLVMMMRSSRTEPPEVSGVLRGATDDIIDSLVCPPPPTDPPVISDDMISGLIVPAPAWSKELYSPEAEAHGGDSVNTGPPKVSSRTNSFEIENLLKSAEQVTGWCRSPAETRRGSPTGSVASAAAGTPSRHLSDADKLRKVLLEVVDTERAYVKHLNNLLENYLEPLKKETFLSNAEINALFGNIQEIVTFQRQFLQNLEEALEAEPNFNHFEFSNQFKNVLFAVGNAFLYYVNHFKLYSSFCASHSKAQKVLHPNEGNQALQEFLSARNPKQQHSSTLESYLIKPIQRILKYPLLLQQLRNLTDVNSEEHLHLVESLKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGGVEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNNSNEVEIIRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAFLKTIRQIIRESVRNMSLPSARPAPLPPRAPHTLDRPKHQVHVMQGSQTLGKTKKPKTTGQRLSAGNIEVGNISRENSQDAEETQDSGPEEPFRQRSKTIGDVVENGGKRVASSAAAPVESDKEPAGSRSEGEDEPPPPPVKRSLGRTPNHLTLSTTSTLSAGSTGSQARLIQSSHQPTHYQPVMVKELGKQESLSLKSSPEKKSSEKKIKVIRSCSGSSINRDRSPNRSLDRASPDRDRVTKVIVCKSPNKSSLKQTKTLHRSPRGSFDQSRSPRGSIDKSKSPQQSFDGSRSPRGSIMKSRENSVDRSRSPKPAPKKGIMRTPQASFDRSPCKSPGASRRSSKSGGEKLARLGTNSLDRATHYSQLAKVEDKAMKMGIVVSKSTESIAKAIEHTTCVQCYLSGKRQSKSS

Description

Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons (PubMed:8999801). May play a role in maintaining proper septate junction functions. Required for eye development and most likely affects corneal lens-formation (PubMed:30290152).

Keywords

Alternative splicing   Cell junction   Complete proteome   Developmental protein   Guanine-nucleotide releasing factor   Reference proteome   Repeat   Synapse  

Feature

chain  Protein still life, isoforms C/SIF type 2
splice variant  In isoform SIF type 2.

Uniprot

A0A2H1V0M9   H9IT00   A0A212F9H4   A0A194PX05   A0A194R1K3   A7UUF2   + More
A7UUF1   A0A2C9H5S5   A0A1J1J3Q4   A0A182IRI1   Q17DC1   A0A1A9XSE8   Q17DC2   A0A1I8P3T5   A0A0L0BW86   A0A1I8P3T1   A0A1A9W4U6   A0A1Y1MYC9   A8JNL5   P91620   A0A182MWA4   A0A1Y1MYD8   A0A182PAU0   A0A182QZ20   A0A182X4G8   A0A182G268   A0A182Y2L8   W8B858   Q7PI66   A0A182FEX4   Q7PNS8   A0A182G2Q4   A0A182TLI9   A0A182K6X6   B0X8E7   A0A182LKG1   A0A182RDJ0   A0A182I4G5   A0A182WBS6   A0A2M4CG31   P91620-1   A0A182NIS4   W5J963   V9I7L8   A0A1A9Z971   A0A0K8TXH3   A0A0K8WJB7   A0A0K8UKF1   E2ARF0   V9I7L3   A0A154PP40   F4WWJ0   A0A026WQR1   V9I671   A0A195BRS1   A0A195D6H1   A0A2A3EQP6   V9I687   V9I787   A0A146LMI1   A0A151WFR5   A0A158NB64   A0A3L8DPB8   M9PBR2   A0A195EVY5   A0A232FKY6   A0A3B0J9C9   A0A0Q5U3V9   A0A0C9Q506   B4MLS7   K7J473   A0A0M9A2L6  

Pubmed

19121390    22118469    26354079    12364791    14747013    17210077    + More
17510324    26108605    28004739    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    8999801    9072802    12537569    30290152    26483478    25244985    24495485    20966253    20920257    23761445    20798317    21719571    24508170    26823975    21347285    30249741    28648823    17994087    20075255   

EMBL

ODYU01000107    SOQ34316.1    BABH01013114    BABH01013115    BABH01013116    AGBW02009593    + More
OWR50370.1    KQ459586    KPI97886.1    KQ460883    KPJ11399.1    AAAB01008960    EDO63930.1    EDO63929.1    CVRI01000067    CRL06594.1    CH477297    EAT44368.1    EAT44369.1    JRES01001347    KNC23494.1    GEZM01017427    JAV90691.1    AE014296    ABW08472.3    D86546    AY118305    AXCM01002879    GEZM01017426    JAV90692.1    AXCN02000421    JXUM01039235    JXUM01039236    JXUM01039237    JXUM01039238    KQ561195    KXJ79397.1    GAMC01011738    JAB94817.1    EAA44262.4    EAA11675.5    JXUM01039934    JXUM01039935    KQ561224    KXJ79303.1    DS232486    EDS42483.1    APCN01002309    GGFL01000129    MBW64307.1    ADMH02001913    ETN60526.1    JR035364    AEY56354.1    GDHF01033564    JAI18750.1    GDHF01001145    JAI51169.1    GDHF01025150    JAI27164.1    GL442063    EFN63959.1    JR035359    AEY56349.1    KQ435007    KZC13633.1    GL888408    EGI61421.1    KK107128    EZA58283.1    JR035358    AEY56348.1    KQ976417    KYM89727.1    KQ976760    KYN08495.1    KZ288193    PBC34058.1    JR035360    AEY56350.1    JR035361    AEY56351.1    GDHC01010030    JAQ08599.1    KQ983206    KYQ46680.1    ADTU01010969    ADTU01010970    ADTU01010971    ADTU01010972    ADTU01010973    ADTU01010974    ADTU01010975    QOIP01000006    RLU22136.1    AGB94142.1    KQ981953    KYN32398.1    NNAY01000080    OXU31169.1    OUUW01000002    SPP76953.1    CH954178    KQS43653.1    GBYB01009153    JAG78920.1    CH963847    EDW73003.2    AAZX01003258    AAZX01013537    AAZX01014402    AAZX01016802    KQ435783    KOX74663.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000007062    UP000075903    + More
UP000183832    UP000075880    UP000008820    UP000092443    UP000095300    UP000037069    UP000091820    UP000000803    UP000075883    UP000075885    UP000075886    UP000076407    UP000069940    UP000249989    UP000076408    UP000069272    UP000075902    UP000075881    UP000002320    UP000075882    UP000075900    UP000075840    UP000075920    UP000075884    UP000000673    UP000092445    UP000000311    UP000076502    UP000007755    UP000053097    UP000078540    UP000078542    UP000242457    UP000075809    UP000005205    UP000279307    UP000078541    UP000215335    UP000268350    UP000008711    UP000007798    UP000002358    UP000053105   

PRIDE

H9IT00    A8JNL5    P91620    M9PBR2   

Pfam

PF00169   PH        + More
PF18385   Tiam_CC_Ex
PF00621   RhoGEF
PF02196   RBD

Interpro

IPR001331   GDS_CDC24_CS        + More
IPR001478   PDZ       
IPR011993   PH-like_dom_sf       
IPR036034   PDZ_sf       
IPR000219   DH-domain       
IPR001849   PH_domain       
IPR003116   RBD_dom       
IPR035899   DBL_dom_sf       
IPR040655   TIAM1_CC-Ex       
IPR000697   WH1/EVH1_dom       

SUPFAM

SSF50156   SSF50156        + More
SSF48065   SSF48065       

Gene 3D

1.20.900.10     2.30.29.30    

CDD

cd00160  RhoGEF

ProteinModelPortal

A0A2H1V0M9   H9IT00   A0A212F9H4   A0A194PX05   A0A194R1K3   A7UUF2   + More
A7UUF1   A0A2C9H5S5   A0A1J1J3Q4   A0A182IRI1   Q17DC1   A0A1A9XSE8   Q17DC2   A0A1I8P3T5   A0A0L0BW86   A0A1I8P3T1   A0A1A9W4U6   A0A1Y1MYC9   A8JNL5   P91620   A0A182MWA4   A0A1Y1MYD8   A0A182PAU0   A0A182QZ20   A0A182X4G8   A0A182G268   A0A182Y2L8   W8B858   Q7PI66   A0A182FEX4   Q7PNS8   A0A182G2Q4   A0A182TLI9   A0A182K6X6   B0X8E7   A0A182LKG1   A0A182RDJ0   A0A182I4G5   A0A182WBS6   A0A2M4CG31   P91620-1   A0A182NIS4   W5J963   V9I7L8   A0A1A9Z971   A0A0K8TXH3   A0A0K8WJB7   A0A0K8UKF1   E2ARF0   V9I7L3   A0A154PP40   F4WWJ0   A0A026WQR1   V9I671   A0A195BRS1   A0A195D6H1   A0A2A3EQP6   V9I687   V9I787   A0A146LMI1   A0A151WFR5   A0A158NB64   A0A3L8DPB8   M9PBR2   A0A195EVY5   A0A232FKY6   A0A3B0J9C9   A0A0Q5U3V9   A0A0C9Q506   B4MLS7   K7J473   A0A0M9A2L6  

PDB

1FOE     E-value=1.01576e-90,     Score=856

KEGG

101739475    K05731 T-lymphoma invasion and metastasis-inducing protein 1 | (RefSeq) protein still life, isoform

GO

GO:0035023   GO:0005089   GO:0035556   GO:0007165   GO:0045202   GO:0030054   GO:0030036   GO:0050770   GO:0043087   GO:0051491   GO:0030676   GO:0050803   GO:0005085   GO:0005515   GO:0005057   GO:0008237   GO:0008152   GO:0016491   GO:0015930  

Subcellular location

   Localizes to the submembranous region of synaptic terminals.   With evidence from 6 publications.

Length:

1678

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02888

Exp number, first 60 AAs:

0.0045

Total prob of N-in:

0.00083

outside

1  -  1678

 

 

Pi

224.85487

Theta

182.608971

Tajima's D

0.724906

CLR

0.280871

CSRT

0.575171241437928

Interpretation

Uncertain